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Satoh, T.,Nishikawa, N.,Kawato, D.,Suemasa, D.,Jung, S.,Kim, Y.,Ree, M.,Kakuchi, T. Royal Society of Chemistry 2014 Polymer chemistry Vol.5 No.2
Well-defined hydroxyl end-functionalized poly(n-hexyl isocyanate), PHIC-(OH)(2) and PHIC-(OH)(3), as rod-type macroinitiators were synthesized by the Cu-catalyzed azide-alkyne cycloaddition reactions of azido end-functionalized PHIC with ethynyl alcohol derivatives. The PHIC-(OH)(2) and PHIC-(OH) 3 were suitable macroinitiators for the ring-opening polymerization of L-LA and epsilon-CL leading to the synthesis of novel rod-coil type miktoarm star copolymers, PHIC-b-PLLA(2), PHIC-b-PLLA(3), PHIC-b-PCL2, and PHIC-b-PCL3, with controlled molecular weights, narrow polydispersities, and controlled arm numbers. Additionally, the thermal and solution properties of the obtained miktoarm star copolymers along with the corresponding block copolymers, PHIC-b-PLLA and PHIC-b-PCL, were characterized by TGA, DSC, and DLS analyses.
Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption
Kim, C.,Yang, H.,Fukushima, Y.,Saw, P.,Lee, J.,Park, J.S.,Park, I.,Jung, J.,Kataoka, H.,Lee, D.,Do Heo, W.,Kim, I.,Jon, S.,Adams, R.H.,Nishikawa, S.I.,Uemura, A.,Koh, G. Cell Press 2014 CANCER CELL Vol.25 No.1
Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho GTPase, during tumor progression. RhoJ blockade provides a double assault on tumor vessels by both inhibiting tumor angiogenesis and disrupting the preformed tumor vessels through the activation of the RhoA-ROCK (Rho kinase) signaling pathway in tumor endothelial cells, consequently resulting in a functional failure of tumor vasculatures. Moreover, enhanced anticancer effects were observed when RhoJ blockade was employed in concert with a cytotoxic chemotherapeutic agent, angiogenesis-inhibiting agent, or vascular-disrupting agent. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.
Resonance Fluorescence Spectra of Zn-Substituted Myoglobin
안정선,C.H. Shin,H.M. Kim,J.O. Cha,여승준,Y. Kanematsu,Y. Nishikawa 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.6
Laser-induced fluorescence spectra, including narrow resonance lines, were measured for Zn-substituted myoglobin (ZnMb) in the lowest optical absorption band at 4 K by using a combination of short light pulses from a CW mode-locked laser for the excitation and a time-correlated single-photon counting method for the detection. The site-energy distribution function, {\it i.e.}, the distribution of the number of chromophore at various sites as a function of the zero-phonon transition energy, was determined from the excitation profile of the narrow resonance fluorescence line. The single-site fluorescence spectrum was determined by use of the saturation effect of laser-induced fluorescence. By comparing the laser-induced fluorescence spectra and the absorption spectrum with the spectra calculated by using the experimentally determined site-energy distribution and single-site fluorescence spectra, we found that the coupling between the electrons of the chromophore and the vibrations of the polypeptide was quite weak. Furthermore, the density of states of vibrational modes of myoglobin weighted by the coupling strength between the chromophore and the polypeptide chain was determined from the single-site fluorescence spectrum by solving an integral equation numerically
Development of the readout system for the K2K SciBar detector
Yoshida, M.,Yamamoto, S.,Murakami, T.,Tanaka, M.,Nakaya, T.,Nishikawa, K.,Joo, K.K.,Kim, B.J.,Kim, J.Y.,Kim, S.B.,Lee, M.J.,Lim, I.T. IEEE 2004 IEEE transactions on nuclear science Vol.51 No.6
Readout electronics for the scintillation bar tracking detector (SciBar) in the K2K neutrino oscillation experiment has been developed. SciBar has 14 336 scintillator bars in total. The deposited energy and timing of particles from neutrino interactions in the scintillator bars are measured by 64-channel multianode photo-multiplier tubes (MAPMTs). Compact custom-designed electronics to record the MAPMT signals were developed, consisting of front-end circuit boards attached to each MAPMT and back-end electronics modules sitting in a VME crate. The front-end circuit board multiplexes pulse-height information from all 64 anodes and generates a fast triggering signal. Two sets of ASICs (IDEAS VA32HDR11 and TA32CG) are employed for these functions. The bias voltages and relay of control signals are also handled on the board. The back-end electronics module controls the front-end board by providing the control, timing, and low-voltage signals. The board also digitizes the multiplexed signal from the front-end. The electronics achieves low noise of less than 0.3 photo-electrons and good linearity up to 300 (150) photo-electrons for MAPMTs at the gain of 5×10<SUP>5</SUP> (10<SUP>6</SUP>).
