Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury

( Won Yong Cho ),( Sung Yoon Lim ),( Ji Hyun Yang ),( Se Won Oh ),( Myung-gyu Kim ),( Sang-kyung Jo ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3

Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed to assess whether these biomarkers could predict adverse outcomes and renal recovery in established AKI patients. Methods: This was a single-center study prospectively enrolling 124 patients diagnosed with AKI. TIMP-2, IGFBP7, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule 1 (KIM-1) levels were measured at the time of diagnosis and the predictive performance of short-term outcomes and renal recovery was assessed. Results: Patients were divided into 4 quartiles according to the initial urinary TIMP-2/IGFBP7 levels. Stage 3 AKI (odds ratio [OR], 17.86), classified by the Kidney Disease Improving Global Outcomes (KDIGO), as well as the third and fourth quartiles of TIMP-2/IGFBP7 (OR, 5.75 and 44.98, respectively), were found to be independent predictors of renal replacement therapy at the time of AKI diagnosis. In addition, KDIGO stage 3 AKI (OR, 2.468) or the third of fourth quartiles of urinary TIMP-2/IGFBP7 (OR, 1.896 and 3.622, respectively) were also found to be useful in predicting nonrecovery of renal function. In a separate analysis of patients with renal recovery at discharge, initial urinary TIMP-2/IGFBP7 or urinary IGFBP7 at discharge could also predict new-onset or progressive chronic kidney disease (CKD). Conclusions: In AKI patients, urine TIMP-2/IGFBP7 could serve as a biomarker for predicting adverse outcomes, renal recovery, or the development and progression of CKD.

온수배관을 이용한 온실의 난방성능

윤용철(Yong Cheol Yoon),신익수(Yik Soo Shin),김현태(Hyeon Tae Kim),배승범(Seoung Beom Bae),최진식(Jin Sik Choi),서원명(Won Myung Suh) (사)한국생물환경조절학회 2012 생물환경조절학회지 Vol.21 No.2

본 연구는 온실의 난방 에너지 절감을 목적으로 온실 내부에 알루미늄 온수배관을 설치하여 난방효과에 대한 기초자료를 구축하고자 수행되었다. 그 연구결과를 요약하면 다음과 같다. 전체 실험을 포함하여 온실내의 높이별 온도편차는 4.0~7.0℃ 정도의 범위로서 그 차이가 크게 나타났다. 팬코일유니트(FCU)를 작동시킨 경우가 작동시키지 않은 경우에 비해 유출입수의 온도차가 3.3℃ 정도 크고, 소비전력량은 36.2~40.1% 정도 증가하였으며, 시간당 방열량은 44.6~52.0% 정도 증가하는 것으로 나타났다. 실험기간동안 순환유량은 0.48~0.49L · s<SUP>?1</SUP> 정도의 범위에 있었고, 평균유속은 1.53~1.56m · s<SUP>?1</SUP> 정도였다. 유출입수의 평균 온도차는 6.24~11.50℃이었다. 최저 외기온 ?14.0~?0.6℃ 범위에서 설정온도별 방열량은 135,930~307,150㎉ 정도의 범위로서 시간당 9,610~19,630㎉ · h<SUP>?1</SUP> 정도의 범위에 있었다. 이것은 최대난방부하의 약 23~53% 정도의 난방에너지를 공급할 수 있을 것으로 나타났다. 전체 방열량과 소비전력량은 각각 2,548,306㎉ 및 3,075.7㎾h이다. 화석연료인 경유로 난방할 경우, 소요되는 경유의 총 소비량은 281.6L 정도이고 비용은 321,000won인 것으로 나타났다. 농가용 전력요금을 적용하면 전력사용에 대한 총비용은 110,730won 정도로서 경유 소비 비용의 33.5% 정도로 나타났다. 실험구의 온도가 대조구보다 약 8.3~14.6℃ 정도 높게 나타났다. This research was conducted to obtain basic data with regard to the heating performance that would be produced by installing an aluminum hot water pipe inside the greenhouse with the goal of reducing the heating energy in greenhouse. The research results are summarized as follows. The degree of difference in relation to the temperature by height within the greenhouse during the entire experiment was significant - within the range of 4.0~7.0℃. The temperature difference between incoming and outgoing water was about 3.3℃ greater when FCU was activated compared to when it was not activated. Meanwhile, the amount of energy consumed increased about 36.2~40.1%. The amount of pyrexia per hour also increased by 44.6~52.0%. During the experiment period, circulated flux was within the range of 0.48~0.49 L · s<SUP>?1</SUP> while average fluid speed was 1.53~1.56 m · s<SUP>?1</SUP>. The average temperature difference between incoming and outgoing water was 6.24~11.50℃. The amount of heating value by each set temperature within the minimum outdoor temperature range of ?14.0~?0.6℃ was 135,930~307,150 ㎉, and the range was within the 9,610~19,630 ㎉ · h<SUP>?1</SUP> per hour. This demonstrated that about 23~53% heating energy of the maximum heating load could be supplied. Total radiating value and amount of energy consumed were 2,548,306 ㎉ and 3,075.7 ㎾h, respectively. When heating takes place using oil, which is a fossil fuel, the total amount of light oil consumed was 281.6 L while the cost was 321,000 won. When the electricity cost for farms is applied, the total cost was about 110,730 won, which is about 33.5% of the cost required compared to oil consumption. The temperature at in the experiment area was about 8.3~14.6℃ higher compared to that of the control area.

