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Zhen-Xian Du,Hai-Yan Zhang,Da-Xin Gao,Hua-Qin Wang,Yong-Jun Li,Guo-Liang Liu 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.3
apoptosis protein (IAP) family, which is known to be over-expressed in various carcinomas and associated with their biologically aggressive characteristics. The aim of this study was to investigate survivin expression in human medullary thyroid carcinoma (MTC) and a MTC cell line TT, correlate suvivin expression with clinicopathologic features of MTC, and test effects of antisurvivin oligonucleotides (ASODNs) on growth and apoptosis of TT cells. Survivin expression was immunohistochemically determined in formalin-fixed and paraffinembedded specimens obtained from 10 cases of normal thyroid (NT) and 10 cases of MTC, and in TT cells. In TT cells, we confirmed survivin expression and its down-regulation by ASODNs using RT-PCR and Western blot analyses, and investigated effects of ASODNs on viability and growth by MTT assay and apoptosis by apoptotic analyses including DNA laddering assay, acridine orange/ethidium bromide staining and flow cytometric cell cycle analysis. Immunohistochemical analysis showed high survivin expression in MTC and TT cells, whereas no immunoreactivity was detectable in NT. Statistical analyses revealed no significant correlation of survivin expression with the clinicopathologic features of MTC. In TT cells, survivin expression at both mRNA and protein levels was confirmed and could be down-regulated by ASODNs concomitant with decrease in viability and growth, and increase in apoptosis. Our results suggest that survivin plays an important role in MTC independent of the conventional clinicopathologic factors, and ASODNs is a promising survivin- targeted gene therapy for MTC.
Jing, Jie-Xian,Wang, Yan,Xu, Xiao-Qin,Sun, Ting,Tian, Bao-Guo,Du, Li-Li,Zhao, Xian-Wen,Han, Cun-Zhi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
To evaluate the value of combined detection of serum CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS for the clinical diagnosis of upper gastrointestinal tract (GIT) cancer and to analyze the efficacy of these tumor markers (TMs) in evaluating curative effects and prognosis. A total of 573 patients with upper GIT cancer between January 2004 and December 2007 were enrolled in this study. Serum levels of CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS were examined preoperatively and every 3 months postoperatively by ELISA. The sensitivity of CEA, CA19-9, CA24-2, AFP, CA72-4, SCC, TPA and TPS were 26.8%, 36.2%, 42.9%, 2.84%, 25.4%, 34.6%, 34.2% and 30.9%, respectively. The combined detection of CEA+CA199+CA242+CA724 had higher sensitivity and specificity in gastric cancer (GC) and cardiac cancer, while CEA+CA199+CA242+SCC was the best combination of diagnosis for esophageal cancer (EC). Elevation of preoperative CEA, CA19-9 and CA24-2, SCC and CA72-4 was significantly associated with pathological types (p<0.05) and TNM staging (p<0.05). Correlation analysis showed that CA24-2 was significantly correlated with CA19-9 (r=0.810, p<0.001). The levels of CEA, CA19-9, CA24-2, CA72-4 and SCC decreased obviously 3 months after operations. When metastasis and recurrence occurred, the levels of TMs significantly increased. On multivariate analysis, high preoperative CA72-4, CA24-2 and SCC served as prognostic factors for cardiac carcinoma, GC and EC, respectively. combined detection of CEA+CA199+CA242+SCC proved to be the most economic and practical strategy in diagnosis of EC; CEA+CA199+CA242+CA724 proved to be a better evaluation indicator for cardiac cancer and GC. CEA and CA19-9, CA24-2, CA72-4 and SCC, examined postoperatively during follow-up, were useful to find early tumor recurrence and metastasis, and evaluate prognosis. AFP, TPA and TPS have no significant value in diagnosis of patients with upper GIT cancer.
Physiological character and molecular mapping of leaf-color mutant wyv1 in rice (Oryza sativa L.)
