Slide Session : OS-CAD-06 ; Cardiology : Erythrocytosis Increased One-Year Mortality in Patients with St-Segment Elevation Myocardial Infarction Un-dergoing Primary Percutaneous Coronary Intervention

( Cheng Wei Liu ),( Yi Ching Lin ),( Chung Ming Tu ),( Pen Chih Liao ),( Kuan Change Chen ),( Yen Wen Wu ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Anemia is associated with poor prognosis in patients with ST-segment elevation myocardial infarction(STEMI). However, it is unclear that erythrocytosis has protective effect in these populations. Hence, we conducted a retrospective cohort study to examine the relationship between erythrocytosis and mortality in patients with STEMI undergoing primary percutaneous coronary intervention (PCI ). Materials and Methods: We screened 1,156 consecutive patients with STEMI undergoing primary PCI in a single center during Feb 2007 and January 2012. There were 201 missing data for door-to-balloon time and 4 missing data for hemoglobin. Of 951 analyzable patients, they were divided into anemia (Hemoglobin<13.0mg/dl in men or <12.0mg/dl in women), normal hemoglobin, and erythrocytosis (hemoglobin =16.0mg/dl in men or =15.0mg/dl in women) groups. The study end point was one-year mortality. Results: There were 148, 535, and 268 patients in anemia, normal hemoglobin, and erythrocytosis groups, respectively. Patients in the anemia group were older and had lower body mass index than other two groups. There was more female, smokers, hypertension, and diabetes in the anemia group. One-year mortality rates were 16.2%, 6.5%, 2.6% (P<0.001) respectively. In univariate proportional hazards regression analysis, age, hemoglobin, total cholesterol, statin use, glycoprotein llb/llla inhibitor use, and TIMI risk score were associated with 1-year mortality in three groups. After adjustment for potential confounders, hemoglobin levels remained an independent predictor of one-year mortality in both anemia (hazard ratio 0.697, 95% CI 0.528-0.960) and erythrocytosis group (hazard ratio 3.129, 95% CI 1.1.474-6.642). Conclusions: Patients with STEMI and anemia had the worst outcomes than normal hemoglobin and erythrocytosis groups. Expectedly, hemoglobin had the protective effect on prognosis in anemia group. However, a hemoglobin level was an independent risk factor of one-year mortality in those with erythrocytosis.

Poster Session : PS 0050 ; Cardiology : Hyperuricemia as an Independent Predictor in Taiwanese Patients with Low Risky St-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

( Cheng Wei Liu ),( I No Cheng ),( Shin Rong Ke ),( Chung Ming Tu ),( Pen Chih Liao ),( Yen Wen Wu ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Hyperuriacemia as an independent predictor of short- and long-term prognosis in patients with myocardial infarction remained controversial. Hence, the study aimed to assess association between hyperuricemia and mortality in patients with ST-segment elevation myocardial infarction(STEMI) undergoing primary percutaneous coronary intervention (pPCI). Materials and Methods: In our five-year retrospective cohort, we analyzed 944 STEMI patients undergoing pPCI; with 88% male, the median of age 57 years and TIMI risk 4 in score. We divided these patient into hyperuricemia (uric acid >7mg/dl) and normal uric acid (uric acid = 7mg/dl) groups. The study end point was six-month and one-year mortality. Results: Baseline characteristics were similar in two groups except creatinine. Patients with hyperuricemia (n=293) had higher six-month (8.2% vs. 4.2%, P=0.019) and oneyear mortality (9.6% vs. 5.0%, P=0.014). In univariate analysis, hyperuricemia was associated with higher one-year mortality (Hazard ratio: 1.967, 95% CI: 1.18-3.27). However, after adjustment for age, gender, body mass index, and creatinine, hyperuricemia was no longer a signifi cant risk factor. In the subgroup analysis divided by Killip`s classifi cation, hyperuricemia remained an independent predictor of one-year mortality in patients at Killip I, even after adjustment for potential confounders. However, the association is not signifi cant in patients at Killip II to IV. There was a signifi - cant interaction between hyperuricemia and Killip`s classifi cation associated with oneyear mortality (P for interaction=0.037). The same association was found between hyperuricemia and six-month mortality. Conclusions: We suggest that the association between hyperuricemia and the outcome of STEMI patients is dependent upon disease-severity and has the greatest impact on low risk groups (i.e., patients classifi ed as Killip I).

