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RISS 인기검색어
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- 저자 : Wyatt A. (검색결과 5 건)
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Defining a “Safe System of Work”
Caponecchia C.,Wyatt A. 한국산업안전보건공단 산업안전보건연구원 2021 Safety and health at work Vol.12 No.4
Providing a “safe system of work” is the essence of the general duties that employers have to their employees under workplace health and safety regulations. Despite this, consistent and appropriate definition of what constitutes a safe system of work is almost non-existent. Available definitions tend to confuse a safe system of work with management practices intended to bring about a safe system, or conflate the broad system suggested in general duties clauses with procedures or work methods that are focused on particular hazards or tasks. This article develops a definition of safe systems of work which recognises the broad scope of the concept and includes psychological health and return to work processes. This definition can be used by a range of stakeholders to better communicate the scope of occupational health and safety duties and more consistently assess whether a safe system has been provided both before and after incidents occur.
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Noncanonical role of singleminded-2s in mitochondrial respiratory chain formation in breast cancer
Wall Steven W.,Sanchez Lilia,Tuttle Kelly Scribner,Pearson Scott J.,Soma Shivatheja,Wyatt Garhett L.,Carter Hannah N.,Jenschke Ramsey M.,Tan Lin,Martinez Sara A.,Lorenzi Philip L.,Gohil Vishal M.,Rijn 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Dysregulation of cellular metabolism is a hallmark of breast cancer progression and is associated with metastasis and therapeutic resistance. Here, we show that the breast tumor suppressor gene SIM2 promotes mitochondrial oxidative phosphorylation (OXPHOS) using breast cancer cell line models. Mechanistically, we found that SIM2s functions not as a transcription factor but localizes to mitochondria and directly interacts with the mitochondrial respiratory chain (MRC) to facilitate functional supercomplex (SC) formation. Loss of SIM2s expression disrupts SC formation through destabilization of MRC Complex III, leading to inhibition of electron transport, although Complex I (CI) activity is retained. A metabolomic analysis showed that knockout of SIM2s leads to a compensatory increase in ATP production through glycolysis and accelerated glutamine-driven TCA cycle production of NADH, creating a favorable environment for high cell proliferation. Our findings indicate that SIM2s is a novel stabilizing factor required for SC assembly, providing insight into the impact of the MRC on metabolic adaptation and breast cancer progression.
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A review of tropical cyclone wind field models
Wills, J.A.B.,Lee, B.E.,Wyatt, T.A. Techno-Press 2000 Wind and Structures, An International Journal (WAS Vol.3 No.2
Engineered structures such as buildings and bridges in certain regions of the world need to be designed to withstand tropical cyclone winds, otherwise known as typhoons or hurricanes. In order to carry out this design, it is necessary to be able to estimate the maximum wind speeds likely to be encountered by the structure over its expected lifetime, say 100 years. Estimation of the maximum wind involves not only the overall strength of the tropical cyclone, but the variation of wind speed with radius from the centre, circumferential position, and with height above the ground surface. In addition, not only the mean wind speed, but also the gust factor must usually be estimated as well. This paper investigates a number of recent mathematical models of tropical cyclone structure and comments on their suitability for these purposes in a variety of scenarios.
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Effects of Expander Processing and Enzyme Supplementation of Wheat-based Diets for Finishing Pigs
Park, J.S.,Kim, I.H.,Hancock, J.D.,Wyatt, C.L.,Behnke, K.C.,Kennedy, G.A. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.2
Two experiments were conducted to determine the effects of expander processing and enzyme supplementation of wheat-based diets on growth performance and nutrient digestibility in finishing pigs. For Exp. 1, 60 finishing pigs (average initial BW of 49.5 kg) were fed meal, standard pellets and expanded pellets in a 70 d growth assay. From 49.5 to 79.0 kg, 79.0 to 111.8 kg, and overall (49.5 to 111.8 kg), ADG and ADFI were not affected by pelleting or standard vs expander conditioning (p>0.22). However, from 49.5 to 79.0 kg, pigs fed pellets have greater gain/feed than pigs fed mash (p<0.04), and pigs fed expanded pellets tended to have greater (p<0.10) gain/feed than pigs fed standard pellets. Overall (i.e. from 49.5 to 111.8 kg), gain/feed (p<0.02) and apparent fecal digestibilities of DM (p<0.001) and N (p<0.02) were improved by pelleting the diets. Also, expander processing further improved gain/feed (p<0.06) and digestibility of DM (p<0.04) compared to standard steam conditioning. Scores for keratinization (p<0.002) and ulceration (p<0.003) of the stomach were increased by pelleting, but the mean scores for the various treatments ranged only from 0.05 to 1.08 (i.e., low to mild keratosis and ulceration). For Exp. 2, 80 pigs (average initial BW of 54.1 kg) were fed mash and pellets (standard or expander) without and with xylanase. The enzyme was added to supply 4,000 units of xylanase activity/kg of diet. Adding xylanase to the mash diet improved gain/feed from 90.7 to 115.9 kg (p<0.04) of the growth assay and digestibility of DM (p<0.05) on d 39. However, in pelleted diets, adding the enzyme did not improve growth performance or digestibility of nutrients. Pelleting tended to increase scores for ulceration (p<0.06), and enzyme supplementation decreased stomach keratinization scores for pigs fed the standard pellets (p<0.01). However, as in Exp. 1, the mean scores for all treatment groups were quiet low (i.e., ranging from normal to mild). In conclusion, pelleting improved efficiency of growth, but additional benefits from expander conditioning were observed only in Exp. 1. Finally, xylanase tended to improve growth performance and nutrient digestibility, only in pigs fed mash diets but not in pigs fed pellets.
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