정신분열증 환자와 우울증 환자의 MMPI-2 프로파일

고윤화,손용훈,윤정흠,오상우,이귀행,박민철 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

Background: Minnesota multiphasic personality inventory-2(MMPI-2) is superior to its predecessor in differential diagnosis. this study was to investigate MMPI-2 profiles of the patients with schizophrenia and depression and to discriminate among two groups. Methods: The sample consisted of 35 patients with schizophrenia(male 24, female 11), 35 patients with depression(male 18, female 17) diagnosed by the diagnostic and statistical manual of mental disorders(DSM-IV) for schizophrenia & depression at department of neuropsychiatry in WonKwang University from January 2005 to December 2007. The data from the results were analyzed statistically by t-test and discriminant analysis. Results: The results were as follows. First, according to t-test results the comparison of schizophrenia patients and depression patients in MMPI-2 among two groups showed significant differences; the validity scales: F, F(P); The clinical scales: D, Pa; The restructured clinical scales: Rcd(dem), RC4, RC6, RC8; The content scales: ANX, DEP, BIZ; The supplementary scales: AGGR, PSYC, Mt, GF, O-H. Second, as a results discriminant analysis, BIZ, D were significant predictors in distinguishing patients with schizophrenia from patients with depression. Third, probability to be discriminated schizophrenia in schizophrenia was 91.4%, probability to be discriminated depression in depression was 85.7%. Conclusion: Finally, we remind readers that although the MMPI-2 may prove to be useful in the task of differential diagnosis, it should be used only in combination with other patient information. 배경: MMPI-2는 감별진단에서 기존의 MMPI 보다 더 우수하다. 본 연구는 정신분열증 환자와 우울증 환자의 MMPI-2 프로파일과 두 집단을 판별하는 연구를 하였다. 방법: 2005년 1월부터 2007년 12월까지 원광대학교 병원 신경정신과에서 정신분열증과 우울증으로 진단된 정신분열증 환자 35명(남성 24명, 여성 11명), 우울증 환자 35명(남성 18명, 여성 17명)이 본 연구에 참여하였다. 자료는 t-검증과 판별분석으로 분석하였다. 결과: 결과는 다음과 같다. 1. t-검증 결과, 두 집단간 유의미한 차이를 보인 척도들로는 타당도 척도에서 F, F(P) 척도, 임상척도에서 D, Pa, 척도, 재구성 임상척도에서 Rcd(dem), RC4, RC6, RC8척도 였다. 내용척도에서는 ANX, DEP, BIZ척도 였으며 보충척도에서는 AGGR, PSYC, MT, GF O-H척도 였다. 2. 판별 분석 결과로서, 정신분열증과 우울증을 구별하는데 가장 유의한 예언요소는 BIZ, D척도로 나타났다. 3. 판별함수를 통한 진단율은 정신분열증을 정신분열증으로 판별해주는 정확도는 91.4%였고, 우울증을 우울증으로 판별해주는 정확도는 85.7%였다. 결론: 본 연구 결과를 통해서 MMPI-2가 두 집단을 감별하는데 유용하다고 증명되었을지 모르지만 더욱 정확하게 감별하기 위해서 환자의 기타 정보를 사용해야 할 것이다.

방사선 조사를 받은 흰쥐 신경뇌하수체 관문의 미세구조 : 관문의 새로운 개념설정 Establishment of a New Concept on the Barrier

