"Tinidazole"(Fasigyn)에 依한 Giardia Lamblia의 驅蟲效果

崔源永,李玉蘭,李元求,이규면,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

"Tinidazole a new antiflagellate drug, was given orally for 3-7 days to 99 children infected with G.lamblia. Stool examination for detection and evaluation of therapeutic on giardiasis were made by formaline-ether concentration techniques. The children were grouped according to doses and the duration of administration of the drug. The results were summarized as follows; 1) Except 1 case out of 99 children, none of the children showed G. lamblia in the stool examination 2 weeks after administration of the drug, regardless of groups. 2) 4 weeks after administration of the drug, group A (10 mg per kg for 7 days) and group B (5 mg per kg for 7 days) children showed 100% of negative conversion, but group C (10 mg per kg for 5 days) children revealed 84.6% of negatives. 3) 6 months later, the negative conversion rates in groups A, B and C were reduced to 54.5%, 57. 1% and 50. 0% respectively. 4) Mild or transient side effects-nausea, abdominal pain, headache or fever and diarrhea were noted in 16 cases (27. 1%) out of 59 cases.

사람 말초혈액 림프구에서 FudR에 의해 유도되는 Fragile Sites

박경란,신웅기,박성국,김원식 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

Chromosomal abnormalities including fragile sites induced by 10 ㎍/ml and 20 ㎍/ml fluorodeoxyuridine (FudR) were studied in lymphocytes cultures of six healthy individuals. A significant decrease in mitotic indexes in respect to control cultures was observed with two FudR concentrations used. The cells showing chromosome aberrations and the total number of cytogenetic alterations were significantly increased both FudR treated cultures with respect to control cultures. Damaged cells showing chromosome aberrations and total number of chromosomal aberrations were not significantly increased in FudR 20 ㎍/ml treated groups compared to FudR lO㎍/ml treated groups. The most frequent type of chromosomal aberration is a gap. A site showing a gap or break was defind as fragile if it appeated in 1% of cells analyzed and in at least three of six individuals studied with the same culture tre atment. Using these criteria, fragile sites 3p14, 6p25, 3q32, 1Oq22, 12q21 and 13q21 were induced in different proportions by different concentration of FudR.

외상성 골낭에 관한 연구

박원길,고재경,김영진,오경란 大韓口腔顎顔面放射線學會 1997 Imaging Science in Dentistry Vol.27 No.2

Traumatic bone cyst is a pathologic cavity that is not lined with epithelium. It is, therefore, not a true cyst. It may be a normal variant rather than a disease process. The etiology of the condition is unknown. This condition is occurred widely ranging ages(2 to 75years), however, most are found during the second decade of life. Radiographically, this condition is radiolucent lesion with well-defined outline, scalloping of superior margins. Cyst enucleation and curettage is the treatment of choice. The authors compared and analyzed the clinicoradiologic features of the five cases of traumatic bone cyst, diagnosed at the Dental college hospital in Chosun University, Kwangju, Korea., The five cases wear shown the followed results; 1. 3cases occurred in second decade of life & no significant sex differences (M:F, 2:3) All cases occurred in mandible. 2. Two patients complained symptoms, but three cases had no symptom with encountering during routine examination. 3. In 3 of 5cases, teeth vitality existed except one tooth and no checking of teeth vitality in two cases. 4. All cases didn't have any accurate trauma history, but one case was in orthodontic treatment, another case was postextraction site area. 5. Radiologically, "scalloping appearance" were evident in all cases; in 3 cases, multilocular tendency & only one case seen intact mandibular canal image. 6. Histologically, all section showed bone trabeculae with blastic activity, 2 cases showed no epithelial lining, and other 2 cases were seen innflammatory cell infiltration in edematous tissue. 7. Surgical intervention (curettage) was that treatment of choi

간질환환자의 말초임파구 염색체에서 Fragile Site의 의의

박경란,김수일,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

To understand chromosomal instability in hepatitis B virus related disease and significance of fragile sites in hepatoma, lymphocytes of peripheral blood from patients of hepatitis, liver cirrhosis and hepatoma were cultured. Fragile sites of chromosomes were counted by chromosome group and the results were as follows. 1. The frequencies of fragile sites were significantly increased in hepatitis, liver cirrhosis and hepatoma compared with control group. 2. The frequency of fragile sites by chromosome group were appeared in chromosome C, A, B and E group in turn on control group, chromosome C, A and B in turn on hepatitis and liver cirrhosis, and chromosome C, B and A in turn on hepatoma respectively. 3. The frequency of fragile sites was significantly increased in liver cirrhosis with HBsAg( + ) in comparison to HBsAg(-) liver cirrhosis. However no differences of frequency were founded in hepatoma by presence of HBsAg. 4. The common specific fragile sites of chromosome were appeared in chromosome 2q13, 5q34, 6p22 and 11q13, It is presumed that chromosomal instability by hepatitis B virus may induce hepatocellular carcinoma, and the common fragile sites found in chromosome 2q13, 5q34, 6p22 and 11q13 would be correlated with sites of oncogenes. However, more study needs to he done in correlation between fragile sites and oncogenes.

