Analytical and mathematical simulation for nonlinear stability of scale-dependent magneto-electro-elastic system

Li, Bin,Xu, Xiaojia,Hu, Zhigang,Liu, Yuzuo,Qi, Menghui,Zheng, Zengquan Techno-Press 2021 Advances in nano research Vol.11 No.4

By using differential quadrature method (DQM), a numerical investigation was provided for nonlinear stability behavior of magneto-electro-elastic (MEE) cylindrical shells at microscale. It is assumed that the cylindrical shell has been subjected to compressive loads leading to buckling phenomena in geometrically nonlinear regime. The non-uniformity of strain field has been inserted in the formulation for considering the microscale effects. The material properties of the shell are considered to be inhomogeneous with graded distribution. After solving the governing equations using DQM, it is realized that if the nanoscale shell is subjected to electrical and magnetic fields, the post-buckling path may be changed with the value of electrical voltage and magnetic potential. Also, strain gradient effects have remarkable influence on post-buckling curves and critical voltages.

Parameter estimation of partial linear model under monotonicity constraints with censored data

Wei Chen,Xiaojia Li,Dehui Wang,Guohua Shi 한국통계학회 2015 Journal of the Korean Statistical Society Vol.44 No.3

We propose a weighted least square method for estimation in the partial linear model with monotonicity constraints and right-censored data. This method uses the Kaplan–Meier weights to account for censoring and monotone B-splines to approximate the unknown monotone function.Weshow that the proposed estimator of regression coefficients is rootn consistent and asymptotically normal under appropriate assumptions. One advantage is that our method can be easily computed using existing software. A simulation study is conducted to evaluate the finite sample performance of the proposed method.

The role of acupuncture and moxibustion in the treatment, prevention, and rehabilitation of patients with COVID-19: A scoping review

Mengjuan Ren,Yunlan Liu,Xiaojia Ni,Zhuoran Kuang,Xufei Luo,Yikai Zhang,Huishan Li,Yaolong Chen 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.4

Introduction This study aims to summarize the available evidence and guideline/consensus recommendations for acupuncture and moxibustion in the treatment, prevention and rehabilitation of patients with coronavirus disease 2019 (COVID-19). Methods A scoping review was performed. Eight electronic databases and other related websites were searched. All studies related to acupuncture and moxibustion for COVID-19 were considered. Descriptive analysis was applied to analyze the all included studies and guideline recommendations. Results We ultimately included 131 eligible studies. The main topics of the included studies were the treatment (82.4%) and prevention (38.9%) of COVID-19. The most included studies were literature reviews (65, 49.6%), protocols of systematic reviews (20, 15.3%), and guidelines and consensuses (18, 13.7%). The 18 (13.7%) COVID-19 guidelines and consensuses included 47 recommendations on acupuncture and moxibustion, which focused on the treatment (21/47, 44.7%), rehabilitation (17/47, 36.2%) and prevention (6, 12.8%) of COVID-19 patients. Zusanli (ST36), Feishu (BL13), Guanyuan (RN4) were recommended mostly for the treatment, rehabilitation and prevention respectively. Conclusion Acupuncture and moxibustion are effective in the treatment of COVID-19 patients to some extent. However, more high-quality of clinical trials still needed to determine the feasibility of acupuncture and moxibustion in COVID-19 patients to better guide clinical practice. Study registration Open Science Framework Registries (Registration DOI: 10.17605/OSF.IO/Z35WN; https://osf.io/z35wn). Introduction This study aims to summarize the available evidence and guideline/consensus recommendations for acupuncture and moxibustion in the treatment, prevention and rehabilitation of patients with coronavirus disease 2019 (COVID-19). Methods A scoping review was performed. Eight electronic databases and other related websites were searched. All studies related to acupuncture and moxibustion for COVID-19 were considered. Descriptive analysis was applied to analyze the all included studies and guideline recommendations. Results We ultimately included 131 eligible studies. The main topics of the included studies were the treatment (82.4%) and prevention (38.9%) of COVID-19. The most included studies were literature reviews (65, 49.6%), protocols of systematic reviews (20, 15.3%), and guidelines and consensuses (18, 13.7%). The 18 (13.7%) COVID-19 guidelines and consensuses included 47 recommendations on acupuncture and moxibustion, which focused on the treatment (21/47, 44.7%), rehabilitation (17/47, 36.2%) and prevention (6, 12.8%) of COVID-19 patients. Zusanli (ST36), Feishu (BL13), Guanyuan (RN4) were recommended mostly for the treatment, rehabilitation and prevention respectively. Conclusion Acupuncture and moxibustion are effective in the treatment of COVID-19 patients to some extent. However, more high-quality of clinical trials still needed to determine the feasibility of acupuncture and moxibustion in COVID-19 patients to better guide clinical practice. Study registration Open Science Framework Registries (Registration DOI: 10.17605/OSF.IO/Z35WN; https://osf.io/z35wn).

