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- 저자 : Won Kyu-Yeoun (검색결과 41 건)
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Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer
Won, Kyu Yeoun,Kim, Gou Young,Kim, Youn Wha,Song, Jeong Yoon,Lim, Sung-Jig Elsevier 2010 Human pathology Vol.41 No.1
<P><B>Summary</B></P><P>The human <I>beclin-1</I> gene, located on chromosome 17q21, has been identified as the mammalian orthologue of Atg6 (autophagy-related gene) and may be a haploinsufficient tumor suppressor gene. The function and expression of beclin-1 in human breast cancer are largely unknown. We investigated the expression of beclin-1 and bcl-2 in human breast cancer. Tissue samples from 125 cases of invasive breast cancer were used for the present study. Immunohistochemical staining for beclin-1 and bcl-2 was evaluated using tissue microarray, then the 2 proteins were correlated with clinicopathologic parameters. Positive beclin-1 expression and bcl-2 expression in breast cancer tissue were observed in 53 cases (42.4%) and 48 cases (38.4%), respectively. Beclin-1 expression was inversely correlated with bcl-2 expression in breast cancer tissue (<I>P</I> = .035). Beclin-1 expression significantly correlated with nuclear pleomorphism and mitotic count. Bcl-2 expression in breast cancer tissue significantly correlated with histologic grade, tubule formation, nuclear pleomorphism, mitotic count, estrogen receptor, and distant metastasis. Our results suggest that beclin-1 might play a role in the inhibition of the development of breast cancer and that inhibition might be due to an interaction with bcl-2 protein.</P>
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Satellite Image Processing Software for Value-Added Products
Hae Yeoun Lee,Won Kyu Park,Seung Bum Kim,Tae Jung Kim,Dong Seok Shin,Heung Kyu Lee 大韓遠隔探査學會 1999 大韓遠隔探査學會誌 Vol.15 No.4
To extract value-added products which are important in scientific area and practical life, e.g. digital elevation models, ortho-rectified images and geometric corrected images, Satellite Technology Research Center at Korea Advanced Institute of Science and Technology has developed a satellite image processing software called "Valadd-Pro". In this paper, "Valadd-Pro" software is briefly introduced and its main components such as precise geometric correction, ortho-rectification and digital elevation model extraction component are described. The performance of "Valadd-Pro" software was assessed on 10m resolution 6000×6000 SPOT panchromatic images (60km×60km) using ground control points from GPS measurements. The height accuracy was measured by comparing our results with 100m resolution DTEDs produced by USGS and 60m resolution DEMs generated from digitized contours produced by National Geography Institute. Also, to show the superior performance of "Valadd-Pro" software, we compared the performance with that of commonly used PCI(R) commercial software. Based on the results, the geometric correction of "Valadd-Pro" software needs fewer ground control points than that of PCI(R) software and the ortho-rectification of "Valadd-Pro" software shows similar performance to that of PCI(R) software. In the digital elevation model extraction, "Valadd-Pro" software is two times more accurate and four times faster than PCI(R) software.
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AUTOMATIC ROAD EXTRACTION FROM 1M-RESOLUTION SATELLITE IMAGES
Lee, Hae Yeoun,Park, Won Kyu,Lee, Heung Kyu 대한원격탐사학회 2000 International Symposium on Remote Sensing Vol.16 No.1
This paper addresses the extraction of roads from 1m-resolution satellite images. Among v~u-ious applications of satellite images, it is important to extract roads for Geographic Information System and urban planning, ete. Many approaches have been studied for airborne and low-resolution satellite images. However, these methods cannot be directly applied to high-resolution satellite images mainly because images contain more noises and roads are not line but regions. In this paper, we propose a region-based strategy for the extraction of roads from 1m-resolution satellite images. Firstly, by using an intensity-based segmentation scheme, regions representing road primitives are efficiently segmented. Secondly, road candidates are selected by region adjacency graph based an a prior knowledge about roads. Then, by comparing the profiles of road candidates with its adjacent profiles, roads can be expanded from road candidates. Using this strategy, we can currently extract most of roads identifiable by human in 1 m-resolution IKONOS satellite images.
