Seismic performance of Bujian Puzuo considering scale ratio and vertical load effects

Yong-Hui Jiang,Jun-Xiao He,Lei Zhu,Lin-Lin Xie,Shuo Fang 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.90 No.5

This study investigated the influence of scale ratio and vertical load on the seismic performance of Puzuo joints in traditional Chinese timber structures. Three low-cyclic reversed loading tests were conducted on three scaled specimens of Bujian Puzuo in Yingxian Wooden Pagoda. This study focused on the deformation patterns and analyzed seismic performance under varying scale ratios and vertical loads. The results indicated that the slip and rotational deformations of Bujian Puzuo were the primary deformations. The scale of the specimen did not affect the layer where the maximum interlayer slip occurred, but it did decrease the proportion of slip deformation. Conversely, the reducing vertical load caused the layer with the maximum slippage and the position of the damaged Dou components to shift upward, and the proportion of slip deformation increased. When the vertical load was decreased by 3.7 times, the maximum horizontal bearing capacity under positive and negative loadings, initial stiffness, and energy dissipation of the specimen decreased by approximately 60%, 58.79%, 69.62%, and 57.93%, respectively. The horizontal bearing capacity under positive loading and energy dissipation of the specimen increased by 35.63% and 131.54%, when the specimen scale was doubled and the vertical load was increased by 15 times.

Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

Yang Hui-Hui,Jiang Hui-Ling,Tao Jia-Hao,Zhang Chen-Yu,Xiong Jian-Bing,Yang Jin-Tong,Liu Yu-Biao,Zhong Wen-Jing,Guan Xin-Xin,Duan Jia-Xi,Zhang Yan-Feng,Liu Shao-Kun,Jiang Jian-Xin,Zhou Yong,Guan Cha-Xi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citratemt) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3α and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition of Idh3α and Slc25a1 induced citratemt accumulation and necroptosis in vitro. Mice with AEC-specific Idh3α and Slc25a1 deficiency exhibited exacerbated lung injury and AEC necroptosis. Interestingly, the overexpression of Idh3α and Slc25a1 decreased citratemt levels and rescued AECs from necroptosis. Mechanistically, citratemt accumulation induced mitochondrial fission and excessive mitophagy in AECs. Furthermore, citratemt directly interacted with FUN14 domain-containing protein 1 (FUNDC1) and promoted the interaction of FUNDC1 with dynamin-related protein 1 (DRP1), leading to excessive mitophagy-mediated necroptosis and thereby initiating and promoting ALI. Importantly, necroptosis induced by citratemt accumulation was inhibited in FUNDC1-knockout AECs. We show that citratemt accumulation is a novel target for protection against ALI involving necroptosis.

Delay-dependent Stabilization of Singular Systems with Multiple Internal and External Incommensurate Constant Point Delays

Yong-Fang Xie,Wei-Hua Gui,Zhao-Hui Jiang 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.4

In this paper, the problem of delay-dependent stabilization for singular systems with multiple internal and external incommensurate constant point delays is investigated. The condition when a singular system subject to point delays is regular independent of time delays is given and it can be easily test with numerical or algebraic methods. Based on Lyapunov-Krasovskii functional approach and the descriptor integral-inequality lemma, a sufficient condition for delay-dependent stability is obtained. The main idea is to design multiple memory less state feedback control laws such that the resulting closed-loop system is regular independent of time delays, impulse free, and asymptotically stable via solving a strict linear matrix inequality (LMI) problem. An explicit expression for the desired memory less state feedback control laws is also given. Finally, a numerical example illustrates the effectiveness and the availability for the proposed method.

Development of an Adaptive-Feedrate Planning and Iterative Interpolator for Parametric Toolpath with Normal Jerk Constraint

Yong Zhang,Hui Zhang,Jiadong Shi,Jiali Jiang,Mingyong Zhao 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.1

Compared to conventional linear and circular segments, the parametric curve has advantages in approximating and machining, guaranteeing higher machining precision and better machining quality. Therefore, in Computer Numerical Control (CNC) systems, parametric toolpath has become more and more popular for its high-performance in practical machining and the performance of the parametric interpolator has become a standard to illustrate the advanced CNC systems. In this paper, adaptive-feedrate planning and the iterative interpolator have been developed to generate sampling points with respect to error and higher order kinematic constraints. Firstly, a jerk-limited feedrate profile and look-ahead algorithm are utilized to provide reachable feedrate at critical points. Afterwards, normal jerk (i.e. the jerk in a normal direction) are limited to improve machining precision and quality. In theory, it is proved that the normal jerk limitations have relationship with curvature derivative and a novel iterative interpolator is proposed to ensure the normal jerk limitation by considering the corresponding constraints at curvature derivative extreme points. Finally, simulation and experiments are conducted to demonstrate the efficiency and contour performance of the proposed method compared to conventional method and time-optimal method.

