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Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer
Young, Jonathan H.,Peyton, Michael,Seok Kim, Hyun,McMillan, Elizabeth,Minna, John D.,White, Michael A.,Marcotte, Edward M. Oxford University Press 2016 Bioinformatics Vol.32 No.9
<P><B>Motivation:</B> Novel approaches are needed for discovery of targeted therapies for non-small-cell lung cancer (NSCLC) that are specific to certain patients. Whole genome RNAi screening of lung cancer cell lines provides an ideal source for determining candidate drug targets.</P><P><B>Results:</B> Unsupervised learning algorithms uncovered patterns of differential vulnerability across lung cancer cell lines to loss of functionally related genes. Such genetic vulnerabilities represent candidate targets for therapy and are found to be involved in splicing, translation and protein folding. In particular, many NSCLC cell lines were especially sensitive to the loss of components of the LSm2-8 protein complex or the CCT/TRiC chaperonin. Different vulnerabilities were also found for different cell line subgroups. Furthermore, the predicted vulnerability of a single adenocarcinoma cell line to loss of the Wnt pathway was experimentally validated with screening of small-molecule Wnt inhibitors against an extensive cell line panel.</P><P><B>Availability and implementation:</B> The clustering algorithm is implemented in Python and is freely available at https://bitbucket.org/youngjh/nsclc_paper.</P><P><B>Contact:</B>marcotte@icmb.utexas.edu or jon.young@utexas.edu</P><P><B>Supplementary information:</B>Supplementary data are available at <I>Bioinformatics</I> online.</P>
Comparative serology of human brucellosis in Korea
Lee, Sung-Il,Choi, Min-Jung,Hur, Jin,Islam, Md Ariful,Khatun, Mst Minara,Baek, Byeong-Kirl,Lee, Chang-Seup,Kakoma, Ibulaimu,Bolye, Stephen M,Srirangananathan, Nammalwar,Young, Edward John The Korean Society of Veterinary Service 2008 韓國家畜衛生學會誌 Vol.31 No.3
The study was carried out to evaluate the diagnostic efficacy of the tube agglutination test (TAT), enzyme-linked immunosorbent assay (ELISA) and the 2-Mercaptoethanol agglutination test (2-MAT) to detect human brucellosis patients in Korea. We examined 87 serum samples of people in the rural farm areas where bovine brucellosis had been reported. People in this study were divided into seven groups- farmers and their families, veterinarians, veterinary quarantine workers, livestock health control officers, artificial inseminators, livestock traders and healthy control individuals. Among 87 people, 65 were males and 22 were females ranging in age from 13 to 72 years. Of 87 serum samples, ELISA detected 21.84%, TAT detected 11.50% and 2-MAT detected 8.05% Brucella positive sera. Brucella specific IgG ELISA antibody titer was recorder higher in the individuals between the ages of 50 and 65 years. The highest prevalence rate of brucellosis(29.4%) was recorded in the cattle farmers and their family members followed by quarantine veterinary office workers (25%) and practicing veterinarians 01.1%). The majority of the Brucella sero-positive individuals in this study had a history of direct contact with animals.