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Li Na,Li Shuangfeng,Wu Yehua,Xiong Lu,Li Tiejun,Xing Dandan,Li Qiuchang,Wu Duozhi 한국유전학회 2021 Genes & Genomics Vol.43 No.12
Background Chronic obstructive pulmonary disease (COPD) is a chronic lung disease and the third leading cause of death in the world. Dexmedetomidine has been reported to efectively inhibit histamine-induced bronchoconstriction. However, the molecular mechanism of dexmedetomidine in COPD has not been found. Objective To explore the role and mechanism of dexmedetomidine in COPD, and to provide theoretical basis for clinical treatment of COPD. Methods The expression of miR-146a was regulated by mimics or inhibitor and the relative expression of apoptotic proteins p53, Bax and Bcl-2 in human bronchial epithelial 16HBE cells was determined by real-time PCR and Western blot. Dexmedetomidine was treated for 16HBE cells and alveolar epithelial type II cells (AEC2), the cell apoptosis was detected by TUNEL and Hoechst33342 staining. A COPD rat model was established by smoking to test the efects of dexmedetomidine on the progression of COPD. The levels of IL-6, IL-1β and TNF-α in serum were measured by ELISA and the protein concentration of bronchoalveolar lavage fuid (BALF) was also detected in dexmedetomidine treated COPD rat model. Results miR-146a promoted 16HBE cell apoptosis and reduced cell proliferation. Additionally, dexmedetomidine was showed to reduce the 16HBEL cell apoptosis through reducing the expression of miR-146a. Moreover, dexmedetomidine regulated cell apoptosis and cell apoptosis through miR-146a in AEC2 cells. More importantly, dexmedetomidine attenuated the morphology and pathology of COPD rat model. Conclusion Dexmedetomidine reduced 16HBE cells and AEC2 cell apoptosis and attenuated COPD by down-regulating miR-146a.
Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging
Chen, Qiaozhen,Zhang, Ying,Hou, Haifeng,Du, Fenglei,Wu, Shuang,Chen, Lin,Shen, Yehua,Chao, Fangfang,Chung, June-key,Zhang, Hong,Tian, Mei Springer-Verlag 2017 European journal of nuclear medicine and molecular Vol.44 No.6
<P>Popular music Gangnam Style can arouse pleasure experience and strong emotional response. The left putamen is positively correlated with the mood arousal level score under the Gangnam Style condition. Our results revealed characteristic patterns of brain activity associated with Gangnam Style, and may also provide more general insights into the music-induced emotional processing.</P>