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Wooram Choi,Jeong Hun Cho,Sang Hee Park,Dong Seon Kim,Hwa Pyoung Lee,Donghyun Kim,Hyun Soo Kim,Ji Hye Kim,Jae Youl Cho The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2
Background: Recently, plant-derived exosome-like nanoparticles (PDENs) have been isolated, and active research was focusing on understanding their properties and functions. In this study, the characteristics and molecular properties of ginseng root-derived exosome-like nanoparticles (GrDENs) were examined in terms of skin protection. Methods: HPLC-MS protocols were used to analyze the ginsenoside contents in GrDENs. To investigate the beneficial effect of GrDENs on skin, HaCaT cells were pre-treated with GrDENs (0-2 × 10<sup>9</sup> particles/mL), and followed by UVB irradiation or H<sub>2</sub>O<sub>2</sub> exposure. In addition, the antioxidant activity of GrDENs was measured using a fluorescence microscope or flow cytometry. Finally, molecular mechanisms were examined with immunoblotting analysis. Results: GrDENs contained detectable levels of ginsenosides (Re, Rg1, Rb1, Rf, Rg2 (S), Gyp17, Rd, C-Mc1, C-O, and F2). In UVB-irradiated HaCaT cells, GrDENs protected cells from death and reduced ROS production. GrDENs downregulated the mRNA expression of proapoptotic genes, including BAX, caspase-1, -3, -6, -7, and -8 and the ratio of cleaved caspase-8, -9, and -3 in a dose-dependent manner. In addition, GrDENs reduced the mRNA levels of aging-related genes (MMP2 and 3), proinflammatory genes (COX-2 and IL-6), and cellular senescence biomarker p21, possibly by suppressing activator protein-1 signaling. Conclusions: This study demonstrates the protective effects of GrDENs against skin damage caused by UV and oxidative stress, providing new insights into beneficial uses of ginseng. In particular, our results suggest GrDENs as a potential active ingredient in cosmeceuticals to promote skin health.
Kim, Manse,Sahu, Abhishek,Kim, Gi Beom,Nam, Gi Hoon,Um, Wooram,Shin, So Jin,Jeong, Yong Yeon,Kim, In-San,Kim, Kwangmeyung,Kwon, Ick Chan,Tae, Giyoong Elsevier 2018 Journal of controlled release Vol.269 No.-
<P><B>Abstract</B></P> <P>Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a silent killer. There are no physical symptoms of the disease in its early stage and current diagnostic techniques cannot detect the small plaques effectively or safely. Plaques formed in blood vessels can cause serious clinical problems such as impaired blood flow or sudden death, regardless of their size. Thus, detecting early stage of plaques is especially more important to effectively reduce the risk of atherosclerosis. Nanoparticle based delivery systems are recognized as a promising option to fight against this disease, and various targeting ligands are typically used to improve their efficiency. So, the choice of appropriate targeting ligand is a crucial factor for optimal targeting efficiency. cRGD peptide and collagen IV targeting peptide, which binds with the α<SUB>v</SUB>β<SUB>3</SUB> integrin overexpressed in the neovasculature of the plaque and collagen type IV present in the plaque, respectively, are frequently used for the targeting of nanoparticles. However, at present no study has directly compared these two peptides. Therefore, in this study, we have prepared cRGD or collagen IV targeting (Col IV-tg-) peptide conjugated and iron oxide nanoparticle (IONP) loaded Pluronic based nano-carriers for systemic comparison of their targeting ability towards <I>in vivo</I> atherosclerotic plaque in Apolipoprotein E deficient (<I>Apo E</I> <SUP>−/−</SUP>) mouse model. Nano-carriers with similar size, surface charge, and IONP loading content but with different targeting ligands were analyzed through <I>in vitro</I> and <I>in vivo</I> experiments. Near infrared fluorescence imaging and magnetic resonance imaging techniques as well as Prussian blue staining were used to compare the accumulation of different ligand conjugated nano-caariers in the aorta of atherosclerotic mice. Our results indicate that cRGD based targeting is more efficient than Col IV-tg-peptide in the early stage of atherosclerosis.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
홍우람(Wooram Hong),김상훈(Sang Hoon Kim),김우레(Woore Kim),김유신(Yushin Kim),김종암(Chongam Kim) 한국전산유체공학회 2007 한국전산유체공학회 학술대회논문집 Vol.2007 No.-
To develop the aerodynamic performance, there are widely two group of studies are achieved The first one is about design of the vehicles geometry and the second one is about aerodynamic devices. Geometry design is highly credible and stable method But it is not flexible and each parts are related interactively. So if one part geometry are modified, the other parts are required to be redesigned The other hand, flow control by aerodynamic device is flexible and modulized method Though it needs energy, relatively little input makes far advanced aerodynamic performance. Synthetic Jet is one of the second group method The device repeats suction and blowing motion in constant frequency. According to the performance, the flow which are near the flight surface are served momentum. This mechanism can reduce the aerodynamic loss by boundary layer and separated flow. Synthetic jet actuator has several parameters, that influence the flow control. This study focus the parameters effects of the synthetic jet - orifice geometry, frequency, jet speed and etc.
