Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score

( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2

Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)

물리치료(학)과 학생들이 지각한 물리치료사의 이미지와 자아존중감과의 관련성 분석

김은애 ( Eun Ae Kim ),이건철 ( Geon Cheol Lee ),배원식 ( Won Sik Bae ),김지혁 ( Chi Hyok Kim ) 대한물리의학회 2013 대한물리의학회지 Vol.8 No.1

PURPOSE: The purpose of this study is to look into relationship between image of physiotherapist and self-esteem of physiotherapy students and desirable image of physiotherapists offer to establish basic materials. METHODS: The subjects of this study are consist of 603 students of department of Physical therapy university and college in Busan and Kim-hae. Data are collected from June 9 to July 9 in 2011 by structured questionnaires. RESULTS: The result are as follows. 1. at the physiotherapist image score, the highest score question is Physiotherapist is specialist(3.45) and the lowest score question is Physiotherapist is treated samely with doctor(2.15). 2. at the self-esteem score, the highest score question is I think that I am at least as valuable as others(3.37) and the lowest score question is I can be poorly sometimes(2.81). 3. at the static results of physiotherapist image score gap by general characteristics, there are significantly different in gender(t=2.27, p=.02), similar profession distinction(t=4.30, p=.00), major satisfaction(t=5.74, p=.00), school system (t=-2.54, p=.01). 4. at the static results of self-esteem score gap by general characteristics, there are significantly different in years (f=5.14, p=.00), gender(t=4.09, p=.00), religion(f=2.87, p=.04), similar profession distinction(t=3.97, p=.00), major satisfaction(t=4.26, p=.00). 5. at the static results of good reputation of physiotherapists increase self-esteem of physiotherapy students score question are significantly different(r=0.53, p=.00). CONCLUSION: Accordingly, these results of this study that there is a very correlation between image of physiotherapist and self-esteem of physiotherapy students. Therefore, good reputation of physiotherapists increase self-esteem of physiotherapy students.

Clinical significance of HIF-2α immunostaining area in radioresistant cervical cancer (초)

김민규 ( Min Kyu Kim ),( Tae Joong Kim ),( You Young Lee ),( Chel Hun Choi ),( Jeong-Won Lee ),( Duk Soo Bae1 ),( Je Ho Lee ),( Byoung Gie Kim ) 대한산부인과학회 2010 대한산부인과학회 학술대회 Vol.96 No.-

권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

온수배관을 이용한 온실의 난방성능

윤용철(Yong Cheol Yoon),신익수(Yik Soo Shin),김현태(Hyeon Tae Kim),배승범(Seoung Beom Bae),최진식(Jin Sik Choi),서원명(Won Myung Suh) (사)한국생물환경조절학회 2012 생물환경조절학회지 Vol.21 No.2

본 연구는 온실의 난방 에너지 절감을 목적으로 온실 내부에 알루미늄 온수배관을 설치하여 난방효과에 대한 기초자료를 구축하고자 수행되었다. 그 연구결과를 요약하면 다음과 같다. 전체 실험을 포함하여 온실내의 높이별 온도편차는 4.0~7.0℃ 정도의 범위로서 그 차이가 크게 나타났다. 팬코일유니트(FCU)를 작동시킨 경우가 작동시키지 않은 경우에 비해 유출입수의 온도차가 3.3℃ 정도 크고, 소비전력량은 36.2~40.1% 정도 증가하였으며, 시간당 방열량은 44.6~52.0% 정도 증가하는 것으로 나타났다. 실험기간동안 순환유량은 0.48~0.49L · s<SUP>?1</SUP> 정도의 범위에 있었고, 평균유속은 1.53~1.56m · s<SUP>?1</SUP> 정도였다. 유출입수의 평균 온도차는 6.24~11.50℃이었다. 최저 외기온 ?14.0~?0.6℃ 범위에서 설정온도별 방열량은 135,930~307,150㎉ 정도의 범위로서 시간당 9,610~19,630㎉ · h<SUP>?1</SUP> 정도의 범위에 있었다. 이것은 최대난방부하의 약 23~53% 정도의 난방에너지를 공급할 수 있을 것으로 나타났다. 전체 방열량과 소비전력량은 각각 2,548,306㎉ 및 3,075.7㎾h이다. 화석연료인 경유로 난방할 경우, 소요되는 경유의 총 소비량은 281.6L 정도이고 비용은 321,000won인 것으로 나타났다. 농가용 전력요금을 적용하면 전력사용에 대한 총비용은 110,730won 정도로서 경유 소비 비용의 33.5% 정도로 나타났다. 실험구의 온도가 대조구보다 약 8.3~14.6℃ 정도 높게 나타났다. This research was conducted to obtain basic data with regard to the heating performance that would be produced by installing an aluminum hot water pipe inside the greenhouse with the goal of reducing the heating energy in greenhouse. The research results are summarized as follows. The degree of difference in relation to the temperature by height within the greenhouse during the entire experiment was significant - within the range of 4.0~7.0℃. The temperature difference between incoming and outgoing water was about 3.3℃ greater when FCU was activated compared to when it was not activated. Meanwhile, the amount of energy consumed increased about 36.2~40.1%. The amount of pyrexia per hour also increased by 44.6~52.0%. During the experiment period, circulated flux was within the range of 0.48~0.49 L · s<SUP>?1</SUP> while average fluid speed was 1.53~1.56 m · s<SUP>?1</SUP>. The average temperature difference between incoming and outgoing water was 6.24~11.50℃. The amount of heating value by each set temperature within the minimum outdoor temperature range of ?14.0~?0.6℃ was 135,930~307,150 ㎉, and the range was within the 9,610~19,630 ㎉ · h<SUP>?1</SUP> per hour. This demonstrated that about 23~53% heating energy of the maximum heating load could be supplied. Total radiating value and amount of energy consumed were 2,548,306 ㎉ and 3,075.7 ㎾h, respectively. When heating takes place using oil, which is a fossil fuel, the total amount of light oil consumed was 281.6 L while the cost was 321,000 won. When the electricity cost for farms is applied, the total cost was about 110,730 won, which is about 33.5% of the cost required compared to oil consumption. The temperature at in the experiment area was about 8.3~14.6℃ higher compared to that of the control area.

