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- 저자 : Xianzhi Song (검색결과 2 건)
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Xiaoyu Li,Xianzhi Zhao,Wen Song,Zibin Tian,Lin Yang,Qinghui Niu,Qi Zhang,Man Xie,Bin Zhou,Yonghong Xu,Jun Wu,Cuiping Zhang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.1
Purpose: This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible mechanism. Materials and Methods: The pancreatic cancer cell line SW1990 was cultured and treated with PAB dose- and time-dependent manners. Cell proliferation and invasion ability were measured by MTT assay and Matrigel/Transwell test, respectively. Semi-quantitative real-time polymerase chain reaction and Western blotting were conducted to detect the expression of EMT markers and the key molecules. Finally, nude mice subcutaneous transplantation tumor model was used to confirm the therapy efficacy of PAB. Results: PAB could inhibit SW1990 cell proliferation and invasion in time- and dose-dependent manners. Vimentin, fibronectin, N-cadherin, Snail, Slug, YAP, TEAD1, and Survivin were down-regulated (p<0.01), while E-cadherin, caspase-9, MST1, and pYAP were up-regulated (p<0.05). Combined PAB and gemcitabine treatment markedly restricted the tumor growth compared with gencitabin or PAB alone groups. Conclusion: PAB could inhibit the proliferation and invasion ability of pancreatic cancer cells through activating Hippo-YAP pathway and inhibiting the process of EMT.
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Simulation of the hydraulic isolation efficiency during multistage hydrajet fracturing
Xin Fan,Gensheng Li,Zhongwei Huang,Shouceng Tian,Xianzhi Song,Chen Yang 한국자원공학회 2015 Geosystem engineering Vol.18 No.5
Effective isolation between target zones is critical to multistage fracturing. Low pressure zone caused by the hydrajet is used to isolate stages in the multistage hydrajet fracturing technology. However, there are few researches available in the literature that investigates the hydraulic isolation efficiency considering the existence of multiple fractures. This paper builds a three-dimensional computational-fluid-dynamics model with FLUENT software to study the flow field along annular sections under different conditions. It is verified that the results obtained from the model are consistent with experimental data along the perforation tunnel. The mass flow rate ratio between two outlets is proposed to analyze the hydraulic isolation efficiency in hydrajet multistage fracturing. The results show that annular fluid converges into the perforation tunnel due to the high-speed hydrajet even though there is a pre-existing fracture behind. Effective hydraulic isolation can be generated by reducing the pressure differences between target zones and the annular injection velocity as well as by enlarging the jet velocity and the area ratio. It is found that there exists an optimum area ratio to get the maximum isolation efficiency. Sensitivity analysis indicates the pressure difference is the dominant factor affecting the hydraulic isolation efficiency. A fully quadratic model derived from the response surface method is presented to predict the hydraulic isolation efficiency for real fracturing. This study will be able to provide practical guidance for the optimization of hydrajet multistage fracturing.
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