국내 정형외과 의료소송 현황 파악

이원(Won Lee),이미진(Mi Jin Lee),김용민(Yong Min Kim),우찬명(Chan Myung Woo),김소윤(So Yoon Kim),김양수(Yang-Soo Kim) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.3

목적: 국내 정형외과 관련 의료소송 판결문의 분석을 통하여 정형외과 의료소송의 현황과 원인이 된 과정을 파악하고자 함이다. 대상 및 방법: 소송시작이 2005년부터 2010년인 정형외과 의료소송 판결문 341건을 대상으로 하여 빈도분석을 실시하였다. 결과: 사건 발생 시점에서 소송 종결 시점까지의 평균 소요기간은 4.22년이었다. 의료소송의 원인이 된 과정은 수술이 46.3%였고, 수술의 종류는 척추 수술이 가장 많았다. 사고의 결과는 장애가 가장 많았고, 최종심 결과는 원고일부승이 40.5%, 원고패(기각)가 34.3%였다. 감염은 전체 중 26.1%에서 발생하였고, 손해배상 청구금액은 평균 181,998,036원이었으며 인용금액은 평균 58,897,161원이었다. 결론: 정형외과 의료소송으로 이어진 의료사고의 주요 원인 과정은 수술이 가장 많았고, 그 중에서도 척추 수술이 가장 많았다. 추후 의료사고의 근본 원인분석을 통해 의료사고를 줄이고 재발을 방지하기 위한 후속 연구가 이루어져야 할 것이다. Purpose: Through the analysis of orthopedics lawsuit rulings, the purpose of this study is to understand the current trends of medical lawsuits in orthopedics in Korea. Materials and Methods: An analysis of medical lawsuits in orthopedics was conducted. As the study method, a quantitative analysis was performed on 341 cases. Results: The average period of lawsuits, from the occurrence of the medical accident to end of the ruling, took an average of 4.22 years. The most frequent procedure that was the main cause of the medical accidents was surgery, at 46.3%. When surgery is the main procedure that caused the medical accidents, the result of examining the types of surgeries showed that spine surgery had the highest percentage. For the outcome of the accident, the highest number of cases resulted in disability and for the final court outcome, 40.5% ruled partially in favor of the plaintiff (the patient) with acknowledgement of only the damage incurred due to medical error of the total sum claimed, and dismissal of the claim made by the plaintiff (patient) accounted for 34.3%; 26.1% of cases develop infection. For the amount of claim for damage, the average amount of claim was 181,998,036 won; in the judgement amount, the average amount of judgement was 58,897,161 won. Conclusion: The most frequent procedure in orthopedics was surgery and spine surgery comprised a large proportion of these surgeries. Future studies to determine root causes of medical accidents should be conducted to reduce medical lawsuits and to plan against the repeating of medical accidents.

