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- 저자 : Xufeng Fu (검색결과 2 건)
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Deciphering the possible role of H2O2 in methylmercury‑induced neurotoxicity in Xenopus laevis
Xufeng Fu,Xiuyu Yang,Xing Du,Qinghua Cui 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Backgrounds Methylmercury (MeHg) is regarded as a developmental neurotoxicant but the detailed mechanism remains not completely clear. Methods The Xenopus laevis embryos were exposed to methylmercury chloride and the expression of neurodevelopment and oxidative stress genes was detected by qRT-PCR or Western blotting. PC12 cells were exposed to various levels of H2O2, and then cell cycle, neurite length, neurodevelopment-related genes, protein expression of apoptosis and autophagy were detected. Results The genes of neurodevelopment and oxidative stress were disrupted by methylmercury chloride and H2O2 were increased interestingly in X. laevis embryos. Then, PC12 cells were exposed to H2O2 and the results showed the cell cycle, neurite length, and neurodevelopment-related genes, the proteins apoptosis and autophagy were changed. Conclusion These results supported the idea that neurodevelopment-related gene expression was regulated by oxidative stress and that apoptosis and autophagy pathways were activated by H2O2 and involved in methylmercury neurotoxicity.
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Experimental Study of Factors Affecting the 7075 Aluminum Alloy Thin-walled Parts Milling Force
Fengyun Yu,Lin Wu,Yunliang Fu,Yanyan Guo,Can Zhao,Xufeng Wang 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.8
Taking 7075 aluminum alloy thin-walled part as the research object, with higher cutting parameters than the normal value selected, a four factors and four levels orthogonal experiment was carried out, in which we chose YG carbide cutting tools for the milling, intercepted the milling force stable section, selected ten peak values and took an average, conducted multiple linear regression analysis using Matlab numerical calculation software and established the milling force empirical formula of 7075 aluminum alloy thin-walled part to study the factors which have influence on its milling force. By range analysis of the experimental results, the cutting force change rule in the manufacturing process of aluminum alloy with the change of cutting parameter was revealed. It is found that the axial cutting depth had the greatest influence on the force perpendicular to the direction of cutting surface, and the radial cutting depth had the minimal impact. By comparative analysis on theoretical value and experimental value of milling forces, we found that the predicted value of the milling force Fx and Fy in theory were in good agreement with the experimental results with a relative error less than 8.7%. Under the experimental conditions, the optimal milling parameters are axial cutting depth of 2mm, radial cutting depth of 0.5mm, feed speed 95mm/min and cutting speed of 23.86m/min. It will provide data and experiment support for milling of thin-walled parts of similar materials, which will have important practical value and theoretical significance for engineering.
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