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Yeo Hyeon Ji,Baek Seung-A,Sathasivam Ramaraj,Kim Jae Kwang,Park Sang Un 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1
This study aimed to comprehensively analyze primary and secondary metabolites of three different-colored (white, pale green, and green) pak choi cultivars (Brassica rapa subsp. chinensis) using gas chromatography attached with time-of-flight mass spectrometry (GC-TOFMS) and high-performance liquid chromatography (HPLC). In total, 53 primary metabolites were identified and subjected to partial least-squares discriminant analysis. The result revealed a significant difference in the primary and secondary metabolites between the three pak choi cultivars. In addition, 49 hydrophilic metabolites were detected in different cultivars. Total phenolic and glucosinolate contents were highest in the pale green and green cultivars, respectively, whereas total carotenoid and chlorophyll contents were highest in the white cultivar. Superoxide dismutase activity, 2,2-diphenyl-1-picrylhydraz scavenging, and reducing power were slightly increased in the white, pale green, and green cultivars, respectively. In addition, a negative correlation between pigments and phenylpropanoids was discovered by metabolite correlation analysis. This approach will provide useful information for the development of strategies to enhance the biosynthesis of phenolics, glucosinolates, carotenoids, and chlorophyll, and to improve antioxidant activity in pak choi cultivars. In addition, this study supports the use of HPLC and GC-TOFMS-based metabolite profiling to explore differences in pak choi cultivars.
Yeo, Hyeon Ji,Shin, Min Jea,Yeo, Eun Ji,Choi, Yeon Joo,Kim, Dae Won,Kim, Duk-Soo,Eum, Won Sik,Choi, Soo Young Elsevier 2019 FREE RADICAL BIOLOGY AND MEDICINE Vol.135 No.-
<P><B>Abstract</B></P> <P>Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) protein is widely expressed in the brain and it is known that this protein is involved in cell survival including dopaminergic neuronal cells. Oxidative stress is known as one of the major causes of degenerative diseases including ischemia. In this study, we investigated the effect of CIAPIN1 protein on hippocampal neuronal (HT-22) cell damage induced by hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) and in an animal model of ischemia using Tat-CIAPIN1 fusion protein which can transduce into cells. Tat-CIAPIN1 protein transduced into HT-22 cells and significantly inhibited cell death, DNA fragmentation, and reactive oxygen species (ROS) generation. Also, Tat-CIAPIN1 protein enhances cell survival via the regulation of Akt, MAPK, NF-κB and apoptotic signaling pathways in the H<SUB>2</SUB>O<SUB>2</SUB> treated cells. In an ischemic animal model, Tat-CIAPIN1 protein transduced into the brain and protected neuronal cell death of hippocampal CA1 region induced by ischemic insult. In conclusion, we demonstrated that Tat-CIAPIN1 protein has protective effects against hippocampal neuronal cell damage induced by ischemic injury, suggesting that Tat-CIAPIN1 protein may provide a potential therapeutic agent for ischemia.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Tat-CIAPIN1 transduces into HT-22 cells and animal brain. </LI> <LI> Transduced Tat-CIAPIN1 protects against H<SUB>2</SUB>O<SUB>2</SUB>-induced cellular toxicity. </LI> <LI> Tat-CIAPIN1 regulates MAPK and apoptosis signaling pathways. </LI> <LI> Tat-CIAPIN1 protects against neuronal cell death in an ischemic animal model. </LI> <LI> Tat-CIAPIN1 can be a therapeutic agent for neuronal diseases including ischemia. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model
