Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma

Yi-Sheng Liu,Ming-Ching Ou,Yi-Shan Tsai,Xi-Zhang Lin,Chien-Kuo Wang,Hong-Ming Tsai,Ming-Tsung Chuang 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.1

To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated. No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C wassignificantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively. In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.

넷플릭스(Netflix) 이용자의 지속적 이용의도의 결정 요인에 관한 연구

오이쥔(Ou Yi Chun),조재희(Jaehee Cho) 한국언론학회 2017 한국언론학보 Vol.61 No.5

In relation to the emergence of Netflix in foreign markets, thi study intends to investigate the satisfaction of Netflix users in Korea and Taiwan as well as their intentions of whether or not to continue using the service. To this end, Netflix usage questionnaires were analysed using innovation adoption and post-acceptance models. This study found out that relative advantage, compatibility, privacy risk, and cost play a significant role in the satisfaction of Korean and Taiwanese users. However, complexity’s effects on users’ continuance intentions to use Netflix was statistically insignificant among both Korean and Taiwanese users. Moreover, triability and observability affect only Korean users’ attitudes toward Netflix. This study is meaningful in that it conducts a cross-national comparisons about a globally powerful OTT service between Korea and Taiwan. This research’s main findings contribute to widening the understanding of the global OTT markets, particularly in Asian countries.

The Relationship between the Landscape Preference of Campus Greenland and Place Attachment

Yi Hsin Yeh,Sheng Jung Ou,Chun Yeng Chang 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Slender RC columns strengthened with combined CFRP and steel jacket under axial load

Yi-Yan Lu,Shan Li,Na Li,Tian-yan Ou 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.19 No.5

This paper presents an experimental study on the effectiveness of simultaneous application of carbon fiber-reinforced polymer (CFRP) and steel jacket in strengthening slender reinforced concrete (RC) column. The columns were 200 mm square cross section with lengths ranging from 1600 to 3000 mm. Ten columns were tested under axial load. The effects of the strengthening technique, slenderness ratio, cross-section area of steel angle and CFRP layer number were examined in terms of axial load-axial strain curve, CFRP strain, steel strip strain and steel angle strain. The experiments indicate that strengthening RC columns with combined CFRP and steel jacket is effective in enhancing the load capacity, ductility and energy dissipation capacity of RC column. Based on the existing models for RC columns strengthened with CFRP and with steel jacket, a design formula considering a slenderness reduction factor is proposed to predict the load capacity of the RC columns strengthened with combined CFRP and steel jacket. The predictions agree well with the experimental results.

GPS-free Vehicular Localization System Using Roadside Units with Directional Antennas

Ou Chia-Ho,Wu Bing-Yi,Lin Cai 한국통신학회 2019 Journal of communications and networks Vol.21 No.1

The success of dedicated short-range communications(DSRC) applications depends on an accurate knowledge of the positionsof vehicles within the network. At present, vehicle localizationis generally performed using some form of vehicle-mountedglobal positioning system (GPS). However, GPS signals may not bealways available. Various GPS-free vehicle localization techniquesusing the ranging information, the prior knowledge of the vehicle’sposition, or the special hardware have been proposed for enhancingthe performance of traditional GPS-based methods. Differentfrom the previous approaches, we propose a GPS-free vehicle localizationsystem using roadside units (RSUs) with directional antennaswithout specific hardware support on the vehicle and theassumption of the prior knowledge of the vehicle. In the proposedapproach, each vehicle determines its position using the informationcontained within beacon messages transmitted by neighboringRSUs deployed along the road only. The performance of the proposedlocalization scheme is evaluated by ns-2 simulations and iscompared with those of recent GPS-free and GPS-assisted localizationsystems. The simulation results show that the proposed localizationscheme achieves a higher positioning accuracy than theexisting GPS-free and GPS-assisted schemes. The feasibility of theproposed system for practical applications is further investigatedexperimentally. The experimental results for the positioning accuracyare consistent with those obtained from the ns-2 simulations.

공정시스템,이동현상,화학공정안전 : 수직 배관 내의 농도변화에 따른 분진폭발 특성

한우섭 ( Ou Sup Han ),한인수 ( In Soo Han ),최이락 ( Yi Rac Choi ),이정석 ( Jung Suk Lee ),이수희 ( Su Hee Lee ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.1

본 연구에서는 수직 배관 내에서 석송자 농도 변화에 따른 분진화염전파 특성을 상세히 조사하였다. 이를 위해 디지털비디오카메라와 PIV(Particle Image Velocimetry)를 사용하여 높이 120 cm, 단면 12 cm의 정방형 수직 덕트 내를 전파하는 분진화염의 입자거동을 해석하였다. 그 결과, 배관 내에 동일 평균농도의 분진운이 존재하는 경우 상방전파보다 하방 전파에 의한 화염전파속도가 크며 농도 약 300g/m3까지의 경우에는 분진농도가 증가할수록 그 비율이 증가하였다. 후방 화염(Post flame)은 배관 측벽과 화염면 사이를 통과하여 전파화염 후방에 유입된 미연소 입자의 발화에 의한 것으로 배관의 밀폐조건과 관계없이 발생하였다. 또한 후방 화염의 발생 빈도는 농도의 증가와 함께 증가하는 것을 알았다. We investigated experimentally the properties of dust explosion through lycopodium particle clouds in a duct to provide the fundamental knowledge. Propagating dust flames in the vertical duct of 120 cm height and 12 cm square cross-section were observed by digital video camera and flame front is visualized using by PIV(particle Image Velocimetry) system. As the result, when the same average dust concentration existed in the vertical duct, downward flame propagation was faster than the upward flame propagation, its rate increased with dust concentration in 300g/m3. Post flames were caused by the ignition of unburned particles which flowed into the rear region of flame from passage between flame and duct wall, and they generated regardless of duct condition. Also, it was found that appearance frequency of post flames during dust flame propagations increased with the increase of dust concentration.