이헌용,안의태,양남길,고정식,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

신경뇌하수체는 뇌의 일부지만 뇌실둘레기관(circumventricular organ)으로서 전형적인 혈액-뇌관문이 없으므로 혈관 안팎의 물질이동이 자유로운 신경내분비기관이다. 이 실험에서는 심한 방사선 조사시에 혈액-신경뇌하수체관문의 형태적 대응을-연구함으로써, 관문의 특성을 분석했으며, 관문의 구성을 구체적으로 설정하여 이를 개념화 할 것을 제안하였다. 체중 200-250g의 숫흰쥐를 sodium thiopenthal 로 마취시킨 후 Mitsubishi선형가속기로 방사선 조사를 시켰다. 조사조건은 거리 80cm, 조사구역 30 X 30cm, 조사깊이 1.2cm, 조사속도 분당 200 rads로 하여 실험군에 따라 3,000 rads 또는 6,000 rads가 되도록 했다. 조사후 6시간, 2일, 6일후에 각군의 동물을 도살 하여 신경뇌하수체를 떼어냈다. 떼어낸 조직은 1% glutaradehyde- 1% paraformaldehyde액에 1차 고정하고, 1% osmium tetroxide액에 2차 고정하였고, araldine혼합액에 포매된 조직은 절편을 만들어 uranyl acetate와 lead citrate액으로 염색해서 전자현미경으로 관찰하였다. 주로 모세혈관주위공간에서 관문구조를 중심으로 관찰한 결과 3,000 rads 조사군과 6,000 rads조사군 모두가 비슷하게 심한 변화를 보였고, 변화의 정도가 2일군에서 가장 심했으며 6일군에서는 약간 안정되는 모습이었으나 변화의 양상은 모든 실험군을 통해서 비슷하였다. 가장 두드러진 변화는 모세혈관주위공간에서 나타났는데 공간의 확장, 큰포식세포의 증가와 활성화, 신경뇌하수체세포속에 들어 있던 신경종말들의 이탈, 먼지 같은 물질의 증가 등을 들 수 있었다. 특히 큰 포식세포의 변화는 매우 특징적이어서 넓은 세포질관(판상족, lamellipoda)을 형성하여 모세혈관과 신경뇌하수체세포사이를 차단시킬 뿐아니라 왕성한 포식작용으로 공간내의 축삭종말들을 용해시켰다. 큰포식세포의 세포질안에는 과립형질내세망들이 매우 발달하였고, 세포질 영역이 매우 넓어진 것으로 볼 때, 이들이 기동타격대로서 활발히 움직이는 매우 효율적인 관문의 구성성분으로 생각되었다. 특히 신경뇌하수체는 전형적인 혈액-뇌관문이 없으므로 신경내분비기능의 수행에는 유리하나 면역활성물질이나 독성물질등 뇌에 해로운 물질의 왕래를 차단하여 제거하거나, 과다하게 분비된 신경호르몬을 조절하는 일이 중요하다고 볼 때, 큰포식세포가 이같은 역할에 적합한 구성성분이라는 결론을 얻었다. 이 실험에서는 효율성이 높은 관문으로서 혈액-신경뇌하수체관문이 구성성분을 차례로 기재하고 이를 개념화 할 것을 제안한다. 모세혈관과 축삭종말사이에 형성되어 있는 혈액-신경뇌하수체관문이 구성을 차례로 표기하면 다음과 같다 (그림 9,10). 1. 유창모세혈관 내피 2. 모세혈관 내피의 기저판 3. 혈관주위세포와 기저판("이차방어선", 한정된 범위내에서 움직일 수 있다). 4. 큰포식세포, 필요에 따라 판상족(lamellipoda)을 넓게 뻗는다.("삼차방어선", 모세혈관 주위공간 속을 이동해 다니는 "기동타격대") 5. 신경뇌하수체세포의 기저판 6. 신경뇌하수체세포의 세포질돌기(호르몬분비 조절) To study the morphological characteristics of the blood-neurohypophysis barrier system in a severely altered situation, the heads of rats were exposed to heavy X-irradiation. Rats weighing 200-250 g each were anesthetized with sodium thiopenthal, and placed on the table of Mitsubishi linear accelerator ML-4MV. Only heads of rats were placed within the exposure area of 30 cm X 30 cm. Irradiation was processed at the distance of 80 cm, with the speed of 200 rads/min in the radiation depth of 1.2cm. Total doses were 3,000 rads or 6,000 rads according to the animals of the different experimental groups. Rats were sacrificed on 6 hours, 2 days or 6 days following radiations. Tissue blocks of neurohypophyses were fixed in the 1% glutaraldehyde-1% paraformaldehyde solution, and they were refixed in the 1% osmium tetroxide solution. Ultrathin sections were contrasted with uranyl acetate and lead citrate solutions. Electron micrographs exhibited dramatic changes within the perivascular space of neurohypopysis. The perivascular space was greatly enlarged, and it contained many macrophages, floating axonal endings and plentiful flocculent materials. The enlargement was largest in the 2 day-group animals. Many macrophages are activated, and it showed tremendous cytoplasmic lamellipoda. Wide plate of macrophagic cytoplasm usually engulfed the floating axon terminals, and are located between the cappillary and the pituicytes. The situation gave the impression that macrophages prevent, filter and/or retrieve the excessive materials transported between the capillary and the axonal endings. Since the perivascular microenvironment of neurohypophysis is more vulnerable as compared with those brain areas equipped with blood-brain barrier, the functional barrier system by macrophages in the neurohypophysis should have important role. The concept of blood-neurohypophyseal barrier with the following components is proposed. The components of the barrier system from the blood pool to the hormonal pool are 1. Endothelium of fenestrated capillary 2. BAsal lamina of endothelium 3. Pericyte("second line of defense". mobile in a limited area) 4. Macrophage, extending its wide cytoplasmic plate(the lamelipoda) in need("third line of defense". freely movable in the perivascular space, "active surveillance system") 5. Basal lamina of pituicyte 6. Cytoplasmic processes of pituicyte

