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Shin, Ji-Yon,Lee, Jung-Min,Shin, Heon-Sub,Park, Sang-Yong,Yang, Jung-Eun,KimCho, So-Mi,Yi, Tae-Hoo The Korean Society of Ginseng 2012 Journal of Ginseng Research Vol.36 No.1
The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside $F_2$ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with $IC_{50}$ of 50 ${\mu}g/mL$ through apoptosis, confirmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 mg/kg weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.
Anti-Cancer Effect of Ginsenoside F₂ against Glioblastoma Multiforme in Xenograft Model in SD Rats
Ji Yon Shin,Jung Min Lee,Heon Sub Shin,Sang Yong Park,Jung Eun Yang,Somi Kim Cho,Tae-Hoo Yi 고려인삼학회 2012 Journal of Ginseng Research Vol.36 No.1
The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside F₂ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with IC?? of 50 ㎍/mL through apoptosis, confi rmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 ㎎/㎏ weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.
Yi, Eun-Ji,Yang, Jung-Eun,Lee, Jung Min,Park, YongJin,Park, Sang-Yong,Shin, Heon-sub,Kook, MooChang,Yi, Tae-Hoo International Union of Microbiological Societies 2013 International journal of systematic and evolutiona Vol.63 No.9
<P>A Gram-reaction-positive, non-motile, non-spore-forming, catalase-negative, facultatively anaerobic, rod-shaped, β-glucosidase-producing lactic acid bacterium, designated strain THK-V8<SUP>T</SUP>, was isolated from the Korean fermented food, Kimchi, and its taxonomic position was investigated by using a polyphasic approach. Strain THK-V8<SUP>T</SUP> was able to grow at 4–40 °C (optimum, 30 °C) and pH 4.0–7.0 (optimum, pH 6.0). Strain THK-V8<SUP>T</SUP> had the ability to transform ginsenoside Rb<SUB>1</SUB> to Rd. On the basis of 16S rRNA gene sequence similarity data, strain THK-V8<SUP>T</SUP> was shown to belong to the genus <I>Lactobacillus</I>. Strain THK-V8<SUP>T</SUP> was related to <I>Lactobacillus koreensis</I> DCY50<SUP>T</SUP> (98.8 % sequence similarity), <I>Lactobacillus parabrevis</I> LMG 11984<SUP>T</SUP> (97.7 %), <I>Lactobacillus senmaizukei</I> L13<SUP>T</SUP> (97.5 %), <I>Lactobacillus hammesii</I> TMW1.1236<SUP>T</SUP> (97.3 %) and <I>Lactobacillus brevis</I> ATCC 14687<SUP>T</SUP> (97.2 %). Subsequently, sequence analysis of the RNA polymerase alpha subunit gene (<I>rpoA</I>) confirmed that strain THK-V8<SUP>T</SUP> showed a maximum <I>rpoA</I> gene sequence similarity value of 93 % with <I>Lactobacillus brevis</I> LMG 6906<SUP>T</SUP>. The G+C content of the genomic DNA was 47.8 mol%. The DNA–DNA hybridization values between strain THK-V8<SUP>T</SUP> and <I>Lactobacillus parabrevis</I> DCY50<SUP>T</SUP> and <I>Lactobacillus parabrevis</I> LMG 11984<SUP>T</SUP> were 46.1±4.9 % and 10.6±2.9 %, respectively. The major fatty acids were summed feature 7 (comprised of C<SUB>19 : 0</SUB> cyclo ω10<I>c</I>/19ω6), C<SUB>14 : 0</SUB>, C<SUB>16 : 0</SUB> and C<SUB>18 : 1</SUB>ω9<I>c</I>. The cell wall peptidoglycan was of the A4α <SMALL>l</SMALL>-Lys–<SMALL>d</SMALL>-Asp type. The phenotypic and molecular properties indicated that strain THK-V8<SUP>T</SUP> represents a novel species within the genus <I>Lactobacillus</I>, for which the name <I>Lactobacillus</I> <I>yonginensis</I> sp. nov. is proposed. The type strain is THK-V8<SUP>T</SUP> ( = KACC 16236<SUP>T</SUP> = JCM 18023<SUP>T</SUP>).</P>
<i>Chryseobacterium gwangjuense</i> sp. nov., isolated from soil
Park, Yong Jin,Son, Heung-Min,Lee, Eun-Hee,Kim, Ju Han,Mavlonov, Gafurjon T.,Choi, Ki Ju,Shin, Hun-Sub,Kook, MooChang,Yi, Tae-Hoo International Union of Microbiological Societies 2013 International journal of systematic and evolutiona Vol.63 No.12
