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Haeun CHO,Geonhee HAN,Kwang Yeon HWANG,Sun Hwa KIM,Yooso YANG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Exosomes are a type of extracellular vesicles with a diameter of 30 to 150 ㎚, and are secreted by multiple cell types. Exosomes can mediate cell-to-cell communication and modulate many physiological and pathological processes by carrying biomolecules such as nucleic acids, proteins and metabolites. In particular, bovine milk is a readily accessible source for mass production of exosome, and milk-exosomes can effectively deliver inflammatory and immunomodulatory active cargo through the gastrointestinal tract in a stable form. Here, we investigated the beneficial effects of bovine milk, especially colostrum-derived exosomes in a murine model of ulcerative colitis induced by dextran sodium sulfate (DSS). Our results showed that oral gavage of colostrum-derived exosomes can alleviate colitis symptoms such as abdominal pain, loss weight, diarrhea and rectal bleeding by regulating intestinal inflammatory immune responses. Collectively, our findings that bovine colostrum-derived exosomes with excellent structural and functional stability offer great potential as natural therapeutics for the recovery of colitis, may broaden the applications of milk consumption.