탈아세틸화된 키틴이 백서 창상치유능에 미치는 영향

정상훈,조용남,조용우,고석원,위성신,유걸 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.5

Chitin and chitosan, polysaccharides made up of polymeric N-acetly glucosamine and D-glucosamine, are widely found in nature, forming the skeletons of crustaceans and insects, as well as the components of bacteria cell walls. Chitin and chitosan have been known to have many useful biological properties such as biocompatibility, biodegradability, antimicrobial activity, and wound healing. There properties have been known to be different depending on the degree of deacetylation of chitin, but it has not yet been fully evaluated. The purpose of this study was to evaluate the wound healing effect by the degree of deacetylation. Full-thickness skin incision was made on the backs of Sprague-Dawley rats. Three concentrations of powder, comprising 90% chitin, 50% chitin and 10% chitin, were separately embedded in the wounds of 3 rat groups. The wound-breaking strength and the collagen-hydroxyproline content of the skin at the wound sites were measured and histological examination was performed at postoperative 3, 7, and 10 days. The 50% chitin group had the highest tensile strenght of all groups. But the 50% chitin and 90% chitin groups had the lowest collagen hydroxyproline levels among all groups. The wounds treated with 50% chitin powder were completely reepithelialized and granulation tissue in the wound was observed 7 days after initial wounding. The arrangement of collagen fibers in the skin was ordered and similar to normal skin The 50% chitin powder is considered to be the most efficient wound healing accelerator among different concentrations of chitin powder.

분석결과 검증 및 신뢰성 확보를 위한 실험실간 협력 실험

박혜진,고광용,한국탁,김일중,이용재,김성헌,이규승 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.2

The residual study of pesticide has been used in various areas, such as food safety, environmental protection, establishment of tolerance, and explaining the pathway and reaction mode of pesticides, and its importance was expected to increase further more. The aspect of food safety, the pesticide residue survey have been practiced at many organizations, but there were no verification of analytical results at present. In this experiment, we focused on instrumental stability, including response of each instrument and the recovery ratio of each organization's method. As samples for this experiment, we prepared cucumber and sesame, and chose 4 pesticides (bifenthrin, chlorpyrifos, diazinon, and ethoprophos), which were mostly detected from pesticide residue survey and widely used for each crop. The standard deviation of peak areas in the chromatogram of each pesticide were under 1.212 %, so it showed that most instruments were stable. The relationship of recovery ratio of each organization were over 0.996 for every pesticide and each organization. Finally, the analytical results for pesticide residue from each participated organization were not statically significant and we could put confidence in the result from each organization.

수용성 키틴이 백서 창상치유에 미치는 영향

강장석,조용남,정상훈,유 결,임진수,권 호,조용우,고석원 大韓成形外科學會 2001 Archives of Plastic Surgery Vol.28 No.1

Direct Growth of Graphene on Insulating Substrate by Laminated (Au/Ni) Catalyst Layer

Yong Hun Ko,Yooseok Kim,정대성,Seung Ho Park,Ji Sun Kim,Jini Shim,Hyeju Yun,Wooseok Song,Chong-Yun Park 한국진공학회 2015 Applied Science and Convergence Technology Vol.24 No.4

A direct growth method of graphene on insulating substrate without catalyst etching and transfer process was developed using Au/Ni/a-C catalyst system. During the growth process, behavior of the Au/Ni catalyst was investigated using EDX, XPS, SEM, and Raman spectroscopy. The Au/Ni catalyst layer was evaporated during growth process of graphene. The graphene film was composed mono-layer flakes. The transmittance of the graphene film was ∼80.6%.