홍우람(Wooram Hong),김상훈(Sang Hoon Kim),김우레(Woore Kim),김유신(Yushin Kim),김종암(Chongam Kim) 한국전산유체공학회 2007 한국전산유체공학회지 Vol.12 No.2
To develop an aerodynamic performance, two groups of studies have been achieved widely. One is about the geometric design of vehicles and the other is about aerodynamic devices. Geometric design is a credible and stable method However, it is not flexible and each part is related interactively. Therefore, if one part of geometry is modified, the other part will be required to redesign. On the other hand, the flow control by aerodynamic devices is flexible and modulized method. Even though it needs some energy, a relatively small amount of input makes more advanced aerodynamic performance. Synthetic jet is one of the method in the second group. The device repeats suctions and blowing motions in constant frequency. According to the performance, the adjacent flow to flight surface are served momentum. This mechanism can reduce the aerodynamic loss of boundary layer and separated flow. A synthetic jet actuator has several parameters, which influences the flow control. This study focuses on the parameter effects of synthetic jet - orifice geometry, frequency, jet speed and etc.
김근영,김광선,명정호,윤찬호,신우람,김철순,고영조,문성현,김경표,김태중,Kim, Keunyoung,Kim, Kwang Seon,Myung, Jungho,Yoon, Chanho,Shin, Wooram,Kim, Cheulsoon,Ko, Young Jo,Moon, Sunghyun,Kim, Kyeongpyo,Kim, Tae Joong 한국전자통신연구원 2019 전자통신동향분석 Vol.34 No.1
The capacity of wireless communications has been considered to be restricted by their fundamental limits, which were first formulated by Shannon in 1948. These limits are for the communication environment that is composed of a transmitter and receiver pair. However, there are usually more than one simultaneously communicating pairs in the environment. In such cases, the capacity is not known. Moreover, performance requirements have been diversified with the development of technology. We believe that wireless communication technologies will eventually progress toward limitless connections. Various wireless transmission and access technologies are introduced in order to overcome their limitations.
Wooram Choi,Hyun Soo Kim,Sang Hee Park,Donghyun Kim,Yong Deog Hong,Ji Hye Kim,Jae Youl Cho 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4
Background: In aged skin, reactive oxygen species (ROS) induces degradation of the extracellular matrix(ECM), leading to visible aging signs. Collagens in the ECM are cleaved by matrix metalloproteinases(MMPs). Syringaresinol (SYR), isolated from Panax ginseng berry, has various physiological activities,including anti-inflammatory action. However, the anti-aging effects of SYR via antioxidant and autophagyregulation have not been elucidated. Methods: The preventive effect of SYR on skin aging was investigated in human HaCaT keratinocytes inthe presence of H2O2, and the keratinocyte cells were treated with SYR (0e200 mg/mL). mRNA andprotein levels of MMP-2 and -9 were determined by real-time PCR and Western blotting, respectively. Radical scavenging activity was researched by 2,2 diphenyl-1-picrylhydrazyl (DPPH) and 2,20-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays. LC3B level was assessed by Western blotting andconfocal microscopy. Results: SYR significantly reduced gene expression and protein levels of MMP-9 and -2 in both H2O2-treated and untreated HaCaT cells. SYR did not show cytotoxicity to HaCaT cells. SYR exhibited DPPH andABTS radical scavenging activities with an EC50 value of 10.77 and 10.35 mg/mL, respectively. SYR elevatedtotal levels of endogenous and exogenous LC3B in H2O2-stimulated HaCaT cells. 3-Methyladenine (3-MA), an autophagy inhibitor, counteracted the inhibitory effect of SYR on MMP-2 expression. Conclusion: SYR showed antioxidant activity and up-regulated autophagy activity in H2O2-stimulatedHaCaT cells, lowering the expression of MMP-2 and MMP-9 associated with skin aging. Our resultssuggest that SYR has potential value as a cosmetic additive for prevention of skin aging.
