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消癌散의 경구투여에 의한 마우스 B16 흑색종 세포의 폐전이에 대한 항전이 효과
주성민,양휘훈,우원홍,정우열,조원준,이기영,전병훈,김원신 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6
We have examined the inhibitory effect of oral administration of Soamsan, a Korean traditional medicine, on lung metastasis by inoculation of mouse B16 melanoma cells into the tail vein. Oral administration of Soamsan for 20 days after tumor inoculation resulted in dose-dependent inhibition of lung metastasis. Soamsan at the dose of 40 mg/day/mouse for 20 days significantly inhibited the metastasis. Treatment with Soamsan (40 mg/days/mouse) for 7 days before and after tumor inoculation result in significant inhibition of lung metastasis. On the other hand, in the case of treatment with Soamsan for 7 days after 7 days from tumor inoculation, the inhibitory effect was not detected. Soamsan significantly inhibited the lung metastasis of B16 melanoma cells in mice pretreated with anti-mouse NK 1.1 monoclonal antibody and untreated nomal mice, whereas it did not inhibit efficiently metastasis in 2-chloroadenosine-pretreated mice. Also, Soamsan enhanced the antigen specific immune response by stimulating the activation of B lymphocytes (Kim et al., 2001). These results suggest that oral administration of Soamsan inhibited lung metastasis of B16 melanoma cells, possibly through a mechanism mediated by the activation of marcrophages and B lymphocytes in the host immune system.
Won, Jun Hui,Oh, Ye Jun,Lee, Ju,Ahn, Han Woong,Lee, Hyung Woo,Cho, Yonho Institute of Electrical and Electronics Engineers 2018 IEEE transactions on applied superconductivity Vol.28 No.3
<P>This paper proposes an algorithm to obtain better results in the integrated control by reflecting the characteristics of the individual control of the front wheel and the rear wheel of tram systems. In the case of the surface transportation, which has recently been introduced, severely curved driving performance is required for the downtown. It is possible to decrease the curve radius and to improve the performance of the straight driving with the individual torque control. Therefore, the individual torque control performance of the motor is the most important point of the surface transportation. The front and rear wheels have different torque characteristics, and the length of the bogie during curve travel also affects these results. This system is more controllable than the system with 1Controller 4Motor (1C4M) in the form of 2C4M with the front and rear wheels being individually controlled, allowing more precise control because of its higher degree of freedom. Because of this individually controlled characteristic, it is possible to control more precisely in the integrated control considering the characteristics of the front wheel and the characteristics of the rear wheel. The validity of the proposed control algorithm is verified by experimental results using a small-scale bogie system.</P>
A case of lupus panniculitis triggered by human papillomavirus quadrivalent vaccine injection
( Ju Yeon Choi ),( Jung Yup Kim ),( Sun Min Lim ),( Jae Yun Lim ),( Han Saem Kim ),( Jung In Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Won Serk Kim ),( Ga Young Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Lupus panniculitis usually manifests deep nodules and plaques involving the skin of trunk and proximal extremities, such as the lateral aspects of the upper arms, thighs, and buttocks. Hereditary character and sunlight are well-known predisposing factors. Rarely, lupus panniculitis was exacerbated following anti-hepatitis B vaccination and a lupus profundus like nodule at the site of numerous vaccinations was reported. Also, lupus erythematosus is probably related to trauma induced process, even though the correlation is poor or questionable. We report a case of a 25-year-old woman presenting erythematous patches on the both upper arms and left buttock. She recognized a palpable nodule on an erythematous base on the left upper arm occurred exactly at the site of the first human papillomavirus (HPV) quadrivalent vaccine injection (Gardasil^{®}). Thirty two months later, erythematous to brownish patches were observed on the right upper arm into which the third HPV vaccine was injected and the left buttock. Serum analysis revealed the presence of antinuclear autoantibodies of 1/640. The histologic examination of three cutaneous lesions showed lymphocytic infiltration in the fat lobules and perivascular area, a lymphoid follicle, and loose edematous stroma around fatty lobules consistent with lupus panniculitis. Herein, we report a rare case of lupus panniculitis triggered by HPV vaccination.
