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A case of halo nevus on the scalp
( Hwa Jung Yook ),( Ji Hee Jung ),( Ju Hee Han ),( Jun Young Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
A 17-year old women presented with a 0.5 cm-sized, flesh-colored patch surrounded by a 1.2 cm-sized depigmented halo with white hairs gradually increasing since the last 1 month on the vertex region of scalp. On physical examination, a sharply demarcated halo of depigmentation with poliosis was seen on the vertex area and no lesions were found in other parts of the body except scalp area. The patient had no history of underlying disease. A punch biopsy on the scalp was performed. Histopathology revealed decreased number of melanocytes with sparse superficial perivascular lymphocytic infiltrate and that from the pigmented center showed multiple nests of melanocytes both within the epidermis and dermis. In immunohistochemistry staining of CD68 was was negative and Melan-A showed positive result. Based on these clinical and histological findings, the patient was diagnosed with halo nevus and the patient has been treated with 308-nm excimer laser. Halo nevus commonly occurs over the back and may affect adults or children. Halo nevus is rarely reported to occur over scalp with poliosis. Poliosis is known to occur with a giant congenital melanocytic nevus, blue nevus, nevus depigmentosus, and halo nevus. To date, there have been two reports of halo nevus with polilosis on scalp in the literature. Herein, we report a case of halo nevus on the scalp.
( Hwa Jung Yook ),( Yeong Ho Kim ),( Ju Hee Han ),( Chul Hwan Bang ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2022 대한피부과학회지 Vol.60 No.1
Background: Dermatofibromas (DF) are fibrohistiocytic tumors of unknown etiology, and multiple DF (MDF) are relatively rare. MDF have been reported in the setting of autoimmune diseases, human immunodeficiency virus infection, or comorbidities treated with immunosuppressive drugs. Objective: The present study investigated whether underlying conditions with impaired immune function are associated with MDF. Methods: A total of 338 patients with DF was enrolled. We divided patients into two groups as MDF and solitary DF (SDF) groups. We retrospectively reviewed patient medical records and classified all patients by underlying diseases. Statistical significance of SDF and MDF for each conditions was analyzed. Results: The demographics and comorbidities were compared between MDF group (n=82) and SDF group (n=256). Among underlying conditions, systemic lupus erythematosus (SLE) (odds ratio, 10.397; 95% confidence interval, 2.743∼39.404; p<0.001) was significantly associated with MDF over SDF. Vitiligo and post status of kidney transplant were related more highly to MDF (p=0.014; p=0.014, respectively) than to SDF. Presence of overall comorbidities, autoimmune diseases, and immunosuppressive drug use were associated with DF number (p<0.001; p<0.001; p<0.001, respectively). Conclusion: We propose an association between MDF and comorbidities, especially SLE and immunosuppressant use. MDF lesions seem to be impacted by compromised immune function. This is of significance since it is essential to search for associated conditions in patients presenting with MDF in dermatologic clinical settings. (Korean J Dermatol 2022;60(1):25∼34)
( Hwa Jung Yook ),( Woo Hyup Lee ),( Joon Ho Son ),( Ju Hee Han ),( Ji Hyun Lee ),( Jun Young Lee ),( Young Min Park ),( Chul Hwan Bang ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Ultrasonographic imaging is an efficient tool for diagnosing subcutaneous mass without invasive procedure. However, there are few studies which applied deep neural network to skin ultrasound images. Objectives: The aim of this study was to evaluate the accuracy of deep neural network in diagnosing epidermal cyst, lipoma and other subcutaneous masses. Methods: We created a dataset of 1317 skin ultrasound images from 198 patients who diagnosed as epidermal cyst, lipoma and the others for learning deep neural network. Performance was evaluated using another set of 95 images (26 ultrasound images of epidermal cysts, 27 of lipoma and 44 of the others) from published articles. Results: The overall accuracy of deep neural network was 86.3%. The accuracy in diagnosis of epidermal cyst, lipoma and the others were 95.83%, 66.67% and 95.35%, respectively. As a result of analysis with GradCam, the deep neural network detected posterior enhancement, hypoechoic feature, and well-defined margin in epidermal cyst. Conclusion: We showed that deep neural network combined with ultrasound might be helpful for clinicians diagnosing subcutaneous masses.
Multiple dermatofibroma associated with autoimmune diseases and immunosuppressive drugs
( Hwa Jung Yook ),( Yeong Ho Kim ),( Ju Hee Han ),( Chul Hwan Bang ),( Ji Hyun Lee ),( Young Min Park ),( Jun Young Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Dermatofibromas are hyperpigmented, benign, firm dermal nodules usually on lower limbs. Multiple dermatofibromas (MDF) have been previously reported in patients with autoimmune diseases such as systemic lupus erythematosus (SLE), immunodeficient condition like HIV infection or under immunosuppressive agents. Objectives: The aim of this study was to analyze the statistical association between MDF and autoimmune diseases or immunosuppressive agents previously mentioned to be related to MDF. Methods: We performed a retrospective study of 338 patients from January 1, 2015, to June 30, 2020, with biopsy-proven dermatofibroma at a single-center, tertiary care hospital in Korea. Basic demographic data, past medical history, and clinical data regarding the number and location were assesed. We performed fisher’s exact test by SPSS. Results: We divided 338 patients into two groups; patients with solitary dermatofibroma (n=256) and patients with MDF (n=82). The odd ratio (OR) of SLE and post renal transplantation (PSKT) associated with MDF group were 5.42 and 9.68, respectively (p value<0.005). Patients under immunosuppressive drugs showed higher association with MDF than SDF (p value<0.001). The most frequent location of dermatofibroma was lower leg (24.3%), followed by thigh (20.1%). Conclusion: We found that patients with SLE, PSKT and using immunosuppressive drugs had a tendency to present MDF.