Scleral Lens Applications Focused on Korean Patients with Various Corneal Disorders

Ko Eun Lee(Ko Eun Lee),Su Young Moon(Su Young Moon),Sanghyu Nam(Sanghyu Nam),Joon Hyuck Jang(Joon Hyuck Jang),Jae Yong Kim(Jae Yong Kim),Hungwon Tchah(Hungwon Tchah),Hun Lee(Hun Lee) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2

Purpose: We aimed to report on the clinical outcomes of scleral lens applications in Korean patients with various corneal disorders. Methods: This retrospective review was conducted for 62 eyes of 47 patients who had been fitted with scleral lenses for variouscorneal disorders. The patients were referred for inadequate spectacle-corrected visual acuity and rigid gas permeable(RGP) or soft contact lens intolerance. Uncorrected visual acuity, habitually corrected visual acuity, best lens-corrected visualacuity, topographic indices, keratometry indices, and lens parameters were evaluated. Results: Twenty-six eyes of 19 patients with keratoconus were enrolled. Other conditions included corneal scar (13 eyes of12 patients), phlyctenules (three eyes), laceration (four eyes), chemical burn (one eye), keratitis (one eye), Peters’ anomaly (oneeye), fibrous dysplasia (one eye), ocular graft-versus-host disease (two eyes of one patient), irregular astigmatism (18 eyes of12 patients), and corneal transplant status (five eyes of four patients). The mean topographic values of the eyes include flatkeratometric value (43.0 ± 6.1 diopters [D]), steep keratometric value (48.0 ± 7.4 D), and astigmatism (4.9 ± 3.6 D). Of the eyesfitted with scleral lenses, best lens-corrected visual acuity (0.10 ± 0.22 logarithm of the minimum angle of resolution [logMAR])was significantly better than the habitually corrected visual acuity (0.59 ± 0.62 logMAR, p < 0.001). Conclusions: Scleral contact lenses are a good alternative for patients with corneal abnormalities and those who are intolerableto RGP contact lenses, resulting in both successful visual outcomes and patient satisfaction, especially concerning keratoconus,corneal scar, and corneal transplant status.

Direct Growth of Graphene on Insulating Substrate by Laminated (Au/Ni) Catalyst Layer

Ko, Yong Hun,Kim, Yooseok,Jung, Daesung,Park, Seung Ho,Kim, Ji Sun,Shim, Jini,Yun, Hyeju,Song, Wooseok,Park, Chong-Yun The Korean Vacuum Society 2015 Applied Science and Convergence Technology Vol.24 No.4

A direct growth method of graphene on insulating substrate without catalyst etching and transfer process was developed using Au/Ni/a-C catalyst system. During the growth process, behavior of the Au/Ni catalyst was investigated using EDX, XPS, SEM, and Raman spectroscopy. The Au/Ni catalyst layer was evaporated during growth process of graphene. The graphene film was composed mono-layer flakes. The transmittance of the graphene film was ~80.6%.

인공고관절 재치환술에 있어서 비구골 결손부위의 파쇄 동종골-수산화인회석 합성물의 이용

김영용(Young-Yong Kim),고한석(Han-Suk Ko),서진수(Jin-Su Seo),이동훈(Dong-Hun Lee),문형태(Hyeong-Tae Moon),강영훈(Yeong-Hun Kang),성열보(Yerl-Bo Sung),안재용(Jae-Yong Ahn),심재익(Jae-Ik Shim),이성종(Sung-Jong Lee),박영진(Young-Jin Par 대한정형외과학회 1998 대한정형외과학회지 Vol.33 No.7

A Novel Network Modeling and Evaluation Approach for Security Vulnerability Quantification in Substation Automation Systems

KO, Jongbin,LEE, Seokjun,LIM, Yong-hun,JU, Seong-ho,SHON, Taeshik 'Institute of Electronics, Information and Communi 2013 IEICE transactions on information and systems Vol.96e.d No.9