http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis
Okada, Y.,Suzuki, A.,Ikari, K.,Terao, C.,Kochi, Y.,Ohmura, K.,Higasa, K.,Akiyama, M.,Ashikawa, K.,Kanai, M.,Hirata, J.,Suita, N.,Teo, Y.Y.,Xu, H.,Bae, S.C.,Takahashi, A.,Momozawa, Y.,Matsuda, K.,Momoh University of Chicago Press [etc.] 2016 American journal of human genetics Vol.99 No.2
<P>Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is challenging. Here, we conducted a large-scale MHC fine-mapping analysis of rheumatoid arthritis (RA) in a Japanese population (6,244 RA cases and 23,731 controls) population by using HLA imputation, followed by a multi-ethnic validation study including east Asian and European populations (n=7,097 and 23,149, respectively). Our study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene, on anti-citrullinated protein autoantibody (ACPA)-positive RA risk (p=1.4 x 10(-) 9), which demonstrated a cis-expression quantitative trait loci (cis-eQTL) effect on HLA-DOA expression. Trans-ethnic comparison revealed different linkage disequilibrium (LD) patterns in HLA-DOA and HLA-DRB1, explaining the observed HLA-DOA variant risk heterogeneity among ethnicities, which was most evident in the Japanese population. Although previous HLA fine-mapping studies have identified amino acid polymorphisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionally identifies the dosage contribution of a non-classical HLA gene to disease etiology. Our study contributes to the understanding of HLA immunology in human diseases and suggests the value of incorporating additional ancestry in MHC fine-mapping.</P>
Neutron and proton energy spectra from the non-mesonic weak decays of HeΛ5 and CΛ12
Okada, S.,Ajimura, S.,Aoki, K.,Banu, A.,Bhang, H.C.,Fukuda, T.,Hashimoto, O.,Hwang, J.I.,Kameoka, S.,Kang, B.H.,Kim, E.H.,Kim, J.H.,Kim, M.J.,Maruta, T.,Miura, Y.,Miyake, Y.,Nagae, T.,Nakamura, M.,Nak Elsevier 2004 Physics letters: B Vol.597 No.3
<P><B>Abstract</B></P><P>We have simultaneously measured the energy spectra of neutrons and protons emitted in the non-mesonic weak decays of HeΛ5 and CΛ12 hypernuclei produced via the (<SUP>π+</SUP>,<SUP>K+</SUP>) reaction with much higher statistics than those of previous experiments. The neutron-to-proton yield ratios for both hypernuclei at a high energy threshold (60 MeV) were approximately equal to two, which suggests that the ratio of the neutron- and proton-induced decay channels, <SUB>Γn</SUB>(Λn→nn)/<SUB>Γp</SUB>(Λp→np), is about 0.5. In the neutron energy spectra, we found that the yield of the low-energy component is unexpectedly large, even for HeΛ5.</P>
PROTEIN POLYMORPHISMS IN NATIVE AND RED JUNGLE FOWLS IN NEPAL
Maeda, Y.,Yamamoto, Y.,Nishida, T.,Hashiguchi, T.,Okada, I.,Rajubhandary, H.B. Asian Australasian Association of Animal Productio 1992 Animal Bioscience Vol.5 No.4
Protein polymorphism of native and red jungle fowls in Nepal was analyzed by electrophoresis. Blood samples were collected in the areas of Solu, Jomson road, Kathmandou, Pokhara and Low land. Out of 17 loci, polymorphism were found at nine loci in native fowls and at three loci in red jungle fowls. The proportion of polymorphic loci ($P_{poly}$) of native and red jungle fowls were $0.529{\pm}0.121$ and $0.176{\pm}0.095$, respectively. The five fowl populations in Nepal formed a different cluster from Sri Lankan and Bangladeshi fowl populations. When the gene frequencies of polymorphic loci were compared between the native fowl populations of Sri Lanka, Bangladesh and Nepal, $Amy-1^A$, $Es-1^A$ and $Akp-2^A$ genes showed inclination of south to north.