전기 방열기가 국화재배온실의 난방에 미치는 영향

서원명 ( Won Myung Suh ),임재운 ( Jae Woon Leem ),김영주 ( Young Ju Kim ),민영봉 ( Young Bong Min ),김현태 ( Hyeon Tae Kim ),허무룡 ( Moo Ryong Huh ),윤용철 ( Yong Cheol Yoon ) 경상대학교 농업생명과학연구원(구 경상대학교 농업자원이용연구소) 2010 농업생명과학연구 Vol.44 No.4

경상대학교 교내에 설치되어 있는 1-2W형 온실을 대상으로 전기 방열기를 이용하여 국화 재배온실의 난방효과를 검토한 결과는 다음과 같다. 실험기간동안 최고, 평균 및 최저 외기온은 각각 -3.8~21.3℃, -5.2~16.1℃ 및 -12.5~14.4℃ 정도의 범위로 나타났으며, 온실 내외의 평균상대습도 각각 43.5~98.6% 및 35.2~100%로 나타났다. 12월 중순부터 2월 상순까지 최저 외기온은 대략 -5.0~-10.0℃ 전후로 나타나 진주기상대의 최근 자료와 비교하면 상대적으로 최저기온이 낮게 나타나는 경향이 있었다. 야간의 경우, 방열기 직하부의 엽온이 방열기 중간 지점에서 측정한 엽온 보다 크게 2~3℃정도 높게 나타나거나 또는 미미하지만 약간 높게 나타나는 경향이 있었다. 근권부의 경우, 직하부나 중간 지점에서의 온도 차이는 거의 없는 것으로 나타났고, 근권부의 최고온도와 기타 최고 온도의 발생 시점을 보면, 약 2시간정도의 지체현상이 있음을 알 수 있었다. 그리고 실험기간동안 난방에 소요된 총 소비전력량, 공급에너지 및 총 난방비는 각각 2,800kWh, 2,408,000kcal 및 112,000won 정도였다. 화석연료인 경유로 난방할 경우, 총 난방비는 224,500won 정도였다. 방열기를 이용하여 난방할 경우, 난방비를 약 50% 정도 줄일 수 있을 것으로 판단되었다. An analysis in heating effects of an electric radiator located in a 1-2W type chrysanthemum (3 cultivars) cultivation greenhouse installed in Gyeongsang National University drew the following conclusions. During the experiment period, the highest, average, and the lowest outside temperatures were in the ranges of -3.8~21.3℃, -5.2~16.1℃ and -12.5~14.4℃, respectively, and the average relative humidity inside and outside the greenhouses were in the ranges of 43.5~98.6% and 35.2~100%, respectively. From mid-December to early February, the lowest outside temperature was recorded as approximately -5.0~-10.0℃, which showed that it tended to be relatively lower than the temperatures recorded at the Jinju Meteorological Observatory. During the night, the leaf temperature measured directly under the radiator tended to be higher by 2~3℃ than that those at the middle point of the radiator, or higher by anegligible amount. In the case of root zone temperature, it was found that there was almost no difference between temperatures of the part directly under and the middle point, and the time when the highest temperature of root zone and other highest temperatures took place showed that there was about a 2-hour delay phenomenon. The total electricity consumption, energy supply and total heating cost during the experiment period were 2,800 kWh, 2,408,000 kcal and 112,000 won, respectively. When diesel, a kind of fossil fuel, was used as heating oil, the total heating cost was around 224,500 won. It was estimated that the total heating cost could be reduced by around 50% if a radiator was used.

