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      • Shear lag effect of varied sectional cantilever box girder with multiple cells

        Zengwei Guo,Xinliang Liu,Longjing Li 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.84 No.3

        This paper proposes a modified bar simulation method for analyzing the shear lag effect of variable sectional box girder with multiple cells. This theoretical method formulates the equivalent area of stiffening bars and the allocation proportion of shear flows in webs, and re-derives the governing differential equations of bar simulation method. The feasibility of the proposed method is verified by the model test and finite element (FE) analysis of a simply supported multi-cell box girder with constant depth. Subsequently, parametric analysis is conducted to explore the mechanism of shear lag effect of varied sectional cantilever box girder with multiple cells. Results show that the shear lag behavior of variable box-section cantilever box girder is weaker than that of box girder with constant section. It is recommended to make the gradient of shear flow in the web with respect to span length vary as smoothly as possible for eliminating the shear lag effect of box girder. An effective countermeasure for diminishing shear lag effect is to increase the number of box chambers or change the variation manner of bridge depth. The shear lag effect of varied sectional cantilever box girder will get more server when the length of central flanges is shorter than 0.26 or longer than 0.36 times of total width of top flange, as well as the cantilever length exceeds 0.29 times of total length of box’s flange. Therefore, the distance between central webs can adjust the shear lag effect of box girder. Especially, the width ratio of cantilever plate with respect to total length of top flange is proposed to be no more 1/3.

      • SCIESCOPUSKCI등재

        Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-α related mechanism

        Tian, Shuying,Guo, Ruixue,Wei, Sichen,Kong, Yu,Wei, Xinliang,Wang, Weiwei,Shi, Xiaomeng,Jiang, Hongyu The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.2

        Present study aimed to investigate the effect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin groups (n=10). Animals in curcumin group were pretreated with curcumin by gastric gavage (200 mg/kg) for 2 days before I/R. Small intestine tissues were prepared for Haematoxylin & Eosin (H&E) staining. Serum diamine oxidase (DAO) and tumor necrosis factor (TNF)-${\alpha}$ levels were measured. Expression of intestinal TNF-${\alpha}$ and tight junction protein (ZO-1) proteins was detected by Western blot and/or immunohistochemistry. Serum DAO level and serum and intestinal TNF-${\alpha}$ leves were significantly increased after I/R, and the values were markedly reduced by curcumin pretreatment although still higher than that of sham group (p<0.05 or p<0.001). H&E staining showed the significant injury to intestinal mucosa following I/R, and curcumin pretreatment significantly improved the histological structure of intestinal mucosa. I/R insult also induced significantly down-regulated expression of ZO-1, and the effect was dramatically attenuated by curcumin-pretreatment. Curcumin may protect the intestine from I/R injury through restoration of the epithelial structure, promotion of the recovery of intestinal permeability, as well as enhancement of ZO-1 protein expression, and this effect may be partly attributed to the TNF-${\alpha}$ related pathway.

      • KCI등재

        Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-α related mechanism

        Shuying Tian,Ruixue Guo,Sichen Wei,Yu Kong,Xinliang Wei,Weiwei Wang,Xiaomeng Shi,Hongyu Jiang 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.2

        Present study aimed to investigate the effect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin groups (n=10). Animals in curcumin group were pretreated with curcumin by gastric gavage (200 mg/kg) for 2 days before I/R. Small intestine tissues were prepared for Haematoxylin & Eosin (H&E) staining. Serum diamine oxidase (DAO) and tumor necrosis factor (TNF)-α levels were measured. Expression of intestinal TNF-α and tight junction protein (ZO-1) proteins was detected by Western blot and/or immunohistochemistry. Serum DAO level and serum and intestinal TNF-α leves were significantly increased after I/R, and the values were markedly reduced by curcumin pretreatment although still higher than that of sham group (p<0.05 or p<0.001). H&E staining showed the significant injury to intestinal mucosa following I/R, and curcumin pretreatment significantly improved the histological structure of intestinal mucosa. I/R insult also induced significantly down-regulated expression of ZO-1, and the effect was dramatically attenuated by curcumin-pretreatment. Curcumin may protect the intestine from I/R injury through restoration of the epithelial structure, promotion of the recovery of intestinal permeability, as well as enhancement of ZO-1 protein expression, and this effect may be partly attributed to the TNF-α related pathway.

      • KCI등재

        Fluorinated and Charged Non-woven Polypropylene Electret Fiber Membrane: A Novel Way in Transformer Oil Regeneration

        Nianrong Zhou,Xiao He,Yuyang Yan,Xinliang Guo,Linshan Zhang,Yunhua He,Xiangyu Tan,Zhengyun Fang 한국전기전자재료학회 2022 Transactions on Electrical and Electronic Material Vol.23 No.2

        The regeneration of transformer oil is a trending topic in the dielectric research field. However, the normal way of regeneration requires high cost and complicate process. In this paper, the non-woven polypropylene (PP) electret films were modifi ed by fluorination and corona method to achieve the regeneration function for transformer oil. The results show that the C-H bonds in polypropylene were replaced by C-F bonds during the fluorination process, resulting in the mean diameter of the fibers being decreased to a value of 1.7 μm. The increased roughness of the fi bers leads to super hydrophobicity. Further research revealed that the insulation properties of aging oil recovered after fi ltration by corona charged fl uorinated fi ber membranes. The result is especially signifi cant for breakdown voltage, the values of which reached half of the original insulating oil. In conclusion, the combination of fl uorinating and corona charging method on PP fi ber membrane shows great potential for insulation oil regeneration.

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