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Clinical course of vestibular schwannoma in pediatric neurofibromatosis Type 2
Choi, Jung Won,Lee, Ji Yeoun,Phi, Ji Hoon,Wang, Kyu-Chang,Chung, Hyun-Tai,Paek, Sun Ha,Kim, Dong Gyu,Park, Sung-Hye,Kim, Seung-Ki Journal of Neurosurgery Publishing Group 2014 Journal of Neurosurgery: Pediatrics Vol.13 No.6
<B>Object</B><P>Neurofibromatosis Type 2 (NF2) is an autosomal-dominant inherited disease, characterized by multiple neoplasia syndromes, including meningioma, schwannoma, glioma, and ependymoma. In this report, the authors present their clinical experience with pediatric NF2 patients. In particular, they focused on the clinical course of vestibular schwannoma (VS), including the natural growth rate, tumor control, and functional hearing outcomes.</P><B>Methods</B><P>From May 1988 to June 2012, the authors recruited patients who were younger than 18 years and fulfilled the Manchester criteria. In total, 25 patients were enrolled in this study. The authors analyzed the clinical course of these patients. In addition, they measured the natural growth rate of VS before any treatment in these children with NF2. Then, they evaluated the tumor control rate and functional hearing outcomes after the treatment of VS.</P><B>Results</B><P>The mean age at the onset of NF2-related symptoms was 9.9 ± 4.5 years (mean ± SD, range 1-17 years). The mean age at the diagnosis of NF2 was 12.9 ± 2.9 years (range 5-17 years). The mean follow-up period was 89.3 months (range 12-311 months). As initial manifestations, nonvestibular symptoms were frequently observed in pediatric patients with NF2. The mean natural growth rate of VS was 0.33 ± 0.41 cm<SUP>3</SUP>/year (range 0-1.35 cm<SUP>3</SUP>/year). The tumor control rate of VS was 35.3% at 3 years after Gamma Knife surgery (GKS). The actuarial rate of useful hearing preservation was 67% in the 1st year and 53% in the 5th year after GKS.</P><B>Conclusions</B><P>Clinical manifestations in children with NF2 were highly variable, compared with their adult counterparts. The natural growth rate of VS in children is slow, and this oncological feature may explain the diverse clinical manifestations besides vestibular symptoms in children with NF2. The treatment outcome of GKS for VS in children with NF2 was not favorable compared with previous reports of affected adults.</P>
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Satellite Image Processing Software for Value-Added Products
Lee, Hae-Yeoun,Park, Won-Kyu,Kim, Seung-Bum,Kim, Tae-Jung,Yoon, Tae-Hun,Shin, Dong-Seok,Lee, Heung-Kyu The Korean Society of Remote Sensing 1999 大韓遠隔探査學會誌 Vol.15 No.4
To extract value-added products which are important in scientific area and practical life, e.g. digital elevation models, ortho-rectified images and geometric corrected images, Satellite Technology Research Center at Korea Advanced Institute of Science and Technology has developed a satellite image processing software called "Valadd-Pro". In this paper, "Valadd-Pro" software is briefly introduced and its main components such as precise geometric correction, ortho-rectification and digital elevation model extraction component are described. The performance of "Valadd-Pro" software was assessed on 10m resolution 6000 $\times$ 6000 SPOT panchromatic images (60km $\times$ 60km) using ground control points from GPS measurements. The height accuracy was measured by comparing our results with 100m resolution $DTEDs^{1)}$ produced by USGS and 60m resolution DEMs generated from digitized contours produced by National Geography Institute. Also, to show the superior performance of "Valadd-Pro" software, we compared the performance with that of commonly used PCI$\circledR$ commercial software. Based on the results, the geometric correction of "Valadd-Pro" software needs fewer ground control points than that of PCI$\circledR$ software and the ortho-rectification of "Valadd-Pro" software shows similar performance to that of PCI$\circledR$ software. In the digital elevation model extraction, "Valadd-Pro" software is two times more accurate and four times faster than PCI$\circledR$ software.ccurate and four times faster than PCI$\circledR$ software.