A case of primary cutaneous plasmacytosis
( Hwa Jung Yook ),( Eun Sun Hong ),( Ju Hee Han ),( Ji Hyun Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
A 37-year old woman presented with pruritic, erythematous to brown patches on abdomen for 4 years. She denied fevers, chills, weight loss, lymphadenopathy and abdominal pain. The patient had no history of underlying disease. The patient had been treated with steroid lotions for 1 month previously, but the lesions got worse. A punch biopsy specimen showed reactive perivascular infiltration of marked hyperchromatic mononuclear cells consistent with plasma cell without atypia. Immunohistochemistry showed CD20 reactive in B cells, CD79A+, CD3-. Kappa and lambda in situ hybridization was positive in plasma cells. Serum protein electrophoresis showed normal pattern. Based on these clinical, histological and laboratory findings, the patient was diagnosed with cutaneous plasmacytosis (CP). The patient was lost to follow-up. CP is a rare skin disorder characterized by multiple reddish brown nodules with polyclonal plasma cell proliferation. It has most been reported to affect the trunk in adults and is predominantly seen in Asians. CP should be differentiated from primary cutaneous plasmacytoma characterized by large infiltrate of monoclonal plasma cells with CD79+, CD19, CD20-. Topical or oral corticosteroid therapy, intralesional corticosteroid, PUVA therapy, NBUVB and PDT can be used for treating CP but there is no consensus on treatment methods. Herein, we report a case of primary CP.
Leukemia cutis: clinical features and outcome of 55 patients
( Hwa Jung Yook ),( Joon Ho Son ),( Ju Hee Han ),( Ji Hyun Lee ),( Jun Young Lee ),( Young Min Park ),( Chul Hwan Bang ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Leukemia cutis (LC) is a skin manifestation of systemic leukemia. The presence of LC is usually considered to indicate a poor prognosis. Objectives: We analyzed the clinical features and prognosis of LC in Korea and to compare findings with previous studies. Methods: We enrolled 55 patients with LC from 2011 to 2019 in Seoul St. Mary’s Hospital. We evaluated the clinical features of LC and distribution according to the type of leukemia. We also investigated survival period of the patients with LC. Results: The ratio of male to female was 1.9:1. The mean age at diagnosis was 45.3 ± 17.7 year. Acute myelocytic leukemia consisted the largest group of 40 (73%) patients, and acute lymphocytic leukemia, chronic myelocytic leukemia, chronic lymphocytic leukemia and myelodysplastic syndrome group included 8 (15%), 2 (4%), 2 (4%), 3 (5%) patients, respectively. The most common feature of cutaneous lesions were plaques (28%). The most affected site was trunk (35%), followed by extremities (28%). The mean survival period of LC was 5.4 months, which was consistent with the results of previous studies as less than 1 year. Conclusion: LC implies poorer prognosis and leukemia relapse. It is important to detect an extramedullary involvement of leukemia and predict the disease progression considering types of leukemia.
A case of blastic plasmacytoid dendritic cell neoplasm
( Hwa Jung Yook ),( Ji Hee Jung ),( Ju Hee Han ),( Jun Young Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
A 76-year-old man presented with an asymptomatic, solitary, 1.5 cm-sized, erythematous nodule on the upper trunk for a month. The lesion increased in size over time. The patient had been diagnosed with hypertension and trigeminal neuralgia. However, he had no history of any hematologic disease. Skin biopsy showed diffuse monomorphous infiltrates of small round cells separated by a grenz zone from the epidermis. In immunohistochemistry staining of CD4, CD56, CD123 showed positive results, while CD3 showed negative result. It was diagnosed as Blastic plasmacytoid dendritic cell neoplasm (BPDCN) and the patient was transferred to hematology. He took bone marrow biopsy and Positron Emission Tomography - Computed Tomography (PET-CT). Bone marrow biopsy and PET-CT was negative for distant metastasis and he took Intensity-modulated radiotherapy. BPDCN was defined in the 2008 World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissue as a malignant proliferation of blastic plasmacytoid dendritic cells. Initially, it was described in 1990’s as agranular CD4+ natural killer cell leukemia due to its unique agranular morphology and phenotype (CD4+, CD56+, CD15+ and CD3-). BPDCN is highly malignant, with a mean survival time of 15.2 months. But, data are limited concerning patients with localized skin-limited BPDCN. Herein, we report a rare case of blastic plasmacytoid dendritic cell neoplasm.