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Association Between the Ku70-1310C/G Promoter Polymorphism and Cancer Risk: a Meta-analysis
Xu, Lu,Ju, Xiao-Bing,Li, Pu,Wang, Jue,Shi, Zhu-Mei,Zheng, Ming-Jie,Xue, Dan-Dan,Xu, Yan-Jie,Yin, Yong-Mei,Wang, Shui,You, Yong-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case-control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).
Zheng, Shuzhen,Friehs, Karl,He, Ning,Deng, Xu,Li, Qingbiao,He, Zheng,Xu, Chenyun,Lu, Yinghua Korean Society for Biotechnology and Bioengineerin 2007 Biotechnology and Bioprocess Engineering Vol.12 No.3
In this study we investigated the effects of carbon and nitrogen sources, and the carbon to nitrogen ratio (C:N) of growth medium on the production of plasmid DNA by $pUK21CMV{\beta}1.2$ harbouring recombinant E. coli. The results indicated that sucrose and casein peptone were the most suitable carbon and nitrogen sources, respectively, for plasmid production, and the plasmid concentration was significantly influenced by the C:N ratio. A Box-Behnken design and surface response methodology were employed to formulate the optimal medium. In the optimized medium, a plasmid concentration of 51.80mg/L and a plasmid selectivity of 23.49mg/g were achieved after 24h of incubation. These values were approximately 3.5 and 1.7 times higher, respectively, than those obtained on the original LB medium.
Structure and function of Zalpha, a Z conformation-specific nucleic acid binding domain
Xu Zheng,Chan Yang Park,So-Young Park,Jinhyuk Choi,Yang-Gyun Kim 한국구조생물학회 2015 Biodesign Vol.3 No.4
Right-handed B-DNA is a predominant form of natural DNA and used for the structural support of genetic information. Nevertheless, DNA can assume many different shapes. Left-handed Z-DNA is one of well-known non-B-DNA structures. An increasing number of studies show direct connections between Z-DNA and its potent roles in biological processes. The discovery of the proteins with Z-DNA binding domain(s), Zα, provides new opportunities to elucidate the relevant biological function of Z-DNA in biological systems. Thus, a great deal of recent researches has focused on questions surrounding Z-DNA and its binding proteins in vivo. In this review, we compare structures of Zα domains from various Z-DNA binding proteins and discuss their conformational specificity adapted from the common fold that prevalently used by many B-DNA binding proteins. In addition, we summarize recent developments regarding the biological roles of Z-DNA and Z-DNA binding proteins.
Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats
Zheng, Xiao-Nan,Wang, Xiao-Wen,Li, Li-Ya,Xu, Zi-Wei,Huang, Hsin-Yi,Zhao, Jin-Sheng,Zhang, Duo,Yin, Xu,Sheng, Jun,Tang, Jin-Tian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).
Zheng, Xu,Lee, Kum Hee,Liu, Hongguang,Park, So-Young,Yoon, Seung Soo,Lee, Jin Yong,Kim, Yang-Gyun Elsevier 2016 Sensors and actuators. B Chemical Vol.222 No.-
<P><B>Abstract</B></P> <P>A new bis(pyridine-2-ylmethyl)amine derivative (<B>1</B>) was synthesized as a colorimetric and fluorescent chemosensor for metal ions. Experimental results indicate that <B>1</B> displays significant colorimetric and fluorescent changes upon binding of Cu<SUP>2+</SUP>. Since <B>1</B> has a high water solubility as well as good cell-permeability, it successfully applied to detect the presence of Cu<SUP>2+</SUP> ion in HepG2 cells in culture medium. Thus, <B>1</B> can be used as a potential Cu<SUP>2+</SUP> chemosensor in aqueous solution and mammalian cells. Further, the fluorescence behavior of <B>1</B> upon Cu<SUP>2+</SUP> binding was well explained by our quantum calculation based on electronic structure.</P>
Carbon nanomaterials for advanced lithium sulfur batteries
Xu, Zheng-Long,Kim, Jang-Kyo,Kang, Kisuk Elsevier 2018 NANO TODAY Vol.19 No.-
