Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

전,후기 노인의 건강행위, 건강상태와 건강관련 삶의 질

정영해 ( Young Hae Chung ),조유향 ( Yoo Hyang Cho ) 대한보건협회 2014 대한보건연구 Vol.40 No.1

연구목적 : 본 연구는 노년 전기와 후기 노인의 건강행위, 건강상태와 건강관련 삶의 질 수준을 파악하고, 관련요인을 파악 하고자 한 것이다. 연구방법 : 2010년 국민건강영양조사 제5기 1차년도 원자료를 사용하여 65세 이상 노인 1,339명을 대상으로 교육, 경제수준, 운동, 흡연, 음주, 만성질병, 성별, 거주지역, 동거인, 주관적건강상태, BMI 및 EQ-5D를 건강설문-검진조사가중치를 사례 수에 맞추어 활용하였으며 SPSS 20.0을 이용하여 분석하였다. 노년전기군(<75세)과 노년후기군(≥75세)을 카이제곱검정과 t-검정으로 비교하였으며, 후진제거방식 회귀분석으로 두 군의 건강관련 삶의 질 관련요인을 비교하였다. 연구결과 : 여성노인이 58.4%로 많았으며, 교육수준은 초졸 이하가 3/4으로, 노년후기군은 여성노인과 초졸 이하가 더 많았고, 노년전기군에는 중졸, 고졸, 대졸이상 노인과 배우자와 함께하는 비율이 많았다. 흡연율 13.3%, 음주율 46.9%, 운동실천율 47.8%, 만성질환율 80.3%이었는데, 노년전기군의 경우 음주와 운동실천율 및 비만이 높았고, 노년후기군은 저체중, 우울증상, 자살을 생각해본 적과 주관적인 건강상태가 유의하게 높았다. 노년전기군의 삶의 질은 노년후기군에 비해 유의하게 높았으며, 삶의 질을 구성한 각 항목은 모두 노년전기군에서 유의하게 낮아 노년후기군보다 삶의 질이 더 좋았다. 노년전기군의 삶의 질 관련요인은 성별, 주관적 건강상태, BMI로 나타났고, 노년후기군에서는 경제수준, 만성질환 유무와 주관적 건강상태가 삶의 질과 관련되었다. 결론 : 노인의 삶의 질을 높이기 위하여, 노년 전기에는 체중관리에 초점을 맞추고 성별에 따라 차별화된 서비스를 제공하며 노년 후기에는 경제상태와 교육수준에 따른 서비스를 제공하고, 전·후기 노인 모두 만성질관관리, 건강관리, 및 일상생활능력 향상을 위한 서비스를 제공되어야 함을 제안한다. Objectives: The purpose of this study was to investigate the difference in quality of life and related factors among the elderly by the young and the old-old. Methods: Elderly data of 1,339 case from National Health and Nutrition Examination Survey (Korea Center for Disease Control, 2010) were analyzed with SPSS 20.0, using complex survey data analysis methods. Most of the instruments were used according to the original survey while some were re-categorized. Gender, education, living area, income status, factors considered to be related to quality of life such as exercise, smoking and drinking habits, existence of chronic diseases, perceived health, and BMI were explored for their relationship with quality of life. Significance level was set to .05. Results: In this study, 58.4% of the subject were female, and approximately 3/4 had education below elementary school. However, there were more female, more elementary school education, and fewer living with significant others among the old-old. Underweight, depression, and suicidal thoughts were more prevalent among the old-old. The old-old perceived their health worse. Quality of life scores were lower for the old-old. In terms of health behaviors, there were more drinking, exercising, and overweight among the young-old. Factors related to quality of life turned out to be gender, perceived health and BMI among the young-old and education, economic status, and perceived health among the old-old. Conclusion: We recommend differentiated health policy and health programs for the young- and the old-old.

유사한 전자상태를 가지는 타이타늄 합금의 영률에 베타 안정화 원소 함량이 미치는 영향

유가영 ( Ga Young Yoo ),박찬희 ( Chan Hee Park ),홍재근 ( Jae Keun Hong ),김승언 ( Seong Eun Kim ),강남현 ( Seong Eun Kim ),염종택 ( Jong Taek Yeom ) 대한금속재료학회(구 대한금속학회) 2013 대한금속·재료학회지 Vol.51 No.4

Previously, Gum Metal (Ti-24(Nb + Ta + V)-(Zr, Hf)-O (at%)) exhibiting an ultralow Young`s modulus, ultrahigh strength and super elasticity was developed by Saito et al., who proposed that three electronic magic numbers, an average electron/atom (e/a) ratio of 4.24, an average bond order (Bo) of about 2.87, and an average “d” electron-orbital energy level (Md) of about 2.45 eV, should be satisfied simultaneously to obtain such “super” properties. The purpose of this study was to find new alloy systems possessing those properties and to examine the effect of beta equivalent content ([Mo]eq) on Young`s moduli of new alloys having the same three electronic numbers mentioned above. It was found that not only three electronic numbers but also [Mo]eq should be considered to obtain a similar Young`s modulus and hardness with respect to the Gum Metal.