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Delayed posterior circulation insufficiency in pediatric moyamoya disease.
Lee, Ji Yeoun,Choi, Young-Hun,Cheon, Jung-Eun,Paeng, Jin Chul,Ryu, Hye Won,Kim, Ki Joong,Phi, Ji Hoon,Wang, Kyu-Chang,Cho, Byung-Kyu,Chae, Jong-Hee,Kim, Seung-Ki Springer-Verlag [etc.] 2014 Journal of neurology: Zeitschrift für Neurolo Vol.261 No.12
<P>Approximately 30% of patients with moyamoya disease (MMD) have presented with involvement of the posterior circulation, mainly the posterior cerebral artery (PCA). Diagnosis of delayed progression of PCA stenosis in MMD may be difficult due to the diversity in clinical features. The goal of this study was to evaluate pediatric MMD patients with delayed PCA involvement after completion of revascularization of the anterior circulation. Forty-one pediatric MMD patients who underwent revascularization of the PCA territory due to delayed posterior circulation insufficiency MMD from 2006 to 2011 were retrospectively reviewed. The average interval between the initial operation and the occipital artery (OA) procedure was 5.0 years. Common symptoms were headaches and transient visual symptoms. The decision to operate was made based on a combination of diagnostic tools. The results obtained with perfusion MRI, SPECT, MR angiography, and EEG supported posterior circulation insufficiency in 78, 41, 73, and 71% of patients, respectively. Encephaloduroarteriosynangiosis (EDAS) using the OA was performed in 15 patients, and 26 patients received multiple burr hole trephination of the occipital area. All patients showed clinical improvement. Clinicians should be aware of the possibility of delayed involvement of the PCA in pediatric MMD patients. The clinical decision regarding treatment should be based on a combination of symptomatology and the results obtained with various tools to assess whether the blood flow in the PCA territory is insufficient. Surgical treatment using indirect revascularization appears to be effective for patients with delayed PCA involvement.</P>
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Choi, Jung Won,Son, Sung Min,Mook-Jung, Inhee,Moon, Youn Joo,Lee, Ji Yeoun,Wang, Kyu-Chang,Kang, Hyun-Seung,Phi, Ji Hoon,Choi, Seung Ah,Chong, Sangjoon,Byun, Jayoung,Kim, Seung-Ki Journal of Neurosurgery Publishing Group 2018 Journal of neurosurgery Vol.129 No.5
<B>OBJECTIVE</B><P>Moyamoya disease (MMD) is a unique cerebrovascular disorder characterized by the progressive occlusion of the bilateral internal carotid arteries. Endothelial colony-forming cells (ECFCs), previously termed “endothelial progenitor cells,” play an important role in the pathogenesis of MMD. In this study, the authors performed morphological and functional studies of the mitochondria of ECFCs from patients with MMD to present new insights into the pathogenesis of the disease.</P><B>METHODS</B><P>The morphology of ECFCs from 5 MMD patients and 5 healthy controls was examined under both a transmission electron microscope and a confocal laser scanning microscope. The oxygen consumption rates (OCRs), mitochondrial membrane potentials (MMPs), intracellular Ca<SUP>2+</SUP> concentrations, mitochondrial enzyme activities, and reactive oxygen species (ROS) levels were measured. Functional activity of the ECFCs was evaluated using a capillary tube formation assay.</P><B>RESULTS</B><P>The ECFCs from the MMD patients displayed a disrupted mitochondrial morphology, including a shorter and more circular shape. The ECFC mitochondria from the MMD patients exhibited functional abnormalities, which were assessed as a decreased OCR and an increased intracellular Ca<SUP>2+</SUP> concentration. Moreover, the ECFCs from MMD patients showed increased ROS levels. Interestingly, treatment with an ROS scavenger not only reversed the mitochondrial abnormalities but also restored the angiogenic activity of the ECFCs from the MMD patients.</P><B>CONCLUSIONS</B><P>The mitochondria of ECFCs from MMD patients, as compared with those from healthy patients, exhibited morphological and functional abnormalities. This finding suggests that the mitochondrial abnormalities may have a role in the pathogenesis of MMD.</P>
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