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Li, Shi-Lai,Su, Ming,Peng, Tao,Xiao, Kai-Yin,Shang, Li-Ming,Xu, Bang-Hao,Su, Zhi-Xiong,Ye, Xin-Ping,Peng, Ning,Qin, Quan-Lin,Chen, De-Feng,Chen, Jie,Li, Le-Qun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the outcomes for patients are still poor. It is important to determine the original type of synchronous multinodular HCC for preoperative assessment and the choice of treatment therapy as well as for the prediction of prognosis after treatment. Aims: To analyze clinicopathologic characteristics and prognoses in patients with multicentric occurrence (MO) and intrahepatic metastasis (IM) of synchronous multinodular hepatocellular carcinoma (HCC). Methods: The study group comprised 42 multinodular HCC patients with a total of 112 nodules. The control group comprised 20 HCC patients with 16 single nodular HCC cases and 4 HCC cases with a portal vein tumor emboli. The mitochondrial DNA (mtDNA) D-loop region was sequenced, and the patients of the study group were categorized as MO or IM based on the sequence variations. Univariate and multivariate analyses were used to determine the important clinicopathologic characteristics in the two groups. Results: In the study group, 20 cases were categorized as MO, and 22 as IM, whereas all 20 cases in the control group were characterized as IM. Several factors significantly differed between the IM and MO patients, including hepatitis B e antigen (HBeAg), cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and the histological grade of the primary nodule. Multivariate analysis further demonstrated that cirrhosis and portal vein and/or microvascular tumor thrombus were independent factors differentiating between IM and MO patients. The tumor-free survival time of the MO subjects was significantly longer than that of the IM subjects ($25.7{\pm}4.8$ months vs. $8.9{\pm}3.1$ months, p=0.017). Similarly, the overall survival time of the MO subjects was longer ($31.6{\pm}5.3$ months vs. $15.4{\pm}3.4$ months, p=0.024). The multivariate analysis further demonstrated that the original type (p=0.035) and Child-Pugh grade (p<0.001) were independent predictors of tumor-free survival time. Cirrhosis (p=0.011), original type (p=0.034) and Child-Pugh grade (p<0.001) were independent predictors of overall survival time. Conclusions: HBeAg, cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and histological grade of the primary nodule are important factors for differentiating IM and MO. MO HCC patients might have a favorable outcome compared with IM patients.
Tao Chunrong,Yuan Guangxiong,Xu Pengfei,Wang Hao,Zhou Peiyang,Yi Tingyu,Li Kai,Cui Tao,Gao Jun,Li Rui,Sun Jun,Zhang Chao,Wang Li,Liu Tianlong,Song Jianlong,Yin Yamei,Nguyen Thanh N.,Li Qing,Hu Wei 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3
Background and Purpose To examine the clinical and safety outcomes after endovascular treatment (EVT) for acute basilar artery occlusion (BAO) with different anesthetic modalities. Methods This was a retrospective analysis using data from the Endovascular Treatment for Acute Basilar Artery Occlusion (ATTENTION) registry. Patients were divided into two groups defined by anesthetic modality performed during EVT: general anesthesia (GA) or non-general anesthesia (non-GA). The association between anesthetic management and clinical outcomes was evaluated in a propensity score matched (PSM) cohort and an inverse probability of treatment weighting (IPTW) cohort to adjust for imbalances between the two groups. Results Our analytic sample included 1,672 patients from 48 centers. The anesthetic modality was GA in 769 (46.0%) and non-GA in 903 (54.0%) patients. In our primary analysis with the PSM-based cohort, non-GA was comparable to GA concerning the primary outcome (adjusted common odds ratio [acOR], 1.01; 95% confidence interval [CI], 0.82 to 1.25; <i>P</i>=0.91). Mortality at 90 days was 38.4% in the GA group and 35.8% in the non-GA group (adjusted risk ratio, 0.95; 95% CI, 0.83 to 1.08; <i>P</i>=0.44). In our secondary analysis with the IPTW-based cohort, the anesthetic modality was significantly associated with the distribution of modified Rankin Scale at 90 days (acOR: 1.45 [95% CI: 1.20 to 1.75]). Conclusion In this nationally-representative observational study, acute ischemic stroke patients due to BAO undergoing EVT without GA had similar clinical and safety outcomes compared with patients treated with GA. These findings provide the basis for large-scale randomized controlled trials to test whether anesthetic management provides meaningful clinical effects for patients undergoing EVT.
Tao Meng,Tie-Zhen Ren,Qian-Qian Xu,Yin-Tao Li,Jian-Li Chang,Zhong-Yong Yuan 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.32 No.-
The Ni/reduced graphene oxide catalysts are synthesized by an in situ hydrothermal method, using thegraphene oxide as the support precursor. The textural and structural properties of the prepared Ni/reduced graphene oxide catalysts are characterized by X-ray diffraction, scanning and transmissionelectron microscopy, thermogravimetric analysis, H2-Temperature-programmed reduction, andelectrochemical impedance spectroscopy. The catalytic performances of the prepared Ni/reducedgraphene oxide catalysts for ammonia decomposition display the enhanced activity. The effect ofreduced graphene oxide support and the influence of nickel content on catalytic activity are evaluated,and the Ni/reduced graphene oxide catalysts exhibit higher catalytic activity than reduced grapheneoxide support and the pure NiO. The ammonia has a conversion of 81.9% and 27.4 mmol/min gcat H2 rateat 700 8C when the 10%-Ni/reduced graphene oxide catalyst used.
