서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Phenyl-N-benzoylchlorothioformimidate 誘導體의 加水分解 反應 메카니즘

權奇星,金千石,李龍九,成洛道 충남대학교 기초과학연구소 1992 연구논문집 Vol.12 No.-

25℃의 30%(v/v) dioxane-물의 혼합용매 속에서 pH 변화에 따른 X와 Y-치환된 phenyl-N-benzoylchlorothioformimidates(S)들의 가수분해 반응 속도상수를 측정하여 반응속도식을 유도하고, 경계 궤도 함수 상호작용, 용매효과, 일반 염기 촉매효과, 열 역학적 활성화 파라미터, 및 가수분해반응 생성물 분석 등의 결과로부터 pH 10.0 이하의 낮은 pH에서는 azocarbocation 중간체를 지나는 S_N1형 반응, pH 11.0 이상의 높은 pH에서는 사면체 중간체를 지나는 친핵성 첨가-제거(Ad_N-E)반응 그리고 pH 10.0과 11.0 사이에서는 이들 두가지 유형의 궤도 조절 반응이 서로 경쟁적으로 일어남을 제안하였다. The rate constants of hydrolysis of phenyl-N-benzoylchlorothioformimidates were determined by UV. spectrophotometry in 30% (v/v) aqueous dioxane at 25℃. On the basis of rate equation, general base catalysis, solvent effect, substituent effect, thermodynamic parameters, frontier orbital interaction and hydrolysis product analysis, it may be concluded that the hydrolysis of phenyl-N-benzoylchlorothioformimidates proceed through S_N1 mechanism via azocarbocation intermidiate below pH 10.0, while above pH 10.00 the hydrolysis proceeds through nucleophilic addition-elimination (Ad_N-E) mechanism. In the range of pH from 10.0 to 11.0 these two reaction occur competitavely.

Higenammine이 심근의 활동전압 및 수축에 미치는 영향

권평중,조성일,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1981 中央醫大誌 Vol.6 No.4

In order to investigate the action mechanism of higenamine on cardiac muscle cells, the isometric contraction and transmembrane action potential in rabbit papillary muscle preparations taken out from tight ventricles were observed. The isometric contraction and action potential were recorded in the control Tyrode solution and higenamine-Tyrode solution in which the preparations were kept beating (1 Hz.) for about 30 minutes to get stable data. The resting membrane potential, amplitude of action potential amplitude of overshoot potential, time of repolarization to 60%, 90% of the amplitude of action potential and the first derivatives of potential recorded transmembrane action potential in control Tyrode solution and higenamine (2.5×10^-7gm/ml) Tyrode solution in which showed about 130%-150% of positive inotropic effect compared with those controls. The following results were obtained. 1. Higenamine showed no effects on the time-to-peak tension. 2. Higenamine showed almost no effects on resting membrane potential, amplitude of action potential and overshoot potential. 3. Higenamine significantly shortened to repolarize 60% or 90% of the action potential from 218ms and 264ms in the controls to 200ms and 246ms respectively. (p<0.005) Therefore. the maximum values of the first derivatives of potential variations (- Vmax) in the plateau phase an d repolarization phase were also significantly increased from 16.3V/sec in the control groups to 17.3V/sec in the higenamine-treated groups. The above results which showed positive inotropic effect and simultaneously shortening of action potential duration by higenamine suggest possible involvement of the increase of slow inward current.

