Study of the Effect of Opacity on the Solar Coronal X-ray Mg XII 0.842 nm Spectral Lines

Xi-Ping Hao,Jian He,Huihui Liu 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.4

Using the intensity ratio of the solar coronal X-ray Mg XII 0.842 nm doublet observed by usingthe SPIRIT instrumentation, we discuss the optical depth at the line center of the Mg XII emissionlines. The optical depth at the line center of the (1/2 − 3/2) component that we calculated is 0.245. Using the measured abundance of magnesium and the results of ionization balance, we calculatethe variation of electron density with the measured distance to the corona and estimate the averageelectron density to be ne = 6.657 × 108 cm−3. Also we discuss the variation of the optical depth atthe line center with the coronal temperature. This study will be significant to solar coronal plasmadiagnostics.

Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques

Hao Tang,Nian-Guang Li,Zhi-Hao Shi,Yu-Ping Tang,Qian-Ping Shi,Ze-Xi Dong,Peng-Xuan Zhang,Jin-ao Duan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10

The binding abilities of scutellarin (Scu) andscutellarein (Scue) with bovine serum albumin (BSA) wereinvestigated using equilibrium dialysis, high performanceliquid chromatography, fluorescence spectroscopy, competitivesite marker and molecular docking. The resultsshowed that the average protein binding ratios of Scu andScue with BSA were (79.85 ± 1.83) and (85.49 ± 1.21) %respectively. Under simulated physiological conditions, thefluorescence data indicated that Scu and Scue bound withBSA through a static mechanism. The thermodynamicparameters indicated that the interactions of Scu-BSA andScue-BSA mainly occurred by van der Waals forces andhydrogen bonds and it was easier for Scue to bind withBSA than Scu, indicating that the glucuronic acid moleculein Scu decreased the binding affinity. Site competitivemarker experiments showed that the binding sites of Scuand Scue mainly located within the sub-domain IIA ofBSA. Furthermore, molecular docking studies indicatedthat one BSA could bind three Scue, while one BSA couldcarry only two Scu. All these results clearly indicated theinteractions of Scu and Scue with BSA, which will lay thefoundation for further research to determine the pharmacologyand pharmacodynamics of Scu and Scue for treatingischemic cerebrovascular disease.

Electronic, Elastic Properties and Hardness of the Novel Tetragonal Silicon

Xi-Ping Hao,Hong-Ling Cui 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.1

Silicon is an important material for technical applications. Recently, a long-puzzling metastablephase of silicon (T12-Si) has been theoretically identified. In this work, we used first-principlescalculations to study the electronic and elastic properties and the hardness of this new siliconallotrope to enrich the relevant information. These properties of cubic Si (c-Si) were also calculatedfor comparison. The results show that the T12-Si is mechanically anisotropic and has a lower bulkmodulus and shear modulus than c-Si. Its theoretical hardness is 10.3 GPa, smaller than the valueof 13.5 GPa for c-Si. Analyses of the electronic properties reveal that T12-Si is an indirect bandgap crystal with a gap value of 0.69 eV, making it a promising semiconductor for future technicalapplications and that covalent sp3-hybridization is the main interaction in this crystal. The reasonthe calculated hardnesses of c-Si and T12-Si are rather small compared to that of diamond is alsodiscussed.

Synthesis of 2-Substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as Potential Anticonvulsant Agents

Cheng-Xi Wei,Li-Ping Guan,Jing-Hao Jia,채규윤,Zhe-Shan Quan 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1

A series of 2-substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles were synthesized. The anticonvulsant effect and neurotoxicity of the compounds (intraperitoneally) were evaluated with the maximal electroshock (MES) test, subcutaneous pentylenetetrazole (sc-PTZ), and rotarod tests in mice. 2-Phenyl- 6- (4H-1,2,4-triazol-4-yl)benzo[d]oxazole (3g) was the most active and also had the lowest toxicity. In the anti-MES potency test, it showed median effective dose (ED50) of 29.5 mg/kg, a median toxicity dose (TD50) of 285 mg/kg, and a protective index (PI) of 9.7, which is greater than the reference drug, carbamazepine, which has a PI of 6.4.

Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways

Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3

Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.

