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RISS 인기검색어
- 검색키워드
- 저자 : Xianghui Zhu (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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SIRT3-Mediated Dimerization of IDH2 Directs Cancer Cell Metabolism and Tumor Growth
Zou, Xianghui,Zhu, Yueming,Park, Seong-Hoon,Liu, Guoxiang,O'Brien, Joseph,Jiang, Haiyan,Gius, David American Association for Cancer Research 2017 Cancer research Vol.77 No.15
<P>These findings identify SIRT3 as a potential tumor suppressor, mediating its effects by limiting the ability of IDH2 to drive cancer cell metabolism and malignant progression.</P><P>The isocitrate dehydrogenase IDH2 produces α-ketoglutarate by oxidizing isocitrate, linking glucose metabolism to oxidative phosphorylation. In this study, we report that loss of SIRT3 increases acetylation of IDH2 at lysine 413 (IDH2-K413-Ac), thereby decreasing its enzymatic activity by reducing IDH2 dimer formation. Expressing a genetic acetylation mimetic IDH2 mutant (IDH2<SUP>K413Q</SUP>) in cancer cells decreased IDH2 dimerization and enzymatic activity and increased cellular reactive oxygen species and glycolysis, suggesting a shift in mitochondrial metabolism. Concurrently, overexpression of IDH2<SUP>K413Q</SUP> promoted cell transformation and tumorigenesis in nude mice, resulting in a tumor-permissive phenotype. IHC staining showed that IDH2 acetylation was elevated in high-risk luminal B patients relative to low-risk luminal A patients. Overall, these results suggest a potential relationship between SIRT3 enzymatic activity, IDH2-K413 acetylation-determined dimerization, and a cancer-permissive phenotype. <I>Cancer Res; 77(15); 3990–9. ©2017 AACR</I>.</P>
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Xusheng Yang,Weijiu Huang,Xianghui Zhu,Ran Zhang,Fei Guo,Li Hu 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.11
The true stress–strain curves of an as-extruded state AA2099 were determined by uniaxial compression tests under varioushot deformation regimes. Constitutive analysis of the curves allowed calculation of the hot deformation activation energy(QHW). The microstructure of the as-compressed specimens were also characterized by electron back scatter diffraction(EBSD). EBSD data analyses showed that the major restoration mechanism corresponding to common industrial extrusionregimes was dynamic recovery. The precipitates in three states (T83, as-homogenized, and as-extruded) were characterizedby X-ray diffraction (XRD) phase analyses and transmission electron microscopy. The results revealed that the QHWwasclosely relevant to the precipitates strengthening. The finite element method simulation results and the microstructure of theextruded products confirmed that AA2099 in as-extruded state possessed good workability.
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Influence of δ' Phase with GP‑I Zones Fillings on Slip Behavior and Cold Rolling Texture in AA2099
Xusheng Yang,Weijiu Huang,Xianghui Zhu,Fei Guo,Yanlong Ma,Linjiang Chai,Ran Zhang 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.9
The cold rolling texture of AA2099 sheets was strongly influenced by the prior heat treatment. Two typical heat treatments,including solid solution (T4) and underaging (T6) were utilized to control slip behavior by different precipitates during coldrolling. A much weaker texture with an orientation scatter towards higher Φ angles was found in the as-rolled T6 specimen(T6R). Slip behavior was analyzed using geometry necessary boundaries distribution. Results show that the T6R specimenexperienced a strong co-planar slip compared to the as-rolled T4 specimen. Prosperity of co-planar slips and limitation ofco-direction slips were main reasons for the weakening of Copper texture component in the T6R specimen. The distinguishslip behavior was caused by existence of δ' phase with GP-I zones fillings in the T6 specimen. This phase could be easilysheared by dislocations and then promoted co-planar slips in further deformation.
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