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RISS 인기검색어
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- 저자 : Yinglu Guo (검색결과 3 건)
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Verruciform Xanthoma of the Penis
Tongli Xia,Guizhong Li,전인선,Yanqun,Na Yinglu Guo,정문기 대한비뇨의학회 2004 Investigative and Clinical Urology Vol.45 No.3
Verruciform xanthoma is an uncommon benign lesion. The most common presentation occurs in the oral cavity; however, it has also been described in other sites, especially the penis. Herein is reported the first case of verruciform xanthoma of the penis in China, the fourteenth case in the literature. Clinically, genital verruciform xanthoma is often confuses with papillomas, verrucous carcinomas and squamous cell carcinomas, and therefore a histopathological diagnosis is necessary. (Korean J Urol 2004;45: 297-298)
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Zhang, Yong,Kim, Kwan‐,Hyun,Zhang, Wei,Guo, Yinglu,Kim, Sung‐,Hoon,Lü,, Junxuan Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.130 No.1
<P><B>Abstract</B></P><P>Androgen receptor (AR) signaling is crucial for the genesis and progression of prostate cancer (PCa). We compared the growth responses of AR(+) LNCaP and LNCaP C4‐2 <I>vs</I>. AR(−) DU145 and PC‐3 PCa cell lines to galbanic acid (GBA) isolated from the resin of medicinal herb <I>Ferula assafoetida</I> and assessed their connection to AR signaling and cell cycle regulatory pathways. Our results showed that GBA preferentially suppressed AR(+) PCa cell growth than AR(−) PCa cells. GBA induced a caspase‐mediated apoptosis that was attenuated by a general caspase inhibitor. Subapoptotic GBA downregulated AR protein in LNCaP cells primarily through promoting its proteasomal degradation, and inhibited AR‐dependent transcription without affecting AR nuclear translocation. Whereas docking simulations predicted binding of GBA to the AR ligand binding domain with similarities and differences with the AR antagonist drug bicalutamide (Bic), LNCaP cell culture assays did not detect agonist activity of GBA. GBA and Bic exerted greater than additive inhibitory effect on cell growth when used together. Subapoptotic GBA induced G<SUB>1</SUB> arrest associated with an inhibition of cyclin/CDK4/6 pathway, especially cyclin D<SUB>1</SUB> without the causal involvement of cyclin‐dependent kinase (CDK) inhibitory proteins P21<SUP>Cip1</SUP> and P27<SUP>Kip1</SUP>. In summary, the novelty of GBA as an anti‐AR compound resides in the distinction between GBA and Bic with respect to AR protein turnover and a lack of agonist effect. Our observations of anti‐AR and cell cycle arrest actions plus the anti‐angiogenesis effect reported elsewhere suggest GBA as a multitargeting drug candidate for the prevention and therapy of PCa.</P>
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Huixi Li,Zhichao Zhang,Jing Peng,Zhongcheng Xin,Meng Li,Bicheng Yang,Dong Fang,Yuan Tang,Yinglu Guo 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.5
Purpose: To investigate whether treatment with low-energy shock wave (LESW) alleviates pain and bladder dysfunction in a mouse model of uroplakin 3A (UPK3A)-induced interstitial cystitis/painful bladder syndrome (IC/PBS). Materials and Methods: Forty female BALB/c mice were divided into four groups (n=10/group): Sham, Sham+LESW, UPK3A, and UPK3A+LESW. At 6 weeks of age, mice were injected with an emulsion containing water and complete Freund's adjuvant with (UPK3A and UPK3A+LESW groups) or without (Sham and Sham+LESW groups) 200 µg of UPK3A. At 10 weeks, mice received a second dose of Freund's adjuvant to booster immunization. At 12 weeks, mice underwent pain assessment and a frequency volume chart (FVC) test as the pretreatment assessment. LESW treatment and pain assessment were conducted from 13 to 15 weeks. One week after the final treatment, pain assessment and the FVC were conducted again as the post-treatment assessment. Mice were euthanized and sacrificed at 17 weeks. Results: The presence of tactile allodynia and bladder dysfunction was significant in the UPK3A-injected mice. LESW raised the pain threshold and improved bladder function with decreased urinary frequency and increased mean urine output. Expression and secretion of local and systemic inflammatory markers, including tumor necrosis factor-α (TNF-α) and nerve growth factor (NGF), increased after UPK3A immunization. These markers were significantly decreased after LESW treatment (p<0.05). Conclusions: LESW treatment attenuated pain and bladder dysfunction in a UPK3A-induced model of IC/PBS. Local and systemic inflammation was partially controlled, with a reduced number of infiltrated inflammatory cells and reduced levels of TNF-α and NGF.
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