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Recent advances in transdermal drug delivery systems: a review
Woo Yeup Jeong,Mina Kwon,Hye Eun Choi,김기수 한국생체재료학회 2021 생체재료학회지 Vol.25 No.3
Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and persistence among patients. TDDS could be applicable in not only pharmaceuticals but also in the skin care industry, including cosmetics. Because this method mainly involves local administration, it can prevent local buildup in drug concentration and nonspecific delivery to tissues not targeted by the drug. However, the physicochemical properties of the skin translate to multiple obstacles and restrictions in transdermal delivery, with numerous investigations conducted to overcome these bottlenecks. In this review, we describe the different types of available TDDS methods, along with a critical discussion of the specific advantages and disadvantages, characterization methods, and potential of each method. Progress in research on these alternative methods has established the high efficiency inherent to TDDS, which is expected to find applications in a wide range of fields.
Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia
Woo Yeup Jeong,김소담,So Yun Lee,Hyeseon Lee,한동욱,양승윤,김기수 한국생체재료학회 2019 생체재료학회지 Vol.23 No.4
Background: Alopecia has become a very common disease that many people around the world are suffered. Minoxidil (MXD) is the most well-known commercialized drug in its treatment. However, in the case of MXD administration, there are some problems with low efficiency of transdermal delivery and additional side effects. Method: MXD and Rhodamine B (Rho B) are encapsulated in poly(Lactide-co-Glycolide) grafted hyaluronate nanoparticles (HA-PLGA/MXD NPs, HA-PLGA/Rho B NPs) which is prepared with W/O/W solvent evaporation method. After then, the investigation is carried out to confirm the feasibility of NPs in alopecia treatment. Results: Both of HA-PLGA/MXD NPs and HA-PLGA/Rho B NPs are successfully prepared. In addition, it is confirmed that HA-PLGA NPs sufficiently delivered to cells without any significant cytotoxicity by cell viability, cellular uptake and skin permeation test. Conclusion: Taken together, HA-PLGA NPs as a transdermal delivery carrier to hair follicle cells can be exploited to develop the efficient and effective platform of transdermal drug delivery for the treatment of various diseases.
지속성 외래복막투석 환자에서 발생한 Chryseobacterium indologenes 와 Sphingomonas paucimobilis 복합균주에 의한 복막염 1예
윤정수 ( Jeong Soo Yoon ),황은아 ( Eun Ah Hwang ),장미현 ( Mi Hyun Chang ),박우영 ( Woo Young Park ),진규복 ( Kyu Bok Jin ),한승엽 ( Seung Yeup Han ),박성배 ( Sung Bae Park ),김현철 ( Hyun Chul Kim ),류남희 ( Nam Hee Ryoo ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.6
The Effect of Low-dose Ketamine on Post-caesarean Delivery Analgesia after Spinal Anesthesia
( Seung Yeup Han ),( Hee Cheol Jin ),( Woo Dae Yang ),( Joon Ho Lee ),( Seong Hwan Cho ),( Won Seok Chae ),( Jeong Seok Lee ),( Yong Ik Kim ) 대한통증학회 2013 The Korean Journal of Pain Vol.26 No.3
Background: Ketamine, an N-methyl-D-aspartate receptor antagonist, might play a role in postoperative analgesia, but its effect on postoperative pain after caesarean section varies with study design. We investigated whether the preemptive administration of low-dose intravenous ketamine decreases postoperative opioid requirement and postoperative pain in parturients receiving intravenous fentanyl with patient-controlled analgesia (PCA) following caesarean section. Methods: Spinal anesthesia was performed in 40 parturients scheduled for elective caesarean section. Patients in the ketamine group received a 0.5 mg/kg ketamine bolus intravenously followed by 0.25 mg/kg/h continuous infusion during the operation. The control group received the same volume of normal saline. Immediately after surgery, the patients were connected to a PCA device set to deliver 25-μg fentanyl as an intravenous bolus with a 15-min lockout interval and no continuous dose. Postoperative pain was assessed using the cumulative dose of fentanyl and visual analog scale (VAS) scores at 2, 6, 24, and 48 h postoperatively. Results: Significantly less fentanyl was used in the ketamine group 2 h after surgery (P = 0.033), but the difference was not significant at 6, 12, and 24 h postoperatively. No significant differences were observed between the VAS scores of the two groups at 2, 6, 12, and 24 h postoperatively. Conclusions: Intraoperative low-dose ketamine did not have a preemptive analgesic effect and was not effective as an adjuvant to decrease opioid requirement or postoperative pain score in parturients receiving intravenous PCA with fentanyl after caesarean section. (Korean J Pain 2013; 26: 270-276)
