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Jang Yuna,Hur Hyun Jung,Myung Woojae,Park Eung Joo,Park Hye Youn 대한의학회 2024 Journal of Korean medical science Vol.39 No.32
Background: This study investigated the relationship between coronavirus disease 2019 (COVID-19), delirium, and 1-year mortality. Factors associated with delirium in COVID-19 patients were identified, along with the influence of psychotropic medications on delirium. Methods: The study used the South Korean National Health Insurance Service database. Adult COVID-19 patients diagnosed between October 2020 and December 2021 were included, with a propensity score-matched control group. Time-dependent Cox regression assessed associations among COVID-19, delirium, and mortality. Logistic regression analyzed the impact of psychotropic medications on delirium incidence. Results: The study included 832,602 individuals, with 416,301 COVID-19 patients. COVID-19 (hazard ratio [HR], 3.03; 95% confidence interval [CI], 2.92–3.13) and delirium (HR, 2.33; 95% CI, 2.06–2.63) were independent risk factors for 1-year mortality. Comorbidities, insurance type, and residence were also related to mortality. Among COVID-19 patients, antipsychotic use was associated with lower delirium incidence (odds ratio [OR], 0.38; 95% CI, 0.30–0.47), while mood stabilizers (OR, 1.77; 95% CI, 1.40–2.21) and benzodiazepines (OR, 8.62; 95% CI, 7.46–9.97) were linked to higher delirium incidence. Conclusion: COVID-19 and delirium are risk factors for 1-year mortality. Some factors associated with delirium in COVID-19 patients are modifiable and can be targeted in preventive and therapeutic interventions.
Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells.
Choi, WooJae,Kim, Eunji,Yum, Soo-Young,Lee, ChoongIl,Lee, JiHyun,Moon, JoonHo,Ramachandra, Sisitha,Malaweera, Buddika Oshadi,Cho, JongKi,Kim, Jin-Soo,Kim, SeokJoong,Jang, Goo Landes Bioscience 2015 Prion Vol.9 No.4
<P>Even though prion (encoded by the PRNP gene) diseases like bovine spongiform encephalopathy (BSE) are fatal neurodegenerative diseases in cattle, their study via gene deletion has been limited due to the absence of cell lines or mutant models. In this study, we aim to develop an immortalized fibroblast cell line in which genome-engineering technology can be readily applied to create gene-modified clones for studies. To this end, this study is designed to 1) investigate the induction of primary fibroblasts to immortalization by introducing Bmi-1 and hTert genes; 2) investigate the disruption of the PRNP in those cells; and 3) evaluate the gene expression and embryonic development using knockout (KO) cell lines. Primary cells from a male neonate were immortalized with Bmi-1and hTert. Immortalized cells were cultured for more than 180??days without any changes in their doubling time and morphology. Furthermore, to knockout the PRNP gene, plasmids that encode transcription activator-like effector nuclease (TALEN) pairs were transfected into the cells, and transfected single cells were propagated. Mutated clonal cell lines were confirmed by T7 endonuclease I assay and sequencing. Four knockout cell lines were used for somatic cell nuclear transfer (SCNT), and the resulting embryos were developed to the blastocyst stage. The genes (CSNK2A1, FAM64A, MPG and PRND) were affected after PRNP disruption in immortalized cells. In conclusion, we established immortalized cattle fibroblasts using Bmi-1 and hTert genes, and used TALENs to knockout the PRNP gene in these immortalized cells. The efficient PRNP KO is expected to be a useful technology to develop our understanding of in vitro prion protein functions in cattle.</P>
Ha Lim Jang,Chanhui Lee,Hyeona Yu,Daseul Lee,Hyuk Joon Lee,Tae Hyon Ha,Hyo Shin Kang,Woojae Myung,Jungkyu Park 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.6
Objective This study aimed to elucidate the distinct response patterns exhibited by patients diagnosed with bipolar disorder (BD) and those with major depressive disorder (MDD) through the application of the short version of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A-SV). Methods A total of 2,458 participants consisting of patients with MDD (n=288), BD (BD I, n=111; BD II, n=427), and control group (n=1,632) completed the TEMPS-A-SV. The response patterns of the participants were classified into distinct profiles using latent profile analysis. The study further examined the impact of covariates such as age, sex, and diagnostic group on derived latent profile memberships. Results The following three latent profiles were identified: High Affective Temperament Group (17.86%), Low Affective Temperament Group (41.25%), and Middle Affective Temperament Group (40.89%). Compared with the patient group with MDD and BD, the control group was more likely to belong in the Low Affective Temperament Group, which showed a higher score on hyperthymic temperament than the Middle Affective Temperament Group. Furthermore, compared with the patients with BD, the MDD patients were more likely to be in the Low Affective Temperament Group rather than the Middle Affective Temperament Group. Conclusion These results indicate that different affective temperaments exist between patients with MDD and BD. Attempting to classify response patterns using the TEMPS-A-SV can help diagnose MDD and BD correctly.