Quan, J.H.,Cha, G.H.,Zhou, W.,Chu, J.Q.,Nishikawa, Y.,Lee, Y.H. Academic Press 2013 Experimental parasitology Vol.133 No.4
Toxoplasma gondii-infected cells are resistant to various apoptotic stimuli, however, the role of the pro-apoptotic BH3-only Bad protein in T. gondii-imposed inhibition of host cell apoptosis in connection with the phosphoinositide 3-kinase (PI3K)-PKB/Akt pathway was not well delineated. Here, we investigated the signaling patterns of Bad, Bax and PKB/Akt in T. gondii-infected and uninfected THP-1 cells treated with staurosporine (STS) or PI3K inhibitors. STS treatment, without T. gondii infection, reduced the viability of THP-1 cells in proportion to STS concentration and triggered many cellular death events such as caspase-3 and -9 activation, Bax translocation, cytochrome c release from host cell mitochondria into cytosol, and PARP cleavage in the host cell. However, T. gondii infection eliminated the STS-triggered mitochondrial apoptotic events described above. Additionally, T. gondii infection in vitro and in vivo induced the phosphorylation of PKB/Akt and Bad in a parasite-load-dependent manner which subsequently inhibited Bax translocation. The PI3K inhibitors, LY294002 and Wortmannin, both blocked parasite-induced phosphorylation of PKB/Akt and Bad. Furthermore, THP-1 cells pretreated with these PI3K inhibitors showed reduced phosphorylation of Bad in a dose-dependent manner and subsequently failed to inhibit the Bax translocation, also these cells also failed to overcome the T. gondii-imposed inhibition of host cell apoptosis. These data demonstrate that the PI3K-PKB/Akt pathway may be one of the major route for T. gondii in the prevention of host cell apoptosis and T. gondii phosphorylates the pro-apoptotic Bad protein to prevent apoptosis.
LiF ( Mg , Cu , Na , Si ) 형광체의 열자극엑소전자 방출
도시홍,정중현,청본정의 (靑本正義),서천사웅 (西川嗣雄),옥천양일 (玉川洋一),기부광효 (磯部光孝) ( Sih Hong Doh,Jung Hyun Jeong,M . Aoki,T . Nishikawa,Y . Tamagawa,M . Isobe ) 한국센서학회 1994 센서학회지 Vol.3 No.2
The TSEE characteristics of LiF(Mg,Cu,Na,Si)phosphor for gamma and beta rays are described. The TSEE glow curve of this phosphor showed 5 peaks in the range from 20 ℃ to 400 ℃; and its main peak appeared at 240℃. The sensitivity of the phospor for ^(60)Co gamma rays was about 450counts/mR. TSEE energy dependence for various beta radiation was nearly constant (±10%) in the mean beta particle energy range from 0.02MeV to 0.8MeV. The efficiency of TSEE of the phosphor for beta radiation was (2∼15)x10^(-3).