Exploring Fatty Acids and Their Biotransformation Products as GPR40 (FFAR1) Agonists

Yeeun PARK,Jeong-Hoo LEE,Ji-Min WOO,Sung-Joon LEE,Jin-Byung PARK 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

Importance-Performance Analysis (IPA) of Cyber Security Management: Focused on ECDIS User Experience

Park, Sangwon,Chang, Yeeun,Park, Youngsoo The Korean Society of Marine Environment and safet 2021 海洋環境安全學會誌 Vol.27 No.3

The mandatory installation of the ECDIS (Electronic Chart Display and Information System) became an important navigational equipment for navigation officer. In addition, ECDIS is a key component of the ship's digitalization in conjunction with various navigational equipment. Meanwhile, cyber-attacks emerge as a new threat along with digitalization. Damage caused by cyber-attacks is also reported in the shipping sector, and IMO recommends that cybersecurity guidelines be developed and included in International Security Management (ISM). This study analyzed the cybersecurity hazards of ECDIS, where various navigational equipment are connected. To this end, Importance-Performance Analysis (IPA) was conducted on navigation officer using ECDIS. As a result, the development of technologies for cyber-attack detection and prevention should be priority. In addition, policies related to 'Hardware and Software upgrade', 'network access control', and 'data backup and recovery' were analyzed as contents to be maintained. This paper is significant in deriving risk factors from the perspective of ECDIS users and analyzing their priorities, and it is necessary to analyze various cyber-attacks that may occur on ships in the future.

Dynamic Long-Range Chromatin Interaction Controls Expression of IL-21 in CD4⁺ T Cells

Park, Joo-Hong,Choi, Yeeun,Song, Min-Ji,Park, Keunhee,Lee, Jong-Joo,Kim, Hyoung-Pyo The American Association of Immunologists, Inc. 2016 JOURNAL OF IMMUNOLOGY Vol.196 No.10

<P>IL-21, a pleiotropic cytokine strongly linked with autoimmunity and inflammation, regulates diverse immune responses. IL-21 can be potently induced in CD4(+) T cells by IL-6; however, very little is known about the mechanisms underlying the transcriptional regulation of the Il21 gene at the chromatin level. In this study, we demonstrated that a conserved noncoding sequence located 49 kb upstream of the Il21 gene contains an enhancer element that can upregulate Il21 gene expression in a STAT3- and NFAT-dependent manner. Additionally, we identified enhancer-blocking insulator elements in the Il21 locus, which constitutively bind CTCF and cohesin. In naive CD4(+) T cells, these upstream and downstream CTCF binding sites interact with each other to make a DNA loop; however, the Il21 promoter does not interact with any cis-elements in the Il21 locus. In contrast, stimulation of CD4(+) T cells with IL-6 leads to recruitment of STAT3 to the promoter and novel distal enhancer region. This induces dynamic changes in chromatin configuration, bringing the promoter and the regulatory elements in close spatial proximity. The long-range interaction between the promoter and distal enhancer region was dependent on IL-6/STAT3 signaling pathway but was disrupted in regulatory T cells, where IL-21 expression was repressed. Thus, our work uncovers a novel topological chromatin framework underlying proper transcriptional regulation of the Il21 gene.</P>

A Connecticut Yankee’s Individuation: The Collective Unconsciousness of an American Imperialistic Dream

( Yeeun Park ) 21세기영어영문학회 2021 영어영문학21 Vol.34 No.3

The imperialistic modernization of Hank Morgan from Mark Twain’s novel A Connecticut Yankee in King Arthur’s Court, who embodies the ideals of his period, such as individualism and mechanization depicts a failure in Jungian individuation, a concept of attaining a mature psyche. Hank regards the collectivist feudal Arthurian kingdom symbolizing the collective unconscious as lacking modern individualism developed by mechanization and hence inferior to his own time period. His consequent project of imperialistic modernization serves as a metaphor for American expansion which destroyed Native American communities with modern machines. The Jungian approach to this narrative attaches Hank’s individualistic qualities to the psyche’s conscious, while collectivistic spirit, an opposing value, is linked to the unconscious. Through the lens of dream analysis, the mythical Arthurian land represents collective unconsciousness in Jung’s theory and Hank, the symbol of nineteenth-century America, meets a dire end due to his unconditional repression. In Jungian terms, although the modern individual succeeds in assimilating the anima’s values, he does not do so for the shadow. The fact that mechanical America fails to attain individuation because of such neglect in accepting the unconscious realm’s collectivistic characteristics holds significant bearing not only upon nineteenth-century America, but also on communities of today where polarization threatens the collective health. Such conflict may ultimately result in a severe resistance endangering the entire community. In this light, the Jungian reading construes a future road to reaching a better community. Understanding the differences between opposites, as within an individual psyche, becomes key to extending the Jungian individuation to a societal level.

