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Choi Su-La,Choi Yun-Sil,Kim Young-Kwan,Sung Nack-Do,Kho Chang-Won,Park Byong-Chul,Kim Eun-Mi,Lee Jung-Hyung,Kim Kyung-Mee,Kim Min-Yung,Myung Pyung-Keun The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.3
We employed human SK-MEL-28 cells as a model system to identify cellular proteins that accompany N-(4-methyl)phenyl-O-(4-methoxy)phenyl-thionocarbamate (MMTC)-induced apoptosis based on a proteomic approach. Cell viability tests revealed that SK-MEL-28 skin cancer cells underwent more cell death than normal HaCaT cells in a dose-dependent manner after treatment with MMTC. Two-dimensional electrophoresis in conjunction with matrixassisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC-induced apoptosis is accompanied by increased levels of caspase-1, checkpoint suppressor-1, caspase-4, NF-kB inhibitor, AP-2, c-Jun-N-terminal kinase, melanoma inhibitor, granzyme K, G1/S specific cyclin D3, cystein rich protein, Ras-related protein Rab-37 or Ras-related protein Rab-13, and reduced levels of EMS (oncogene), ATP synthase, tyrosine-phosphatase, Cdc25c, 14-3-3 protein or specific structure of nuclear receptor. The migration suppressing effect of MMTC on SK-MEL-28 cell was tested. MMTC suppressed the metastasis of SK-MEL-8 cells. It was also identified that MMTC had little angiogenic effect because it did not suppress the proliferation of HUVEC cell line. These results suggest that MMTC is a novel chemotherapeutic and metastatic agents against the SK-MEL-28 human melanoma cell line.
Choi, Won-Sik,Nam, Seok-Woo,Kim, Il-Doo,Kim, Seung-Han,Park, Kun-Ho,Bae, In-Kyung,Park, Eun-Sil,Jeon, Hwang-Ju,Lee, Sung-Eun Hindawi Limited 2015 Journal of chemistry Vol.2015 No.-
<P>Pesticidal activities of 4-[5-(2-cyclopropylaminopyrimidin-4-yl)-4-(4-chloro-2-fluoro-phenyl)thiazol-2-yl]-1-methylpiperidine, designated as Comp I, have been determined against a mosquito larva,<I>Culex pipiens pallens</I>, and a phytopathogenic fungus,<I>Phytophthora capsici</I>. Comp I was used as the leading compound in this study. The compounds were synthesized by reacting them with two functional groups, 3-thiophenyl and 2-thiophenyl groups, instead of 4-chloro-2-fluorophenyl group in Comp I. Other functional groups such as 2-aminothiazole, 2-(1-methylpiperazin-4-yl)thiazole, and 2-(piperazin-4-yl)thiazole were also introduced instead of 2-methylpiperidin-4-yl-thiazole of Comp I. Compounds designated as XIII-6~XV-7 were newly synthesized and their structures were confirmed by<SUP>1</SUP>H- and<SUP>13</SUP>C-NMR spectroscopy. Mosquito larvicidal activities of all the synthesized compounds against<I>C. pipiens pallens</I>were examined and Comp I among them showed the strongest larvicidal activity as 0.513 mM of LC50value. The fungicidal activities of all the synthesized compounds against<I>P. capsici</I>were examined using the whole plant method. Among the XIII-6~XV-7 chemicals, 5-(2-cyclopropylaminopyrimidin-4-yl)-4-(thiophen-2-yl)thiazol-2-amine (VIII-6) showed the most potent antifungal activity<I>in vivo</I>. While the EC50value of the commercial fungicide dimethomorph was 4.26 <I>μ</I>M, EC50of VIII-6 was 0.94 <I>μ</I>M. Therefore, thiazole derivatives can be considered as viable candidates for the control of mosquito larvae and plant diseases.</P>
( Won-sil Choi ),( Seung-ok Yang ),( Ji-hyun Lee ),( Eun-ji Choi ),( Yun-hee Kim ),( Jiyoon Yang ),( Mi-jin Park ) 한국목재공학회 2020 목재공학 Vol.48 No.5