신경섬유종증 환자에게서 발생한 특발성 혈소판 감소증 1예

권세훈,김형호,강지인,장재혁,원경준,장재현,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Idiopathic thrombocytopenic purpura is a disease characterized by thrombocytopenia in peripheral blood with positive anti-platelet antibody titer, no splenomegaly, the presence of megakarocyte. The causes of idiopathic thrombocytopenic purpura were usually related to autoimmune disease, infection and drugs. A 46-years-old man was admitted for evaluation of abdominal mass. He has many cafe-au-lait spots and nodules in almost skin for 30 years. Several years ago, he palpated mass in Lt. inguinal area. hIe has known the abdominal mass after checking abdomen CT in local clinic and visited our hospital for evaluation of abdominal mass. At admission, laboratory tests showed hemoglobin 12.5 g/dL, hematocrit 38.4 %, WBC 5,460 /㎣ (neutrophil 64.5%, lymphocyte 21.7%, monocyte 4.1%, eosinophil 5.4%), reticulocyte 0.7%, Platelet 52,000 /㎣, total protein 6.51 g/dL, albumin 3.80 g/dL, alkaline pohsphatase 161 IU/L, AST 110.7 IU/L, ALT 64.9 IU/L, total bilirubin 0.44 ㎎/dL, BUN 18.4 ㎎/dL, creatinine 0.79 ㎎/dL. Peripheral blood smear showed normocytic normochromic anemia, thrombocytopenia. Bone marrow aspiration smear showed normoplastic myeloid and erythroid precursor. The bone marrow biopsy section shows normocellular marrow (35%) for his age and mildly increasing myeloid cell lineage. We have experienced a case of idiopathic thrombocytopenic purpura in a patient being in neurofibromatosis and therefore reporting it with documentary records. 저자들은 신경섬유종증 환자에서 특별한 원인을 발견할 수 없었음에도 특발성 혈소판 감소증이 발생한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

교합성 골수강내 금속정으로 치료한 대퇴골 골절의 치료

권칠수,안종국,김용욱,김진혁,정병현,성열보,강재철 인제대학교 1995 仁濟醫學 Vol.16 No.4

대퇴골 간부 골절시 교합성 골수강내 금속정을 이용한 견고한 고정은 조기 관절 운동과 조기 체중부하가 가능한 보편적인 수술적 치료방법으로 그 사용이 증가하고 있다. 그리고 최근에는 골수강내 금속정이 대퇴골 간부 골절 뿐만 아니라 대퇴골의 근위부나 원위부에 치우친 골절이나 청소년기의 대퇴골 간부 골절의 치료에도 확대되고 있다. 본 논문은 대퇴골 골절 환자 54례를 대상으로 금속정 삽입술의 적응증의 확대와 그에 수반되는 문제점에 관하여 증례 분석 및 결과를 문헌 고찰과 함께 보고하고자 한다. The rigid internal fixation of femur shaft fracture with intramedullary nailing enables early joint motion and weight bearing. This procedure has been used with wide popularity because it is possible simultaneously to preserve the range of motion and to obtain the bone union. But in the proximal and distal femur fracture, the interlocking screws are too close to the fracture site, the rigid fixation cannot be achieved and when early weight bearing is permitted, failure of the metal is possible. Also, when femur fractures in the adolescence be treated with traction followed by casting, sometimes angular deformity and shortening may develope. These problems have solved to the use by intramedullary nailing. The authors reviewed and analyzed 54 cases of the fractures of femur treated by interlocking nails at Sang-Gye Paik Hospital from August 1989 to July 1992. The results were as follows ; 1.Among the 54 patients, male were 42 and female were 12. 2.The mean time of bone union was 19.3 weeks. 3.The authors usually used the closed locked nailing technique to fix the mid-shaft fracture of femur. In cases such as mid-shaft fracture combined wish proximal or distal femoral fracture, for the stability of fracture and the early mobilization, a reconstruction nail or modified nailing technique was used and an excellent bone union was obtained without any complication. 4.In a mid-shaft fractures of the femur in adolescents or young adult, the authors used interlocking nails of proper length or diameter by cutting-off the distal portion of the nail or by over-reaming of the too narrow medullary canal, and the outcome was favorable.

