痲疹篇 저자와 저술 시기에 대한 고찰

유철호(Chul-Ho Yoo),김남일(Nam-Il Kim) 한국의사학회 2012 한국의사학회지 Vol.25 No.2

A thesis insisting that Sugjong’s medical doctor Yoo Itae(劉以泰) and the author of Marjinpyeon Yoo Itae(劉爾泰) are not a same person and his activities were in Heonjong(현종) period, and his writing Marjinpyeon is in 1846, is published. In this study, I’d like to reveal that Yoo Itae(劉爾泰), the Marjinpyeon’s author and Yoo Itae(劉以泰), Sugjong’s medical doctor are a same person through analysis of Geochang Yoo’s genealogy, articles, The True Record of the Joseon Dynasty, Seungjeonilgi, Taeweonseonsaengan, Sancheong-gun’s paper, Sancheong Hyanggyo’s paper, Sancheong-gun’s paper, The geographic paper, Dongyuhagan, Sawoo Munjib, and analysis of folk story, the wrote year of his Marjinpyeon and Inseomunkyunrok and his birth year. According to my analysis, Yoo Itae(劉爾泰) the Maninpyeon’s author and Yoo Itae(劉以泰), Sugjong’s medical doctor are a same person. And Marjinpyeon is written in 1696, the year of Byongja, and other his books, InseoMungyonlok at 1709, the year of Gichug. In conclusion, Yoo Itae(劉以泰劉爾泰) was a famous medical doctor at Sancheong, born in 1652 (HyoJong the 3rd year) and passed in 1715 (SugJong the 41th year), left books of Marjinpyeon, Silheomdanbang, and Inseomunkyunrok.

Ethanol Extract of Ganoderma lucidum Augments Cellular Anti-oxidant Defense through Activation of Nrf2/HO-1

Lee, Yoo-hwan,Kim, Jung-hee,Song, Choon-ho,Jang, Kyung-jeon,kim, Cheol-hong,Kang, Ji-Sook,Choi, Yung-hyun,Yoon, Hyun-Min KOREAN PHARMACOPUNCTURE INSTITUTE 2016 Journal of pharmacopuncture Vol.19 No.1

Objectives: The mushroom Ganoderma lucidum has been widely used as a traditional herbal medicine for many years. Although several studies have focused on the anti-oxidative activity of this mushroom, the molecular mechanisms underlying its activity have not yet been clearly established. The present study investigated the cytoprotective effect of ethanol extract of Ganoderma lucidum (EGL) against oxidative stress (hydrogen peroxide, $H_2O_2$) and elucidated the underlying mechanisms in a C2C12 myoblast cell line. Methods: Oxidative stress markers were determined by using the comet assay to measure reactive oxygen species (ROS) generation and deoxyribonucleic acid (DNA) damage. Cell viability and Western blotting analyses were employed to evaluate the cellular response to EGL and $H_2O_2$ in C2C12 cells. Transfection with nuclear factor erythroid 2-related factor 2 (Nrf2)-specific small interfering ribonucleic acid (siRNA) was conducted to understand the relationship between Nrf2 expression and $H_2O_2$-induced growth inhibition. Results: The results showed that EGL effectively inhibited $H_2O_2$-induced growth and the generation of ROS. EGL markedly suppressed $H_2O_2$-induced comet-like DNA formation and phosphorylation of histone H2AX at serine 139 ($p-{\gamma}H2AX$), a widely used marker of DNA damage, suggesting that EGL prevented $H_2O_2$-induced DNA damage. Furthermore, the EGL treatment effectively induced the expression of Nrf2, as well as heme oxygenase-1 (HO-1), with parallel phosphorylation and nuclear translocation of Nrf2 in the C2C12 myoblasts. However, zinc protoporphyrin IX, a HO-1 inhibitor, significantly abolished the protective effects of EGL against $H_2O_2$-induced accumulation of ROS and reduced cell growth. Notably, transient transfection with Nrf2-specific siRNA attenuated the cytoprotective effects and HO-1 induction by EGL, indicating that EGL induced the expression of HO-1 in an Nrf2-dependent manner. Conclusion: Collectively, these results demonstrate that EGL augments the cellular anti-oxidant defense capacity through activation of Nrf2/HO-1, thereby protecting C2C12 myoblasts from $H_2O_2$-induced oxidative cytotoxicity.

