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Xianghong Tian,Wei Zhao,Xiaoyong Yan 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.1
In this paper, a novel approach to multi-hop range-free localization algorithm in wireless sensor network is proposed using principal component regression. The localization problem in the wireless sensor network is formulated as a multiple regression problem, which is resolved by principal component regression. The proposed methods are simple and efficient that no additional hardware is required for the measurements, and only hop-counts information and location information of the beacons are used for the localization. The proposed method consists of two phases: the offline training phase and the online localization phase. In offline training phase, the real distances and the hop-counts among sensor nodes are collected to build localization model. In online localization phase, each unknown sensor node finds its own location using the localization model. The experimental results show that compared with previous localization methods, the proposed method exhibits excellent and robust performances not only in the isotropic sensor networks but also in the anisotropic sensor networks.
Wang, Yuan-Kai,Yan, Ya-Xian,Kim, Hyeun Bum,Ju, Xianghong,Zhao, Song,Zhang, Keshan,Tzipori, Saul,Sun, Xingmin TaylorFrancis 2015 Human Vaccines & Immunotherapeutics Vol.11 No.9
<P><I>Clostridium difficile</I> is the major cause of hospital-acquired infectious diarrhea and colitis in developed countries. The pathogenicity of <I>C. difficile</I> is mainly mediated by the release of 2 large potent exotoxins, toxin A (TcdA) and toxin B (TcdB), both of which require neutralization to prevent disease occurrence. We have generated a novel chimeric protein, designated mTcd138, comprised of the glucosyltransferase and cysteine proteinase domains of TcdB and the receptor binding domain of TcdA and expressed it in <I>Bacillus megaterium</I>. To ensure that mTcd138 is atoxic, 2 point mutations were introduced to the glucosyltransferase domain of TcdB, which essentially eliminates toxicity of mTcd138. Parenteral immunizations of mice and hamsters with mTcd138 induced protective antibodies to both toxins and provided protection against infection with the hyper-virulent <I>C. difficile</I> strain UK6.</P>
Takeshi Nakahara,Chikage Mitoma,Akiko Hashimoto-Hachiya,Masakazu Takahara,Gaku Tsuji,Hiroshi Uchi,Xianghong Yan,Junichi Hachisuka,Takahito Chiba,Hitokazu Esaki,Makiko Kido-Nakahara,Masutaka Furue 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10
Opuntia ficus-indica (OFI) is a cactus species widely used as an anti-inflammatory, antilipidemic, and hypoglycemic agent. It has been shown that OFI extract (OFIE) inhibits oxidative stress in animal models of diabetes and hepatic disease; however, its antioxidant mechanism remains largely unknown. In this study, we demonstrated that OFIE exhibited potent antioxidant activity through the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and the downstream antioxidant enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), which inhibited the generation of reactive oxygen species in keratinocytes challenged with tumor necrosis factor α or benzo[α]pyrene. The antioxidant capacity of OFIE was canceled in NRF2 knockdown keratinocytes. OFIE exerted this NRF2-NQO1 upregulation through activation of the aryl hydrocarbon receptor (AHR). Moreover, the ligation of AHR by OFIE upregulated the expression of epidermal barrier proteins: filaggrin and loricrin. OFIE also prevented TH2 cytokine-mediated downregulation of filaggrin and loricrin expression in an AHRdependent manner because it was canceled in AHR knockdown keratinocytes. Antioxidant OFIE is a potent activator of AHRNRF2-NQO1 signaling and may be beneficial in treating barrier-disrupted skin disorders.