기능성 소화불량환자에서 체감각 , 뇌간청각 및 시각 유발전위
강영우,한승엽,임정근 대한소화기학회 1997 대한소화기학회지 Vol.29 No.6
Background/Aims: Although gastrointestinal dysmotility have played an important role in pathophysiology of functional dyspepsia, visceral perception abnormalities due to visceral hypersensitivity are now thought to be a major pathophysiologic mechanism of functional dyspepsia. Visceral hypersensitivity occurred at both visceral afferent pathway and autonomic regulation of central system. The present study was performed to evaluate the possible role of abnormal central perception in the pathophysiology of functional dyspepsia by using various evoked potentials. Methods: The study population consisted of 22 patients with functional dyspepsia and 22 healthy volunteers attending Keimyung University hospital from June 1995 to December 1995. They were studied somaiosensory evoked potentials(SSEP), brainstem auditory evoked potentials(BAEP) and visual evoked potentials(VEP) and compared the absolute latencies, interpeak latencies and amplitudes of each evoked potential between two groups. Results: There were no significant differences in absolute latencies of EP, N13, N19 and P22 waves and amplitudes of EP, N13 and N19/P22 at SSEP between functional dyspepsia and norrnal control. There were no significant differences in absolute latencies of I, II, III, IV and V waves, and interpeak latencies of I -III, m- V and I V at BAEP between functional dyspepsia and normal control. There were no significant differences in absolute latencies and amplitudes of P100 at VEP between functional dyspepsia and normal control. Conclusions: The present study could not reveal abnormal central percepition by using somatosensory, auditory and visual evoked potentials in patients with functional dyspepsia.
The Effect of Low-dose Ketamine on Post-caesarean Delivery Analgesia after Spinal Anesthesia
Han, Seung Yeup,Jin, Hee Cheol,Yang, Woo Dae,Lee, Joon Ho,Cho, Seong Hwan,Chae, Won Seok,Lee, Jeong Seok,Kim, Yong Ik The Korean Pain Society 2013 The Korean Journal of Pain Vol.26 No.3
Background: Ketamine, an N-methyl-D-aspartate receptor antagonist, might play a role in postoperative analgesia, but its effect on postoperative pain after caesarean section varies with study design. We investigated whether the preemptive administration of low-dose intravenous ketamine decreases postoperative opioid requirement and postoperative pain in parturients receiving intravenous fentanyl with patient-controlled analgesia (PCA) following caesarean section. Methods: Spinal anesthesia was performed in 40 parturients scheduled for elective caesarean section. Patients in the ketamine group received a 0.5 mg/kg ketamine bolus intravenously followed by 0.25 mg/kg/h continuous infusion during the operation. The control group received the same volume of normal saline. Immediately after surgery, the patients were connected to a PCA device set to deliver 25-${\mu}g$ fentanyl as an intravenous bolus with a 15-min lockout interval and no continuous dose. Postoperative pain was assessed using the cumulative dose of fentanyl and visual analog scale (VAS) scores at 2, 6, 24, and 48 h postoperatively. Results: Significantly less fentanyl was used in the ketamine group 2 h after surgery (P = 0.033), but the difference was not significant at 6, 12, and 24 h postoperatively. No significant differences were observed between the VAS scores of the two groups at 2, 6, 12, and 24 h postoperatively. Conclusions: Intraoperative low-dose ketamine did not have a preemptive analgesic effect and was not effective as an adjuvant to decrease opioid requirement or postoperative pain score in parturients receiving intravenous PCA with fentanyl after caesarean section.