A case of symmetric lipomatosis of the tongue
( Ju Yeon Choi ),( Jung Yup Kim ),( Sun Min Lim ),( Jae Yun Lim ),( Han Saem Kim ),( Jung In Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Symmetric lipomatosis of the tongue (SLT) characterizes the symmetric and nonencapsulated lipomas infiltrating muscle fibers. It is an extremely rare condition and considered as different disease from multiple symmetric lipomatosis in affected age, body region, and ethnic group and in the relevance to alcoholism. We report a case of a 56-year-old man presenting multiple symmetric yellowish nodules on both lateral borders of the tongue. There was no pain or discomfort on the tongue. He was a chronic alcoholic and afflicted with pellagra, hypertension, diabetes, and anemia. The histologic examination of the lesion showed mature adipose tissue infiltrating lingual muscles consistent with SLE. He did not want the surgical resection of the lesions. Therefore, lipomas were treated by four times of intralesional injection of triamcinolone (8mg/cc). However, there was no significant change in the size of the lipomas. Herein, we report a rare case of SLT comorbid with pellagra.
( Ju-yeon Choi ),( Jung Yup Kim ),( Sunmin Lim ),( Jae Yun Lim ),( Han-saem Kim ),( Jung-in Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: In recent years, a novel picosecond Nd:YAG laser is gradually used in treatment of benign pigmentary lesions. Objectives: The purpose of this study is to identify the clinical efficacy and safety of picosecond Nd:YAG laser in treating skin pigmentary disorders in Koreans. Methods: A retrospective photographic and chart review of patients treated with 532-nm or 1,064-nm picosecond laser was performed. Clinical improvement was assessed by two blinded physicians using 5-point global assessment scale (GAS). Results: Within 8-months, total 48 patients with Fitzpatrick skin types II-V, 79.2% women, mean age 31.8±21.2 years, were included. The pigmentary disorders consist of nevus of Ota (20.8%), melasma (18.8%), lentigines (16.7%), postinflammatory hyperpigmentation (PIH), cafe-au-lait macules (CALM, 10.4%), freckles (6.3%), congenital melanocytic nevus, melanonychia (4.3%), blue nevus, nevus spilus, Becker’s nevus, and argyria (2.1%). Patients with CALM showed the best improvement (GAS 3.8±0.76). In contrast, a patient with blue nevus showed the least improvement, which was worse than before. The highest number of treatment sessions was observed in patients with PIH (6.6±3.4 times). Duration of follow-up was the longest in patients with nevus of Ota (22.5±5.4 weeks). There was no persistent complication after treatment. Conclusion: The picosecond Nd:YAG laser is effective and safe modality for treating benign pigmentary disorders.
Ju, Yanghua,Choi, Seung-Jun,Lee, Hui-Su,Kim, Hyun-Sook,Won, Sul-Mui,Chun, Yoon-Hong,Yoon, Jong-Seo,Kim, Hyun-Hee,Lee, Joon-Sung The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.11
Purpose: Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question. Methods: We prepared Dermatophagoides farinae-sensitized mice as an asthma model, and then infected them with RSV and analyzed the changes in airway responsiveness and the cell populations and cytokine levels of bronchoalveolar lavage fluid. Results: RANTES synthesis increased in response to RSV infection in both control mice and in asthma model (D. farinae) mice. However, there was no significant difference in the amount of RANTES produced following RSV infection between control and D. farinae mice. RSV infection affected neither interferon-${\gamma}$ synthesis nor airway responsiveness in either control or D. farinae mice. Conclusion: RSV infection did not induce more RANTES in a murine model of asthma than in control mice.
