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Anti-proliferative, anti-inflammatory and antioxidant effects of curcumin analogue A2
Zhi-Yun Du,Xingchuan Wei,Mou-Tuan Huang,Xi Zheng,Yue Liu,Allan H. Conney,Kun Zhang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.10
In the present study, we determined the antiproliferative,anti-inflammatory and antioxidant effects of acurcumin analogue, 2,6-bis(3,4-dihydroxybenzylidene) cyclohexanone(designated as A2). In vitro studies showed that A2had a stronger inhibitory effect on the growth of mousemacrophage RAW 264.7 cells than curcumin. A2 also showeda stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases inNF-jB activation and IL-1b expression as well as in aldosereductase activity. A2 was a stronger antioxidant than curcuminas determined by inhibition of lipid peroxidation,inhibition of 1,1-diphenyl-2-picryl-hydrazyl free radical formation,and inhibition of 2,20-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical formation. In vivo studiesindicated that A2 was more potent than curcumin for inhibitingTPA-induced ear edema and TPA-induced increases inIL-1b. In addition, oral administration of A2 at a dose of2,000 mg/kg body weight did not cause acute toxicity inmice. Taken together, the results of our study indicate that thecurcumin analogue A2 has stronger anti-proliferative, antiinflammatoryand antioxidant activities than curcumin.