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Satoh, Hiroyasu,Tohno, Setsuko,Minami, Takeshi,Oishi, Takao,Hayashi, Motoharu,Tohno, Yoshiyuki The Korean Society of Pharmacology 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.5
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were $-0.178{\pm}0.081$ (p<0.05) and $-0.088{\pm}0.022$ (p<0.05) in male (n=30), and $-0.095{\pm}0.026$ (p<0.05) and $-0.069{\pm}0.017$ (p<0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p<0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.
Hiroyasu Satoh,Setsuko Tohno,Takeshi Minami,Takao Oishi,Motoharu Hayashi,Yoshiyuki Tohno 대한약리학회 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.5
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were −0.178±0.081 (p< 0.05) and −0.088±0.022 (p< 0.05) in male (n=30), and −0.095±0.026 (p< 0.05) and −0.069±0.017 (p<0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca,Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p<0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.
Lee, Sueun,Saito, Kyohei,Lee, Hye-Ra,Lee, Min Jae,Shibasaki, Yuji,Oishi, Yoshiyuki,Kim, Byeong-Su American ChemicalSociety 2012 Biomacromolecules Vol.13 No.4
<P>We report the synthesis of a well-defined hyperbrancheddoublehydrophilic block copolymer of poly(ethylene oxide)-<I>hyperbranched</I>-polyglycerol (PEO-<I>hb</I>-PG) to develop an efficientdrug delivery system. In specific, we demonstrate the hyperbranchedPEO-<I>hb</I>-PG can form a self-assembled micellar structureon conjugation with the hydrophobic anticancer agent doxorubicin,which is linked to the polymer by pH-sensitive hydrazone bonds, resultingin a pH-responsive controlled release of doxorubicin. Dynamic lightscattering, atomic force microscopy, and transmission electron microscopydemonstrated successful formation of the spherical core–shelltype micelles with an average size of about 200 nm. Moreover, thepH-responsive release of doxorubicin and in vitro cytotoxicity studiesrevealed the controlled stimuli-responsive drug delivery system desirablefor enhanced efficiency. Benefiting from many desirable features ofhyperbranched double hydrophilic block copolymers such as enhancedbiocompatibility, increased water solubility, and drug loading efficiencyas well as improved clearance of the polymer after drug release, webelieve that double hydrophilic block copolymer will provide a versatileplatform to develop excellent drug delivery systems for effectivetreatment of cancer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2012/bomaf6.2012.13.issue-4/bm300151m/production/images/medium/bm-2012-00151m_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm300151m'>ACS Electronic Supporting Info</A></P>
Oikawa, Yurie,Lee, Sueun,Kim, Do Hyung,Kang, Dae Hwan,Kim, Byeong-Su,Saito, Kyohei,Sasaki, Shigeko,Oishi, Yoshiyuki,Shibasaki, Yuji American Chemical Society 2013 Biomacromolecules Vol.14 No.7
<P>This paper describes the one-pot synthesis of a polyglycidol (PG)-based polymer, poly(ethoxyethyl glycidyl ether) (PEEGE)-<I>b</I>-[<I>hyperbranched</I> polyglycerol (<I>hb</I>PG)-<I>co</I>-PEEGE]<SUB><I>x</I>/<I>y</I></SUB>, its micelle formulation, and the ability to encapsulate a model therapeutic molecule. Amphiphilic block copolymers were prepared by the sequential addition of ethoxyethyl glycidyl ether (EEGE) to glycidol. The composition of the block copolymers varied from 62:38 to 92:8. Block copolymers with composition <I>x</I>:<I>y</I> ≥ 66:34 were soluble only in organic solvents. Micelles were formulated by injection of deionized water into a tetrahydrofuran block copolymer solution with or without pyrene as a model hydrophobic molecule. The critical micelle concentration was 18.2–30.9 mg/L, and the micelle size was 100–250 nm. The pyrene-containing micelle rapidly collapsed on acidic exposure, allowing conversion of hydrophobic PEEGE to hydrophilic PG, thus, facilitating the release of the encapsulated pyrene. Cytotoxicity data showed high biocompatibility of PG-based block copolymers, suggesting their potential as a drug delivery carrier.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2013/bomaf6.2013.14.issue-7/bm400275w/production/images/medium/bm-2013-00275w_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm400275w'>ACS Electronic Supporting Info</A></P>