Down-regulation of Protease-activated Receptor 4 in Lung Adenocarcinoma is Associated with a More Aggressive Phenotype

Jiang, Ping,Yu, Guo-Yu,Zhang, Yong,Xiang, Yang,Hua, Hai-Rong,Bian, Li,Wang, Chun-Yan,Lee, Wen-Hui,Zhang, Yun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

The role of protease-activated receptors (PARs) in lung tumors is controversial. Although PAR4 is preferentially expressed in human lung tissues, its possible significance in lung cancer has not been defined. The studies reported herein used a combination of clinical observations and molecular methods. Surgically resected lung adenocarcinomas and associated adjacent normal lung tissues were collected and BEAS-2B and NCI-H157 cell lines were grown in tissue culture. PAR4 expression was evaluated by RT-PCR, RT-qPCR, Western blotting and immunohistochemistry analysis. The results showed that PAR4 mRNA expression was generally decreased in lung adenocarcinoma tissues as compared with matched noncancerous tissues (67.7%) and was associated with poor differentiation (p=0.017) and metastasis (p=0.04). Western blotting and immunohistochemical analysis also showed that PAR4 protein levels were mostly decreased in lung adenocarcinoma tissues (61.3%), and were also associated with poor differentiation (p=0.035) and clinical stage (p=0.027). Moreover, PAR4 expression was decreased in NCI-H157 cells as compared with BEAS-2B cells. In conclusion, PAR4 expression is significantly decreased in lung adenocarcinoma, and down-regulation of PAR4 is associated with a more clinically aggressive phenotype. PAR4 may acts as a tumor suppressor in lung adenocarcinoma.

Surgical Management for Giant Liver Hemangiomas Greater Than 20 cm in Size

( Hui Jiang ),( Zhe Yu Chen ),( Pankaj Prasoon ),( Hong Wu ),( Yong Zeng ) 대한소화기기능성질환·운동학회 2011 Gut and Liver Vol.5 No.2

Background/Aims: The aim of this study was to investigate the primary management experience for giant liver hemangiomas greater than 20 cm in size. Methods: Records of patients referred for evaluation of radiologically and/or histopathologically proven giant liver hemangiomas between January 2007 and March 2010 were retrospectively analyzed. The reasons for referral, results of imaging studies, preoperative and surgical treatments, and outcome were reviewed. Results: A retrospective analysis was performed for 14 patients diagnosed with a giant hemangioma on the basis of an imaging study and/or a histopathological examination. All cases were diagnosed as giant liver hemangioma with at least one lesion greater than 20 cm in size. Abdominal discomfort was the main presenting complaint for the referral in 9 patients (64.2%). Abdominal ultrasound established the diagnosis in 12 patients (85.7%). Twelve patients underwent liver resection, 2 of whom underwent staged resection. Enucleation was performed in 2 patients. Selective transcatheter arterial embolization was implemented in 9 patients. Postoperative morbidity occurred in 3 patients (21.4%). No complications related to the hemangiomas occurred during follow up. Conclusions: Liver resection is indicated for giant liver hemangiomas with abdominal discomfort, especially for lesions greater than 20 cm in size. Staged operations are performed for patients with multiple lesions. Preoperative selective transcatheter arterial embolization alleviates progressive abdominal pain. (Gut Liver 2011;5:228-233)

Laminarin improves developmental competence of porcine early stage embryos by inhibiting oxidative stress

Jiang, Hao,Liang, Shuang,Yao, Xue-Rui,Jin, Yong-Xun,Shen, Xing-Hui,Yuan, Bao,Zhang, Jia-Bao,Kim, Nam-Hyung Elsevier 2018 Theriogenology Vol.115 No.-