Identification and characterization of Metarhizium majus isolated from the edible insect Protaetia brevitarsis in Korea

Kwak Kyu‐Won,Aktaruzzaman Md.,Kim Eunsun,Kim Sun Young,Hong Seung‐Beom,Park Ji Yeong,Park Kwanho,Koo Bonwoo,Kim Yong‐Soon 한국곤충학회 2021 Entomological Research Vol.51 No.12

Edible insects are considered novel protein sources, and the edible insect breeding industry is growing rapidly. However, fungal pathogens are a major threat to this industry, and appropriate identification of causative agents is important for the development of antifungal agents. In 2019, strains of the fungal pathogen Metarhizium were isolated from infected second and third instar larvae of the economically important edible insect Protaetia brevitarsis, which were collected from separate farms in Gimhae-si, Gyeongsangnam-do, Korea. Based on morphological characteristics and multilocus phylogenetic analysis of the internal transcribed spacer region, and 50-region of gene encoding the 1-α elongation factor, the fungal strains were identified as Metarhizium majus. Here, we report the detailed phylogenetic characteristics and morphological description of this species, which is prevalent in Korea. Identification of the principal disease-causing agent can help develop disease prevention and antifungal strategies for application in edible insect-rearing farms.

‘경영인의 지혜(Managerial Wisdom)’ 습득을 위한 SSWB 모델의 효과성 연구

김주원(Kim, Joo-Won),박용승(Park, Yong-Seung) 한국경영교육학회 2020 경영교육연구 Vol.35 No.5

[연구목적] 본 연구는 SSWB 모델을 실제 경영학습현장에 대입하기 위해 개발된 프로그램을 소개하고 SSWB 모델의 효과성을 검증하고자 함을 목적으로 한다. [연구방법] 본 연구는 연구자가 근무하고 있는 서울소재 K와 S대학의 책임경영, 기업윤리, 그리고 리더십 수강생 110명을 대상으로 2019년 가을학기에 시행되었다. 측정 도구는 연구자가 개발한 ‘경영인의 지혜’ 이며 사전 사후 검사를 위해 SPSS 25를 활용하여 대응표본 t검증을 실시하였다. [연구결과] 본 연구를 통해 경영인의 지혜에 대한 7개의 하위요인인 고차지식, 자기성찰, 앎의 욕구, 영성 및 초월, 공감, 모순인지 모두 통계적으로 유의미하게 분석되었다. 즉, SSWB 모델을 활용한 프로그램은 경영인의 지혜 수준을 향상시키며 따라서 본 모델의 효과성은 입증되었다. [연구의 시사점] 본 연구는 지금까지의 지혜 학습에 관련된 연구가 관념적인 논증을 거치거나 인터뷰를 통한 질적 연구에 국한되어 있었던 데 반해 실제 양적인 측정을 시도하였다는 것에 큰 의미가 있다. 게다가, 국내 최초로 경영인의 지혜를 개념화하고 측정 도구와 프로그램을 개발한 연구자가 직접 프로그램의 효과성을 검증했다는 것에서도 그 의의를 찾아볼 수 있다. 이는 연구의 방향과 흐름의 일관됨은 물론 같은 주제의 맥락을 하나로 집결시켜 정확한 연구의 본질에 충실할 수 있었음을 의미한다. 또한, 본 연구의 결과로 볼 때 지혜 학습의 가능성이 타당화되었다. 이는 추상적으로 여겨졌던 지혜의 학문적 진입은 물론, 실천적 대입에 대한 촉발제가 되었다는 점에서도 큰 의의를 지닌다. [Purpose] The purpose of this study is to first introduce the program developed to apply the SSWB model to the actual management learning site. The purpose is to verify the effectiveness of the SSWB model through comparative analysis before and after implementation of the program. [Methodology] The study was conducted in the fall semester of 2019 on 110 students of responsible management, management ethics, and leadership at K and S universities in Seoul where researchers work. For this study, pretest-posttest was conducted using the ‘Management Wisdom’ measurement tool developed by the researcher, and the analysis and verification were conducted using SPSS 25. [Findings] As a result, all factors resulted in statistically significant results. In other words, the SSWB model can be interpreted as improving the level of management wisdom. Therefore, it has been verified that this is a useful program for learning the wisdom of managers. [Implications] This study is significant in that the research related to learning wisdom has been limited to qualitative research through interview or through ideological reasoning so far, while actual quantitative measurement has been attempted. Moreover, the significance of the program can be found in the fact that the researchers who have conceptualized the wisdom of managers and developed measurement tools and programs for the first time in Korea have personally verified the effectiveness of the program. This means that the direction and flow of research are consistent, as well as the context of the same subject can be brought together to be faithful to the exact nature of the study. Also, the possibility of learning wisdom has been justified. This is of great significance not only in the academic entry of wisdom, which was considered abstract, but also in the fact that it was the trigger for practical college entrance.