수정된 DP 정합을 이용한 필기체 한자 인식

권희용,전상엽 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

온라인 필기체 한자는 동일인의 동일 문자조차도 획수, 획순 및 형태의 변화가 다양할 뿐만 아니라 인식 대상이 방대하여 인식이 매우 어렵다. 또한 한자는 기본 자소의 조합에 의한 글자가 아닌 각각의 글자가 독립적으로 이루어져 있어 연속된 획들 간의 관련도를 파악하기 어렵고 획수도 1획에서 28획까지 다양하게 분포를 한다. 따라서 본 연구에서는 대분류 단계로 시작 획 비교를 하고 이어진 세 분류 단계에서 문자의 특징으로 방향코드와 특이점을 추출해내고 획수 및 각 획의 특징을 고려하여 DP 정합을 하는 2단계 인식 시스템을 제안하였다. 이로써 최적의 속도로 입력한 문자를 찾아낼 수 있도록 하였다. In this paper, we propose two step handwriting chinese character recognition system. It is very difficult to recognize them because there are many variations on the number of strokes, orders and shapes even in a character written by a person, and there are too many characters about 100 thousand and strokes from 1 to 28, to classify. And also, Chinese characters are not composed of basic components like consonants and vowels, but independent simple units. So it is hard to analyze the relationship among the consecutive strokes. We propose a new two step recognition system; In the class classifying step, we compare the first stroke of an input character with that of models and classify the class, in the recognizing step, we extract the direction codes and characteristic points from strokes as a character's features, then matches them with those of model patterns using DP algorithm considering with the numbers of strokes and the features. In the experiments, we show that the proposed algorithm effectively classifies the input characters.

소형 트럭용 CNG/가솔린 겸용 엔진 개발과 성능 분석

권오운,김재수,박용국,김성준 江原大學校 産業技術硏究所 2006 産業技術硏究 Vol.26 No.B

A diesel truck of 1 ton is re-powered by a gasoline engine and the fuelling system of gasoline engine is modified to gasoline/CNG bi-fuel system. The engine characteristics such as fuel economy and power are evaluated by driving test, sloping test and dynamometer. The driving test prove the driving cost is saved by 55% and the maximum speed is raised by 13%, which is mainly due to the higher calorific value of CNG. The sloping test is done on thc road of which slope is 15%. The truck shows the mean velocity of 88km/h, which means that are-powered truck is working fine. The BHP are measurcd by dynamomcter. The-power and torque produced by a re-powered truck are reduced by 13% and 14% respectively from the power of gasoline engine. The BHP reduction is one of main problems which one has to solve in near future.

Film중감지와 Film의 활용에 따른 화질특성의 고찰

권용재,이상모,김순희,김도형,최태균 한국건강관리협회 2000 건협 Report Vol.3 No.-

말초혈액에서 Tg mRNA에 대한 역전사 중합효소 연쇄 반응법의 갑상선 재발암의 분자생물학적 진단

권성일,박기룡,김현영,신채희,임영찬,최영식,박요한,이강대,장희경,이재화,염하용 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.4