흰쥐에서 갑상샘 절제 후 재생에 따른 세포 및 세포사이물질의 변화

황영일,정용환,이왕재,황덕호,유영복,김혜숙,장가용 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.4

경찰활동상 GIS의 확대보급에 따른 쟁점과 과제

유영현,유영재 동국대학교 사회과학연구원 2008 사회과학연구 Vol.14 No.2

Geographical information system(GIS) is a new information technology that can be used to enhance the effectiveness of policing. It is used to identify the crime hot spots, trace the criminals, and develop the crime intervention schemes. The police of the Western countries began to use GIS in policing in the last 20 years. The Korean police adopted GIS, but the use of GIS in policing has been very limited. GIS based crime analysis is a way to achieve the systematization of the police work scientifically. This paper begins with an overview of GIS and some examples of crime mapping analytic methods. Based on suggested methods and cases, and with a descriptive sketch of the development process of GIS in the korea police, this paper discusses some technical and organizational issues for the advancement of the use of GIS. Also, this paper explores the problem of information in GIS. Introduction of new information technologies by the rapid growth of IT industries, especially GIS, has changed the citizens' lives. Technical improvement in handling information by national agencies has many problems such as possibilities of surveillance, supervision and control by the government. Gathering information by police has great importance, and its role also is increasing. Police deal with individual's information more frequently than any other national agencies. Consequently, as necessities of information activity is expanding and gathering and processing the information is easier, the possibility that policing on individual information infringes on citizens' constitutional rights is becoming real. Policing by the government is a kind of infringement. So, in order to gather and process individual's information we need to have legal bases on police enforcement. But we still don't have legally proper provisions. We can't deny the necessities of gathering and processing individual's information by the police. Therefore, suitable provisions and legal bases for that should be maintained and prepared. As for the infringement by the police, I propose precisely prescribing the conditions and limits of information activities, and liability for violation in the related legislation on police enforcement. 현대사회의 복잡하고 다변화된 사회에서 시민이 요구하는 치안서비스에 부응하려면 보다 적극적인 사전예방적 치안활동이 필요한데 이를 위해서 정보란 필수적인 것이다. 따라서 경찰업무의 많은 부분은 정보를 통하여 정보력에 따라 좌우된다고 할 수 있다. 이 정보와 관련하여 경찰은 수집과 공개라는 양가적 지위에 서게 된다. 종전에는 경찰은 직무수행을 위해 경찰이 정보를 수집하는 것은 당연한 권한으로 여겼을 뿐 법적 문제는 관심 밖이었지만 최근 사회전반에서 고도화된 정보기술은 개인의 자율성을 해치고 민주주의 자체를 위협할 수 있다는 인식이 본격화되기 시작하면서, 정보활동에 대한 생각에 변화를 가져오게 된 것이다. 지리정보시스템은 범죄자 프로파일링, 지역사회경찰활동, 범죄예방적 서비스에 확대에 기여하였으며, 정보제공자로서 경찰로 하여금 각종 정보를 쉽게 수집할 수 있게 되었지만 경찰은 정보의 수집과 정보의 공개에 있어서 법적인 근거와 그 집행에 있어 해석 적용에 있어 여러 가지 문제점을 직면하고 있다. 따라서 이 연구에서는 과학기술의 발달에 따른 지리정보시스템보급에 따라 경찰활동시 쟁점을 살펴봄으로써 미력하나마 인식을 환기하고자 한 것이다.

흰쥐 시상하부에서 NMDA에 의한 c-fos의 발현

이영기,최기열,이원돈,유영복,이왕재,황덕호,조사선,장가용 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.3

유통업의 지식경영 도입 방안에 관한 연구

Yoo,Sang-jin,Cha,Young-han 한국산업경영학회 2002 한국산업경영학회 발표논문집 Vol.2002 No.2

In this study, an effective methodology to introduce knowledge management system into the retail business is suggested by overall analysis of examples those were carried out in business area. Different from existing studies, which focus on theoretical aspect only, this study focuses its attention on theoretical & practical aspect simultaneously and tries to find a long-term & integrated knowledge management strategy. With examining the examples of knowledge management, this study deals with the fundamental conception, the procedure and the organization of knowledge management. Moreover, this study practically analyzes the knowledge management system of the company named "H", one of the retail business companies. By clarifying the problems, which is involved in the knowledge management process of the above company, this study suggests an improvement methodology to introduce and settle down knowledge management system into retail business company for the future. This study has good results in the viewpoint that it gives a definite direction of knowledge management introduction. However, there is some limitation such as the insufficiency of examples and the omission of documented analysis. Therefore, this study leaves some task to be achieved in the future.