This study was aimed to investigate the changes of chemical composition of the volatile organic compounds (VOCs) emitted from red pine needles in the process of needle abscission or senescence. The VOCs in intact, senescent, and litter red pine needle samples were analyzed by headspace-solid phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC/MS). And then, multivariate statistical interpretation of the processed data sets was conducted to investigate similarities and dissimilarities of the needle samples. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to investigate the dataset structure and discrimination between samples, respectively. From the data preview, the levels of major components of VOCs from needles were not significantly different between needle samples. By PCA investigation, the data reduction according to classification based on the chlorophyll a / chlorophyll b (Ca/Cb) ratio were found to be ideal for differentiating intact, senescent, and litter needles. The following OPLS-DA taking Ca/Cb ratio as y-variables showed that needle samples were well grouped on score plot and had the significant discriminant compounds, respectively. Several compounds had significantly correlated with Ca/Cb ratio in a bivariate correlation analysis. Notably, the litter needles had a higher content of oxidized compounds than the intact needles. In summary, we found that chemical compositions of VOCs between intact, senescent, and litter needles are different each other and several compounds reflect characteristic of needle.
Helical tomotherapy for spine oligometastases from gastrointestinal malignancies
Choi, Yun-Seon,Kim, Jun-Won,Lee, Ik-Jae,Han, Hee-Ji,Baek, Jong-Geal,Seong, Jin-Sil The Korean Society for Radiation Oncology 2011 Radiation Oncology Journal Vol.29 No.4
Purpose: This study evaluated the treatment effectiveness and proper radiation dose of helical tomotherapy (HT) in spine oligometastases from gastrointestinal cancers. Materials and Methods: From 2006 to 2010, 20 gastrointestinal cancer patients were treated with HT for spine oligometastases (31 spine lesions). The gross tumor volume (GTV) was the tumor evident from magnetic resonance imaging images fused with simulation computed tomography images. Clinical target volume (CTV) encompassed involved vertebral bodies or dorsal elements. We assumed that the planning target volume was equal to the CTV. We assessed local control rate after HT for 31 spine metastases. Pain response was scored by using a numeric pain intensity scale (NPIS, from 0 to 10). Results: Spine metastatic lesions were treated with median dose of 40 Gy (range, 24 to 51 Gy) and median 5 Gy per fraction (range, 2.5 to 8 Gy) to GTV with median 8 fractions (range, 3 to 20 fraction). Median biologically equivalent dose (BED, ${\alpha}/{\beta}$ = 10 Gy) was 52 $Gy_{10}$ (range, 37.5 to 76.8 $Gy_{10}$) to GTV. Six month local control rate for spine metastasis was 90.3%. Overall infield failure rate was 15% and outfield failure rate was 75%. Most patients showed pain relief after HT (93.8%). Median local recurrence free survival was 3 months. BED over 57 $Gy_{10}$ and oligometastases were identified as prognostic factors associated with improved local progression free survival (p = 0.012, P = 0.041). Conclusion: HT was capable of delivering higher BED to metastatic lesions in close proximity of the spinal cord. Spine metastases from gastrointestinal tumors were sensitive to high dose radiation, and BED (${\alpha}/{\beta}$ = 10 Gy) higher than 57 $Gy_{10}$ could improve local control.