Familial, Cognitive, and Behavioral Characteristics of Adolescents with Depression

Yeeun Lee,Bung-Nyun Kim,Min-Hyeon Park,Subin Park 대한소아청소년정신의학회 2017 소아청소년정신의학 Vol.28 No.3

Objectives: Adolescent depression is a complex disorder influenced by a variety of personal and familial factors. In this study, we compared the familial, cognitive, and behavioral characteristics of adolescents with and without diagnosed depression. Methods: Forty adolescents with depressive disorder were recruited from two psychiatric clinics, along with 46 healthy adolescents from a middle school and a high school. We then compared the participants’ cognitive and behavioral characteristics and the child-rearing attitudes of their parents. Results: Compared to the healthy adolescents, the adolescents with depression exhibited lower self-esteem, higher emotional reappraisal, greater disruptive behavior, and lower attention. Furthermore, compared to the mothers of the healthy adolescents, the mothers of those with depression reported less affective, less autonomic, and more rejecting parenting attitudes towards their children. Conclusion: We found that attentional problems, negative parenting attitudes, negative self-cognition, and expressive suppression are all associated with adolescent depression. Parenting education and interventions appear to be needed to correct the negative cognitions of adolescents with depression.

Changes in the health-related quality of life of critically ill patients before and during the COVID-19 pandemic in Korea

Yeeun Park,Kyong Park 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Characterization of inhibitory constituents of NO production from <i>Catalpa ovata</i> using LC-MS coupled with a cell-based assay

Park, Sangmin,Shin, Hyeji,Park, Yeeun,Choi, Ilgyu,Park, Byoungduck,Lee, Ki Yong Elsevier 2018 Bioorganic chemistry Vol.80 No.-

<P><B>Abstract</B></P> <P>An effective screening method for inhibitors of NO production in natural products using LC-QTOF MS/MS coupled with a cell-based assay was proposed. The ethyl acetate fraction of <I>Catalpa ovata</I> exhibited a strong inhibitory effect on NO production in lipopolysaccharide-induced BV2 microglia cells. We attempted to identify the active constituents of <I>C. ovata</I> by using LC-QTOF MS/MS coupled with a cell-based assay. Peaks at approximately 14–15 min on the MS chromatogram were estimated to be the bioactive constituents. A new iridoid compound, 6-<I>O-trans</I>-feruloyl-3β-hydroxy-7-deoxyrehamaglutin A (<B>4</B>), and nine known compounds (<B>1</B>–<B>3, 5</B>–<B>10</B>) were isolated from the ethyl acetate fraction of <I>C. ovata</I> by repeated column chromatography. Compounds <B>3</B>, <B>4</B>, <B>5</B>, <B>7</B>, and <B>8</B> significantly attenuated lipopolysaccharide-stimulated NO production in BV2 cells. Our results indicate that LC-QTOF MS/MS coupled with a cell-based NO production inhibitory assay successfully predicted active compounds without a time-consuming isolation process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> LC-QTOF MS/MS coupled with a cell-based NO production inhibitory assay was developed. </LI> <LI> EtOAc fraction of <I>Catalpa ovata</I> showed inhibitory effect on NO production. </LI> <LI> Compounds between 14 and 15 min on Mass chromatogram inhibited NO production. </LI> <LI> Anti-inflammatory activity was tested on isolated compounds including a new compound. </LI> <LI> Predicted active compounds from developed method matched with the experimental data. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

생성형 AI는 인간 관리자를 대체할 수 있는가? 자동 생성된 관리자 응답이 고객에 미치는 영향

박예은 ( Yeeun Park ),안현철 ( Hyunchul Ahn ) 한국지식경영학회 2023 지식경영연구 Vol.24 No.4

최근 생성형 AI, 특히 ChatGPT와 같은 대화형 인공지능이 고객 서비스를 자동화하는 기술적 대안으로 주목받고 있다. 그러나 고객 서비스 자동화에 있어 현재의 생성형 AI 기술이 기존 인간 관리자를 효과적으로 대체할 수 있는지, 조건이나 환경에 따라 어떤 상황에서는 유리하고 다른 상황에서는 불리한지에 대한 연구는 아직 충분히 이루어지지 않은 상태이다. 이러한 배경에서 본 연구는 “고객 서비스 활동과 관련하여 생성형 AI가 인간 관리자를 대체할 수 있는가?”라는 질문에 답하기 위해, 음식 배달 플랫폼의 고객 온라인 리뷰에 대한 실험과 설문조사를 수행하였다. 또한 고객의 온라인 리뷰가 긍정적일 때와 부정적일 때에 따라 차이가 있는지 정교화 가능성 모델의 관점을 적용하여 가설을 도출하고 해당 가설이 지지되는지를 분석을 통해 확인하였다. 분석 결과, 긍정적인 리뷰에 대해서는 생성형 AI가 인간 관리자를 효과적으로 대체할 수 있지만, 부정적인 리뷰에 대해서는 완벽한 대체가 어려워 인간 관리자의 개입이 더 바람직한 것으로 확인되었다. 이러한 본 연구의 결과는 생성형 AI를 이용하여 고객 서비스 자동화하고자 하는 기업들에게 유의미한 실무적인 통찰을 제공해 줄 수 있을 것이다. Generative AI, especially conversational AI like ChatGPT, has recently gained traction as a technological alternative for automating customer service. However, there is still a lack of research on whether current generative AI technologies can effectively replace traditional human managers in customer service automation, and whether they are advantageous in some situations and disadvantageous in others, depending on the conditions and environment. To answer the question, Can generative AI replace human managers in customer service activities?, this study conducted experiments and surveys on customer online reviews of a food delivery platform. We applied the perspective of the elaboration likelihood model to generate hypotheses about whether there is a difference between positive and negative online reviews, and analyzed whether the hypotheses were supported. The analysis results indicate that for positive reviews, generative AI can effectively replace human managers. However, for negative reviews, complete replacement is challenging, and human managerial intervention is considered more desirable. The results of this study can provide valuable practical insights for organizations looking to automate customer service using generative AI.