동일한 환자에서 조혈모세포이식 전후의 호중구감소 기간 중 감염양상에 대한 비교연구 : 중심정맥관 관련 패혈증을 중심으로 Based on Central Venous Catheter Related Septicemia

류재호,노규태,이영석,이영호,권혁찬,김재석,김효진,이영민,박혜원,박근희 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.1

연구배경: 동일한 환자를 대상으로 조혈모세포이식 전 일반 병실에서의 관해유도 항암제치료 및 강화요법으로 인한 호중구감소 기간의 감염양상과 고용량 항암제치료 후 무균실에서의 조혈모세포이식 시 호중구감소 기간의 감염양상을 중심정맥관 관련 패혈증을 중심으로 비교 연구함으로써 효율적인 감염관리지침을 마련하고자 하였다. 대상 및 방법: 1999년 1월부터 2001년 7월까지 2년 7개월간 동아대학교병원 일반병실에서 악성혈액질환으로 항암제 치료를 받다가 조혈모세포이식을 시행받았던 22명을 대상으로 중심정맥관 관련 패혈증의 형태를 비교분석하였다. 결과: 대상 환자들의 일반병실과 무균실에서의 입원기간은 각각 32±13일, 33±19일, 호중구 감소기간은 15±12일, 17±18일, 호중구 감소기간의 발열 횟수는 14회, 14회로서 입원병실의 종류에 따른 차이는 없었다. 환자들의 중심정맥관 사용일수는 일반병실에서 29일(7~545일), 무균실에서 100.5일(25~606일)이었으며, 총 사용일수는 각각 1,515일, 3,250일로서 무균실에서의 중심정맥관 사용일수가 의미 있게 길었다(P=0.001). 중심정맥관 사용 일수에 대한 감염률은 각각 5.28/1,000일, 3.08/1,000일로서 일반병실에서 그 빈도가 높았으나 통계적 유의성은 보이지 않았다(P=0.141). 결론: 중심정맥관 삽입 후 일반병실에서 항암제 치료를 받던 환자가 조혈모세포이식을 위하여 무균실에 입원하는 경우, 중심정맥관을 교체하는 것이 감염관리를 위하여 바람직할 것으로 생각된다. Background: We compared the incidence of central venous catheter (CVC) related septicemia during neutropenic period in the same patient, which developed following chemotherapy for remission induction and consolidation, or hematopoietic stem cell transplantation (HSCT). Methods: We retrospectively reviewed the medical records and laboratory data of 22 patients with hematologic malignancies who received anticancer chemotherapy followed by HSCT at Dong-A University Hospital between January, 1999 and July, 2001. We investigated the duration of hospitalization, duration of neutropenic period, duration of catheterization, microbiologically documented organisms and incidence of CVC related septicemia. Results: The data in general ward (before HSCT) and laminar air flow room (after HSCT) were as follows: duration of hospitalization was 32±13 days and 33±19 days, duration of neutropenic period was 15±12 days and 17±18 days, median duration of catheterization was 29 days (7~545 days) and 100.5 days (25~606 days) (P=0.001), and incidence of CVC related septicemia was 5.28/1000 days and 3.08/1000 days, respectively. In the CVC related septicemia, the most common etiologic organism was coagulase negative staphylococcus. Conclusion: We suggest that the exchange of CVC before admission to laminar air flow room could decrease the incidence of CVC related septicemia in HSCT recipients.

단일 단계 접착제의 변연 미세누출

조영곤,정진호,기영재,최희영,진철희,유상훈,김종욱,박병철 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.2

This study evaluated the marginal microleakage of five single step adhesives. Class V cavity preparations with occlusal margins in enamel and gingival margins in dentin were prepared on both buccal and lingual surfaces of extracted human molar teeth. Prepared teeth were randomly divided into five groups and restored using one of the single step adhesives and composite resins: Prompt L-Pop/Filtek Z-250 (Group 1), AQ Bond/Metafil CX (Group 2), One-Up Bond F/Palfique Toughwell (Group 3), Futurabond/Admira (Group 4), Xeno III/Spectrum TPH (Group 5). The restored teeth were thermocycled. Microleakage was assessed by dye penetration using 2% methylene blue dye solution. The teeth were bisected buccolingually and evaluated for microleakage under steromicroscope. The data were statistically analysed by Kruskal-Wallis test and Mann-Whitney tests. The results of this study were as follows; 1. Microleakage of enamel margins in group 3 was statistically higher than that in groups 1, 2, 4, 5 (p < 0.05) 2. Microleakage of dentin margins in group 1 was statistically higher than that in groups 2, 5, and that in group 3 was statistically higher than that in groups 2, 4, 5 (p < 0.05). 3. Dentin marginal microleakage was higher than enamel marginal microleakage in all experimental groups. In conclusion, Prompt L-Pop showed the least leakage at enamel margin, and AQ Bond showed at dentin margin in this study. Marginal miroleakage in dentin was higher than that in enamel.

그레이브스병에서 방사성 요오드 치료에 따른 갑상선 자극 호르몬 수용체 결합억제 면역글로불린(Thyrotropin Binding Inhibitory Immunoglobulin, TBII)의 변화

조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.