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The characteristic of the synonymous codon usage and phylogenetic analysis of hepatitis B virus
Xiaoming Qi,Chaojun Wei,Yonghong Li,Yu Wu,Hui Xu,Rui Guo,Yanjuan Jia,Zhenhao Li,Zhenhong Wei,Wanxia Wang,Jing Jia,Yuanting Li,Anqi Wang,Xiaoling Gao 한국유전학회 2020 Genes & Genomics Vol.42 No.7
Background Hepatitis B virus (HBV) infection is a crucial medical issue worldwide. The dependence of HBV replication on host cell machineries and their co-evolutionary interactions prompt the codon usage pattern of viral genes to translation selection and mutation pressure. Objective The evolutionary characteristics of HBV and the natural selection effects of the human genome on the codon usage characteristics were analyzed to provide a basis for medication development for HBV infection. Methods The codon usage pattern of sequences from different HBV genotypes of our isolates and reference HBV genome sequences downloaded from the National Center for Biotechnology Information (NCBI) database were analyzed by computing the relative synonymous codon usage (RSCU), nucleotide content, codon adaptation index (CAI) and the effective number of codons (ENC). Results The highest ENC values were observed in the C genotypes, followed by the B genotypes. The ENC values indicated a weak codon usage bias (CUB) in HBV genome. The number of codons differentially used between the three genotypes was markedly higher than that of similarly used codons. High CAI values indicated a good adaptability of HBV to its host. The ENC plot indicated the occurrence of mutational pressure in the three genotypes. The mean Ka/Ks ratios in the three genotypes were lower than 1, which indicated a negative selection pressure. The CAI and GC3% plot indicated the existence of CUB in the HBV genome. Conclusions Nucleotide composition, mutation bias, negative selection and mutational pressure are key factors influencing the CUB and phylogenetic diversity in HBV genotypes. The data provided here could be useful for developing drugs for HBV infection.
Hong Guo,Zisong Bai,Yangyang Xu,Xueqin Wu,Ning Li,Yan Zhu,Xiaoming Wang,Peng Zhang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.7
Pongamia pinnata (Linn.) Pierre has anti-inflammatory activity and could significantly decrease serum tumor necrosis factor-a and IL-10 in arthritic rats. Previous research indicated the typical chemical constituent in P. pinnata is furanoflavone. Guided by anti-inflammatory active assay and UPLC-HRESIMS chromatography, 22 compounds were isolated from the ethanol extract of P. pinnata seedpods. One novel furanoflavone, 40-hydroxypinnatin, was elucidated by HRESIMS, 1D- and 2D-NMR spectra. The 21 known compounds, including 9 furanoflavone, were identified by comparing their NMR data with the previous data in reference. In the known compounds, 5 were isolated for the first time from the species. The anti-inflammatory activities were assayed by assessing LPS-induced NO production in BV-2 cells. 12 compounds can inhibit the production of NO without cytotoxicity at concentration of 50 lM. Among them, compounds 4 can significantly inhibit the production of NO, with the IC50 value of 31.36 lM.
Yuanyuan Guo,Youchao Sun,Longbiao Li,Xiaoming Tang 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.7
In view of the abnormal, missing and multi-source reliability data, a complete reliability data processing method for civil machinery parts are formed. The abnormal data in the original reliability data set is screened out by Pauta criterion. The vacant data is supplemented by linear interpolation. Each subjective index weight of multi-source data is determined by analytic hierarchy process (AHP) and Euclidean distance. Each objective index weight is determined by the discrete degree of the index weight. The comprehensive reliability model about a certain mechanical part with multi-source data is established and validated to be practical through case analysis. The proposed method obtains more accurate assessment of part reliability, and is thus valuable for the safe operation and maintenance of civil aircraft.
Song Lei,Qiu Xiaoming,Zhang Cun,Zhou Hang,Guo Wenmin,Ye Yu,Wang Rujia,Xiong Hui,Zhang Ji,Tang Dongfang,Zou Liwei,Wang Longsheng,Yu Yongqiang,Guo Tingting 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.2
Objective: This study aimed to determine the predictive performance of non-contrast CT (NCCT) signs for hemorrhagic growth after intracerebral hemorrhage (ICH) when stratified by onset-to-imaging time (OIT). Materials and Methods: 1488 supratentorial ICH within 6 h of onset were consecutively recruited from six centers between January 2018 and August 2022. NCCT signs were classified according to density (hypodensities, swirl sign, black hole sign, blend sign, fluid level, and heterogeneous density) and shape (island sign, satellite sign, and irregular shape) features. Multivariable logistic regression was used to evaluate the association between NCCT signs and three types of hemorrhagic growth: hematoma expansion (HE), intraventricular hemorrhage growth (IVHG), and revised HE (RHE). The performance of the NCCT signs was evaluated using the positive predictive value (PPV) stratified by OIT. Results: Multivariable analysis showed that hypodensities were an independent predictor of HE (adjusted odds ratio [95% confidence interval] of 7.99 [4.87–13.40]), IVHG (3.64 [2.15–6.24]), and RHE (7.90 [4.93–12.90]). Similarly, OIT (for a 1-h increase) was an independent inverse predictor of HE (0.59 [0.52–0.66]), IVHG (0.72 [0.64–0.81]), and RHE (0.61 [0.54– 0.67]). Blend and island signs were independently associated with HE and RHE (10.60 [7.36–15.30] and 10.10 [7.10–14.60], respectively, for the blend sign and 2.75 [1.64–4.67] and 2.62 [1.60–4.30], respectively, for the island sign). Hypodensities demonstrated low PPVs of 0.41 (110/269) or lower for IVHG when stratified by OIT. When OIT was ≤ 2 h, the PPVs of hypodensities, blend sign, and island sign for RHE were 0.80 (215/269), 0.90 (142/157), and 0.83 (103/124), respectively. Conclusion: Hypodensities, blend sign, and island sign were the best NCCT predictors of RHE when OIT was ≤ 2 h. NCCT signs may assist in earlier recognition of the risk of hemorrhagic growth and guide early intervention to prevent neurological deterioration resulting from hemorrhagic growth.