( Hyeon Ji Yeo ),( Eun Ji Yeo ),( Min Jea Shin ),( Yeon Joo Choi ),( Chi Hern Lee ),( Hyeok Yil Kwon ),( Dae Won Kim ),( Won Sik Eum ),( Soo Young Choi ) 생화학분자생물학회 2018 BMB Reports Vol.51 No.7
A major feature of type 1 diabetes mellitus (T1DM) is hyperglycemia and dysfunction of pancreatic β-cells. In a previous study, we have shown that Tat-DJ-1 protein inhibits pancreatic RINm5F β-cell death caused by oxidative stress. In this study, we examined effects of Tat-DJ-1 protein on streptozotocin (STZ)-induced diabetic mice. Wild type (WT) Tat-DJ-1 protein transduced into pancreas where it markedly inhibited pancreatic β-cell destruction and regulated levels of serum parameters including insulin, alkaline phosphatase (ALP), and free fatty acid (FFA) secretion. In addition, transduced WT Tat-DJ-1 protein significantly inhibited the activation of NF-kB and MAPK (ERK and p38) expression as well as expression of COX-2 and iNOS in STZ exposed pancreas. In contrast, treatment with C106A mutant Tat-DJ-1 protein showed no protective effects. Collectively, our results indicate that WT Tat-DJ-1 protein can significantly ameliorate pancreatic tissues in STZ-induced diabetes in mice. [BMB Reports 2018; 51(7): 362-367]
Tat-CIAPIN1 protein prevents against cytokine-induced cytotoxicity in pancreatic RINm5Fβ-cells
( Hyeon Ji Yeo ),( Min Jea Shin ),( Dae Won Kim ),( Hyeok Yil Kwon ),( Won Sik Eum ),( Soo Young Choi ) 생화학분자생물학회 2021 BMB Reports Vol.54 No.9
Cytokines activate inflammatory signals and are major mediators in progressiveβ-cell damage, which leads to type 1 diabetes mellitus. We recently showed that the cell-permeable Tat-CIAPIN1 fusion protein inhibits neuronal cell death induced by oxidative stress. However, how the Tat-CIAPIN1 protein affects cytokine- inducedβ-cell damage has not been investigated yet. Thus, we assessed whether the Tat-CIAPIN1 protein can protect RINm5Fβ-cells against cytokine-induced cytotoxicity. In cytokineexposed RINm5Fβ-cells, the transduced Tat-CIAPIN1 protein elevated cell survivals and reduced reactive oxygen species (ROS) and DNA fragmentation levels. The Tat-CIAPIN1 protein reduced mitogen-activated protein kinases (MAPKs) and NF-βB activation levels and elevated Bcl-2 protein, whereas Bax and cleaved Caspase-3 proteins were decreased by this fusion protein. Thus, the protection of RINm5Fβ-cells by the Tat-CIAPIN1 protein against cytokine-induced cytotoxicity can suggest that the Tat-CIAPIN1 protein might be used as a therapeutic inhibitor against RINm5Fβ-cell damage. [BMB Reports 2021; 54(9): 458-463]
Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages
( Hyeon Ji Yeo ),( Min Jea Shin ),( Ji Ho You ),( Jeong Su Kim ),( Min Young Kim ),( Dae Won Kim ),( Duk-soo Kim ),( Won Sik Eum ),( Soo Young Choi ) 생화학분자생물학회 2019 BMB Reports Vol.52 No.12
Cytokine-induced apoptosis inhibitor 1 (CIAPIN1), known as an anti-apoptotic and signal-transduction protein, plays a pivotal role in a variety of biological processes. However, the role of CIAPIN1 in inflammation is unclear. We investigated the protective effects of CIAPIN1 in lipopolysaccharide (LPS)-exposed Raw 264.7 cells and against inflammatory damage induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in a mouse model using cell-permeable Tat-CIAPIN1. Transduced Tat-CIAPIN1 significantly reduced ROS production and DNA fragmentation in LPS-exposed Raw 264.7 cells. Also, Tat- CIAPIN1 inhibited MAPKs and NF-κB activation, reduced the expression of Bax, and cleaved caspase-3, COX-2, iNOS, IL-6, and TNF-α in LPS-exposed cells. In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-α expression. Therefore, these findings suggest that Tat-CIAPIN1 might lead to a new strategy for the treatment of inflammatory skin disorders. [BMB Reports 2019; 52(12): 695-699]