Suture Repair in Endoscopic Surgery for Craniovertebral Junction

Mei-Yin Yeh,Wen-Cheng Huang,Jau-Ching Wu,Chao-Hung Kuo,Hsuan-Kan Chang,Tsung-Hsi Tu,Peng-Yuan Chang,Yu-Shu Yen,Henrich Cheng 대한척추신경외과학회 2019 Neurospine Vol.16 No.2

Objective: Endoscopic approaches to the craniovertebral junction (CVJ) have been established as viable and effective surgical treatments in the past decade. One of the major complications is leakage of the cerebrospinal fluid (CSF). This study aimed to investigate the efficacy and feasibility of suture closure at the nasopharyngeal mucosa upon durotomy. Methods: A series of consecutive patients who underwent different endoscopic approaches to the CVJ were retrospectively reviewed. The pathologies, surgical corridors, neurological and functional outcomes, radiological evaluations, and complications were analyzed. Different strategies of repair for the intraoperative CSF leakage were described and compared. Results: A total of 22 patients covering 13 years were analyzed. There were 12, 2, and 8 patients who underwent transnasal, transoral, and combined approaches, respectively. There were 8 patients (36.4%) who experienced intraoperative CSF leakage, and were grouped into 2: 4 in the nonsuture (NS) group and 4 in the suture-repaired (SR) group. The NS group had 3 (75%) persistent CSF leakages postoperation that caused 1 mortality, whereas patients of the SR group had only 1 minor CSF rhinorrhea that healed spontaneously within days. Conclusion: In this series of 22 patients who required anterior endoscopic resection of pathologies at the CVJ, there was 1 (4.5%) serious complication related to CSF leakage. For patients who had no durotomy, the mucosal incision at the nasopharynx usually healed rapidly and there were few procedure-related complications. For patients with intraoperative CSF leakage, suture closure was technically challenging but could significantly lower the risks of postoperative complications.

Improving discharge uniformity of industrial-scale very high frequency plasma sources by launching a traveling wave

Hsin-Liang Chen,Yen-Cheng Tu,Cheng-Chang Hsieh,Deng-Lain Lin,Chin-Jung Chang,Keh-Chyang Leou 한국물리학회 2016 Current Applied Physics Vol.16 No.7

Very high frequency (VHF) PECVD has been demonstrated to be able to significantly increase the deposition rate without compromising the film quality for the manufacture of silicon heterojunction and silicon thin film solar cells. To further reduce the production costs by enhancing the throughput, larger electrode and higher frequency are often required at the same time. Nevertheless, raising frequency in large-area PECVD results in non-uniform discharge caused by the standing wave effect and deteriorates the processing uniformity. In this study, a technique that generates a traveling wave via superposing two specific standing waves launched simultaneously is proposed to resolve this issue. An industrial-scale linear plasma reactor with length and width of 125 and 10 cm, respectively, is adopted for experimental tests and two 80 MHz power supplies are utilized to separately control the standing waves. The experimental results show that the discharge gap is only partially covered by plasma discharge when only one standing wave is applied. However, as both standing waves are launched, the non-uniformity of plasma discharge can be effectively reduced to <±5%. In addition, numerical simulation is also conducted in this study to clarify whether the proposed technique can be applied to large-area rectangular PECVD (substrate size: 1.4 m 1.1 m). By arranging multiple feeding points on opposite sides of the powered electrode, the simulation results indicate the non-uniformity of electric field can be maintained within ±10%.

Influence of doping and annealing temperature on the structural and optical properties of Mg2SiO4:Eu3þ synthesized by combustion method

Hsin-Liang Chen,Yen-Cheng Tu,Cheng-Chang Hsieh 한국물리학회 2016 Current Applied Physics Vol.16 No.7

This paper presents the structural and optical properties of europium doped magnesium orthosilicate nanophosphor prepared by combustion method and further annealed at varying temperatures. The structural and optical properties were investigated by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Field emission scanning electron microscope (FESEM), High resolution Transmission electron microscope (HRTEM), Diffuse Reflectance Spectra (DRS) and Photoluminescence spectra (PL) together with decay time. The XRD results confirmed the phase formation of Mg2SiO4. FESEM and TEM results indicated spherical particles in nanometer size. Photoluminescence spectra of Mg2SiO4:Eu3þ nanophosphors exhibited five groups of peaks 5D0 / 7FJ (J ¼ 0, 1, 2, 3, 4) transitions. Intensity parameters (U2 U4) and other radiative properties such as radiative transition probability, total radiative transition probability, radiative life time, branching ratio and stimulated emission cross-section were calculated using Judd- Ofelt theory. The lifetime measurement indicates a decreasing trend up to 5 mol% of Eu3þ concentration.