형질전환 제초제저항성 벼 밀양 204호의 농업적 특성

정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.

산재보상을 신청한 뇌심혈관질환의 특성 분석

유재홍,하은희,김수근,김정연,김용규,이의철,이철호,손준석 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 이 연구는 뇌 · 심혈관 질환으로 업무상재해를 신청한 사례 중에서 승인된 사례와 불승인된 사례의 특성을 비교하여 뇌 · 심혈관 질환의 업무상 재해여부를 판단하는데 필요한 기초 자료를 제공하고자 한다. 방법: 2000년부터 2004년까지 근로복지공단에 업무상 재해로 요양이 신청되어 승인여부가 결정된 뇌 · 심혈관 질환자 12,309명을 대상으로 하였다. 승인여부와 관련된 특성을 확인하기 위해 연도별, 업종별, 규모별, 직업별, 성별, 연령별, 질환별, 생존유무별 그리고 기존질환 유무에 대하여 카이제곱 검정과 다변량 로지스틱 회귀분석을 이용하였다. 결과: 다변량 로지스틱 분석에서 뇌 · 심혈관 질환의 불승인에 대한 승인의 비차비는 광업을 기준으로 하였을 때에 전기가스 상수도업이 4.18(95% CI=1.43~12.17), 건설업이 2.39 (95% CI=1.22~4.69), 제조업이 2.10 (95% CI=1.08~4.07)이었고, 장치기계조작원 및 조립원에 비하여 서비스 근로자 및 상점과 시장 판매근로자 군이 1.90(95% CI=1.47~2.47), 전문가 군이 1.83(95% CI=1.50~2.23), 기술공 및 준전문가 군이 1.63(95% CI=1.35~1.97), 입법 공무원과 고위 임직원 및 관리자 군이 1.62(95% CI=1.24~2.12)이었고, 여성이 남성에 비하여 1.31(95% CI=1.13~1.53), 심장질환에 비하여 뇌혈관질환이 2.75(95% CI=2.42~3.13), 사망한 경우가 생존한 경우에 비하여 6.01(95% CI=4.89~7.38)이었다. 결론: 우리나라에서 뇌심혈관질환으로 업무상 재해를 신청하는 건수는 증가하고 있고 승인율은 비교적 높았으며 승인에 영향을 미치는 요인으로는 업종, 규모, 직종, 성, 연령, 질환, 생존유무 등이 확인되었다. 특히 업종과 직종에 따라서 승인율의 차이가 큰 것이 어떠한 요인의 영향 때문인지에 대한 검토가 필요하고, 특히 뇌실질내 출혈의 경우에 다른 질환에 비하여 승인율이 매우 높았던 것은 업무수행성에 대한 인정기준의 잘못된 적용의 결과 이므로 시정이 필요하겠다. Objectives: This study was performed to provide fundamental data to judge whether or not cerebro and cardiovascular diseases are work-related, by comparing the characteristics between approved and non-approved cases among the worker's compensation claims. Methods: We collected 12,309 cerebro and cardiovascular disease claims based on the worker's compensation records of the Labor Welfare Corporation from 2000 to 2004. The approved and non-approved cases were analyzed according to factors such as the calendar year, industry, company size, occupation, gender, age group, classification of cerebro and cardiovascular diseases, fatality and underlying diseases. We used x²-test and multivariate logistic regression for the analysis. Results: According to multivariate logistic regression, electricity gas and water supply (OR=4.18, 95% CI=1.43~12.17), construction (OR=2.39, 95% CI=1.22~4.69) and manufacturing (OR=2.10, 95% CI=1.08~4.07) industries had a higher approval rate than mining and quarrying industries. Service workers and sales & marketing department workers (OR=1.90, 95% CI=1.47~2.47), professionals (OR=1.83, 95% CI=1.50~2.23), technicians and associate professionals (OR=1.63, 95% CI=1.35~1.97) and legislators and senior officials and managers (OR=l.62, 95% CI=1.24~2.12) had a higher approval rate than plant and machine operators and assemblers. Female workers had a higher approval rate (OR=1.31, 95% CI=1.13~1.53) than male workers. Cerebrovascular diseases had a higher approval rate (OR=2.75, 95% CI=2.42~3.13) than cardiovascular diseases. Fatal cases had a higher approval rate (OR=6.01, 95% CI=4.89~7.38) than surviving cases. Conclusion: For cerebro and cardiovascular diseases, workers' compensation claims are increasing, approval rates are relatively high and factors such as industry, company size, occupation, gender and fatality are related. A remarkable difference in the approval rate was found according to industry and occupation, suggesting the need for further study to identify which factors influence the approval rate. The approval rate for intracerebral hemorrhage arising in the course of employment (COE) was significantly higher than that arising out of employment (AOE), suggesting the need to correct the approval criteria.

