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- 저자 : Yanqiu Huang (검색결과 4 건)
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Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy
Ping Huang,Xiaoqin Zhao,Yi Sun,Xinlei Wang,Rong Ouyang,Yanqiu Jiang,Xiaoquan Zhang,Renyue Hu,Zhuqi Tang,Yunjuan Gu 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.4
Background: Fatty acid-binding protein 4 (FABP4) has been demonstrated to be a predictor of early diabetic nephropathy. However, little is known about the relationship between FABP4 and diabetic retinopathy (DR). This study explored the value of FABP4 as a biomarker of DR in patients with type 2 diabetes mellitus (T2DM).Methods: A total of 238 subjects were enrolled, including 20 healthy controls and 218 T2DM patients. Serum FABP4 levels were measured using a sandwich enzyme-linked immunosorbent assay. The grade of DR was determined using fundus fluorescence angiography. Based on the international classification of DR, all T2DM patients were classified into the following three subgroups: non-DR group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. Multivariate logistic regression analyses were employed to assess the correlation between FABP4 levels and DR severity.Results: FABP4 correlated positively with DR severity (<i>r</i>=0.225, <i>P</i>=0.001). Receiver operating characteristic curve analysis was used to assess the diagnostic potential of FABP4 in identifying DR, with an area under the curve of 0.624 (37% sensitivity, 83.6% specificity) and an optimum cut-off value of 76.4 μg/L. Multivariate logistic regression model including FABP4 as a categorized binary variable using the cut-off value of 76.4 μg/L showed that the concentration of FABP4 above the cut-off value increased the risk of NPDR (odds ratio [OR], 3.231; 95% confidence interval [CI], 1.574 to 6.632; <i>P</i>=0.001) and PDR (OR, 3.689; 95% CI, 1.306 to 10.424; <i>P</i>=0.014).Conclusion: FABP4 may be used as a serum biomarker for the diagnosis of DR.
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( Xiang Wang ),( Yanqiu Huang ),( Yanqing Sheng ),( Pei Su ),( Yan Qiu ),( Caihuan Ke ),( Danqing Feng ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.3
Mussels are major fouling organisms causing serious technical and economic problems. In this study, antifouling activity towards mussel was found in three compounds isolated from a marine bacterium associated with the sea anemone Haliplanella sp. This bacterial strain, called PE2, was identified as Vibrio alginolyticus using morphology, biochemical tests, and phylogenetic analysis based on sequences of 16S rRNA and four housekeeping genes (rpoD, gyrB, rctB, and toxR). Three small-molecule compounds (indole, 3-formylindole, and cyclo (Pro-Leu)) were purified from the ethyl acetate extract of V. alginolyticus PE2 using column chromatography techniques. They all significantly inhibited byssal thread production of the green mussel Perna viridis, with EC<sub>50</sub> values of 24.45 μg/ml for indole, 50.07 μg/ml for 3-formylindole, and 49.24 μg/ml for cyclo (Pro-Leu). Previous research on the antifouling activity of metabolites from marine bacteria towards mussels is scarce. Indole, 3-formylindole and cyclo (Pro-Leu) also exhibited antifouling activity against settlement of the barnacle Balanus albicostatus (EC<sub>50</sub> values of 8.84, 0.43, and 11.35 μg/ml, respectively) and the marine bacterium Pseudomonas sp. (EC<sub>50</sub> values of 42.68, 69.68, and 39.05 μg/ml, respectively). These results suggested that the three compounds are potentially useful for environmentally friendly mussel control and/or the development of new antifouling additives that are effective against several biofoulers.
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ZnFe2O4/Graphite Composite with High Performance as Anode Material for Lithium-Ion Batteries
Baolin Yao,Ziyue Wang,Chenxi Ding,Min Feng,Zhen Li,Yanqiu Huang 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.1
ZnFe 2 O 4 /graphite composite was synthesized by a thermal decomposition method using expanded graphite as matrix. TheZnFe 2 O 4 nanoparticles with the size of 20–30 nm were embedded into the interlayers of graphite. The porous structureformed by the graphite sheets can not only alleviate the adverse eff ects caused by the volume change of the ZnFe 2 O 4 duringcycling, but also improve the lithium storage performance. The specifi c capacity of 1450 mAh g − 1 is achieved after150 charge/discharge cycles at 0.1 A g − 1 . Moreover, the composite still delivers the specifi c capacity of 229 mAh g − 1 atthe ultrahigh current density of 10 A g − 1 after 1800 cycles, showing outstanding electrochemical performance and excellentcycling stability. The composite has great potential for use in the high-power lithium-ion batteries.
ScienceON
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