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- 저자 : Xufeng Guo (검색결과 3 건)
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Three new sesquiterpene lactones from Inula britannica
Xufeng Zhang,Jing-Ling Du,Jie Ren,Feng-Mei Ye,Yang-Guo Xie,Xiangrong Cheng,Shi Kai Yan,Huizi Jin 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
One new 1,10-secoeudesmanolide (1), twoeudesmanolides (2 and 3), together with nine knowncompounds (4–12) were isolated from the aerial parts ofInula britannica. The structures of the new compoundswere elucidated by detailed spectroscopic analysis,including HRESIMS and 2D-NMR spectroscopic method. In addition, compounds 1–4 were tested for their inhibitoryeffects against LPS-induced NO production in RAW264.7macrophages.
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Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis
Jun Wang,Xufeng Guo,Jixiang Zhang,Jia Song,Mengyao Ji,Shijie Yu,Jing Wang,Zhuo Cao,Weiguo Dong 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.6
Purpose: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC. Materials and Methods: All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study by odds ratio (OR) together with its 95% confidence interval (CI), respectively. Results: A total of 15 case-control studies were included. Overall, no evidence has indicated that the -1195A allele, -765C allele, 8473C allele, and 511Ala allele are associated with susceptibility to CRC (-1195G>A: OR=1.11, 95% CI: 0.82-1.51, p=0.78; -765G>C: OR=1.08, 95% CI: 0.96-1.21, p=0.07; 8473T>C: OR=1.03, 95% CI: 0.89-1.18, p=0.91; Val511Ala:OR=0.71, 95% CI: 0.46-1.09, p=0.94). However, stratified analysis with ethnicity indicated that individuals with -765GC or GC/CC genotypes had an increased risk of CRC among Asian populations (GC vs. GG: OR=1.05, 95% CI: 0.87-1.28, p=0.03; GC+CC vs. GG: OR=1.08, 95% CI: 0.96-1.21, p=0.07). Conclusion: This meta-analysis indicated that -765G>C polymorphism was significantly associated with susceptibility to CRC in Asian populations.
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Experimental Study of Factors Affecting the 7075 Aluminum Alloy Thin-walled Parts Milling Force
Fengyun Yu,Lin Wu,Yunliang Fu,Yanyan Guo,Can Zhao,Xufeng Wang 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.8
Taking 7075 aluminum alloy thin-walled part as the research object, with higher cutting parameters than the normal value selected, a four factors and four levels orthogonal experiment was carried out, in which we chose YG carbide cutting tools for the milling, intercepted the milling force stable section, selected ten peak values and took an average, conducted multiple linear regression analysis using Matlab numerical calculation software and established the milling force empirical formula of 7075 aluminum alloy thin-walled part to study the factors which have influence on its milling force. By range analysis of the experimental results, the cutting force change rule in the manufacturing process of aluminum alloy with the change of cutting parameter was revealed. It is found that the axial cutting depth had the greatest influence on the force perpendicular to the direction of cutting surface, and the radial cutting depth had the minimal impact. By comparative analysis on theoretical value and experimental value of milling forces, we found that the predicted value of the milling force Fx and Fy in theory were in good agreement with the experimental results with a relative error less than 8.7%. Under the experimental conditions, the optimal milling parameters are axial cutting depth of 2mm, radial cutting depth of 0.5mm, feed speed 95mm/min and cutting speed of 23.86m/min. It will provide data and experiment support for milling of thin-walled parts of similar materials, which will have important practical value and theoretical significance for engineering.
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