『드라큘라』의 우생학과 자가면역질환: 타자와 공유하는 미래

박예은 ( Yeeun Park ) 한국비교문학회 2022 比較文學 Vol.- No.87

본고는 로베르토 에스포지토의 바이오폴리틱스 면역 이론을 토대로 빅토리안 시대 소설인 『드라큘라』를 해석하며, 19세기 대영제국의 작가인 브램 스토커의 글에서 종종 20세기 독일의 나치로만 대표되던 우생학적 관점을 찾는다. 당시 타자를 향한 두려움과 드라큘라 백작의 구현을 연결지었을 때, 소설 속 타자성은 살균하여 제거되어야 할 병리학적 요소로 그려진다. 이 글은 19세기 유럽 사회에 만연했던 일종의 퇴행성 이론인 디제너레이션 담론들 - 세자레 롬브로소의 범죄이론, 몰리 로버츠의 유기적 사회이론 등의 생명정치적 영향을 다룬다. 에스포지토에 의거하면 디제너레이션, 즉 퇴보적이며 타락한 “야만인”을 감염병의 요인으로 지목하는 풍토는 나치 정권 이전인 빅토리안 영국에서부터 존재해 왔다. 『드라큘라』는 얼핏 이러한 당대 공동체의 우생학적 관점에 동조하는 듯 보이나, 동시에 그와 같은 타자 배타적, 양분적인 태도에 대한 비판이 기저에 내제되어 있다. 면역주권자인 반 헬싱의 무리가 타자인 뱀파이어를 감염요소로 여겨 박멸하려는 시도는 종내에 자기파멸적인 결과를 야기한다. 이 분석은 “다름”에 대한 거부감은 인간 심리를 관통한다는 사실을 전개하며, 따라서 문화권과 시대를 막론하고 타자와 퇴행적 질병의 연관관계가 형성됨을 시사한다. 자가면역질환이라는 주제를 바탕으로 『드라큘라』 속 디제너레이션에 대한 집단적 대응을 기각하는 방식 읽기는, 타자성을 마주하는 공동체들이 향후 취해야 할 입장에 대한 암시로 작용한다는 점에서 의의를 띈다. This essay attempts to read Bram Stoker’s Dracula using Roberto Esposito’s theory on immunity, contending that the Victorian novel written by a British author displays eugenic principles preceding the German Nazism in the next century. By uncovering the analogy between the Victorian period’s anxiety on foreignness and the text’s portrayal of the vampire, it ventures to bring focus on how otherness is perceived as a pathological threat that must be disinfected. This is done through examining the nineteenth-century discourse on degeneration, which relies on theories such as the Lombrosian criminology and biologically organic community. Supporting Esposito’s claim that the perspective of degeneration as a source of contagion existed in Victorian England before the Nazi regime, this paper also argues that Victorian novels, though seemingly adhering to such biopolitical approach at the exterior of their plots, contain criticisms about the binary depiction of otherness as infection. Such analysis implies a universal thread that transpierces disparate countries and periods in terms of human perception associating foreignness with degenerative disease. Dracula’s overrule of the collective attitude on degeneracy through its theme of autoimmune crisis serves as a reminder to recognize its destructiveness when confronting differences for future communities.

Familial, Cognitive, and Behavioral Characteristics of Adolescents with Depression

Lee, Yeeun,Kim, Bung-Nyun,Park, Min-Hyeon,Park, Subin Korean Academy of Child and Adolescent Psychiatry 2017 소아청소년정신의학 Vol.26 No.1

Objectives: Adolescent depression is a complex disorder influenced by a variety of personal and familial factors. In this study, we compared the familial, cognitive, and behavioral characteristics of adolescents with and without diagnosed depression. Methods: Forty adolescents with depressive disorder were recruited from two psychiatric clinics, along with 46 healthy adolescents from a middle school and a high school. We then compared the participants' cognitive and behavioral characteristics and the child-rearing attitudes of their parents. Results: Compared to the healthy adolescents, the adolescents with depression exhibited lower self-esteem, higher emotional reappraisal, greater disruptive behavior, and lower attention. Furthermore, compared to the mothers of the healthy adolescents, the mothers of those with depression reported less affective, less autonomic, and more rejecting parenting attitudes towards their children. Conclusion: We found that attentional problems, negative parenting attitudes, negative self-cognition, and expressive suppression are all associated with adolescent depression. Parenting education and interventions appear to be needed to correct the negative cognitions of adolescents with depression.