Mihara, Y.,Maruyama, Y.,Okada, Y.,Kido, H.,Nishida, O.,Fujita, H.,Ito, M. The Korean Society of Marine Engineering 2004 한국마린엔지니어링학회지 Vol.28 No.2
A marine diesel engine should realize optimal efficiency operation while reducing NOx. Fuel injection systems by electronic control can become effective means for that. Although it would be able to get more precise engine control compared to the mechanical injection system, it needs some accurate and instant information in order to bring its ability into full play while sailing on the sea. Very important information of them is shaft torque and continuous combustion pressure of all cylinders. The system presented in this report can deliver those data.
Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12
CLEAR investigators,Kurreeman, Fina A.S.,Stahl, Eli A.,Okada, Y.,Liao, K.,Diogo, D.,Raychaudhuri, S.,Freudenberg, J.,Kochi, Y.,Patsopoulos, Nikolaos A.,Gupta, N.,Sandor, C.,Bang, S.Y.,Lee, H.S.,Padyuk University of Chicago Press [etc.] 2012 American journal of human genetics Vol.90 No.3
We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show that we can effectively discover RA risk alleles. Thirteen putatively associated SNPs that had not yet exceeded genome-wide significance (p < 5 x 10<SUP>-8</SUP>) in our previous RA genome-wide association study (GWAS) were analyzed in independent sample sets consisting of 4,366 cases and 17,765 controls of European, African American, and East Asian ancestry. Additionally, we conducted an overall association test across all 65,833 samples (a GWAS meta-analysis plus the replication samples). Of the 13 SNPs investigated, four were significantly below the study-wide Bonferroni corrected p value threshold (p < 0.0038) in the replication samples. Two SNPs (rs3890745 at the 1p36 locus [p = 2.3 x 10<SUP>-12</SUP>] and rs2872507 at the 17q12 locus [p = 1.7 x 10<SUP>-9</SUP>]) surpassed genome-wide significance in all 16,659 RA cases and 49,174 controls combined. We used available GWAS data to fine map these two loci in Europeans and East Asians, and we found that the same allele conferred risk in both ethnic groups. A series of bioinformatic analyses identified TNFRSF14-MMEL1 at the 1p36 locus and IKZF3-ORMDL3-GSDMB at the 17q12 locus as the genes most likely associated with RA. These findings demonstrate empirically that a multiethnic approach is an effective strategy for discovering RA risk loci, and they suggest that combining GWASs across ethnic groups represents an efficient strategy for gaining statistical power.
The Weak Decay Widths of Λ Hypernuclei
H. Bhang,S. Ajimura,K. Aoki,A. Banu,T. Fukuda,O. Hashimoto,J. I. Hwang,S. Kameoka,B. H. Kang,E. Kim,김정호,T. Maruta,Y. Miura,Y. Miyake,T. Nagae,M. Nakamura,S. N. Nakamura,H. Noumi,S. Okada,Y. Okayasu,H. 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We have measured both the mesonic and nonmesonic weak decay widths of ^(12)_ΛC. For the mesonic decay, we have improved the accuracy of Γ_π^0 so that it reduced the error of Γ_(nm) from ≥10% to ≤5%. For the nonmesonic decay, we have solved the long standing Γ_n/Γ_p puzzle by measuring the ratio 0.51 ± 0.14 in the exclusive measurement. At the same time we have measured the width of the 3-body nonmesonic decay Γ_(2N) = 0.27 ± 0.13 for the first time. Combining the accurate Γ_n/Γ_p ratio and the first measured value Γ_(2N), we have finally obtained the Γ_n and Γ_p themselves taking account of the 3-body process. We have measured all the weak decay widths of _(12)_ΛC so that it provides the first complete set of widths for the investigation of ΔS = 1 baryon-baryon weak interaction.