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Anna Yoo,아타나스데미레프,Ji Seon Lee,Sang Dal Kim,남두현 한국미생물학회 2006 The journal of microbiology Vol.44 No.6
A standard type II polyketide synthase (PKS) gene cluster was isolated while attempting to clone the biosynthetic gene for lipstatin from Streptomyces toxytricini NRRL 15,443. This result was observed using a Southern blot of a PstI-digested S. toxytricini chromosomal DNA library with a 444 bp amplified probe of a ketosynthase (KS) gene fragment. Four open reading frames [thioesterase (TE), β-ketoacyl systhase (KAS), chain length factor (CLF), and acyl carrier protein (ACP)], were identified through the nucleotide sequence determination and analysis of a 4.5 kb cloned DNA fragment. In order to confirm the involvement of a cloned gene in lipstatin biosynthesis, a gene disruption experiment for the KS gene was performed. However, the resulting gene disruptant did not show any significant difference in lipstatin production when compared to wild-type S. toxytricini. This result suggests that lipstatin may not be synthesized by a type II PKS.
Magnetic Resonance Imaging-Based Volumetric Analysis and Its Relationship to Actual Breast Weight
Yoo, Anna,Minn, Kyung Won,Jin, Ung Sik Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.3
Background Preoperative volume assessment is useful in breast reconstruction. Magnetic resonance imaging (MRI) and mammography are commonly available to reconstructive surgeons in the care of a patient with breast cancer. This study aimed to verify the accuracy of breast volume measured by MRI, and to identify any factor affecting the relationship between measured breast volume and actual breast weight to derive a new model for accurate breast volume estimation. Methods From January 2012 to January 2013, a retrospective review was performed on a total of 101 breasts from 99 patients who had undergone total mastectomy. The mastectomy specimen weight was obtained for each breast. Mammographic and MRI data were used to estimate the volume and density. A standard statistical analysis was performed. Results The mean mastectomy specimen weight was 340.8 g (range, 95 to 795 g). The mean MRI-estimated volume was $322.2mL^3$. When divided into three groups by the "difference percentage value", the underestimated group showed a significantly higher fibroglandular volume, higher percent density, and included significantly more Breast Imaging, Reporting and Data System mammographic density grade 4 breasts than the other groups. We derived a new model considering both fibroglandular tissue volume and fat tissue volume for accurate breast volume estimation. Conclusions MRI-based breast volume assessment showed a significant correlation with actual breast weight; however, in the case of dense breasts, the reconstructive surgeon should note that the mastectomy specimen weight tends to overestimate the volume. We suggested a new model for accurate breast volume assessment considering fibroglandular and fat tissue volume.
Eccrine porocarcinoma: retrospective study and review of cases reported in Korea
( Anna Kim ),( Jiehyun Jeon ),( Aeree Kim ),( Soo Hong Seo ),( Il Hwan Kim ),( Hae Jun Song ),( Yoo Sang Baek ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Eccrine porocarcinoma (EPC) is rare malignant cutaneous adnexal tumor. Since 1998, many EPC cases has been reported in Korea. All previous studies were limited to case report and none has comprehensively reviewed multiple cases. Objectives: To clinicopathologically review all EPC cases from our institutions as well as case reports in Korea. Methods: The patients were retrospectively selected from skin biopsy registry from our institutions. Available histopathological slides were re-examined by an experienced dermatopathologist. EPC cases reported in Korea before June 2019 were retrieved by searching PubMed, Google scholar, KoreaMed, and KoMCI. Results: Nine EPC cases from our institutions were included in the study. In addition, we found 27 reports of 28 EPC cases from Korea. In total of 37 EPC cases, there were 19 males (M:F ratio 1.06:1), and the mean age at diagnosis was 65.6 years. The most common site of primary tumor was head and neck (29.7%). Wide excision was the most common (78.4%) treatment method. Metastasis was confirmed in 21.1%. Conclusion: EPC is rarely reported cutaneous carcinoma in Korea. EPC usually affects old age patients with no sexual predilection. Due to possible metastasis, careful diagnosis and appropriate metastasis work up is warranted in EPC.
신풍제약 돔필®정(말레인산 돔페리돈 12.72 mg)의 생물학적 동등성 평가
유안나,김성철,이경희,박종민,남두현 한국병원약사회 2003 病院藥師會誌 Vol.20 No.4
The bioequivalence of two tablet formulations of 12.72㎎ domperidone maleate (Shinpoong "Dompil®" table vs. Janssen Korea "Motilium-M®" tablets) was assessed in healthy Korea volunteers after oral administration in a randomized crossover study. Blood samples were collected at specified time intervals, and plasma concentration was measured as the amount of domperidone base using a validated HPLC method. The pharmacokinetic parameters of AUC_(0→48), C_(max), T_(max) and t_(1/2) were determined from plasma concentration-time profile of two formulations. No significant statistical differences were observed between these two formulations. On the evaluation of bioequivalence according to KFDA Guideline, 90% confidence limits after logarithmic transformation fell within the acceptable range (log 0.8~log 1.25). Based on these data, it can be concluded that two domperidone maleate tablets showed comparable pharmacokinetic profiles, which means that the Shinpoong "Dompil®" tablet is bioequivalent to the Janssen Korea "Motilium-M®"