Zhang, Kan,Li, Ping,Guo, Shiying,Jeong, Jong Yeob,Jin, Bingjun,Li, Xiaoming,Zhang, Shengli,Zeng, Haibo,Park, Jong Hyeok The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.45
<P>In this paper, we precisely controlled the <I>d</I>-spacing of vertically aligned MoS2 arrays ranging from 6.2 to 10 Å <I>via</I> heating-controlled deintercalation of NH4<SUP>+</SUP> ions. The finely controllable interlayer nanoarchitecture resulted in an optimal <I>d</I>-spacing of 7.3 Å, which on nitrogenous reduced graphene oxide (N-RGO) delivered a reversible capacity of 295 mA h g<SUP>−1</SUP> after 2000 cycles at 1 A g<SUP>−1</SUP> for Na<SUP>+</SUP> intercalation.</P>
Applications of Bacterial Cellulose-Based Composite Materials in Hard Tissue Regenerative Medicine
Liu Yingyu,Liu Haiyan,Guo Susu,Qi Jin,Zhang Ran,Liu Xiaoming,Sun Lingxiang,Zong Mingrui,Cheng Huaiyi,Wu Xiuping,Shanxi Medical University School and Hospital of Stomatology 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.7
BACKGROUND: Cartilage, bone, and teeth, as the three primary hard tissues in the human body, have a significant application value in maintaining physical and mental health. Since the development of bacterial cellulose-based composite materials with excellent biomechanical strength and good biocompatibility, bacterial cellulose-based composites have been widely studied in hard tissue regenerative medicine. This paper provides an overview of the advantages of bacterial cellulose-based for hard tissue regeneration and reviews the recent progress in the preparation and research of bacterial cellulose-based composites in maxillofacial cartilage, dentistry, and bone. METHOD: A systematic review was performed by searching the PubMed and Web of Science databases using selected keywords and Medical Subject Headings search terms. RESULTS: Ideal hard tissue regenerative medicine materials should be biocompatible, biodegradable, non-toxic, easy to use, and not burdensome to the human body; In addition, they should have good plasticity and processability and can be prepared into materials of different shapes; In addition, it should have good biological activity, promoting cell proliferation and regeneration. Bacterial cellulose materials have corresponding advantages and disadvantages due to their inherent properties. However, after being combined with other materials (natural/ synthetic materials) to form composite materials, they basically meet the requirements of hard tissue regenerative medicine materials. We believe that it is worth being widely promoted in clinical applications in the future. CONCLUSION: Bacterial cellulose-based composites hold great promise for clinical applications in hard tissue engineering. However, there are still several challenges that need to be addressed. Further research is needed to incorporate multiple disciplines and advance biological tissue engineering techniques. By enhancing the adhesion of materials to osteoblasts, providing cell stress stimulation through materials, and introducing controlled release systems into matrix materials, the practical application of bacterial cellulose-based composites in clinical settings will become more feasible in the near future.
Gan Tang,Lingfeng Yin,Xiaoming Guo,Jin Cui 한국강구조학회 2015 International Journal of Steel Structures Vol.15 No.1
Fabricated corrugated steel silos are widely used for grain storage, and the corrugated steel plates with bolt lap connectionsare often used as the silo wall. This paper aims to research the mechanical performance of bolt connections of corrugated steelplates. Experiments were conducted for eight groups of specimens subjected to various parameters. The finite element modelstook into account the material nonlinearities, geometry nonlinearities and contact nonlinearities. The major factors (platethickness and wave height) were selected, and parametric studies were performed. It is found that the ultimate bearing capacitiesof corrugated steel plate specimens are smaller than those of the flat steel plate specimens, and the ultimate displacements ofthe former are larger than those of the latter. The attaching degree between the nuts and the steel plates is a primary factor ofthe difference. The finite element results are in good agreement with the experimental results. The ultimate bearing capacityof single-bolt connections of corrugated steel plates shows an increasing trend with the increase in plate thickness, and theultimate displacement and ultimate bearing capacity both increase as the wave height decreases. When the wave height of thespecimen decreases to 0 mm, the ultimate bearing capacity and ultimate displacement increase significantly.