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Quan, Y.,Cao, H.L.,Gu, M. Techno-Press 2016 Wind and Structures, An International Journal (WAS Vol.22 No.2
Across-wind aerodynamic damping ratios are identified from the wind-induced acceleration responses of 15 aeroelastic models of rectangular super-high-rise buildings in various simulated wind conditions by using the random decrement technique. The influences of amplitude-dependent structural damping ratio and natural frequency on the estimation of the aerodynamic damping ratio are discussed and the identifying method for aerodynamic damping is improved at first. Based on these works, effects of turbulence intensity $I_u$, aspect ratio H/B, and side ratio B/D on the across-wind aerodynamic damping ratio are investigated. The results indicate that turbulence intensity and side ratio are the most important factors that affect across-wind aerodynamic damping ratio, whereas aspect ratio indirectly affects the aerodynamic damping ratio by changing the response amplitude. Furthermore, empirical aerodynamic damping functions are proposed to estimate aerodynamic damping ratios at low and high reduced speeds for rectangular super-high-rise buildings with an aspect ratio in the range of 5 to 10, a side ratio of 1/3 to 3, and turbulence intensity varying from 1.7% to 25%.
Quan, J.H.,Cha, G.H.,Zhou, W.,Chu, J.Q.,Nishikawa, Y.,Lee, Y.H. Academic Press 2013 Experimental parasitology Vol.133 No.4
Toxoplasma gondii-infected cells are resistant to various apoptotic stimuli, however, the role of the pro-apoptotic BH3-only Bad protein in T. gondii-imposed inhibition of host cell apoptosis in connection with the phosphoinositide 3-kinase (PI3K)-PKB/Akt pathway was not well delineated. Here, we investigated the signaling patterns of Bad, Bax and PKB/Akt in T. gondii-infected and uninfected THP-1 cells treated with staurosporine (STS) or PI3K inhibitors. STS treatment, without T. gondii infection, reduced the viability of THP-1 cells in proportion to STS concentration and triggered many cellular death events such as caspase-3 and -9 activation, Bax translocation, cytochrome c release from host cell mitochondria into cytosol, and PARP cleavage in the host cell. However, T. gondii infection eliminated the STS-triggered mitochondrial apoptotic events described above. Additionally, T. gondii infection in vitro and in vivo induced the phosphorylation of PKB/Akt and Bad in a parasite-load-dependent manner which subsequently inhibited Bax translocation. The PI3K inhibitors, LY294002 and Wortmannin, both blocked parasite-induced phosphorylation of PKB/Akt and Bad. Furthermore, THP-1 cells pretreated with these PI3K inhibitors showed reduced phosphorylation of Bad in a dose-dependent manner and subsequently failed to inhibit the Bax translocation, also these cells also failed to overcome the T. gondii-imposed inhibition of host cell apoptosis. These data demonstrate that the PI3K-PKB/Akt pathway may be one of the major route for T. gondii in the prevention of host cell apoptosis and T. gondii phosphorylates the pro-apoptotic Bad protein to prevent apoptosis.
Licochalcone A regulates hepatic lipid metabolism through activation of AMP-activated protein kinase
Quan, H.Y.,Kim, S.J.,Kim, D.Y.,Jo, H.K.,Kim, G.W.,Chung, S.H. Elsevier 2013 Fitoterapia Vol.86 No.-
Licochalcone A (LA) is a major phenolic ingredient of Glycyrrhiza plant. Although multiple pharmacological activities of LA have been reported, effect on hepatic lipid metabolism is unknown yet. The present study showed LA to suppress the hepatic triglyceride accumulation in HepG2 cells and ICR mice fed on a high fat diet (HFD). LA inhibited lipogenesis via suppression of sterol regulatory element-binding protein 1c (SREBP1c) and its target enzymes (stearoyl-CoA desaturase 1, fatty acid synthase and glycerol-3-phosphate acyltransferase) transcription. In addition, LA up-regulated gene expression of proteins such as peroxisome proliferator-activated receptor α (PPARα) and fatty acid transporter (FAT/CD36), which are responsible for lipolysis and fatty acid transport, respectively. These effects were mediated through activation of AMP-activated protein kinase (AMPK), and were abrogated when HepG2 cells were treated with an AMPK inhibitor, compound C. To explore how LA activates AMPK, oxygen consumption rate and ATP levels were measured in HepG2 cells. LA significantly inhibited the mitochondrial respiration and ATP levels, suggesting that LA activated AMPK indirectly. In animal study, LA (5 and 10mg/kg) was orally administered to six-week-old mice once a day for 3weeks. In vitro results were likely to hold true in vivo experiment, as LA markedly lowered the triglyceride levels and activated AMPK signaling pathway in the liver of ICR mice fed on a HFD. In conclusion, the current study suggests that LA suppressed hepatic triglyceride accumulation through modulation of AMPK-SREBP signaling pathway and thus LA may be a potential therapeutic agent for treating fatty liver disease.
Y. Quan,H.L. Cao,M. Gu 한국풍공학회 2016 Wind and Structures, An International Journal (WAS Vol.22 No.2
Across-wind aerodynamic damping ratios are identified from the wind-induced acceleration responses of 15 aeroelastic models of rectangular super-high-rise buildings in various simulated wind conditions by using the random decrement technique. The influences of amplitude-dependent structural damping ratio and natural frequency on the estimation of the aerodynamic damping ratio are discussed and the identifying method for aerodynamic damping is improved at first. Based on these works, effects of turbulence intensity Iu, aspect ratio H/B, and side ratio B/D on the across-wind aerodynamic damping ratio are investigated. The results indicate that turbulence intensity and side ratio are the most important factors that affect across-wind aerodynamic damping ratio, whereas aspect ratio indirectly affects the aerodynamic damping ratio by changing the response amplitude. Furthermore, empirical aerodynamic damping functions are proposed to estimate aerodynamic damping ratios at low and high reduced speeds for rectangular super-high-rise buildings with an aspect ratio in the range of 5 to 10, a side ratio of 1/3 to 3, and turbulence intensity varying from 1.7% to 25%.
Quan, Z.-X.,Xiao, Y.-P.,Roh, S. W.,Nam, Y.-D.,Chang, H.-W.,Shin, K.-S.,Rhee, S.-K.,Park, Y.-H.,Bae, J.-W. Microbiology Society 2008 International journal of systematic and evolutiona Vol.58 No.6
<P>A Gram-negative, non-spore-forming, non-motile, yellow-pigmented, strictly aerobic bacterial strain, designated En5(T), was isolated from the East Sea of Korea and was subjected to a polyphasic taxonomy study. Strain En5(T) grew optimally at 30 degrees C, in the presence of 1-3 % (w/v) NaCl and at pH 5.3-7.6. The major respiratory lipoquinone was MK-6 and the major fatty acids were iso-C(15 : 0), iso-C(17 : 0) 3-OH and iso-C(17 : 1)omega9c. The DNA G+C content of strain En5(T) was 30.1 mol%. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain En5(T) formed a distinct evolutionary lineage within the family Flavobacteriaceae and shared 93 % sequence similarity with the type strains of both Galbibacter mesophilus and Zhouia amylolytica. On the basis of its phenotypic and phylogenetic properties, strain En5(T) is suggested to represent a novel species of a new genus in the family Flavobacteriaceae, for which the name Joostella marina gen. nov., sp. nov. is proposed. The type strain is En5(T) (=KCTC 12518(T)=DSM 19592(T)=CGMCC 1.6973(T)).</P>