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RISS 인기검색어
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- 저자 : Yining Yin (검색결과 2 건)
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Development of a Love Wave Based Device for Sensing Icing Process with Fast Response
Wen Wang,Yining Yin,Yana Jia,Mengwei Liu,Yong Liang,Yufeng Zhang,Minghui Lu 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3
This work addresses the theoretical and experimental investigations of a Love wave based device employing waveguide structure of SiO2/36° YX-LiTaO3 for sensing icing process. The mass loading efect induced by the icing process modulates the acoustic wave propagation, and corresponding changes in device frequency can be collected to evaluate the icing process. The waveguide structure confnes the acoustic wave energy into SiO2 thin-flm, which contributes well to the improvement of the mass loading sensitivity. The corresponding sensing mechanism was analyzed by solving the acoustic propagation equations in layered structure. The sensing device patterned by delay-line on 36° YX-LiTaO3 substrate with SiO2 guiding layer was photolithographically developed as the sensor element, and characterized by using the high-low temperature chamber. The icing process was simulated by dropping appropriate water on top of the device surface. Very clear and fast frequency response was observed from the proposed sensing device in the icing process, and also, the infuence of SiO2 guiding layer thickness on sensor response was also investigated.
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Ji Haoyu,Ma Wenya,Liu Xu,Chen Hongyang,Liu Yining,Ren Zhongyu,Yin Daohong,Cai Ao,Zhang Zizhen,Wang Xin,Huang Wei,Shi Leping,Tian Yanan,Yu Yang,Wang Xiuxiu,Li Yang,Liu Yu,Cai Benzhi 생화학분자생물학회 2025 Experimental and molecular medicine Vol.57 No.-
Doxorubicin (DOX) is a first-line chemotherapy agent known for its cardiac toxicity. DOX-induced cardiotoxicity (DIC) severely limits the use for treating malignant tumors and is associated with a poor prognosis. The sensitivity to DIC varies among patients, but the precise mechanisms remain elusive. Here we constructed a mouse model of DIC using DOX to investigate potential mechanisms contributing to the differential susceptibility to DIC. Through surface-enhanced Raman spectroscopy and single-cell RNA sequencing, we explored the mechanisms underlying DIC phenotypic variations. In vitro and in vivo studies with small-molecule drugs were conducted. DIC-insensitive mice displayed preserved ejection fractions, lower DOX levels in cardiac tissues and higher levels in the serum. Single-cell RNA sequencing revealed differences of gene expression in cardiac endothelial cells between DIC-insensitive and DIC-sensitive groups. The expression of IFN-γ pathway-related genes was high in DIC-insensitive mice. IFN-γ administration decreased the DOX distribution in cardiac tissues, whereas PPAR-γ activation increased DIC susceptibility. IFN-γ stimulation upregulated P-glycoprotein expression, leading to increased DOX efflux and DIC insensitivity. Our model provides insights into the mechanisms of DIC sensitivity and potential preventive strategies.
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