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- 저자 : Xiaolei Pan (검색결과 4 건)
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Xiaolei Qiu,Rongrong Zhang,Lu Wen,Fuli Jiang,Hongjun Mao,Wei Yan,Shiping Xie,Xinming Pan 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.8
Objective The etiology of schizophrenia is unknown and is associated with abnormal spontaneous brain activity. There are no consistent results regarding the change in spontaneous brain activity of people with schizophrenia. In this study, we determined the specific changes in the amplitude of low-frequency fluctuation/fractional amplitude of low-frequency fluctuation (ALFF/fALFF) and regional homogeneity (ReHo) in patients with drug-naïve first-episode schizophrenia (Dn-FES). Methods A comprehensive search of databases such as PubMed, Web of Science, and Embase was conducted to find articles on resting-state functional magnetic resonance imaging using ALFF/fALFF and ReHo in schizophrenia patients compared to healthy controls (HCs) and then, anatomical/activation likelihood estimation was performed. Results Eighteen eligible studies were included in this meta-analysis. Compared to the spontaneous brain activity of HCs, we found changes in spontaneous brain activity in Dn-FES based on these two methods, mainly including the frontal lobe, putamen, lateral globus pallidus, insula, cerebellum, and posterior cingulate cortex. Conclusion We found that widespread abnormalities of spontaneous brain activity occur in the early stages of the onset of schizophrenia and may provide a reference for the early intervention of schizophrenia
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Dependence assessment in human reliability analysis under uncertain and dynamic situations
Xianghao Gao,Xiaoyan Su,Hong Qian,Xiaolei Pan 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.3
Since reliability and security of man-machine system increasingly depend on reliability of human, humanreliability analysis (HRA) has attracted a lot of attention in many fields especially in nuclear engineering. Dependence assessment among human tasks is a important part in HRA which contributes to anappropriate evaluation result. Most of methods in HRA are based on experts’ opinions which are subjectiveand uncertain. Also, the dependence influencing factors are usually considered to be constant,which is unrealistic. In this paper, a new model based on DempstereShafer evidence theory (DSET) andfuzzy number is proposed to handle the dependence between two tasks in HRA under uncertain anddynamic situations. First, the dependence influencing factors are identified and the judgments on thefactors are represented as basic belief assignments (BBAs). Second, the BBAs of the factors that varyingwith time are reconstructed based on the correction BBA derived from time value. Then, BBAs of allfactors are combined to gain the fused BBA. Finally, conditional human error probability (CHEP) isderived based on the fused BBA. The proposed method can deal with uncertainties in the judgments anddynamics of the dependence influencing factors. A case study is illustrated to show the effectiveness andthe flexibility of the proposed method.
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Jianle Wang,Majid Nisar,Chongan Huang,Xiangxiang Pan,Dongdong Lin,Gang Zheng,Haiming Jin,Deheng Chen,Naifeng Tian,Qianyu Huang,Yue Duan,Yingzhao Yan,Ke Wang,Congcong Wu,Jianing Hu,Xiaolei Zhang,Xiangy 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has remained elusive. Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under oxidative stress. We subsequently activated SIRT3 using honokiol to evaluate its therapeutic potential for IVDD. We assessed SIRT3 expression in degenerative nucleus pulposus (NP) tissues and oxidative stressinduced nucleus pulposus cells (NPCs). SIRT3 was knocked down by lentivirus and activated by honokiol to determine its role in oxidative stress-induced NPCs. The mechanism by which honokiol affected SIRT3 regulation was investigated in vitro, and the therapeutic potential of honokiol was assessed in vitro and in vivo. We found that the expression of SIRT3 decreased with IVDD, and SIRT3 knockdown reduced the tolerance of NPCs to oxidative stress. Honokiol (10 μM) improved the viability of NPCs under oxidative stress and promoted their properties of anti-oxidation, mitochondrial dynamics and mitophagy in a SIRT3-dependent manner. Furthermore, honokiol activated SIRT3 through the AMPKPGC- 1α signaling pathway. Moreover, honokiol treatment ameliorated IVDD in rats. Our study indicated that SIRT3 is involved in IVDD and showed the potential of the SIRT3 agonist honokiol for the treatment of IVDD.
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Handling dependencies among performance shaping factors in SPAR-H through DEMATEL method
Xu Zhihui,Shang Shuwen,Su Xiaoyan,Qian Hong,Pan Xiaolei 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.8
The Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method is a widely used method in human reliability analysis (HRA). Performance shaping factors (PSFs) refer to the factors that may influence human performance and are used to adjust nominal human error probabilities (HEPs) in SPAR-H. However, the PSFs are assumed to be independent, which is unrealistic and can lead to unreasonable estimation of HEPs. In this paper, a new method is proposed to handle the dependencies among PSFs in SPAR-H to obtain more reasonable results. Firstly, the dependencies among PSFs are analyzed by using decision-making trial and evaluation laboratory (DEMATEL) method. Then, PSFs are assigned different weights according to their dependent relationships. Finally, multipliers of PSFs are modified based on the relative weights of PSFs. A case study is illustrated that the proposed method is effective in handling the dependent PSFs in SPAR-H, where the duplicate calculations of the dependent part can be reduced. The proposed method can deal with a more general situation that PSFs are dependent, and can provide more reasonable results.
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