Xian-chun Sang,Li-kui Fang,Yuenyong Vanichpakorn,Ying-hua Ling,Peng Du,Fang-ming Zhao,Zheng-lin Yang,Guang-hua He 한국유전학회 2010 Genes & Genomics Vol.32 No.2
The seed of an excellent indica restorer line Jinhui10 (Oryza sativa L. ssp. indica) was treated by ethyl methanesulfonate (EMS); a leaf-color mutant displaying distinct phenotype throughout development grown in paddy field was identified from the progeny. The mutant leaf showed white-yellow at seedling stage and then turned to yellow-green at tillering stage, after that, virescent color appeared until to maturity. The mutant was thus temporarily designed as wyv1. The chlorophyll contents decreased significantly and the changing was consistent with the chlorotic level of wyv1 leaves. Chlorophyll fluorescence kinetic parameters measured at the seedling stage showed that co-efficiency of photochemical quenching (qP),actual photosystem II efficiency (ΦPS II), electron transport rate (ETR) and initial chlorophyll fluorescence level (Fo), net photosynthetic rate (Pn) and maximum photochemical efficiency (Fv / Fm) significantly decreased in severe chlorotic leaf of the mutant compared with that of wild type. However,no significant differences were observed for Pn and Fv/Fm between virescent leaf and normal green leaf. Genetic analysis suggested that the mutant phenotype was controlled by a single recessive nuclear gene which was finally mapped between SSR marker Y7 and Y6 on rice chromosome 3 based on F2 population of Xinong1A / wyv1. Genetic distances were 0.06 cM and 0.03 cM respectively, and the physical distance was 84kb according to the sequence of indica rice 9311. The results must facilitate map-based cloning and functional analysis of WYV1 gene.
Gene Mapping Related to Yellow Green Leaf in a Mutant Line in Rice (Oryza sativa L.)
Peng Du,Ying Hua Ling,Xian Chun Sang,Fang Ming Zhao,Rong Xie,Zheng Lin Yang,Guang Hua He 한국유전학회 2009 Genes & Genomics Vol.31 No.2
A mutant, which derived from the restorer line Jinhui10 treated with EMS, showed completely yellow green leaves, and it had low chlorophyll content and poor agronomic characteristics during the growing stage. The F1 plants from the cross between normal × the mutant showed normal green leaves, and the segregation ratio of normal to yellow green leaves was 3:1 in F2 population. It indicated that the trait was controlled by a single recessive nuclear gene, temporarily designated as ygl3. The gene ygl3 was mapped between RM468 and RM3684 with genetic distances 8.4 cM and 1.8 cM on chromosome 3. This result would be used as genetic information for fine mapping and map-based cloning of ygl3 gene.
Flexural Behavior of Circular Hollow RC Piers with Reduced Amounts of Inner Hoops
Zhong-Xian Li,Chun-yu Du,Xiao Liang,Bo Zhao 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.2
Reversed cyclic loading tests of two circular hollow RC piers were conducted in this study to investigate the effect of different amounts of inner and outer circular hoops on their flexural behavior. The test results showed that the column with a smaller amount of inner circular hoops presented better flexural response than the as-built column with an equal amount of inner and outer circular hoops. Also, the demand developed on the inner circular hoops was smaller than the outer one within the plastic hinge regions, which verified that using a smaller amount of inner circular hoops was reasonable and effective. By examining the confining stress experienced by the concrete in the radial and circumferential directions based on a detailed theoretical analysis, a modeling approach was proposed to take the confinement effect in circular hollow RC piers into consideration. The proposed modeling approach was validated through comparisons with the experimental study and satisfactory agreement was found.
Lijuan Jiang,Xian-Lei Shi,Yue Lv,Honghui Gong,Shuangshuang Liu,Mengmeng Du,Qianqian Hu,Keren Shi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.113 No.-
The development of highly efficient, economical and environmentally friendly catalytic systems is ofgreat significance from the green chemistry point of view. In this paper, we presented a succinct approachto create a heterogeneous acid–base bifunctional catalyst for one-pot tandem reaction from the commerciallyavailable textile fiber. The ultra-high strength textile fiber polyetheretherketone (PEEK) was functionalizedby a post-grafting method to combine two antagonistic active functions in a synergisticcatalyst, and the resulting fiber samples were characterized in detail by morphology, mechanical properties,elemental analysis, X-ray photoelectron spectroscopy, inductively coupled plasma-atomic emissionspectrometry, X-ray diffraction, Fourier transform infrared spectroscopy, ultraviolet–visible spectrum,nuclear magnetic resonance spectroscopy and thermogravimetric analysis, and further revealed thatthe amines and the heteropolyacid were immobilized by acid–base interactions in the PEEK surface layerwith sufficient stability. Moreover, the acid–base bifunctional catalyst can be successfully applied in theacceleration of the one-pot tandem deacetalization–Knoevenagel reactions with high-efficiency (lowercatalyst dosage 0.3 mol%, higher product yields 81–92%), whereas the homogeneous catalysts wereunable to initiate the reaction due to their mutual neutralization in solution, and the catalytic mechanismwas elucidated by comparison. Furthermore, the fibrous catalyst could maintain its activities more than10 cycles with a simple post-processing, and the mediated system was capable of enlarging to the gramscale,which are envisaged for industrial operations and cleaner productions.