보육실습에 대한 보육시설장 및 보육교사와 예비보육교사의 인식 및 요구

최석란;신지연;서원경 서울여자대학교 2004 아동연구 Vol.10 No.-

[초록없음]

Methotrexate가 脾臟에 미치는 影響에 관한 硏究

朴景蘭,李永浩,金源式 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

In order to study the morphological changes of spleen after treatment with methotrexate, ICR mice were used as experimental animal. The experimental mice were divided into control, 50mg/kg and 500mg/kg of methotrexate treated groups. Methotrexate injected intravenously via tail vein once on the 8th day of pregancy. The mice were sacrificed on the 1st, 2nd 3rd and 4th day after treatment, the spleens were removed and fixed in 10% neutral buffered formalin solution for 48hrs. Spleens were cutted 5㎛ thick and stained with H-E, then observed under the light microscope. The results were as follows: 1. The size of spleen were reduced after MTX treatment more on dose day by day. 2. The periarterial lymphatic sheath (PALS) and germinal center were also reduced after MTX treatment. 3. The lymphocytes of white pulp showed nuclear pyknotic changes and many nuclear debris were found after MTX treatment. 4. The brown hemosiderin pigments were increased markedly in the red pulp of MTX treated groups. 5. Marked proliferation of fibrous trabeculae were found in the red pulp of MTX treated mice.

사람 말초혈액 림프구에서 Bromodeoxyuridine에 의해 유도되는 Fraglie Sites

박경란,김원식 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Chromosomal abnormalities including fragile sites induced by 50㎍/ml and 100㎍/ml bromodeoxyuridine (BrdU) was studied in lymphocytes cultures of six healthy individuals. A significant decrease in mitotic indexes in respect to control cultures was observed with both BrdU concentrations used. The cells showing chromosome aberrations and the total number of cytogenic alterations were significantly increased both BrdU treated cultures with respect to control cultures. Damaged cells showing chromosome aberrations and total number of chromosomal aberrations were increased in BrdU, 100㎍/ml treated groups compared to BrdU 50㎍/ml treated groups. The most frequent type of chromosomal aberration is a gap. A site showing a gap or break was defind as fragile if it appeared in 1% of cells analyzed and in at least three of six individuals studied with the same culture treatment. Using these criteria, fragile sites 4q31, 5q31, 6p22, 6q13, 9q21, and 15q24 were induced in different proportions by different concentration of BrdU.

皮膚自家移植후의 形態學的 變化에 관한 硏究

梁原模,李永浩,申台均,朴景蘭,金源式 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

The skin of abdominal wall homografted t the back of rats and observed the morphological changes of grafted tissues and mother tissues on the 1 day, 1 week & 2 weeks after operation. For light microscopic observation, the tissues were fixed within 10% neutral buffered formalin solution and stained with routine hematoxylin & eosin and alcian blue-safranin. The results were as follows; 1. The grafted abdominal skin were degenerated markedly on 1 day after operation but some cells near hair follicle remained alive. 2. In the grafted skin, the epidermis was formed newly at the upper part of muscle layer on 1 weeks after operation. 3. The epidermis of grafted skin was thicker than mother skin on 2 weeks after operation, and there were many small cells having long nucleus arranged vertically to the basal lamina. 4. Few mast cells were found in the lower portion of muscle layer on 1 day after graft operation, but the mast cells which contain heparin mainly increased in number gradually from 1 weeks to 2 weeks after operation.

숯을 이용한 건축재료 개발을 위한 기초적 연구

최원기,박혜란,서승직 대한건축학회 2004 대한건축학회논문집 Vol.20 No.3

In recent years, consmners have a growing interest in green building materials. Why do they use green bui1ding materials? The reasons why they use green building materials are those that earn hiP marks for resource management, impact on indoor environmental quality(IEQ) and performance(energy efficiency and water efficiency, etc). The purpose of this paper is to develop the High Functional Multi-Purpose Green Panel(hereafter referred to as Hi-FMPGP) using the charcoal having the characteristics of porous, absorbent and. moisture control effect In this paper, experimental studies have been performed through the four different models according to the charcoal content. As a result, this experiment shows that the model No.3 with lots of charcoal content is better than reference model without the charcoal content to the all performance. Consequently, we verified that the new Hi-FMPGP has the advantage to previously predicted performances, namely, water content ratio, surface evaporation rate, surface temperature, time lag effect and emissivity. Therefore, Hi-FMPGP is quite within the realms of possibility as a green building material. Finally, additional studies should be performed on the basis of these experimental results for complete green building materials.

Pulmonary Aspergilloma : 1 수술 치험례 A Case

신원창,손광현,홍성란 인제대학교 1985 仁濟醫學 Vol.6 No.4

심한 객혈을 동반한 우측 상엽부의 mycetoma 병조를 절제한 후 임상 경과 완쾌되었다. 병리조직학적 검사상 Aspergilloma의 균사 및 아포로 구성된 fungus ball이 증명되었다. Pulmonary aspergilloma with massive hemoptysis is an occasionally fatal condition. A 43 year old house wife has had a severe recurrent hemoptysis for about 3 months. She received various medical treatment including anti-tuberculous measures without improvement. Roentgenographic findings were multicystic and soft patchy appearance at the posterior segment of the right upper lobe by A-P and lateral tomogram and also in computed tomogram. Pre-operatively fungus in the sputum culture was identified at the laboratory. Choice of surgical excision of the involved lobe was decided. Specimen showed beautiful fungus ball in the cavity and bronchiectasis of the communicated bronchi. Pathologic examination showed beautiful aspergillus fumigatus involving the lung parenchyma. Post-operatively hemoptysis was disappeared and 6th months follow up showed good recovery, For the reasons of the complex clinical pictures of the patient, authers report the case with a literature reviews.