Glycyrol의 면역세포 활성효과 및 항진균 효과

이주영,박지혜,김송이,이주희,한용문 동덕여자대학교 종합약학연구소 2006 동덕약학연구지 Vol.10 No.-

In this study, we determined proliferate effect on T-lymphocytes and antifungal activity of glycyrol that was isolated from Glycyrrhizae Radix (Leguminosae). In addition, immunoadjuvant activity of glycyrol was determined. Results showed that Gylcyrol (GCR) suppressed the proliferation of murine splenocytes that were treated with Concanavalin A (Con A). In case of the immunoadjuvant effect, glycyrol had no enhancement on antibody production. Data from experiments of antifungal activity in vitro, the component resulted in inhibition of Candida albicans growth. The antifungal effect appeared to be more potent than fluconazole. These data indicate that Glycyrol has no specific immunological effect on T- and B-cells, but the component contains antifungal activity.

형질전환 제초제저항성 벼 밀양 204호의 농업적 특성

정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희,Jeong Eung-Gi,Yi Gi-Hwan,Won Yong-Jea,Park Hyang-Mi,Cheon Nam-Soo,Choi Jun-Ho,Ku Yeon-Chung,Han Chang-Deok,Eun Mu-Yeong,Kim Tae-Sas,Nam Min-Hee 한국식물생명공학회 2005 식물생명공학회지 Vol.32 No.2

밀양 204호는 작물과학원 영남농업연구소 생명공학연구팀이 직파적응 제초제저항성 벼 품종을 육성할 목적으로 '98년 bar 유전자를 동진벼에 아그로박테리움법으로 형질 전환하여 제초제저항성 벼를 양성하였다. '98/'99년 동계에 단간 내도복 양질인 주남벼를 인공교배하여 약배양 등 육종프로그램에 적용하여 우량계통을 선발하고 밀양 204호로 계통명을 부여하였다. GM 벼와 Non-GM 벼의 농업적 특성을 UPOV 및 국립종자관리소의 품종등록 기준에 따른 농업적특성 중 차이가 있었던 것은 엽색도, 지엽의 형태, 간장, 수당립수 등 이었다. This study was conducted to investigated the major characteristics of genetically modified rice of 'Milyang 204' originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Jun-ambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of 'Milyang 204' showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic 'Milyang 204' showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the non-transgenic varieties rice.

Dysphagia in Infants After Open Heart Procedures

Yi, Sook-Hee,Kim, Sang-Jun,Huh, June,Jun, Tae-Gook,Cheon, Hee Jung,Kwon, Jeong-Yi Lippincott Williams Wilkins, Inc. 2013 AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITA Vol.92 No.6

OBJECTIVE: The aims of this study were to evaluate the prevalence and the clinical predictors of dysphagia and to determine the characteristics of videofluoroscopic swallowing study findings in infants after open heart procedures. DESIGN: This study is a retrospective review of 146 infants who underwent open heart surgery. The infants with dysphagia were compared with those without dysphagia. The videofluoroscopic swallowing study findings of the infants with dysphagia were also evaluated. RESULTS: Of the 146 infants who underwent open heart surgery, 35 (24.0%) had dysphagia symptoms. The infants with dysphagia had lower body weight at operation, more malformation syndromes, longer operation times, and more complex operations than did the infants without dysphagia. In addition, the infants with dysphagia required more time to achieve full oral feeding and had longer hospital stays. Thirty-three infants underwent videofluoroscopic swallowing study: 32 (97.0%) exhibited at least one abnormal finding among the videofluoroscopic swallowing study parameters and 21 (63.6%) exhibited tracheal aspiration. CONCLUSIONS: Given the high rate of aspiration in the infants who underwent open heart procedures, monitoring and prompt recognition of the signs and the risk factors of dysphagia may substantially improve infant care with oral feeding and reduce the duration of hospital stays.

민관협력 노인구강건강증진사업 수혜자 평가

이희용 ( Hee Yong Yi ),유기준 ( Ki Jun Yu ),이수진 ( Soo Jin Lee ),정민지 ( Min Ji Jeong ),정수빈 ( Su Bin Jeong ),문애란 ( Ae Ran Moon ),목보람 ( Bo Ram Mok ),송연희 ( Yeon Hee Song ) 대한구강보건학회 2014 大韓口腔保健學會誌 Vol.38 No.1