Sonographic observation of the paradoxical masseteric bulging and clinical implication of functional compartment

Kyu-Ho Yi(Kyu-Ho Yi),Hyungkyu Bae(Hyungkyu Bae),Soo-Bin Kim(Soo-Bin Kim),Woo-Ram Kim(Woo-Ram Kim),Won Lee(Won Lee),Ji-Soo Kim(Ji-Soo Kim),Hee-Jin Kim(Hee-Jin Kim) 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1

Masseter are commonly botulinum neurotoxin targeted muscle for facial contouring in aesthetic field. However, paradoxical masseteric bulging is common adverse effect that has not been discussed with ultrasonographic observations. Retrospective study has been conducted from October, 2021 to January, 2023, out of 324 patients have done blinded botulinum neurotoxin injection in the masseter at the middle and lower portion of the masseter with each side of 25 units (letibotulinum neurotoxin type A), 3 patients demonstrated paradoxical masseteric bulging has been reported and the image observed by ultrasonography by physician. Based on the observations made, we can infer that the function of the moving muscle involves twisting of the muscle fibers during contraction, along with the twisting of the deep inferior tendon, which causes the muscle to be divided into anterior and posterior compartments rather than into superficial and deep compartments of masseter. In ultrasonographic observe the skin surface of a patient with paradoxical masseteric bulging, it is observable that either the anterior or posterior part contracts significantly. The functional units of anterior and posterior compartment are observable as muscular contraction of inward movement of the muscle from either the anterior or posterior functional unit.

Evaluation of Concrete Bond Characteristics for the Re-repair Scope Decision of Deteriorated Partial Depth Repair Sections

Won Kyong Jung,Hyun Seok Kim,Jun Young Park,Han Jin Oh,Hyung Bae Kim 한국도로학회 2018 한국도로학회 학술대회 발표논문 초록집 Vol.2018 No.05

In recent years, pavement distresses have been caused by diverse factors such as spalling, deterioration of repaired sections, blow-up, and alkali aggregate reaction due to changing climate environment of a concrete pavement and its construction and maintenance conditions (supply of materials, increase in use of de-icers, etc,). As a leading repair method for deteriorated concrete pavements, partial-depth repair is implemented in accordance with guidelines of material properties for joints of a concrete pavement and field application evaluation systems, but still some of the repaired sections become deteriorated again at an early stage due to poor construction quality and failure of response to environmental impacts. Distresses that can be corrected with partial-depth repairs are largely divided into those of repair materials and of the existing pavement bonded to repair materials, and combined distress of repair materials and the existing pavement. Although re-repair methods should be different by distress type and scale than conventional pavement repair methods, appropriate repair methods and guidance for re-repairs have not been in place so far, and therefore currently, re-repair practices follow the existing manual of partial depth repairs. Therefore, this study evaluated concrete bond characteristics by removing method and repair scope for an experimental section of frequently distressed pavements to determine a re-repair scope and method for deteriorated partial depth repair sections of concrete pavement, the number of which has increased over time.