연구배경: 갑상선암은 다른 조직에 발생한 암에 비해 비교적 천천히 자라므로 대부분 예후가 양호하지만, 일부에서는 주위 조직으로 침윤하거나 혹은 원격 전이로 인하여 치명적인 결과를 초래할 수 있다. 갑상선전절제술 및 131^I 제거술 후 경과 관찰시 갑상선암의 재발과 전이의 진단에 있어 131^I 스캔과 혈청 Tg의 측정이 현재 임상에서 가장 많이 이용되고 있으나 이 방법에는 여러 가지의 결점이 있다. 최근 Tg mRNA에 대한 RT-PCR법을 이용한 여러 연구결과는 131^I 스캔과 혈청 Tg 측정의 결점을 보완할 수 있는 좋은 보조적인 진단법으로 이용할 수 있을 가능성을 제시하였다. 이에 말초혈액에서 측정한 Tg mRNA에 대한 RT-PCR법이 갑상선 절제술 및 방사성요드 치료 후 갑상선암의 재발 및 전이 유무의 진단에 유용한가를 알아보고자 이 연구 시행하였다. 방법: 분화된 갑상선암으로 진단된 후 갑상선전절제술을 시행받고 방사성요드 치료를 받은 환자 중 현재까지 한차례에 이상 추적 방사성요드 전신 스캔을 시행하고 추적관찰이 가능했던 유두선암 35예, 여포선암 5예를 대상으로 연구를 시행하였다. 대상군은 131^I 스캔 소견상 음성인 군(Group Ⅰ), 잔여조직이 있는 군(Group Ⅱ), 국소전이가 있는 군(Group Ⅲ), 및 원격전이 군(Group Ⅳ)으로 구분하였다. 정상 대조군은 갑상선질환이 없는 10예의 건강인으로 하였다. 대상환자의 말초혈액을 이용한 Tg mRNA에 대해 특이적인 primer를 이용하여 RT-PCR 및 nested RT-PCR을 시행하였다. 결과: 본 연구 결과는 다음과 같다. 1) 131^I 스캔 소견상 음성인 군 21예 중 1예에서 Tg가 양성소견을 보였다. Anti Tg Ab가 양성인 4예 모두 Tg가 음성을 보였다. 잔여조직이 있거나 국소전이 및 원격전이를 보인 군 19예 중 Tg가 양성인 경우는 4예였으나, Tg mRNA는 전예에서 양성이었다. 2) 131^I 스캔에서 국소 및 원격전이 소견을 보인 8예 중 4예에서 Tg가 음성으로 131^I 스캔과 혈청 Tg 사이에 불일치 소견을 보였다. 3) 말초혈액에서 특이적인 primer를 이용하여 RT-PCR 및 nested RT-PCR을 시행한 결과 대상군 40예 및 정상 대조군 10예 모두에서 Tg mRNA가 양성을 보였다. 결론: 본 연구에서 갑상선 절제술 및 방사성요드 치료 후 갑상선암의 재발 및 전이 유무를 평가함에 있어 역전사 중합효소 연쇄 반응법을 이용한 Tg mRNA 측정의 의의는 재평가되어야 한다고 생각된다. Background: Differentiated thyroid cancer is the most common endocrine malignancy. Despite advances in the treatment of thyroid cancer, disease recurrence and metastasis may occur in as many as 20% of patients, and so continues to pose major problems in its clinical management. Serum thyroglobulin (Tg) measurements, by immunoassay, are used to detect residual or recurrent thyroid cancer following thyriod ablation. However, the usefulness of immunoassay is limited by both the requirement for thyroid hormone withdrawal, to attain optimal test sensitivity, and interference by the antithyroglobulin antibody (Anti-Tg Ab). Recent studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of Tg mRNA in the peripheral blood of patients with differentiated thyroid carcinomas. We performed this study to evaluated the usefulness RT-PCR of Tg mRNA in peripheral blood of patients with thyroid carcinoma following a total thyroidectomy and radioiodine ablation therapy. Methods: Forty cases that underwent a total thyroidectomy and radioiodine ablation therapy were included in this study. Of the 40 patients, 35 were papillary carcinomas and 5 were follicular carcinomas. Ten normal control subjects were also studied. Tg mRNA was extracted. Then RT-PCR and nested RT-PCR, were run with specific Tg primers. Concurrently, DNA sequencing of the isolates was carried out to prove the isolates were identical to the nucleotide sequence of the Tg. Results: The Tg was detected in 4 of 19 patients, with either a residual thyroid bed, or metastasis, on a 131^I whole body scan and in 1 of 21 patients with a negative radioiodine scan. Surprisingly, the Tg mRNA was detected in all the patients and normal controls. Conclusion: From our results we can not recommend Tg mRNA, detected by RT-PCR in peripheral blood, as a tumor marker superior to that of the Tg serum level. We consider an intensive re-evaluation of the method is required before considering its clinical applications (J Kor Soc Endocrinol 17:501∼513, 2002).

정상교합자의 치열궁 형태

권용철,성정옥,권오원,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.1

This study was designed to investigate dental arch shapes buccally and lingually at Bracket Level of Koreans. This involved studying 63 inviduals (37 males, 26 females) with normal occlusion ranging in age from 17 to 24 yesrs old. The landmarks were digitized and measurements and statistical analysis were performed by NEC 9801 V-M computer. The Results were as Follows: Bicanine width, Bipremolar width and Bimolar width were larger in males than in females. Buccal and lingual arch form and coordination form were obtained by NEC 9801 V-M computer. The parabolic equations which represents buccal and lingual arch form were obtained.