Methyleugenol reduces cerebral ischemic injury by suppression of oxidative injury and inflammation
Choi, Yoo Keum,Cho, Geum-Sil,Hwang, Sunyoung,Kim, Byung Woo,Lim, Ji. H.,Lee, Jae-Chul,Kim, Hyoung Chun,Kim, Won-Ki,Kim, Yeong Sik Informa UK Ltd. 2010 Free radical research Vol.44 No.8
<P>The present study tested the cytoprotective effect of methyleugenol in an <I>in vivo</I> ischemia model (i.e. middle cerebral artery occlusion (MCAO) for 1.5 h and subsequent reperfusion for 24 h) and further investigated its mechanism of action in <I>in vitro</I> cerebral ischemic models. When applied shortly after reperfusion, methyleugenol largely reduced cerebral ischemic injury. Methyleugenol decreased the caspase-3 activation and death of cultured cerebral cortical neurons caused by oxygen-glucose deprivation (OGD) for 1 h and subsequent re-oxygenation for 24 h. Methyleugenol markedly reduced superoxide generation in the ischemic brain and decreased the intracellular oxidative stress caused by OGD/re-oxygenation. It was found that methyleugenol elevated the activities of superoxide dismutase and catalase. Further, methyleugenol inhibited the production of nitric oxide and decreased the protein expression of inducible nitric oxide synthase. Methyleugenol down-regulated the production of pro-inflammatory cytokines in the ischemic brain as well as in immunostimulated mixed glial cells. The results indicate that methyleugenol could be useful for the treatment of ischemia/inflammation-related diseases.</P>
Choi, Kyu-Ho,Yoo, Ie-Ryung,Han, Eun-Ji,Kim, Yeon-Sil,Kim, Gi-Won,Na, Sae-Jung,Sun, Dong-Il,Jung, So-Lyung,Jung, Chan-Kwon,Kim, Min-Sik,Lee, So-Yeon,Kim, Sung-Hoon The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.1
Purpose We assessed the prognostic value of metabolic tumor volume (MTV) measured using$^{18}F$-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC). $Methods$ We retrospectively reviewed 56 patients (51 men, five women; mean age $56.0{\pm}8.8$years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value ($SUV_{peak}$) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared $SUV_{peak}$, MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS). Results On the initial FDG PET/CT scans, the median $SUV_{peak}$ was 7.8 (range, 1.8-19.0) and MTV was17.0 $cm^3$ (range, 0.1-131.0 $cm^3$). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of $SUV_{peak}$ 6.2 and MTV 20.7 $cm^3$ were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p<0.05). Conclusion The MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.
Choi, In-Sil,Kim, Dae-Hyuk,Lee, Chang-Won,Kim, Jae-Won,Chung, Young-Ryun The Korean Society for Microbiology and Biotechnol 1998 Journal of microbiology and biotechnology Vol.8 No.5
Random amplified polymorphic DNA (RAPD) markers were used to survey genetic variability among 34 Botrytis cinerea isolates from nine different host plants in Korea. For RAPD analysis, 115 arbitrary decamer primers were initially screened for polymorphic major DNA bands with 11 representative B. cinerea isolates. Eleven primers that initially detected polymorphisms were tested a second time with additional 23 isolates of B. cinerea as well as one isolate of Botrytis squamosa as an outgroup. The RAPD analyses revealed that all isolates except one showed different molecular phenotypes. Dendrograms obtained from dissimilarity matrices using the unweighted paired group method of arithmetic means (UPGMA) showed the 36.4% to 90.0% similarity among all B. cinerea isolates. The B. squamosa isolate showed the least similarity to all B. cinerea isolates. The cluster analyses indicated no correlation among all the characteristics examined including molecular phenotypes, host and geographic origins, year of isolation, or pathogenicity. The RAPD data suggest that a high level of genetic variation exists among Korean populations of B. cinerea and it seems to be caused by heterokaryosis among preexisting molecular phenotypes.
Choi, Yong Jun,Kim, Yae-Jean,Yong, Dongeun,Byun, Jung-Hyun,Kim, Taek Soo,Chang, Yun Sil,Choi, Min Ji,Byeon, Seung Ah,Won, Eun Jeong,Kim, Soo Hyun,Shin, Myung Geun,Shin, Jong Hee U.S. Department of Health and Human Services * Cen 2018 Emerging Infectious Diseases Vol.24 No.9
<P>We recently observed the emergence of fluconazole-resistant <I>Candida parapsilosis</I> bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hospitals for several years, as revealed by microsatellite typing.</P>