Kim, Hyun Ryoung,You, Dong Gil,Park, Sang-Jun,Choi, Kyu-Sil,Um, Wooram,Kim, Jae-Hun,Park, Jae Hyung,Kim, Young-sun American Chemical Society 2016 MOLECULAR PHARMACEUTICS Vol.13 No.5
<P>Monitoring of drug release from a heat-activated liposome carrier provides an opportunity for real-time control of drug delivery and allows prediction of the therapeutic effect. We have developed short-chain elastin-like polypeptide-incorporating thermosensitive liposomes (STLs). Here, we report the development of STL encapsulating gadobenate dimeglumine (Gd-BOPTA), a MRI contrast agent, and doxorubicin (Dox) (Gd-Dox-STL). The Dox release profile from Gd-Dox-STL was comparable to Gd-Dox-LTSL; however, the serum stability of Gd-Dox-STL was much higher than Gd-Dox-LTSL. MRI studies showed that the difference in T<SUB>1</SUB> relaxation time between 37 and 42 °C for Gd-Dox-STL was larger than the difference for Gd-Dox-LTSL. Although relaxivity for both liposomes at 42 °C was similar, the relaxivity of Gd-Dox-STL at 37 °C was 2.5-fold lower than that of Gd-Dox-LTSL. This was likely due to Gd-BOPTA leakage from the LTSL because of low stability at 37 °C. Pharmacokinetic studies showed plasma half-lives of 4.85 and 1.95 h for Gd-Dox-STL and Gd-Dox-LTSL, respectively, consistent with <I>in vitro</I> stability data. <I>In vivo</I> MRI experiments demonstrated corelease of Dox and Gd-BOPTA from STL under mild hyperthermia induced by high-intensity focused ultrasound (HIFU), which suggests STL is a promising tumor selective formulation when coupled with MR-guided HIFU.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mpohbp/2016/mpohbp.2016.13.issue-5/acs.molpharmaceut.6b00013/production/images/medium/mp-2016-00013v_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/mp6b00013'>ACS Electronic Supporting Info</A></P>
Kim, Wooram,Park, Mijung,Park, Yeonsoo,Kwon, Younja,Jo, Youngmin Elsevier 2018 Journal of industrial and engineering chemistry Vol.68 No.-
<P><B>Abstract</B></P> <P>An environmentally favorable (chlorine-free) solid oxidizer, guanidinium dinitramide [GDN; NH<SUB>2</SUB>C(NH<SUB>2</SUB>)NH<SUB>2</SUB>N(NO<SUB>2</SUB>)<SUB>2</SUB>], was newly synthesized from guanidine carbonate [NH<SUB>2</SUB>C(NH)NH<SUB>2</SUB>·1/2H<SUB>2</SUB>CO<SUB>3</SUB>]. Two different crystalline forms (α-type and β-type) appeared according to the applied solvents and synthesis conditions. Moisture, during extraction, might become trapped in a crystal between inner molecules. Therefore, despite having the same chemical composition, Raman-IR and TGA-DSC revealed different physical characteristics of the two forms. Peaks of Raman shift near 1000cm<SUP>−1</SUP> implied different chemical structures. Thermal analysis revealed an exothermic temperature 155.7°C for α-type but one of 191.6°C for β-type. The caloric value of α-type was 536.4J/g, which was 2.5 times larger than that of the β-type, which was 1310J/g. While the synthesized GDN of α-type showed a steep exothermic decomposition, the β-type was slowly decomposed after melting through an endothermic process. This work implied that despite of the same molecular formula some different core thermal properties would appear depending on synthesis conditions.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>