Prevention of medical malpractice and disputes through analysis of lawsuits related to coronary angiography and intervention

Cheol Won Hyeon,Won Lee,So Yoon Kim,Ji Yong Park,Su Hwan Shin 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3

Background/Aims: Possible fatal complications arising from coronary angiography (CAG), percutaneous coronary intervention (PCI), and coronary artery disease itself, are likely to cause medical disputes. Presenting the current status and reasons for judgments given in lawsuits related to CAG/PCI, this study aimed to identify ways to prevent unnecessary disputes and medical malpractice suits related to CAG/PCI through lawsuit analysis. Methods: A total of 13 cases (20 judgments) found in the Supreme Court of Korea’s Written Judgment Management System from 1998 to 2017 were analyzed. Results: Coronary artery injury was the most common causative complication that led to lawsuits (n = 6, 46%). Six cases (46%) were ruled in favor of the plaintiff for violation of duty of care (n = 4) and duty of explanation (n = 2), respectively. Cases that violated duty of care included two errors in intra-procedure device manipulation, one in pre-procedure diagnosis, and one in management of post-procedure complication. Lack of explanation regarding the risk of complications was pointed out in both cases that violated duty of explanation. The average awarded amount for the damages was 114,436,064 Korean won. Conclusions: Physicians need not fear unfair judgments so long as they follow standard of care because the Court consistently looked at the probability, the foreseeability, and the evidence. Therefore, maintaining standard of care is important. Besides, specific, detailed, and comprehensible explanations, including the risk of complications in addition to the necessity of procedures, are important to ensure the patient clearly understands the possible risk of adverse outcomes.

해군 근무환경에서 노출될 수 있는 염화알루미늄의 피부독성 예방을 위한 보호크림 개발 및 효능평가

박창용(Chang-Yong Park),어원석(Won Souk Eoh),이준원(Joon-Won Lee),오영현(Young-Hyun Oh),정미경(Mi Kyoung Jung),김병직(Byungjick Kim2) 한국해군과학기술학회 2023 Journal of the KNST Vol.6 No.3

This study aimed to investigate the protective effects of a skin protection cream against aluminum chloride, a substance that can cause skin irritation and burns when exposed to the skin. After confirming the safety of the protective cream through skin sensitivity tests, we examined whether the cream could reduce the skin toxicity caused by aluminum chloride using a full-thickness cultured skin. The test results showed a significantly higher level of procollagen synthesis in the group where the skin protection cream was applied compared to the group exposed to aluminum chloride. Additionally, aluminum chloride was found to persist even after washing, but the protection cream inhibited its persistence. These results demonstrate that the skin protection cream can contribute to the prevention of occupational skin diseases among naval personnel and maintenance crew involved in tasks such as ship maintenance.

윈도우 기반 응용프로그램 제공 서비스를 위한 Win32 API 메시지 인가 시스템의 개발

김영호,정민아,원용관,Kim, Young-Ho,Jung, Mi-Na,Won, Yong-Gwan 한국정보처리학회 2004 정보처리학회논문지 C : 정보통신,정보보안 Vol.11 No.1

