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Jang, Kang Won,Lee, Kyung Hye,Kim, Soo Hyuk,Jin, Taewon,Choi, Eun Young,Jeon, Hyun Ju,Kim, Eunsuk,Han, Ye Sun,Chung, Ji Hyung Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.12
<P><B>Abstract</B></P><P>Transcriptional factor nuclear factor‐kappaB (NF‐κB) plays a crucial role in human breast cancer cell invasion and metastasis. The carboxyl terminus of Hsc70‐interacting protein (CHIP) is a U‐box‐type ubiquitin ligase that induces ubiquitination and proteasomal degradation of its substrate proteins. In this study, we investigated the role of CHIP in the NF‐κB pathway in the invasion of MDA‐MB‐231 cells, a highly aggressive breast cancer cell line. We showed that overexpression of CHIP significantly inhibits the invasion of the MDA‐MB‐231 cells. The overexpression of CHIP suppressed expression of urokinase plasminogen activator (uPA) and matrix metalloproteinase‐9 (MMP‐9) in MDA‐MB‐231 cells. Moreover, CHIP strongly inhibited the nuclear localization and the transcriptional activity of NF‐κB. The activation of the IkappaB kinase complex (IKK) was also blocked by CHIP overexpression. Importantly, CHIP overexpression resulted in a significant decrease in the level of TNF receptor‐associated factor 2 (TRAF2), an upstream key player in the NF‐κB pathway. However, the level of TRAF2 was restored after treatment with a proteasome inhibitor, MG‐132. Moreover, CHIP overexpression promoted the ubiquitination of TRAF2. We also found cell invasion significantly decreased in cells transfected with TRAF2 small interfering RNA (siRNA). In contrast, when CHIP expression was suppressed by siRNA in poorly invasive MCF‐7 cells, cell invasion significantly increased in conjunction with enhanced NF‐κB activation and TRAF2 levels. Taken together, these results suggest that CHIP regulates NF‐κB‐mediated cell invasion via the down‐regulation of TRAF2. J. Cell. Biochem. 112: 3612–3620, 2011. © 2011 Wiley Periodicals, Inc.</P>
Jang, Hye Yeon,Kim, Do Hyung,Lee, Haeng Jung,Kim, Won Dong,Kim, Seog-Young,Hwang, Jung Jin,Lee, Seung Jin,Moon, Dae Hyuk Elsevier 2019 Biochemical pharmacology Vol.160 No.-
<P><B>Abstract</B></P> <P>Combination of MEK inhibitor and 5-FU had showed limited efficacy in clinical trials. We previously reported that acquired resistance to 5-FU was related with continued activation of <I>salvage</I> pathway. Here we investigated whether combination of 5-FU and a MEK inhibitor had treatment sequence-dependent synergistic effects in <I>KRAS</I> or <I>BRAF</I> mutant colon cancer models. Treatment with 5-FU followed by selumetinib (FS) induced highest cell death and synergy compared with reverse (SF) and concomitant (cFS) treatment in six cell lines. SF or cFS combination induced synergy in 1 or 2 cell lines, respectively, in which the synergy was less than that by FS combination. FS enhanced apoptosis and decreased anchorage-independent growth. Induction of thymidine kinase 1, a rate-limiting enzyme in <I>salvage</I> pathway, by 5-FU was abrogated by subsequent treatment with selumetinib, and ERK reactivation after selumetinib was prohibited by pretreatment with 5-FU. FS altered mRNA expression in groups of genes distinct from SF. Administration of 5-FU (10 or 30 mg/kg/day) for 7 days, followed by selumetinib (10 or 25 mg/kg/day) for another 7 days, in colo205 and HCT8 xenograft models significantly decreased tumor growth compared with a single agent. However, co-administration in the reverse sequence did not show the difference in tumor size compared with the treatment of single agent. Decreased expression of Ki67 was observed in tumors from mice treated with FS. Our results suggest that sequential administration of 5-FU plus selumetinib would be a promising strategy for patients having <I>KRAS</I> or <I>BRAF</I> mutant colon cancers.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Performance Analysis of DS/CDMA DPSK System with PLL Gain
Jang, Moon-Kee,Kim, Joon-Bae,Kim, Won-Sub,Ju, Jong-Hyuk,Park, Jin-Soo 청주대학교 산업과학연구소 2003 産業科學硏究 Vol.20 No.2
