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Zheng, Wenhao,Dong, Xiaoqiao,Wang, Din,Hu, Qiang,Du, Quan The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.6
Objective : To explore the clinical efficacy and safety of microvascular decompression (MVD) combined with internal neurolysis (IN) in the treatment of recurrent trigeminal neuralgia (TN) after MVD. Methods : Sixty-four patients with recurrent TN admitted to the hospital from January 2014 to December 2017 were divided into two groups according to the surgical method. Twenty-nine patients, admitted from January 2014 to December 2015, were treated with MVD alone, whereas 35 admitted from January 2016 to December 2017 were treated with MVD+IN. The postoperative efficacy, complications, and pain recurrence rate of the two groups were analyzed. Results : The efficacy of the MVD+IN and MVD groups were 88.6% and 86.2%, and the cure rates were 77.1% and 65.5% respectively. There was no statistically significant difference between the two groups (p>0.05). The cure rate (83.3%) of patients in the MVD+IN group, who were only found thickened arachnoid adhesions during the operation that could not be fully released, was significantly higher than that of the MVD group (30.0%) (p<0.05), while the efficacy (91.7% vs. 70%) of the two groups was not statistically different (p>0.05). For patients whose arachnoid adhesions were completely released, there had no significant difference (p>0.05) in the efficacy (87% vs. 94.7%) and recurrence rate (5.0% vs. 11.1%). The incidence of postoperative facial numbness (88.6%) in the MVD+IN group was higher than that in the MVD group (10.3%) (p<0.01). The long-term incidence of facial numbness was not statistically significant (p>0.05). In the 18-36 months follow-up, the recurrence rate of patients in the MVD+IN group (9.7%) and in the MVD group (16%) were not statistically different (p>0.05). Conclusion : A retrospective comparison of patients with recurrent TN showed that both MVD and MVD combined with IN can effectively treat recurrent TN. Compared with MVD alone, MVD combined with IN can effectively improve the pain cure rate of patients with recurrent TN who have only severe arachnoid adhesions. The combination does not increase the incidence of long-term facial numbness and other complications.
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Yingbo Zhang,Dening Zou,Xiaoqiao Wang,Fengshe Xia,Yong Wang,Wei Zhang 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7
The effect of Al content on the microstructure and ductile-brittle transition temperature (DBTT) of 18Cr–Al–Si ferritic heatresistantstainless steel have been studied by Charpy impact testing over temperatures ranging from 20 to 90 ℃. Charpy impacttest results show that DBTT increased with increasing Al content. Meanwhile, fracture morphology changed with increasingAl content, where the amount of dimples decreased and cleavage facets increased, indicating increases in the tendency forbrittle fracture. Furthermore, ferrite grain size, volume fraction and size of (Cr, Fe)23C6 carbides increased with increasingAl content, which led to decreasing toughness and increasing DBTT.
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Du Yuanfeng,Yang Dingbo,Dong Xiaoqiao,Du Quan,Wang Ding,Shen Yongfeng,Yu Wenhua 한국유전학회 2021 Genes & Genomics Vol.43 No.12
Background Subarachnoid hemorrhage (SAH) is a severe neurological emergency, resulting in cognitive impairments and threatening human's health. Currently, SAH has no efective treatment. It is urgent to search for an efective therapy for SAH. Objective To explore the expression of Omi protein after subarachnoid hemorrhage in rats. Methods SAH rat model was established by injecting blood into the prechiasmatic cistern. Neurological defcit was assessed by detecting neurological defcit scores and brain tissue water contents. Apoptotic cells were evaluated by TUNEL staining and IHC staining. Omi and Cleaved caspase 3 expressions in nerve cells were determined by double staining using IF. Apoptosis-related proteins were measured by Western blotting assay. Results SAH rat model was successfully established, showing more apoptotic cells and high neurological defcit scores in SAH rat. In SAH rat model, Omi expression in nerve cells was elevated and the upregulation of Omi mainly occurred in cytoplasm, accompanied by the degradation of XIAP and the increased cleaved caspase 3/9 and cleaved PARP. Once treated with UCF-101, a specifc inhibitor of Omi, the increased cell apoptosis, left/right brain moisture contents and neurological defcits were notably reversed in SAH rat brain. Of note, SAH-induced the increases of apoptosis-related protein in nerve cells were also rescued by the administration of UCF-101. Conclusions UCF-101-mediated Omi inhibition decreased the degradation of XIAP and subsequently inhibited the activation of apoptosis-related proteins, decreased nerve cell apoptosis, leading to the improvement on early brain injury in SAH rat. UCF-101-based Omi inhibition may be used to treat SAH with great potential application.
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아동의 질문 능력 발달에 영향을 미치는 인지적 요인 및 개입 방안에 대한 개관
성혜빈,김서란,신유주,정서윤,조수미,Xiaoqiao Wang,송현주 한국심리학회 산하 한국발달심리학회 2024 한국심리학회지 발달 Vol.37 No.2
질문은 지식과 경험이 한정적인 아동들이 정보를 능동적으로 획득할 수 있는 주요 학습 기제이며, 인간 고유의 능력으로 추정된다. 영아기에 가리키기와 같은 비언어적 형태로 나타나던 질문은 생후 1.5년경부터 점차 언어적 형태로 산출되기 시작하며, 아동의 연령이 증가하면서 더욱 정교해진다. 질문을 통해 효율적으로 필요한 정보를 획득하려면 적합한 대상에게 적절한 내용의 질문을 해야 하며 주어진 답변의 유용성을 평가할 수 있어야 한다. 또한 답변을 단순히 수용하는 데 그치지 않고 후속 반응이나 질문을 통해 추가 정보를 획득할 수 있는 책략을 활용할 줄 알아야 한다. 이러한 일련의 과정을 원활히 처리하기 위해서는 여러 기초적인 인지 능력이 요구된다. 본 연구는 질문의 정보 획득 기능(epistemic function)에 초점을 두고 아동의 질문하기 능력 발달 과정을 살펴보았다. 또한 메타인지, 확률 추론, 범주화 능력, 집행기능과 같은 기초 인지 능력이 질문하기에 미치는 영향에 대한 선행 연구를 개관하였다. 마지막으로 아동의 질문 발달을 촉진할 수 있는 개입 방안을 검토하고, 향후 연구에 대해 제언하였다. Questioning is the primary learning mechanism whereby children with limited knowledge actively gather information. As children grow older, their questions become more efficient. To effectively search for information, one must direct appropriate questions to suitable sources and evaluate the informativeness of the answers received. Moreover, individuals should be adept at employing strategies, such as follow-up questions, to acquire additional information. Cognitive abilities are required to navigate these processes. This review presents an overview of prior research on the developmental trajectories of children’s questioning abilities, with emphasis on the epistemic function of questions. The influence of general cognitive abilities - metacognition, probabilistic reasoning, categorization skills, and executive functions - on questioning is also reviewed. Lastly, interventions to enhance children’s questioning abilities are reviewed and areas of future research are suggested.
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