이현우(Hyunwoo Lee),장우재(Woojae Jang),김재성(Jaesung Kim),정진태(Jintai Chung) 한국소음진동공학회 2024 한국소음진동공학회 논문집 Vol.34 No.2
In this study, we experimentally investigated the vibration generated in the housing of a permanent magnet synchronous motor and proposed a design guideline for reducing this vibration by establishing a finite element model of the motor. We acquired the frequency spectra of the vibration signals at various rotational speeds of the motor and identified the excitation frequencies induced by the electromagnetic force of the motor. In addition, the natural frequencies and mode shapes of the motor were obtained through modal testing, and an operational deflection shape analysis was conducted to analyze the dynamic behavior of the motor during operation. The resonance of the motor housing was identified using signal and dynamic characteristic analyses. To reduce vibration, a finite element model that considered the main components and structure of the motor was established, and a vibration reduction method was proposed that involved improving the motor housing structure.
Yoon Joohyun,Yu Hyeona,Jang Yoonjeong,Lee Daseul,Park Yun Seong,Ihm Hong Kyu,Ryoo Hyun A,Cho Nayoung,Lee Jakyung,Kim Yeoju,Park Jungkyu,Kang Hyo Shin,Ha Tae Hyon,Myung Woojae 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.5
Objective Mood instability (MI) is a clinically significant trait associated with psychiatric disorders. However, there are no concise measurements to evaluate MI. The initial Mood Instability Questionnaire-Trait (MIQ-T) was developed to fill this gap. The current study aimed to create a short form of MIQ-T (MIQ-T-SF) that measures MI with high validity and reliability in the Korean general population.Methods Of the 59 items in the MIQ-T, 17 items were chosen for the MIQ-T-SF following the factor analysis process. In total, 540 participants completed the MIQ-T-SF. Cronbach’s alpha and McDonald’s omega were used to evaluate reliability. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to determine construct validity. Concurrent validity was confirmed via comparisons with Personality Assessment Inventory-Borderline Features Scale. Measurement invariance across gender and age groups was confirmed before analyzing differences in scores using Kruskal-Wallis test.Results The MIQ-T-SF displayed expected correlations and high internal consistency (α=0.71–0.90, Ωt=0.72–0.92). Using EFA and CFA, a five-factor structure was confirmed. Measurement invariance was supported, and gender differences were observed.Conclusion The MIQ-T-SF is an accurate and reliable method to detect MI in the Korean general population. The study’s results offer new perspectives for future studies on MI.
Network Structure of Interpersonal Sensitivity in Patients With Mood Disorders: A Network Analysis
Yuna Kim,Junwoo Jang,Hyo Shin Kang,Jakyung Lee,Daseul Lee,Hyeona Yu,Yoonjeong Jang,Joohyun Yoon,Hyukjun Lee,Tae Hyon Ha,Jungkyu Park,Woojae Myung 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.9
Objective Interpersonal sensitivity, characterized by a heightened awareness of others’ behavior and emotions, is linked to mood disorders. However, current literature lacks a comprehensive analysis of how some items of the Interpersonal Sensitivity Measure (IPSM) interrelate and contribute to the overall construct. This study constructed a network for interpersonal sensitivity symptomatology to identify core IPSM items in patients with mood disorders. Methods The IPSM, a 36-item self-report scale, was utilized to evaluate interpersonal sensitivity symptoms in 837 participants (major depressive disorder [MDD], n=265; bipolar I disorder [BD I], n=126; and bipolar II disorder [BD II], n=446). We performed exploratory graph analysis, employing regularized partial correlation models to estimate the network structure. Centrality analysis identified core IPSM symptoms for each mood disorder group. Network comparison tests assessed structural differences between the MDD and BD subgroups. Results Network analysis detected five communities. Item 10 (“I worry about being criticized for things that I have said or done”) showed the highest value in strength. Multiple items on “Interpersonal Worry/Dependency” and “Low Self-Esteem” showed high strength centrality. Network structure invariance and global strength invariance test results indicated no significant differences between the MDD and BD subgroups. Conclusion Our findings emphasize the importance of addressing “Interpersonal Worry/Dependency” and “Low Self-Esteem” in the IPSM network among mood disorder patients based on core items of the network. Additionally, targeted treatments and comprehensive strategies in this aspect could be crucial for managing mood disorders. Psychiatry Investig 2024;21(9):1016-1024