폴리에틸렌 분진의 농도에 따른 발화특성

최이락(Yi-Rac Choi),한우섭(Ou-Sup Han) 한국가스학회 2014 한국가스학회 학술대회논문집 Vol.2014 No.6

ABS 분진의 화재·폭발 위험성 평가

최이락(Yi-Rac Choi),한우섭(Ou-Sup Han),이근원(Keun-Won Lee) 한국가스학회 2014 한국가스학회 학술대회논문집 Vol.2014 No.11

Preoperative BRAF Mutation is Predictive of Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma

Zhou, Yi-Li,Zhang, Wei,Gao, Er-Li,Dai, Xuan-Xuan,Yang, Han,Zhang, Xiao-Hua,Wang, Ou-Chen Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background and Objective: The optimal resection extent for clinically unilateral papillary thyroid microcarcinoma (PTMC) remains controversial. The objective was to investigate risk factors associated with occult contralateral carcinoma, and put emphasis on the predictive value of preoperative BRAF mutation. Materials and Methods: 100 clinically unilateral PTMC patients all newly diagnosed, previously untreated were analyzed in a prospective cohort study. We assessed the T1799A BRAF mutation status in FNAB specimens obtained from all PTMC patients before undergoing total thyroidectomy (TT) and central lymph node dissection (CLND) for PTMC. Univariate and multivariate analyses were used to reveal the incidence of contralateral occult cancer, difference of risk factors and predictive value, with respect to the following variables: preoperative BRAF mutation status, age, gender, tumor size, multifocality of primary tumor, capsular invasion, presence of Hashimoto thyroiditis and central lymph node metastasis. Results: 20 of 100 patients (20%) had occult contralateral lobe carcinoma. On multi-variate analysis, preoperative BRAF mutation (p = 0.030, OR = 3.439) and multifocality of the primary tumor (p = 0.004, OR = 9.570) were independent predictive factors for occult contralateral PTMC presence. However, there were no significant differences between the presence of occult contralateral carcinomas and age, gender, tumor size, capsular invasion, Hashimoto thyroiditis and central lymph node metastasis. Conclusions: Total thyroidectomy, including the contralateral lobe, should be considered for the treatment of unilateral PTMC if preoperative BRAF mutation is positive and/or if the observed lesion presents as a multifocal tumor in the unilateral lobe.

2-Chloro-N-(Cyano-2-thienyl methyl) acetamide의 열적 위험성 및 분해 특성

최이락(Yi-Rac Choi),서동현(Dong-Hyun Seo),한우섭(Ou-Sup Han) 한국가스학회 2022 한국가스학회지 Vol.26 No.5

2-Chloro-N-(Cyano-2-thienyl methyl) acetamide(CCTA)는 농약을 합성하는데 사용하는 중간체로써 상온 및 상압에서는 안정하지만 열축적 시 분해될 수 있다. 본 연구에서는 열중량분석기(TGA) 실험을 통해 온도에 따른 질량변화 측정으로 분해거동을 확인하고, 시차주사열량계(DSC)를 이용하여 열분해특성을 평가하였다. CCTA는 약 91 ℃에서 발열 분해반응이 급격하게 발생하였으며, Kissinger method, Kissinger-Akahira- Sunose(KAS) method, Flynn-Wall-Ozawa(FWO) method를 이용한 활성화 에너지 계산 결과, 각각 162 kJ/mol, 140 kJ/mol, 139 kJ/mol 으로 나타났다. 활성화에너지를 이용하여 계산된 24시간 이내 최대발열속도에 도달하는 온도인 T<SUB>D24</SUB>는 52~55 ℃로 평가되었다. 2-Chloro-N-(Cyano-2-thienyl methyl) acetamide (CCTA) is an intermediate used for synthesizing pesticides. It is stable at room temperature and pressure but can be decomposed when heat is accumulated. In this study, the decomposition characteristics were evaluated by measuring the weight change according to temperature using a Thermogravimetry analyzer(TGA), and the thermal decomposition characteristics were evaluated using Differential Scanning Calorimeter(DSC). The exothermic decomposition reaction occurred rapidly at about 91 ℃, and the activation energy determined by using Kissinger method, Kissinger– Akahira-Sunose(KAS) method, and Flynn-Wall-Ozawa(FWO) method were 162 kJ/mol, 149 kJ/mol and 139 kJ/mol, respectively. T<SUB>D24</SUB>, the temperature at which the maximum heating rate is reached within 24 hours, was evaluated as 52~55 ℃ using the estimated activation energy.