<P><B>Abstract</B></P> <P>Laminarin (LMA), a β-glucan mixture with good biocompatibility, improves the growth performance and immune response when used as food additives and nutraceuticals. The aim of the present research was to explore the effects of LMA on porcine early stage embryo development, as well as the underlying mechanisms. The results showed that the developmental competence of porcine early stage embryos was dramatically improved after LMA supplementation during the in vitro culture period. The presence of 20 μg/mL LMA during the in vitro culture period significantly improved cleavage rate, blastocyst formation rates, hatching rate, and total cell number in the blastocyst compared to that in the control group. Notably, LMA attenuated the intracellular reactive oxygen species generation induced by H<SUB>2</SUB>O<SUB>2</SUB>. Furthermore, LMA not only increased intracellular glutathione levels, but also ameliorated mitochondrial membrane potential. In addition, the expression of a zygotic genome activation related gene (<I>YAP1</I>), pluripotency-related genes (<I>OCT4</I>, <I>NANOG,</I> and <I>SOX2</I>), and hatching-related genes (<I>COX2</I>, <I>GATA4,</I> and <I>ITGA5</I>) were up-regulated following LMA supplementation during porcine early stage embryo development. These results demonstrate that LMA has beneficial effects on the development of porcine early stage embryos via regulation of oxidative stress. This evidence provides a novel method for embryo development improvement associated with exposure to LMA.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Laminarin has beneficial effects on the development of porcine early stage embryos. </LI> <LI> Laminarin attenuates intracellular reactive oxygen species generation. </LI> <LI> Laminarin increases intracellular glutathione levels and ameliorates ΔΨm. </LI> <LI> Laminarin up-regulates the expression of ZGA/pluripotency/hatching related genes. </LI> </UL> </P>

Epithelial-Mesenchymal Transition and Migration of Prostate Cancer Stem Cells Is Driven by Cancer-Associated Fibroblasts in an HIF-1alpha/beta-Catenin-Dependent Pathway

Yong Luo,Ling Lan,Yong-Guang Jiang,Jia-Hui Zhao,Ming-Chuan Li,Neng-Bao Wei,Yun-Hua Lin 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2

Although cancer stem cells (CSCs) play a crucial role in seeding the initiation of tumor progression, they do not always possess the same potent ability as tumor metastasis. Thus, precisely how migrating CSCs occur, still remains unclear. In the present study, we first comparatively analyzed a series of prostate CSCs, which exhibited a dynamically increasing and disseminating ability in nude mice. We observed that the transcriptional activity of HIF-1 and -catenin became gradually elevated in these stem cells and their epithelial-mesenchymal transition (EMT) characteristic altered from an epithelial type to a mesenchymal type. Next, we further used cancer-associated fibroblasts (CAFs), which were cultured from surgically re-sected tissues of prostate cancer (PCa) to stimulate prostate CSCs. Similar results were reconfirmed and showed that the protein levels of both HIF-1 and -catenin were markedly improved. In addition, the EMT phenotype displayed a homogenous mesenchymal type, accompanied with increased aggressive potency in vitro. Most importantly, the aforementioned promoting effect of CAFs on prostate CSCs was completely repressed after “silencing” the activity of -catenin by transfection of stem cells with ShRNA. Taken together, our observations suggest that prostate migrating CSCs, with a mesenchymal phenotype, could be triggered by CAFs in a HIF-1alpha/beta-catenin-depen-dent signaling pathway.

Reentry Attitude Tracking Control Based on Fuzzy Feedforward for Reusable Launch Vehicle

Yu-Hui Wang,Qian-Xian Wu,Chang-Sheng Jiang,Guo-Yong Huang 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.4

This paper presents a novel fuzzy tracking control method, which is used for the reentry attitude tracking problem of a reusable launch vehicle. Based on Takagi-Sugeno fuzzy description of reentry attitude dynamics, the tracking error of attitude angles is studied. Without the need of an augmented system, exponential stability of the tracking error can be obtained by a fuzzy feedforward controller. In addition, to achieve a good tracking performance, H∞ and decay rate η control methods are considered. The solutions to the robust fuzzy tracking control problem can be obtained by applying linear matrix inequalities and fuzzy logic controller tools. The simulation results demonstrate the effectiveness of the proposed method.

Decentralized Robust H∞ Output Feedback Control for Value Bounded Uncertain Large-scale Interconnected Systems

Zhao-Hui Jiang,Yong-Fang Xie,Wei-Hua Gui,Can Huang 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.1

In this paper, decentralized robust H∞ output feedback control problem for large-scale interconnected system with value bounded uncertainties in the state, control input and interconnection matrices is investigated. A new bounded real lemma for the large-scale interconnected systems is derived by Lyapunov stability theory and linear matrix inequality method. Based on the new bounded real lemma, a sufficient condition expressed as matrix inequalities for the existence of a decentralized robust H∞ output feedback controller is obtained. The controller which enables the closed-loop large-scale system robust stable and satisfies the given H∞ performance is designed through a homotopy iterative method. Finally, a numerical example is given to illustrate the effectiveness of the proposed method.