이동통신채널에서 수신된 신호는 다중경로 페이딩에 의해 진폭과 위상에 영향을 받게 된다 따라서 본 논문에서는 송수신기 사이에서 발생된 위상차를 Tikhonov 확률밀도함수로 모델링하고 PLL 이득에 따른 DS/CDMA/ DPSK 시스템의 성능을 분석하였다. 그 결과, 본 논문에서 제안된 시스템에 PLL의 이득을 조정함으로써 위상이 완전 동기된 DPSK 시스템의 성능에 근접하게 됨을 알 수 있었다 컴퓨터 모의실험결과, 제안된 시스템에서 PLL 이득이 1dB인 경우 두 시스템간의 성능차는 4.8dB, PLL이득이 7dB인 경우 0.4dB로 근접하는 것을 알 수 있었으며 PLL 이득을 30dB 이상인 경우 제안된 시스템이 완전동기된 DPSK 시스템과 같은 성능을 나타냄을 알 수 있었다 A received signal in mobile communication environments exhibits variation in both amplitude and phase due to the multipath fading Therefore we analyzed the performance of DS/CDMA (Direct Sequence / Code Division Multiple Access) DPSK(Difference Phase Shift Keying) system for the variations of PLL(Phase Locked Loop) gain with Tikhonov probability density function, assuming that the phase difference between transmitter and receiver signals is phase error As a result, it is discovered that the performance of system could be improved by the control of PLL gain in compared w t h the DPSK system which does not consider the phase error If the PLL gain is 1dB, the difference of two systems is 48dB and 04dB at 7dB And if 30dB, it coincides From above, it also verified that the limit of gain is 30dB
Supratentorial Leptomeningeal Hemangioblstoma : Case Report
Jang, Han Won,Byun, Woo Mok,Lee, Jae Kyo,Cho, Jae Ho,Cho, Kil ho,Hwang, Mi Soo,Park, Bok Hwan,Choi, Joon Hyuk 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2S
혈관아세포종은 소뇌에 가장 흔하게 발생하며 von Hippel-Lindau disease와 연관될 수 있다. 저자들은 천막상부 연수막에서 기원한 혈관아세포종의 자기공명영상과 병리학적 소견에 대해서 기술하고자 한다. Hemangioblastoma is a benign tumor that most commonly occurs in the cerebellum and associated with von Hippel-Lindau (VHL) disease. Supratentorial hemanigoblastomas are exceptionally rare. We describe the magnetic resonance imaging (MRI) and histopathologic findings of a supratentorial leptomeningeal hemangioblastoma.
Jang, Yong Hyun,Hong, Nam-Soo,Moon, Sun Young,Eun, Dong Hyuk,Lee, Won Kee,Chi, Seong Geun,Kim, Jun Young,Lee, Weon Ju,Lee, Seok-Jong,Kim, Do Won S. Karger AG 2017 Dermatology Vol.233 No.2
<P>Background: In alopecia totalis (AT) and alopecia universalis (AU), the chance of full hair regrowth is known to be less than 10%. However, this information is based on a few older studies conducted in the 1950s and 1960s. Objective: We investigated the current long-term prognosis of individuals with AT/AU. Methods: A retrospective chart review was performed in patients with AT/AU between 1994 and 2005. Outcome data were collected by reviewing outpatient clinical files or by phone interviews. Finally, the long-term assessment of 70 patients with valid outcome data was performed. Results: Twelve out of 70 patients with AT/AU (17.1%) had complete hair regrowth. Five out of 24 patients with AT (20.8%) showed complete hair regrowth, and 7 of 46 patients with AU (15.2%) achieved complete regrowth. Seventeen out of 70 patients with AT/AU (24.2%) reported hair regrowth greater than or equal to 90%. Thirty patients with AU (65.2%) remained in an alopecic state without improvement, while 5 patients with AT (20.8%) showed no hair regrowth. Conclusion: Our results suggest that the long-term prognosis of AT/AU is more favorable than previously thought. However, the clinical burden of AT/AU is still substantial. (C) 2017 S. Karger AG, Basel</P>
Jang, Jae-Won,Lee, Jung-Kil,Hur, Hyuk,Seo, Bo-Ra,Lee, Jae-Hyun,Kim, Soo-Han Medknow Publications Pvt Ltd 2011 Surgical neurology international Vol.2 No.-
<P><B>Background:</B></P><P>Although the vertebral artery injuries (VAI) associated with cervical spine trauma are usually clinically occult, they may cause fatal ischemic damage to the brain stem and cerebellum.</P><P><B>Methods:</B></P><P>We performed a prospective study using computed tomographic angiography (CTA) to determine the frequency of VAI associated with cervical spine injuries and investigate the clinical and radiological characteristics. Between January 2005 and August 2007, 99 consecutive patients with cervical spine fractures and/or dislocations were prospectively evaluated for patency of the VA, using the CTA, at the time of injury.</P><P><B>Results:</B></P><P>Complete disruption of blood flow through the VA was demonstrated in seven patients with unilateral occlusion (7.1%). There were four men and three women with a mean age of 43 (range, 33-55 years). Unilateral occlusion of the right vertebral artery occurred in four patients and of the left in three. Regarding the cervical injury type, two cases were cervical burst fractures (C6 and C7), two had C4-5 fracture/dislocations, two had a unilateral transverse foraminal fracture, and one had dens type III fracture. All patients presented with good patency of the contralateral VA. None of the patients developed secondary neurological deterioration due to vertebrobasilar ischemia during the follow-up period with a mean duration of 23 months.</P><P><B>Conclusions:</B></P><P>VAI should be suspected in patients with cervical trauma that have cervical spine fractures and/or dislocations or transverse foramen fractures. CTA was useful as a rapid diagnostic method for ruling out VAI after cervical spine trauma.</P>