A case of granular cell tumor on the tongue
( Ju Yeon Choi ),( Jae Yun Lim ),( Han Saem Kim ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Ho Joo Jung ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Granular cell tumors (GCTs) are rare and mostly benign neoplasms. They are commonly seen in the skin, tongue, breasts, and larynx. Histogenesis of GCT is uncertain, but they are reported to be neural crest origin. A 65-year-old woman presented with an asymptomatic and well-demarcated skin-colored mass on tongue. About 10 years ago, the mass developed and has gradually grown. Physical examination showed the presence of a non-tender, firm, 1 X 1cm sized dome shaped nodule. Histopathologic examination revealed an ill-defined dermal nodule composed of large cells with abundant eosinophilic granular cytoplasm. The overlying squamous epithelium showedpseudoepitheliomatous hyperplasia. Immunohistochemical stain revealed positivity for S-100 protein. Based on these findings, we diagnosed this neoplasm as GCT on the tongue.
A case of osteochondroma masquerading as viral wart
( Ju Yeon Choi ),( Jae Yun ),( Lim ),( Han Saem Kim ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Ho Joo Jung ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Osteochondroma is one of the most common benign bone tumors. It is easy for dermatologists to misdiagnose osteochondroma on the fingers or toes as other cutaneous tumors including pilomatricoma, epidermal cyst, and glomus tumor. We report a case of a 42-year-old woman presenting with a palpable mass on the left thumb. Skin biopsy was performed in the other hospital a year ago and she heard the result as a viral wart. In our hospital, the tumor was checked by X-ray, which showed a calcified nodule on the distal phalanx. Bizarre parosteal osteochondromatosis proliferation was suspected on MRI but bony connection between a bony spur and the distal phalanx was obscure. We additionally performed a computed tomography, which revealed a 5mm-sized bony spur connected with cortical bone. Specimen after orthopedic surgery showed fibrous tissue and cartilage cap composed of hyaline cartilage. Based on these findings, we concluded her tumor is an osteochondroma masquerading as viral wart.
A Study on the Control Method of Lateral Displacement and Yaw Angle in Curved Driving of IRWs System
Won, Jun Hui,Oh, YeJun,Lee, Ju,Ahn, Han Woong,Lee, Hyung Woo,Cho, Yonho Institute of Electrical and Electronics Engineers 2018 IEEE transactions on applied superconductivity Vol.28 No.3
<P>This paper proposes an optimal control algorithm through lateral displacement and yaw angle in curved road of shallow-depth subway systems. In the case of the surface transportation, which has recently been introduced, curved driving performance is required for the downtown. The existing research works are the main research theme of the lateral displacement restoration control, but there is a limit to smooth operation when the curve is run only by receiving the lateral information. However, when the yaw angle displacement information is obtained, it is possible to consider the turning angle of the vehicle while the vehicle is driving in a curved road. However, it is difficult to control because the change of yaw angle is more sensitive than lateral drift. Therefore, this paper suggests an algorithm that uses yaw angle displacement control. The validity and usefulness of the proposed control algorithm is verified by experimental results using a small-scale bogie system.</P>
The Korean Social Life, Health and Aging Project-Health Examination Cohort
Ju-Mi Lee,Won Joon Lee,Hyeon Chang Kim,Wungrak Choi,Jina Lee,Kiho Sung,Sang Hui Chu,Yeong-Ran Park,Yoosik Youm 한국역학회 2014 Epidemiology and Health Vol.36 No.-
The Korean Social Life, Health, and Aging Project (KSHAP) is a population-based longitudinal study of health determinants among elderly Koreans. The target population of the KSHAP are people aged 60 years or older and their spouses living in a rural community of Korea. A complete enumeration survey was conducted in the first wave of the KSHAP on 94.7% (814 of 860) of the target population between December 2011 and July 2012. The KSHAP-Health Examination (KSHAP-HE) cohort consists of 698 people who completed additional health examinations at a public health center (n=533) or at their home (n=165). Face-to-face questionnaires were used to interview participants on their demographics, social network characteristics, medical history, health behaviors, cognitive function, and depression symptoms. Health center examinations included anthropometric measures, body impedance analysis, resting blood pressure measurement, radial artery tonometry, bone densitometry, the timed up-and-go test, and fasting blood analysis. However, only anthropometric measures, blood pressure measurement, and non-fasting blood analysis were available for home health examinations. Collaboration is encouraged and access to the KSHAP baseline data will be available via the website of the Korean Social Science Data Archive (http://www.kossda.or.kr).