나라꽃 무궁화 품종중 가로수용, 분화용 및지피용으로 조경적 활용도가 높은 품종 선정

강호철 ( Ho Chul Kang ),김동엽 ( Dong Yeob Kim ),하유미 ( Yoo Mi Ha ) 한국전통조경학회(구 한국정원학회) 2016 한국전통조경학회지 Vol.34 No.2

본 연구는 조경수용 무궁화 우수품종 보급을 위한 유전자원 수집과 특성을 평가하기 위해 최근 국내외에서 육성된 127품종의 1년생접목묘를 이용하여 2014년부터 2015년까지 2년 동안 생육 및 형태적 특성조사를 실시하였다. 수집된 품종 중 키가 큰 가로수 및 독립수용품종, 왜성형 분화 및 지피용 품종 등을 선정하여 무궁화를 조경수로 활용도를 높이는데 기여하고자 하였으며 얻어진 결과는 다음과 같다. 최근 국내외에서 육성된 나라꽃 무궁화 품종들의 생육특성을 조사하기 위해 먼저 접목 1년생 수고를 조사한 결과 20~120cm까지다양하게 나타났다. 무궁화 ``주몽``과 ``홍가로수``, 종간교잡종 Hibiscus hybrid ``Daewangchun``, ``Daeil``, ``Lohengrin``, ``Jina``, ``Yeonam`` 등이 키가 100cm 이상으로 가장 큰 품종으로 조사되었다. 최근 국내외에서 육성된 무궁화 127품종 중 조경적 활용가치가 높은 교목성 가로수로이용할 수 있는 품종은 무궁화 ``주몽``과 ``홍가로수``, 종간교잡종 Hibiscus hybrid ``Daewangchun``, Hibiscus hybrid ``Daeil``, Hibiscus hybrid ``Lohengrin``, Hibiscus hybrid ``Jina``, Hibiscus hybrid ``Yeonam`` 등이 있었다. 분화 및 분재용으로 이용할 수 있는 왜성형 품종으로는 ``Red Heart``, ``백령도``, 종간교잡종 ``진선``, ``꼬마``, ``여천``, ``야음`` 등이 있었으며, 키가 30cm 미만의 아주 작은 품종으로는 ``안동``, ``청조``, ``Lil Kim`` 등이 포함되었다. 수고가 작은 왜성형으로 가지의 생장이 아래로 향하는 ``탐라``, ``Melrose``, ``비단``, ``하이리``, ``별이``, ``병화``, ``미백``, ``한양``, ``청암``, ``Lil Kim Violet``, ``종무``, ``은하수``, 종간교잡종 Hibiscus hybrid ``Saehanseo``와 Hibiscus hybrid ``Yousoon``은 화단 및 지피용소재로 이용가치가 높았다. This study was carried out to characterize 127 recently developed cultivars of Rose of Sharon (Hibiscus spp.) in Korea and foreign Countries for landscape uses. The examined factors were growth characteristics such as tree height of a 1-year grafted plant(cm), plant type, growth habit, leaf characteristics such as shape and size, flower characteristics such as color, shape, size, and red eye during 2014 and 2015 for landscape uses. The results are obtained as follows; Hibiscus hybrid ``Daewangchun``, ``Daeil``, ``Lohengrin``, ``Yeonam``, ``Joomong``, ``Jina``, and H. syriacus ``Honggarosu`` had vigorous shoot growth and tall tree size of 100cm. New Hibiscus cultivars, Hibiscus hybrid ``Daewangchun`` and ``Daeil``, having vigorous growth, uniform plant habit, upright, and compact branches were developed through interspecific crosses between H. syriacus ``Samchully`` (♀) and H. sinosyriacus ``Seobong`` (♂). This newly developed cultivar ``Daewangchun``, ``Daeil``, ``Lohengrin``, ``Yeonam``, ``Joomong``, ``Jina``, and H. syriacus ``Honggarosu`` having tall vigorous growth d unique flower with long red eye can be used as street tree or specimen plant in landscape. Otherwise, H. syriacus ``Tamla``, ``Melrose``, ``Bidan``, ``Hi Lea``, ``Byeollee``, ``Byunghwa``, ``Mibak``, ``Hanyang``, ``Chungam``, ``Lil Kim Violet``, ``Jongmoo``, ``Eunhasu``, Hibiscus hybrid ``Saehanseo``, and Hibiscus hybrid ``Yousoon`` were selected as small tree of 30~39cm. They had dwarf form in tree seemed to be suitable for pot or flower bed planting on both indoor and outdoor conditions. H. syriacus ``Antong``, ``Chungjo``, and ``Lil Kim`` were less than 30 cm of tree size. H. syriacus ``Antong``, ``Chungjo``, and ``Lil Kim``, characterized by its compact, upright and outwardly spreading plant habit; freely branching habit; dark green-colored leaves; good garden performance. Therefore, the new cultivars with tall and small tree size were a promising cultivar as a ground covers or pot planting as woody landscape plant.