Characterization of Phenolic Compounds from Rhododendron alutaceum
Hai-Zhou Li,Rong-Tao Li,He-Jiao Song,Hong-Mei Li,Yu-Yin Pan 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11
A new phenolic glycoside, 3'-keto rhododendrin (1) and a new sesquilignan, alutaceuol (2), together with twelve known phenolic compounds, were isolated from the leaves of Rhododendron alutaceum. Their structures were elucidated by extensive spectroscopic data analysis and comparison with literature values. In addition, the detailed analysis of 2D NMR data led us to conclude that the chemical shifts of dihydrobuddlenol B (5) need to be revised.
( Qiu Chun Li ),( Ya Chen Hu ),( Yin Fei Wu ),( Xiao Chun Wang ),( Xiao Lei Xie ),( Ming Xin Tao ),( Jun Lei Yin ),( Zhi Jie Lin ),( Yang Jiao ),( Li Juan Xu ),( Xinan Jiao ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5
As Salmonella enterica serovar Pullorum remains a major economic problem for the poultry industries of countries with no efficient control measures, we presented a multidrug resistance strain S06004 (isolated from a clinically sick chicken in China in 2006) for genome sequencing. The genome comparison showed that the strain contained two prophages, the ST104 and prophage-4 (Fels2) of E. coli LF82, which were not detected in the only published genomes of S. Pullorum RKS5078 and CDC1983-67. In addition, the GyrA Ser83 point mutation, drugresistant genes, and many antibiotic pump systems that are present in S06004 may be contributing to the multidrug resistance of this strain.
In Vivo Evaluation of Curcumin-loaded Nanoparticles in a A549 Xenograft Mice Model
Yin, Hai-Tao,Zhang, De-Geng,Wu, Xiao-Li,Huang, Xin-En,Chen, Gang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Curcumin (Cum) has been reported to have potential chemo-preventive and chemotherapeutic activity through influencing various processes, inducing cell cycle arrest, differentiation and apoptosis in a series of cancers. However, the poor solubility of Cum limits its further applications in the treatment of cancer. We have previously reported Cum-loaded nanoparticles (Cum-NPs) prepared with amphilic methoxy poly(ethylene glycol)-polycaprolactone (mPEG-PCL) block copolymers. The current study demonstrated superior antitumor efficacy of Cum-NPs over free Cum in the treatment of lung cancer. In vivo evaluation further demonstrated superior anticancer effects of Cum-NPs by delaying tumor growth compared to free Cum in an established A549 transplanted mice model. Moreover, Cum-NPs showed little toxicity to normal tissues including bone marrow, liver and kidney at a therapeutic dose. These results suggest that Cum-NPs are effective to inhibit the growth of human lung cancer with little toxicity to normal tissues, and could provide a clinically useful therapeutic regimen. They thus merit more research to evaluate the feasibility of clinical application.
Theoretical and numerical analysis of the influence of initial stress gradient on wave propagations
Tao, Ming,Chen, Zhenghong,Li, Xibing,Zhao, Huatao,Yin, TuBing Techno-Press 2016 Geomechanics & engineering Vol.10 No.3
The investigation of stress wave propagation in a medium with initial stress has very important application in the field of engineering. However, the previous research less consider the influence of initial stress gradient on wave propagation. In the present paper, the governing equation of wave propagation in elastic continuum material with inhomogeneous initial stress is derived, which indicated that the inhomogeneous initial stress changed the governing equation of wave propagation. Additionally, the definite problem of wave propagation in material with initial stress gradient is verified by using mathematical physics method. Based on the definite problem, the elastic displacement-time relationship of wave propagation is explored, which indicated that the inhomogeneous initial stress changed waveform and relationship of displacement-time histories. Furthermore, the spall process of blasting wave propagation from underground to earth surface is simulated by using LS-DYNA.
Tunable Bandgap of Monolayer Black Phosphorus by Using Vertical Electric Field: a DFT Study
Tao Wang,Yan Liu,Qing Guo,Bin Zhang,Kuang Sheng,Can Li,You Yin 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.6
Using a ab initio plane-wave ultrasoft pseudopotential method based on the generalized gradientapproximation (GGA), we investigate the bandgap tuning in monolayer black phosphorus byapplying external electric fields perpendicular to the layers. The bandgap continuously decreaseswith increasing applied electric fields, eventually rendering them metallic. We use the giant Starkeffect, which is essentially characterized by an interlayer spacing to explain the rate of change ofthe bandgap with the applied external field. The atomic distance and charges also contribute to thesemiconductor-to-metal transition. Our investigations show the bandgap change for the fabricationof novel electronic and photonic devices.
Li, Hong-Sheng,Chen, Jin-Hu,Zhang, Wei,Shang, Dong-Ping,Li, Bao-Sheng,Sun, Tao,Lin, Xiu-Tong,Yin, Yong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Objective: To evaluate the effect of intravenous contrast on dose calculation in radiation treatment planning for oesophageal cancer. Methods: A total of 22 intravein-contrasted patients with oesophageal cancer were included. The Hounsfield unit (HU) value of the enhanced blood stream in thoracic great vessels and heart was overridden with 45 HU to simulate the non-contrast CT image, and 145 HU, 245 HU, 345 HU, and 445 HU to model the different contrast-enhanced scenarios. 1000 HU and -1000 HU were used to evaluate two non-physiologic extreme scenarios. Variation in dose distribution of the different scenarios was calculated to quantify the effect of contrast enhancement. Results: In the contrast-enhanced scenarios, the mean variation in dose for planning target volume (PTV) was less than 1.0%, and those for the total lung and spinal cord were less than 0.5%. When the HU value of the blood stream exceeded 245 the average variation exceeded 1.0% for the heart V40. In the non-physiologic extreme scenarios, the dose variation of PTV was less than 1.0%, while the dose calculations of the organs at risk were greater than 2.0%. Conclusions: The use of contrast agent does not significantly influence dose calculation of PTV, lung and spinal cord. However, it does have influence on dose accuracy for heart.