<P><B>Abstract</B></P> <P>Taking advantage of a high theoretical energy density of 2567 Wh kg<SUP>-1</SUP>, lithium sulfur batteries (LSBs) have been considered promising candidates for next-generation energy storage systems. Nevertheless, challenging issues involving both sulfur cathode and lithium anode hinder their practical applications, which are followed by the extensive research efforts to resolve them. A wide variety of carbon nanomaterials with different characteristics has played an important role in enhancing the performance of LSBs <I>via</I> immobilizing sulfur in cathodes, accommodating the volume expansion of sulfur, enhancing the reaction kinetics and stabilizing lithium anodes. This report overviews the state-of-the-art progress in designing and fabricating nanocarbon for advanced LSBs with particular focuses on the correlations among porosity, electrical conductivity and surface chemistry as some of the most critical factors. More importantly, statistical analysis of electrochemical performance of batteries collected from literatures allows us to identify substantial disparities between the current achievements and the requirements for real-world applications. In an effort to bridge this gap, we highlight recent advances in the design of LSBs with improved sulfur loading, enhanced charge transfer and minimized electrolyte/sulfur ratio. Conclusions and perspectives for future development of nanocarbon in LSBs are proposed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The fundamentals of LSBs, carbon nanomaterials and sulfur/carbon cathodes are discussed. </LI> <LI> Design principles of nanocarbon to overcome the intrinsic challenges of LSBs are summarized. </LI> <LI> The gap between the current achievements and the practical LSBs in real-market is bridged. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Zheng Xu,Jianzhong Zhang,Zakiud Din,Yongbin Wu,Ming Cheng 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.6
This paper develops an online inter-turn short-circuit fault (ISF) detection method for inverter-fed permanent magnet synchronous machine (PMSM) systems. A high-frequency (HF) mathematical model of a PMSM with an ISF is established. Based on the presented HF model, the HF responses of the PMSM with various severity of ISF under HF voltage injectionare analyzed in detail, where both the short-circuit ratio and the fault resistance are considered to evaluate the fault severity. In the proposed fault diagnosis method, the amplitude of the HF negative-sequence component is used to determine the fault severity, and the initial phase is used to locate the position of the faulty phase. The simulation and experimental results verify the effectiveness of the proposed method.
Effects of Modified MMT on Mechanical Properties of EVA/MMT Nanocomposites and Their Foams
Xu, Zheng Run,Park, Hae Youn,Kim, Ho Young,Seo, Kwan Ho WILEY-VCH Verlag 2008 Macromolecular symposia Vol.264 No.1
<P>In this study, nanocomposites of poly(ethylene-co-vinyl acetate) with two kinds of organically modified montmorillonite (OMMT) were prepared by melt intercalation. Their structures and mechanical properties were characterized by X-ray diffraction (XRD) and tensile test respectively. Especially, foaming of these nanocomposites mixed with chemical blowing agent was carried out through compression molding. Influences of OMMT on foaming ratio and mechanical properties were investigated by density test, tensile test and tear test. Results revealed that both kinds of OMMT with proper content increased tensile strength and Young's modulus of nanocomposites without a compromise of elongation at break. For foaming, OMMTs apparently improved foaming ratio and in particular, one of them can improve tear strength, tensile strength, Young's modulus and elongation although the density was decreased.</P>
Sensing formic acid with a water-based chitosan lanthanide luminescence film
Xu Zheng,Xi Chen,Xudong Yu,Yifan Yang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-
A sensitive and selective formic acid sensor could be useful in detecting this corrosive acid in industrial,medical, and environmental settings. Herein, we present a film for detection of formic acid. We introducedchitosan as a film-forming factor to creatively overcome the problem that chitosan dissolves inacids. A carboxylic acid-carbon dot solution was used to replace the strong acid solution and prepare aluminescent film in which the color changed from green to blue when it was exposed to formic acid. Integrated data analysis of the film was used to distinguish vapor from formic acid/water solutions at differentconcentrations and with a detection limit of 0.01% v/v. The selectivity of the sensor was also investigated. After fumigation with ethanol and other common solvents, there was no response similar to thatfor formic acid. It is believed that films based on lanthanide complexes and chitosan could prevent corrosionand injury from formic acid.