<P>A Gram-stain-negative, strictly aerobic, non-motile, rod-shaped bacterial strain, THG-A18<SUP>T</SUP>, was isolated from soil of Gwangju province in South Korea. Strain THG-A18<SUP>T</SUP> grew optimally at 25–30 °C, at pH 7.0–8.0 and in the absence of NaCl. Strain THG-A18<SUP>T</SUP> displayed β-glucosidase activity, which enabled it to convert ginsenoside Rb<SUB>1</SUB> to Rd. According to 16S rRNA gene sequence analysis, strain THG-A18<SUP>T</SUP> was shown to belong to the genus <I>Chryseobacterium</I>. The closest phylogenetic neighbours were <I>Chryseobacterium ginsenosidimutans</I> THG 15<SUP>T</SUP> (97.9 % 16S rRNA gene sequence similariity), <I>C. defluvii</I> B2<SUP>T</SUP> (97.7 %), <I>C. daeguense</I> K105<SUP>T</SUP> (97.6 %), <I>C. taiwanense</I> BCRC 17412<SUP>T</SUP> (97.5 %), <I>C. indoltheticum</I> LMG 4025<SUP>T</SUP> (97.4 %), <I>C. gregarium</I> P 461/12<SUP>T</SUP> (97.4 %) and <I>C. lathyri</I> RBA2-6<SUP>T</SUP> (97.3 %), but DNA–DNA relatedness values between these strains and strain THG-A18<SUP>T</SUP> were below 41.9 %. The G+C content of the genomic DNA was 36.4 mol%. The major respiratory quinone (MK-6) and fatty acids [iso-C<SUB>15 : 0</SUB>, iso-C<SUB>17 : 0</SUB> 3-OH, summed feature 3 (comprising C<SUB>16 : 1</SUB>ω7<I>c</I> and/or C<SUB>16 : 1</SUB>ω6<I>c</I>) and summed feature 9 (comprising iso-C<SUB>17 : 1</SUB>ω9<I>c</I> and/or 10-methyl C<SUB>16 : 0</SUB>)] supported the affiliation of strain THG-A18<SUP>T</SUP> with the genus <I>Chryseobacterium</I>. The polar lipids of strain THG-A18<SUP>T</SUP> were phosphatidylethanolamine, four unidentified aminolipids and seven unidentified lipids. A number of physiological and biochemical tests allowed phenotypic differentiation of strain THG-A18<SUP>T</SUP> from recognized species of the genus <I>Chryseobacterium</I>. The name <I>Chryseobacterium gwangjuense</I> sp. nov. is proposed, with THG-A18<SUP>T</SUP> ( = KACC 16227<SUP>T</SUP> = LMG 26579<SUP>T</SUP>) as the type strain.</P>
내시경적 치료로 제거하지 못한 총담관 결석에서의 복강경 담관 탐색술 성적
이현섭(Hyun Sub Lee),민석기(Seog Ki Min),이선영(Sun Young Yi),이현국(Hyeon Kook Lee) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.3
Purpose: With the advent of endoscopic technology, ERCP (endoscopic retrograde cholangiopancreatography)/ES (endoscopic sphincterotomy) has become the main treatment for CBD stones. However, when ERCP fails to remove CBD stones, it remains unclear whether laparoscopic treatment is an alternative or not. The aim of this study was to investigate the outcome of LCBDE for the management of difficult choledocholithiasis. Methods: This study was a retrospective analysis of 68 LCBDE cases that were performed at the Ewha Womans University School of Medicine, Mokdong Hospital from January, 2000 to March, 2006. Group A was defined that primary LCBDE was performed without ERCP/ES. Group B was defined that secondary LCBDE was performed after ERCP/ES had failed. The operative outcomes and postoperative complications were compared between the two groups. Results: Primary LCBDE was performed for 33 patients (Group A) and secondary LCBDE after failure of ERCP/ES was performed for 35 patients (Group B). No significant differences in gender, mean age and associated diseases were noted between the two groups. The stone clearance rate was 100% for both groups. There were no significant differences between the two groups for the mean operative time (201.5 min for Group A vs 188.7 min for Group B: P=0.415), the open conversion rate (9.1% vs 0%, respectively: P=0.068), the complication rate (12.1% vs 8.6%, respectively: P=0.630) and the duration of the hospital stay (14.3 days vs 11.9 days, respectively: P=0.169). The recurrence rate along with a mean follow-up of 24 months showed no significant difference between the two groups (12.1% vs 2.9%, respectively). Conclusion: When ERCP is impossible or stone retrieval is incomplete, LCBDE is an alternative treatment for difficult CBD stones.