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RISS 인기검색어
- 검색키워드
- 저자 : Xuehua Nan (검색결과 3 건)
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Microarray Study of Genes Differentially Modulated in Response to Nitric Oxide in Macrophages
Xuehua Nan,Oky Maeng,신효정,안현정,염영일,이혜영,백상기 한국통합생물학회 2008 Animal cells and systems Vol.12 No.1
Nitric oxide (NO) has been known to playimportant roles in numerous physiologic processes includingUsing a mouse cDNA gene chip, we examined expressionpatterns and time course of NO-dependent genes in mousemacrophage RAW264.7 cells. Genes shown to be up-regulated more than two fold or at least at two serial timepoints were further selected and validated by RT-PCR.Finally, 81 selected genes were classified by function assignaling, apoptosis, inflammation, transcription, translation,ionic homeostasis and metabolism. Among those, genesrelated with signaling, apoptosis and inflammation, such asguanylate cyclase 1, soluble, alpha3 (Gucy1a3 ); proteinkinase C, alpha (Pkcα(Lck); BCL2/adenovirus E1B 19 kDa-interacting protein(Bnip3); apoptotic protease activating factor 1 (Apaf1); X-linked inhibitor of apoptosis (Xiap); cyclin G1 (Ccng1);chemokine (C-C motif) ligand 4 (Ccl4); B cell translocationgene 2, anti-proliferative (Btg2); lysozyme 2 (Lyz2); secretedphosphoprotein 1 (Spp1); heme oxygenase (decycling) 1(Hmox1); CD14 antigen (Cd14); and granulin (Grn) mayplay important roles in NO-dependent responses in murinemacrophages.
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Microarray Study of Genes Differentially Modulated in Response to Nitric Oxide in Macrophages
Nan, Xuehua,Maeng, Oky,Shin, Hyo-Jung,An, Hyun-Jung,Yeom, Young-Il,Lee, Hay-Young,Paik, Sang-Gi The Korean Society for Integrative Biology 2008 Animal cells and systems Vol.12 No.1
Nitric oxide(NO) has been known to play important roles in numerous physiologic processes including neurotransmission, vasorelaxation, and cellular apoptosis. Using a mouse cDNA gene chip, we examined expression patterns and time course of NO-dependent genes in mouse macrophage RAW264.7 cells. Genes shown to be upregulated more than two fold or at least at two serial time points were further selected and validated by RT-PCR. Finally, 81 selected genes were classified by function as signaling, apoptosis, inflammation, transcription, translation, ionic homeostasis and metabolism. Among those, genes related with signaling, apoptosis and inflammation, such as guanylate cyclase 1, soluble, alpha3(Gucy1a3); protein kinase C, alpha($Pkc{\alpha}$); lymphocyte protein tyrosine kinase(Lck); BCL2/adenovirus E1B 19 kDa-interacting protein(Bnip3); apoptotic protease activating factor 1(Apaf1); X-linked inhibitor of apoptosis(Xiap); cyclin G1(Ccng1); chemokine(C-C motif) ligand 4(Ccl4); B cell translocation gene 2, anti-proliferative(Btg2); lysozyme 2(Lyz2); secreted phosphoprotein 1(Spp1); heme oxygenase(decycling) 1(Hmox1); CD14 antigen(Cd14); and granulin(Grn) may play important roles in NO-dependent responses in murine macrophages.
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Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer
Kang, Jin Young,Nan, Xuehua,Jin, Mi Sun,Youn, Suk-Jun,Ryu, Young Hee,Mah, Shinjee,Han, Seung Hyun,Lee, Hayyoung,Paik, Sang-Gi,Lee, Jie-Oh Elsevier 2009 Immunity Vol.31 No.6
<P><B>Summary</B></P><P>Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes. PE-DTPA, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid, is a synthetic phospholipid derivative. Two major factors contribute to the ligand specificity of TLR2-TLR1 or TLR2-TLR6 heterodimers. First, the lipid channel of TLR6 is blocked by two phenylalanines. Simultaneous mutation of these phenylalanines made TLR2-TLR6 fully responsive not only to diacylated but also to triacylated lipopeptides. Second, the hydrophobic dimerization interface of TLR2-TLR6 is increased by 80%, which compensates for the lack of amide lipid interaction between the lipopeptide and TLR2-TLR6. The structures of the TLR2-lipoteichoic acid and the TLR2-PE-DTPA complexes demonstrate that a precise interaction pattern of the head group is essential for a robust immune response by TLR2 heterodimers.</P>
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