Effectiveness and Safety of Dabrafenib in the Treatment of 20 Chinese Children with BRAFV600E-Mutated Langerhans Cell Histiocytosis

Ying Yang,Dong Wang,Lei Cui,Hong-Hao Ma,Li Zhang,Hong-Yun Lian,Qing Zhang,Xiao-Xi Zhao,Li-Ping Zhang,Yun-Ze Zhao,Na Li,Tian-You Wang,Zhi-Gang Li,Rui Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1

Purpose We sought to investigate the effectiveness and safety of dabrafenib in children with BRAFV600E-mutated Langerhans cell histiocytosis (LCH). Materials and Methods A retrospective analysis was performed on 20 children with BRAFV600E-mutated LCH who were treated with dabrafenib. Results The median age at which the patients started taking dabrafenib was 2.3 years old (range, 0.6 to 6.5 years). The ratio of boys to girls was 2.3:1. The median follow-up time was 30.8 months (range, 18.9 to 43.6 months). There were 14 patients (70%) in the risk organ (RO)+ group and six patients (30%) in the RO– group. All patients were initially treated with traditional chemotherapy and then shifted to targeted therapy due to poor control of LCH or intolerance to chemotherapy. The overall objective response rate and the overall disease control rate were 65% and 75%, respectively. During treatment, circulating levels of cell-free BRAFV600E (cfBRAFV600E) became negative in 60% of the patients within a median period of 3.0 months (range, 1.0 to 9.0 months). Grade 2 or 3 adverse effects occurred in five patients. Conclusion Some children with BRAFV600E-mutated LCH may benefit from monotherapy with dabrafenib, especially high-risk patients with concomitant hemophagocytic lymphohistiocytosis and intolerance to chemotherapy. The safety of dabrafenib is notable. A prospective study with a larger sample size is required to determine the optimal dosage and treatment duration.

Experimental Study of Composite Steel Plate Shear Wall with Flush End-Plate Connection

Jin-Guang Yu,Xiao-Tian Feng,Ji-Ping Hao,Xi Gao 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.1

This paper presents an investigation on the structural performance of steel plate shear wall (SPSW) with fl ush end-plate beam–column connections and infi ll precast reinforced concrete (precast RC) panels. Two single-span two-story SPSW specimens, including unstiff ened SPSW (NBRP) and precast RC panel restrained SPSW (Con-BRP), are fi rst tested, followed with a parametric study by fi nite element method. Precast RC cover panels are installed on both sides of the infi ll steel plate and are disconnected from steel frame. Test results indicate that the use of precast RC cover panels increases the load carrying and energy dissipation capacities of the SPSW structure, but decreases its ductility. It is also eff ective in reducing the inward fl exural deformation of columns. Moreover, the stiff ening eff ect of the infi ll steel plate on the beam–column connections remains, which is a result of the precast RC cover panel’s resistance to the local buckling and the tears of the infi ll steel plates. The infl uence of the gap size between the precast RC cover plate and frame members on the failure mode of the specimen Con-BRP is also investigated, based on which a maximum gap size is recommended. Conclusions are drawn that SPSW structure with fl ush end-plate beam–column connections and precast RC cover panels fully exploits the strength of infi ll steel plates and exhibits excellent structural performance.

Comparison of carcass and meat quality traits between lean and fat Pekin ducks

Ding, Si-Ran,Li, Guang-Sheng,Chen, Si-Rui,Zhu, Feng,Hao, Jin-Ping,Yang, Fang-Xi,Hou, Zhuo-Cheng Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.7

Objective: According to market demand, meat duck breeding mainly includes 2 breeding directions: lean Pekin duck (LPD) and fat Pekin duck (FPD). The aim of the present study was to compare carcass and meat quality traits between 2 strains, and to provide basic data for guidelines of processing and meat quality improvement. Methods: A total of 62 female Pekin ducks (32 LPDs and 30 FPDs) were slaughtered at the age of 42 days. The live body weight and carcass traits were measured and calculated. Physical properties of breast muscle were determined by texture analyzer and muscle fibers were measured by paraffin sections. The content of inosine monophosphate (IMP), intramuscular fat (IMF) and fatty acids composition were measured by high-performance liquid chromatography, Soxhlet extraction method and automated gas chromatography respectively. Results: The results showed that the bodyweight of LPDs was higher than that of FPDs. FPDs were significantly higher than LPDs in subcutaneous fat thickness, subcutaneous fat weight, subcutaneous fat percentage, abdominal fat percentage and abdominal fat shear force (p<0.01). LPDs were significantly higher than FPDs in breast muscle thickness, breast muscle weight, breast muscle rate and breast muscle shear force (p<0.01). The muscle fiber average area and fiber diameter of LPDs were significantly higher than those of FPDs (p<0.01). The muscle fiber density of LPDs was significantly lower than that of FPDs (p<0.01). The IMF of LPDs in the breast muscle was significantly higher than that in the FPDs (p<0.01). There was no significant difference between the 2 strains in IMP content (p>0.05). The polyunsaturated fatty acid content of LPDs was significantly higher than that of FPDs (p<0.01), and FPDs had higher saturated fatty acid and monounsaturated fatty acid levels (p<0.05). Conclusion: Long-term breeding work resulted in vast differences between the two strains Pekin ducks. This study provides a reference for differences between LPD and FPD that manifest as a result of long-term selection.