Gliotoxin ameliorates TNBS-induced colitis through regulation of NF-kB, and up-regulation of HO-1

김상욱 ( Kim Sang Ug ),( Jay Min Oh ),( Yeon Hwa Kim ),( Jung Moo Hur ),( Kyo Sang Yoo ),( Yong Sung Kim ),( Joo Jin Yeom ),( Tae Hyeon Kim ),( Suck Chei Choi ),( Chang Duk Jun ),( Yong Ho Nah ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-

<Background & aims> During inflammation in colon, cells of the gut mucosa produce or express various inflammatory mediators, including IL-8, TNF-a and IL-1b, and intercellular adhesion molecule 1 (ICAM-1). These cytokines and chemokines have recently been

Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

관동맥 우회로술 중 경식도 심초음파도로 관찰한 도부타민 투여후와 우회로술후의 좌심실 국소벽운동

김희열,김종진,윤호중,유기동,박지원,이길환,노태호,채장성,김재형,홍순조,최규보 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.8

Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes

Kim, Se-Jin,Ho Hur, Joon,Park, Channy,Kim, Hyung-Jin,Oh, Gi-Su,Lee, Joon No,Yoo, Su-Jin,Choe, Seong-Kyu,So, Hong-Seob,Lim, David J,Moon, Sung K,Park, Raekil Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.2

<P>Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice. Cisplatin increases the catalytic activity of caspase-3 and caspase-8 proteases and the production of free radicals, which were significantly suppressed by pretreatment with bucillamine. Bucillamine induces the intranuclear translocation of Nrf2 and thereby increases the expression of γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase (GSS), which further induces intracellular antioxidant glutathione (GSH), heme oxygenase 1 (HO-1) and superoxide dismutase 2 (SOD2). However, knockdown studies of HO-1 and SOD2 suggest that the protective effect of bucillamine against cisplatin is independent of the enzymatic activity of HO-1 and SOD. Furthermore, pretreatment with bucillamine protects sensory hair cells on organ of Corti explants from cisplatin-induced cytotoxicity concomitantly with inhibition of caspase-3 activation. The auditory-brainstem-evoked response of cisplatin-injected mice shows marked increases in hearing threshold shifts, which was markedly suppressed by pretreatment with bucillamine <I>in vivo</I>. Taken together, bucillamine protects sensory hair cells from cisplatin through a scavenging effect on itself, as well as the induction of intracellular GSH.</P>

소기업 기업가의 기업가적 자기효능감과 지각된 심각성이 실패에 대한 두려움을 매개로 기업가적 성과에 미치는 영향

유봉호(Yoo, Bong-Ho),김춘광(Kim, Choon-Kwang) 한국경영교육학회 2021 경영교육연구 Vol.36 No.6

[연구목적] 본 연구는 소기업 기업가의 기업가적 자기효능감과 지각된 심각성이 실패에 대한 두려움과 기업가적 성과에 어떤 영향을 미치는 살펴 본 탐색적 · 실증적 성격의 연구이다. [연구방법] 기업가적 자기효능감, 지각된 심각성을 독립변수로 상정하고, 실패에 대한 두려움을 매개로 기업가적 성과에 어떤 영향을 미치는지 확인하였다. 이를 위해, 서울 · 경기 지역 소재 소기업 기업가 총 167명 응답을 취합하여 분석하였다. [연구결과] 기업가적 자기효능감은 기업가적 성과에 직접 영향을 미쳤지만 실패에 대한 두려움에는 유의한 영향을 미치지 않았다. 반대로 지각된 심각성은 기업가적 성과에 직접 영향을 미치지 않으면서 실패에 대한 두려움에 유의한 영향을 미치는 것으로 나타났다. 또한 실패에 대한 두려움은 기업기적 성과에 유의한 영향을 미쳤다. 이로써 실패에 대한 두려움은 지각된 심각성과 기업가적 성과 사이에서 완전매개효과를 갖는 것이 확인되었다. [연구의 시사점] 이는 소기업 기업가의 기업가적 자기효능감과 지각된 심각성이 기업경영에 미치는 영향을 확인했다는 점, 실패에 대한 두려움을 매개로 기업가적 성과에 미치는 영향을 확인했다는 점, 기업 경영의 부정적 요소에 대한 메커니즘을 확인했다는 점 등에서 학술적 · 실무적 의의가 있다고 할 수 있다. [Purpose] This study is an exploratory and empirical study designed to examine how entrepreneurial self-efficacy and perceived severity of entrepreneurs in small enterprises affect the fear of failure and entrepreneurial performance in small businesses. [Methodology] By postulating entrepreneurial self-efficacy and perceived severity as independent variables, this study intended to identify how they affect entrepreneurial performance by the medium of fear of failure. To this end, a total of 167 responses from the survey conducted with entrepreneurs in small enterprises in Seoul and Gyeonggi regions were utilized for the final analysis. [Findings] It was found that entrepreneurial self-efficacy directly influenced entrepreneurial performance but did not significantly affect fear of failure. On the contrary, perceived severity had a significant effect on fear of failure but did not directly affect entrepreneurial performance. What’s more, the fear of failure had a significant effect on entrepreneurial performance. Therefore, it has been confirmed that fear of failure acts as a complete intermediary between perceived severity and entrepreneurial performance. [Implications] This study is of academic and practical significance in that it identifies the impact of entrepreneurial self-efficacy and perceived severity of entrepreneurs in small enterprises on corporate management, the impact on entrepreneurial performance through fear of failure, and the mechanism of negative elements of corporate management.