Allosteric inhibition site of transglutaminase 2 is unveiled in the N terminus

Kim, Nayeon,Kang, Joon Hee,Lee, Won-Kyu,Kim, Seul-Gi,Lee, Jae-Seon,Lee, Seon-Hyeong,Park, Jong Bae,Kim, Kyung-Hee,Gong, Young-Dae,Hwang, Kwang Yeon,Kim, Soo-Youl Springer-Verlag 2018 Amino acids Vol.50 No.11

A Randomized Phase 2 Trial of Consolidation Chemotherapy After Preoperative Chemoradiation Therapy Versus Chemoradiation Therapy Alone for Locally Advanced Rectal Cancer: KCSG CO 14-03

Kim, Sun Young,Joo, Jungnam,Kim, Tae Won,Hong, Yong Sang,Kim, Jeong Eun,Hwang, In Gyu,Kim, Beom Gyu,Lee, Keun-Wook,Kim, Ji-Won,Oh, Ho-Suk,Ahn, Joong Bae,Zang, Dae Young,Kim, Dae Yong,Oh, Jae Hwan,Baek Elsevier 2018 International journal of radiation oncology, biolo Vol.101 No.4

<P><B>Purpose</B></P> <P>Preoperative chemoradiation therapy (CRT) followed by total mesorectal excision (TME) in locally advanced rectal cancer is the standard of care. To date, the role of consolidation chemotherapy after CRT has rarely been addressed through randomized trials. This study aimed to evaluate the efficacy of CRT followed by consolidation chemotherapy compared with CRT alone.</P> <P><B>Methods and Materials</B></P> <P>This study enrolled patients with adenocarcinoma of the rectum and cT3 or cT4 disease with any N category and no metastasis. In arm A (control arm), we planned CRT (50.4 Gy in 28 fractions) with capecitabine followed by TME. In arm B, 2 cycles of capecitabine and oxaliplatin were administered 1 week after the completion of CRT before TME (capecitabine, 1700 mg/m<SUP>2</SUP> per day from day 1 to 14, and oxaliplatin, 100 mg/m<SUP>2</SUP> on day 1, every 3 weeks). The downstaging rate (the proportion of ypT0 to ypT2 and ypN0M0) was the primary endpoint, which was to be tested with a 1-sided type I error of 15% and with 85% power.</P> <P><B>Results</B></P> <P>From September 2014 to February 2016, 110 patients (56 in arm A and 54 in arm B) were randomized and 108 (55 in arm A and 53 in arm B) started CRT. TME was conducted per protocol in 96 patients (52 in arm A and 44 in arm B). In arms A and B, downstaging was achieved in 21.2% and 36.4% (<I>P</I> = .077), respectively, and the pathologic complete response rate was 5.8% and 13.6% (<I>P</I> = .167), respectively. Grade ≥3 adverse events occurred in 3.6% of patients in arm A and 9.4% of patients in arm B during the preoperative treatment phase and in 1.9% and 9.0%, respectively, during the postoperative recovery phase.</P> <P><B>Conclusions</B></P> <P>Consolidation chemotherapy with 2 cycles of capecitabine and oxaliplatin demonstrated a marginal improvement in the downstaging rate. However, a phase 3 trial of this strategy is discouraged because of the high dropout rate and safety issues.</P>

Adrenocortical carcinoma and a sporadic MEN1 mutation in a 3-year-old girl: a case report

Kim Sung Eun,Lee Na Yeong,Cho Won Kyoung,Yim Jisook,Lee Jae Wook,Kim Myungshin,Chung Jae Hee,Jung Min Ho,Suh Byung-Kyu,Ahn Moon Bae 대한소아내분비학회 2022 Apem Vol.27 No.4

Childhood adrenocortical carcinoma (ACC) is a rare disease that is mostly linked to familial cancer syndrome. Although the prevalence of ACC is extremely low in children, it is clinically important to diagnose ACC early because age and tumor stage are closely related to prognosis. From this perspective, understanding the underlying genetics and possible symptoms of ACC is crucial in managing ACC with familial cancer syndromes. In this report, we present the case of a 3-year-old girl who initially presented with symptoms of precocious puberty and was later found to have ACC by imaging analysis. On genetic analysis, the patient was found to have a <i>MEN1</i> gene mutation. <i>MEN1</i> mutations are found in patients with multiple endocrine neoplasia type 1 (MEN1), usually precipitating multiple endocrine tumors, including pituitary adenoma, parathyroid hyperplasia, and adrenal tumors. Although <i>MEN1</i> mutation is usually inherited in an autosomal dominant manner, neither of the patient’s parents had the same mutation, making hers a case of sporadic <i>MEN1</i> mutation with initial presentation of ACC. The clinical course and further investigations of this patient are discussed in detail in this report.