Prediction of Cognitive Progression in Individuals with Mild Cognitive Impairment Using Radiomics as an Improvement of the ATN System: A Five-Year Follow-Up Study

Song Rao,Wu Xiaojia,Liu Huan,Guo Dajing,Tang Lin,Zhang Wei,Feng Junbang,Li Chuanming 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.1

Objective: To improve the N biomarker in the amyloid/tau/neurodegeneration system by radiomics and study its value for predicting cognitive progression in individuals with mild cognitive impairment (MCI). Materials and Methods: A group of 147 healthy controls (HCs) (72 male; mean age ± standard deviation, 73.7 ± 6.3 years), 197 patients with MCI (114 male; 72.2 ± 7.1 years), and 128 patients with Alzheimer’s disease (AD) (74 male; 73.7 ± 8.4 years) were included. Optimal A, T, and N biomarkers for discriminating HC and AD were selected using receiver operating characteristic (ROC) curve analysis. A radiomics model containing comprehensive information of the whole cerebral cortex and deep nuclei was established to create a new N biomarker. Cerebrospinal fluid (CSF) biomarkers were evaluated to determine the optimal A or T biomarkers. All MCI patients were followed up until AD conversion or for at least 60 months. The predictive value of A, T, and the radiomics-based N biomarker for cognitive progression of MCI to AD were analyzed using Kaplan-Meier estimates and the log-rank test. Results: The radiomics-based N biomarker showed an ROC curve area of 0.998 for discriminating between AD and HC. CSF Aβ42 and p-tau proteins were identified as the optimal A and T biomarkers, respectively. For MCI patients on the Alzheimer’s continuum, isolated A+ was an indicator of cognitive stability, while abnormalities of T and N, separately or simultaneously, indicated a high risk of progression. For MCI patients with suspected non-Alzheimer’s disease pathophysiology, isolated T+ indicated cognitive stability, while the appearance of the radiomics-based N+ indicated a high risk of progression to AD. Conclusion: We proposed a new radiomics-based improved N biomarker that could help identify patients with MCI who are at a higher risk for cognitive progression. In addition, we clarified the value of a single A/T/N biomarker for predicting the cognitive progression of MCI.

Computational and experimental characterization of estrogenic activities of 20(S, R)-protopanaxadiol and 20(S, R)-protopanaxatriol

Tiehua Zhang,Shuning Zhong,Ligang Hou,Yongjun Wang,XiaoJia Xing,Tianzhu Guan,Jie Zhang,Tiezhu Li 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.5