Objectives: The purpose of this study was to evaluate the effectiveness of a seniors` oral health promotion program for establishing a cooperation model between public and private sectors. Methods: This study was carried out targeting the seniors frequenting a community center in the Sosagudistrict of Bucheon-si in the Gyeonggi-do province of South Korea. Data were obtained from self ad ministered questionnaires or personal interviews with elders after they participated in the oral health promotion program. Their perceived satisfaction with their oral health before and after the oral health program was compared. The data were analyzed by t-tests, ANOVA, paired t-tests, and logistic regressionusing SPSS to assess the effects of explanatory factors on the seniors` satisfaction of the oral health promotion program. Results: In total, 22.7% of participants had a positive idea about the oral health promotion program before their participation. The mean score of change in and difference of satisfaction with oral health tended to increase in each of the following groups: women, aged 80-84 years, number of permanent teeth, full denture wearers, and those who did not require dentures. Satisfaction notably increased 0.4points in the group of full denture wearers (P<0.05). Moreover, after 1 month, the satisfaction level of the subjects who participated in the oral health promotion program increased 5.2 times (95% CI, 1.04-25.49) compared to dissatisfaction levels. Ultimately, satisfaction with oral health shows a major impact on the satisfaction with an oral health promotion program. Conclusions: The subjects who received the oral health promotion program responded very positively, but this program needs overall consideration about work processes and further reliable evaluations.

영상 레이더 위성체의 궤도환경하 성능 검증 시험 결과

서희준(Hee-jun Seo),김태윤(Tae-Youn Kim),조혁진(Hyokjin Cho),박성욱(Sung-wook Park),전수환(Soo-hwan Jun),이혜진(Hye-jin Yi) 한국항공우주학회 2022 한국항공우주학회 학술발표회 논문집 Vol.2022 No.11

열진공챔버 냉각수 오염에 관한 고찰

서희준(Hee-jun Seo),이혜진(Hye-jin Yi),박성욱(Sung-wook Park),조혁진(Hyokjin Cho),전수환(Soo-hwan Jun),이상훈(Sang-hoon Lee),정상헌(Sang-hun Jung),백선기(Sun-ki Baek),김근식(Keun-sik Kim) 한국항공우주학회 2020 한국항공우주학회 학술발표회 논문집 Vol.2020 No.11

Poster Session : PS 0805 ; Upper GI Tract : The IL-1B Genetic Polymorphism is Associated with Low-Dose Aspirin-Induced Peptic Ulcer in Koreans

( Hee Man Kim ),( Kyong Joo Lee ),( Ja Sung Kim ),( Kyun Ghee Choi ),( Sang Heun Lee,),( Seung Woo Yi ),( Song Wook Chun ),( Jea Hee Cho ),( Ki Jun Han ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcer. There are few data on Koreans. Methods: This study investigated the relationship of SNPs of COX-1, IL1B, TNF and IL- 1RN genes on aspirin-induced peptic ulcer in Korean adults.The subjects taking a lowdose aspirin of 100 mg for at least 4 weeks were enrolled in the study. The subjects were divided into two groups: the control group that had no peptic ulcer in upper GI endoscopy, and the peptic ulcer group that had gastric or duodenal ulcer in upper GI endoscopy. The DNA was extracted from the subjects` whole blood, polymerase chain reaction was performed to detect SNP, and mutation analysis was performed. Results: A total of 48 patients consisting of 23 patients with peptic ulcer and 25 healthy controls were enrolled. In IL-1ß -581C/T (rs1143627), the prevalence of CC, CT and TT alleles were 21.74%, 65.22%, and 13.04% in the peptic ulcer group, whereas 16%, 40%, and 44% in the control group, respectively. In IL1B-1061C/T (rs16944), the CC, CT and TT alleles were 13.04%, 65.22%, and 21.74% in peptic ulcer group, whereas 44%, 40%, and 16% in the control group, respectively. After adjustment for age and gender, the CT and CC allele of IL-1ß -581C/T had an odds ratio of 4.625 (95% confi-dence interval: 1.054-20.303) for peptic ulcer. In IL-1ß -1061C/T, the CT and TT allele had an odds ratio of 4.625 (95% confi dence interval: 1.054-20.303) for peptic ulcer. Conclusions: The C allele of IL-1ß -581C/T and T allele of IL-1ß -1061C/T had an increased risk of low-dose aspirin-induced peptic ulcer in Korean adults. It would be reasonable to screen patients for these SNPs before low-dose aspirin is prescribed, and to prevent peptic ulcer induced by low-dose aspirin.

Rapid and Simple Procedure for Homogenizing Leaf Tissues Suitable for Mini‐Midi‐Scale DNA Extraction in Rice

Yi, Gihwan,Choi, Jun‐,Ho,Lee, Jong‐,Hee,Jeong, Unggi,Nam, Min‐,Hee,Yun, Doh‐,Won,Eun, Moo‐,Young Taylor Francis 2005 Preparative biochemistry & biotechnology Vol.35 No.3

<P>We describe a rapid and simple procedure for homogenizing leaf samples suitable for mini/midi‐scale DNA preparation in rice. The methods used tungsten carbide beads and general vortexer for homogenizing leaf samples. In general, two samples can be ground completely within 11.3±1.5 sec at one time. Up to 20 samples can be ground at a time using a vortexer attachment. The yields of the DNA ranged from 2.2 to 7.6 µg from 25–150 mg of young fresh leaf tissue. The quality and quantity of DNA was compatible for most of PCR work and RFLP analysis.</P>