컴퓨터 자원의 대용량화 및 네트워크 속도의 증가로 인하여 사용자가 네트워크를 통해 원격지의 서버에 접속하여 컴퓨터론 사용하는 요구가 증가되었다. 이에 따라 중앙집중형 컴퓨팅을 통한 응용프로그램 제공 서비스도 활성화되었다. 중앙집중형 컴퓨팅 시스템은 중앙의 대용량컴퓨터 시스템에 설치된 응용프로그램을 공유 프로토콜을 통하여 원격 사용자에게 제공하는 응용프로그램 공유 서비스(ASP: Application Service Provision) 시스템 모델이다. 중앙집중형 컴퓨팅 시스템을 통한 응용프로그램 공유 서비스는 기밀성, 가용성 무결성 등의 보안 사항이 반드시 유지되어야 한다. 기존 원격 컴퓨팅인 Telnet, FTP 접속은 단순히 파일 및 데이터의 접근 권한을 제어함으로 보안이 유지된다. 그러나 윈도우 기반 시스템의 경우 다수의 사용자가 통일한 권한을 통해 통일한 응용프로그램을 제공받기 때문에 사용자들 사이에 기밀성 및 무결성을 저해 할 수 있다. 또한 다수의 사용자가 하나의 응용프로그램에 파일열기, 복사, 서식 수정 등의 여러 기능 명령어를 전송하기 때문에 파일 및 데이터 접근 제어만을 통해서는 시스템의 기밀성 유지한 수 없다. 또한 기밀성의 문제는 곧 가용성 및 무결성의 문제로 이어질 수 있다. 본 논문에서는 윈도우 기반 중앙집중형 컴퓨팅 시스템의 응용프로그램 공유 서비스를 지원함에 있어 사용자가 실행하는 Win32 API 메시지 명령어 접근제어 시스템을 제안한다. 제안하는 시스템은 GUI(Graphical User Interface) 기반의 서버에서 사용자가 서버에 접속하여 발생하는 모든 메시지(마우스, 키보드, I/O, etc....)들을 감시한다. 감시된 메시지 기반의 명령어는 미리 설정된 사용자별 보안 정책에 기반 하여 해당 응용프로그램에게 전달 여부가 결정된다. 이러한 메시지 기반 상세 보안을 통해 기밀성 침해의 우려가 있는 메시지 명령어를 차단하고, 기능 명령어 차단에 의한 자원의 기밀성을 해결하였다. The growth of computer resource and network speed has increased requests for the use of remotely located computer systems by connecting through computer networks. This phenomenon has hoisted research activities for application service provision that uses server-based remote computing paradigm. The server-based remote computing paradigm has been developed as the ASP (Application Service Provision) model, which provides remote users through application sharing protocol to application programs. Security requirement such as confidentiality, availability, integrity should be satisfied to provide ASP service using centralized computing system. Existing Telnet or FTP service for a remote computing systems have satisfied security requirement by a simple access control to files and/or data. But windows-based centralized computing system is vulnerable to confidentiality, availability, integrity where many users use the same application program installed in the same computer. In other words, the computing system needs detailed security level for each user different from others, such that only authorized user or group of users can run some specific functional commands for the program. In this paper, we propose windows based centralized computing system that sets security policies for each user for the use of instructions of the application programs, and performs access control to the instructions based on the security policies. The system monitors all user messages which are executed through graphical user interface by the users connecting to the system. Ail Instructions, i.e. messages, for the application program are now passed to authorization process that decides if an Instruction is delivered to the application program based on the pre-defined security polices. This system can be used as security clearance for each user for the shared computing resource as well as shared application programs.

한ㆍ중 비즈니스 관계의 갈등과 그 해결방안에 대한 모색

김주원(Ju Won KIM),김용준(Yong June KIM) 한국무역상무학회 2015 貿易商務硏究 Vol.66 No.-

This research is, first of all, a theoretical study concerning 'conflict.' Only then, we could obtain ways in which we manage and resolve various problems arising fromconflicts in business between Korean and Chinese companies. In doing this, we also tried to grasp cultural characteristics, or factors, in Chinese ways of carrying out negotiations that lead to conflicts with us. On the basis of these preliminary considerations, we developed practical techniques of conflict management and types of negotiation strategy. We thereby could suggest broader strategic implications for better performance in international business. Concretely, this research investigates techniques of conflict management and types of negotiation strategy. For such techniques and types, we suggest, (1) Sharing technique or reconciliatory compromising negotiation and its compromise strategy, (2) collaborative technique or cooperative negotiation and its win-win strategy, (3) competitive technique or competitive negotiation and its profit-seeking attack strategy, (4) accommodative technique or receptive negotiation and its relation-maintaining yield strategy,(5) avoidant technique or evasive negotiation and its indifference-showing avoidance strategy. This research contributes to promote understanding on negotiation culture of chinese corporate. and we provide the guideline of the conflict management and the insight for the efficiency strategy of chinese business negotiation. But, empirical data and statistical examinations should be added to our present research for the future prospective ones.