Background: As the main metabolites of ginsenosides, 20(S, R)-protopanaxadiol [PPD(S, R)] and 20(S, R)-protopanaxatriol [PPT(S, R)] are the structural basis response to a series of pharmacological effects of their parent components. Although the estrogenicity of several ginsenosides has been confirmed, however, the underlying mechanisms of their estrogenic effects are still largely unclear. In this work, PPD(S, R) and PPT(S, R) were assessed for their ability to bind and activate human estrogen receptor α(hERα) by a combination of in vitro and in silico analysis. Methods: The recombinant hERα ligand-binding domain (hERa-LBD) was expressed in E. coli strain. The direct binding interactions of ginsenosides with hERα-LBD and their ERα agonistic potency were investigated by fluorescence polarization and reporter gene assays, respectively. Then, molecular dynamics simulations were carried out to simulate the binding modes between ginsenosides and hERα-LBD to reveal the structural basis for their agonist activities toward receptor. Results: Fluorescence polarization assay revealed that PPD(S, R) and PPT(S, R) could bind to hERα-LBD with moderate affinities. In the dual luciferase reporter assay using transiently transfected MCF-7 cells, PPD(S, R) and PPT(S, R) acted as agonists of hERα. Molecular docking results showed that these ginsenosides adopted an agonist conformation in the flexible hydrophobic ligand-binding pocket. The stereostructure of C-20 hydroxyl group and the presence of C-6 hydroxyl group exerted significant influence on the hydrogen bond network and steric hindrance, respectively. Conclusion: This work may provide insight into the chemical and pharmacological screening of novel therapeutic agents from ginsenosides.

Efficacy of acupuncture for cardiopulmonary cerebral resuscitation: A systematic review and meta-analysis

Liu Yunlan,Ren Mengjuan,Kuang Zhuoran,Luo Xufei,Li Huishan,Zhang Yikai,Wen Wanxin,Cai Yefeng,Ni Xiaojia,Chen Yaolong 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.1

Background: Cerebral resuscitation is one of the main therapeutic aims in the treatment of cardiac arrest (CA) patients who experience a return of spontaneous circulation (ROSC). However, the therapeutic effects of current treatments are not ideal. The purpose of this study was to evaluate the efficacy of neurological function of acupuncture combined with conventional cardiopulmonary cerebral resuscitationthe (CPCR) for patients after ROSC. Methods: Seven electronic databases and other related websites were searched to identify studies on acupuncture combined with conventional CPCR for patients after ROSC. R software was used to conduct a meta-analysis, and the outcomes that could not be pooled were analyzed using a descriptive analysis. Results: Seven RCTs involving 411 participants who had experienced ROSC were eligible for inclusion. The main acupoints were Neiguan (PC6), Shuigou (DU26), Baihui (DU20), Yongquan (KI1), and Sanyinjiao (SP6). Compared to conventional CPCR, acupuncture combined with conventional CPCR led to signifi- cantly higher Glasgow Coma Scale (GCS) scores on day 3 (mean difference (MD) = 0.89, 95% CI: 0.43, 1.35, I 2 = 0%), day 5 (MD = 1.21, 95% CI: 0.27, 2.15; I 2 = 0%), and day 7 (MD = 1.92, 95% CI: 1.35, 2.50; I 2 = 0%). Conclusion: Acupuncture-assisted conventional CPCR may have a potential role in improving neurologi- cal function in CA patients after ROSC, but the certainty of evidence is very low and more high-quality studies are required.

Response of Carbon and Nitrogen Metabolism and Secondary Metabolites to Drought Stress and Salt Stress in Plants

Gaochang Cui,Yu Zhang,Wenjin Zhang,Duoyong Lang,Xiaojia Zhang,Zhixian Li,Xinhui Zhang 한국식물학회 2019 Journal of Plant Biology Vol.62 No.6

Carbon and nitrogen metabolism provide the mainenergy and basic nutrients for plants. However, environmentalstress seriously affects carbon and nitrogen metabolism and thushinders plant growth, especially drought stress and salt stress. Hence, numerous studies have been conducted to investigate theresponse of carbon and nitrogen metabolism to drought stressand salt stress by photosynthesis, sucrose and starch metabolism,nitrogen uptake and amino acids. Previous researchers alsostudied the response of secondary metabolism under bothstresses on account of secondary metabolism may conferprotection against environmental stresses. Our review highlightsthe diverse responses of carbon and nitrogen metabolism todrought stress and salt stress and the content changes of threesecondary metabolites in plants under stresses.