Antioxidant and hepatoprotective effects of Korean ginseng extract GS-KG9 in a D-galactosamine-induced liver damage animal model

Yun Ho Jo,Hwan Lee,Myeong Hwan Oh,Gyeong Hee Lee,You Jin Lee,Ji Sun Lee,Min Jung Kim,Won Yong Kim,Jin Seong Kim,Dae Seok Yoo,Sang Won Cho,Seon Woo Cha,Mi Kyung Pyo 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.4

BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6 groups. Rats were orally administrated with GS-KG9 (300, 500, or 700 mg/kg) or silymarin (25 mg/kg) for 2 weeks. The rats of the GS-KG9- and silymarin-treated groups and a control group were then intraperitoneally injected Ga1N at a concentration of 650 mg/kg for 4 days. To investigate the protective effect of GS-KG9 against GalN-induced liver injury, blood liver function indicators, anti-oxidative stress indicators, and histopathological features were analyzed. RESULTS: Serum biochemical analysis indicated that GS-KG9 ameliorated the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in GalN-treated rats. The hepatoprotective effects of GS-KG9 involved enhancing components of the hepatic antioxidant defense system, including glutathione, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT). In addition, GS-KG9 treatment inhibited reactive oxygen species (ROS) production induced by GalN treatment in hepatocytes and significantly increased the expression levels of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins, which are antioxidant proteins. In particular, by histological analyses bases on hematoxylin and eosin, Masson"s trichrome, α-smooth muscle actin, and transforming growth factor-β1 staining, we determined that the administration of 500 mg/kg GS-KG9 inhibited hepatic inflammation and fibrosis due to the excessive accumulation of collagen. CONCLUSIONS: These findings demonstrate that GS-KG9 improves GalN-induced liver inflammation, necrosis, and fibrosis by attenuating oxidative stress. Therefore, GS-KG9 may be considered a useful candidate in the development of a natural preventive agent against liver injury.

두개골의 3차원 영상 분석을 위한 전산화단층촬영 방법의 비교 : 상층 두께가 3차원 영상의 계측에 미치는 영향

정호걸,김기덕,박혁,김동욱,정해조,김희중,유선국,김용욱,박창서 대한구강악안면방사선학회 2004 Imaging Science in Dentistry Vol.34 No.3

Purpose : To evaluate the quantitative accuracy of three-dimensional (3D) images by means of comparing distance measurements on the 3D images with direct measurements of dry human skull according to slice thickness and scanning modes. Materials and Mathods : An observer directly measured the distance of 21 line items between 12 orthodontic landmarks on the skull surface using a digital vernier caliper and each was repeated five times. The dry human skull was scanned with a Helical CT with various slice thickness (3, 5, 7 mm) and acquisition modes (Conventional and Helical). The same observer measured corresponding distance of the same items on reconstructed 3D images with the internal program of V-works 4.0 (Cybermed Inc., Seoul, Korea). The quantitative accuracy of distance measurements were statistically evaluated with Wilcoxons’ two-sample test. Results : 11 line items in Conventional 3 mm, 8 in Helical 3mm, 11 in Conventional 5 mm, 10 in Helical 5 mm, 5 in Conventional 7 mm and 9 in Helical 7 mm showed no statistically significant difference. Average difference between direct measurements and measurements on 3D CT images was within 2 mm in 19 line items of Conventional 3 mm, 20 of Helical 3 mm, 15 of Conventional 5 mm, 18 of Helical 5 mm, 11 of Conventional 7mm and 16 of Helical 7 mm. Conclusion : Considering image quality and patient’s exposure time, scanning protocol of Helical 5 mm is recommended for 3D image analysis of the skull in CT.